CorDynamics adds a powerful capability to its leading suite of

pulmonary arterial hypertension models – the ability to record

pulmonary artery pressures in the rat

Multiple options

1) single pressure OR dual pressure

- for differential effects on both arterial beds

2) increased frequency of pulmonary artery pressure readings

- characterize development of PAH

- critical to test efficacy in prevention AND reversal mode

- design studies with more efficiency

Telemetry pressure catheter was placed into pulmonary artery via

right ventricle

- animals were allowed to recover, administered SU5416, then placed

in low oxygen environment

- low technical failure rate

Clinical observations consistent with development of strong

pulmonary hypertension

- At Day 42, 438% increase in pulmonary artery pressure vs. baseline

- at Day 42, animals euthanized and robust RV hypertrophy confirmed

- mean RV/LV+S ratio was .624 ± .079; normal = ~ .300

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Telemetered Hemodynamic Evaluation of Vehicle Administration in the Rat Pulmonary Arterial Hypertension Model Induced with Semaxanib (Day 1) and a Low

Oxygen Environment - Systolic Pulmonary Artery Pressure

Vehicle

Days of Hypoxia