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No
ReÁreCo TítPlu
ReOvdrcoopin Mstzeco Th Ai Aige Ai Wsomdisuimgerehudifre Socade
ReI bPoHo InRebatim
MDY
ombre:
ferencia: ea Científicaorreo Electró
tulo: uripotent Stem
sumen de laverall my researiving pluripoteonverted towarpportunity to dduced pluripot
y work has covudy of tissue debrafish) and tiomprehension o
he aims of my c
m 1: To identify
m 2: To generaenetic diseases
m 3: To genera
Whereas I underomatic cell typeajor unmet meseases are a murvive with dialymmunosuppressenerated for thelated to kidneyuman iPSCs (hfferentiate patiesearch has exte
ome of the objeall of ERC Startieveloping new s
sumen del Cbecame interesostdoctoral felloospital of Santa
2008 I movedegenerative Meanking of new ime (Nature Pro
MINISTERIO
E ECONOMÍACOMPETITIV
MONTSERYC‐2014
a: Biomedicnico: nmo
m Cells for Regen
a Memoria: arch career haency, cell differrds cells with iddevelop novel sent stem cells (
vered the genedifferentiation. ssue homeostaof mammalian o
current research
y the molecula
ate and correct
ate protocols fo
rstand that the e, I firmly belieedical need. I hamajor public heysis or transplasive regimen ehe first time a my developmentiPSCs) from paient derived hiPensive experien
ectives of my cng Grant from strategies in Re
Currículum Vsted in organ reowship from tha Creu i Sant Pa
d to the Centeredicine of Barcinduced pluripootocols, 2010).
A VIDAD
ERRAT PULI4‐16242 cina ontserrat@ib
nerative Medic
s been focusedrentiation and entical propertstrategies for n(iPS).
eration of patieI have also coasis regulation organ regenera
h line are as fol
r and cellular m
patient‐specifi
or renal differen
results obtaineeve that providave chosen thisealth problem iantation, theseemployed on thmodel of kidnet and regeneratatients with gPSCs towards rence and resourc
current researc2014, revealinegenerative Me
Vitae: egeneration anhe Fundaçao pau in Barcelona.
r of Regeneratelona (CMRB), otent stem cellBased on my
AYUDASCONVO
Turno d
IDO, NURIA
becbarcelona
ine
d in stem cellsorgan regenerties of human enuclear somatic
nt derived iPS ombined my badeveloped duration.
lows:
mechanisms pro
ic transgene‐an
ntiation for the
ed during the coing this informs research topicin Europe and procedures arhe patient. Furey regenerationtion. Third, othenetic based denal cells (ureteces allowing me
h line have beeg the interest oedicine and Biom
d stem cells duara a Ciência e
ive Medicine oas research as(iPSC) lines. Inprevious know
S RAMÓN YOCATORIA
de acceso g
A
a.eu
s biology and iration. The discembryonic stemc reprogrammi
cells for the prackground in oring my pre‐do
omoting kidney
nd feeder‐free i
establishment
ourse of my resmation will openc for a number worldwide, an
re expensive, drthermore, then in mice, offerhers and I havedisorders. Foueric bud progene to tackle thes
en selected forof the scientificmedicine discip
uring my masteTecnología (Po
of Barcelona (Cssociate. Theren 2010 I first cowledge on stem
Y CAJAL A 2014
general
n the identificacovery in 2006m cells, offered ng and disease
roduction of in rgan regeneratoctoral studies
y regeneration i
induced pluripo
of kidney disea
search line cannn new venues of reasons. Firsnd although paemanding and re is a shortagring an unprecee reported metrth, I have conitors). Fifth, thse major questio
r funding from c community foplines.
er and PhD traiortugal). In 2007
CMRB), as rese, I participatedo‐authored howm cells and tiss
SDD
SDE
DDC
SDP
ation of the m6 that any somme during the e modelling by
vitro platformstion in differenfor the genera
n a model of ki
otent stem cells
ase models
not be generalifor the developst, the high incitients with Endcan be prone tge of organs foedented opporthodologies for‐authored for he institution wons.
the European or this type of m
ning that finish7 I was hired as
arch associateI in developing
w to reprogram ue developme
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
molecular and cmatic cell type olast eight yearthe generation
s for compoundnt animal modeation of massiv
idney regenera
s (iPSCs) from p
ized to the genepment of theraidence and pood Stage Renal to life‐long sideor transplantatrtunity to addrer the generatiothe first time
where I am curre
Research Counmultidisciplinar
hed in 2006. Ths a post‐doctor
In 2008 I move strategies for cord blood stent I reasoned
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
cellular mechanof our body cas an unpreceden of patient sp
d screening andels (teleost fishve strategies fo
tion in mamma
patients with ki
eration of any oapeutics targetor prognosis of Disease (ESRDe effects due toion. Second, I ess major queson of transgenee, the possibilitently conductin
ncil (ERC) withinry approaches w
he same year I ral researcher a
ed to the Centthe generationem cells for thethat iPSCs cou
nisms an be ented ecific
d the h and or the
als
idney
other ting a renal ) can o the have stions e‐free ty to ng my
n the when
got a at the
ter of n and e first ld be
obtealsrecogeMin Naofpu TaorbestheIn
MDY
btained by meast whether derso found, for teplaced by GATollaborated in oerm cells, neuraethods 2012, Nthe generationature Communf kidney organurposes [Nature
aking advantagerder to understeen selected foudies have ideeart can be reastitute for Bioe
MINISTERIO
E ECONOMÍACOMPETITIV
ans of safe stratrmal fibroblast he first time, tTA3. The work other projects aal cells, endothNature Commun of platforms fication 2014). Moids, suitable e Cell Biology (2
e of my experttand how to actor funding fromntified, for theactivated and eengineering of C
A VIDAD
tegies using specould be reproghat OCT4, the resulted in a
aimed to characelial cells, retinnications 2013,for the study ofMoreover, my for the study 2013)].
tise in the fieldtivate endogen
m the Europeane first time, howelicit heart regeCatalonia (IBEC)
AYUDASCONVO
Turno d
ecific transcriptgrammed to plonly transcripthigh‐impact pucterize the genonal cells or bloo, Protein and Cef disease progreinterest on orgof iPSCs differ
ds of somatic reous programs Research Counw the reactivateneration [Cell ).
S RAMÓN YOCATORIA
de acceso g
tion factors deturipotency. Notion factor belieublication in Comic integrity ood cells. These sell 2013, Naturession and comgan regeneratiorentiation tow
eprogramming in order to regncil (ERC) withition of endogeStem Cell, in p
Y CAJAL A 2014
general
erminant for linot only I succeedeved to be indell Stem Cell (of human iPSCsstudies were pue Communicatmpound screenion provide newards renal line
and organ regenerate the adin the call of ERenous regenerapress 2014]. Fro
SDD
SDE
DDC
SDP
neage specificaded at demonstispensable for 2013), in whers as well as in thublished in Stemion 2014. In theing for therapy knowledge foreages and com
generation I amult mammalianRC Starting Grative programs om January 201
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
ation. With this trating that thissomatic reprogre I am the firhe differentiatim Cells 2011, Ne same mannery by means of hr the generatiompound screen
m developing a n kidney. Indeeant from 2014. that are dorm15 I am junior
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
in mind, I set os was the case,gramming, courst co‐author. Ion of iPSCs towNature 2012, Nar I have participiPSCs (Nature 2n, for the first ing for therap
massive strateed this approachWithin this linant in adult mgroup leader a
out to but I ld be I also wards ature pated 2012, time, peutic
egy in h has e my urine at the
No
ReÁreCo TítSte
ReIn ‐ cecestean ‐ so1 ‐ difusthfibtrapu ‐ corelinretrehusppu OviN
ReCUJu ED‐1 ‐2 RE‐JuFu ‐S
MDY
ombre:
ferencia: ea Científicaorreo Electró
tulo: em cells and re
sumen de lathe last 10‐yea
Embryoell types. The fiells are more simem cells cannond 1 in Cell.
Inducedource of cells foNature Commu
Direct fferentiation prsing a specific ce reprogrammbroblasts into iansplantation. ublished in this
Spermaonditions withoestore spermatones have not beenewal in vitroeatments compuman SSC lines permatogenesisublications have
verall, my reseNSCs) or male fe
sumen del CURRENT POSITOne 2014,
DUCATION: 999, Degree in
005, Ph.D. in Im
ESEARCH EXPERune 2014, Indeunded by the N
ep 2009‐May 2
MINISTERIO
E ECONOMÍACOMPETITIV
TAPIA , NRYC‐2014
a: Biomedicnico: nata
egenerative me
a Memoria: ars, I have been
onic and epiblainal goal was tomilar to mouseot be fully extra
d pluripotent sor patient‐speciunications.
reprogrammingrotocols for all combination ofming efficiency induced neuralMy group is ntopic, including
atogonial stem out any geneticogenesis after een identified y. Establishing apromise the fe could be derivs. In addition, he been publishe
arch is focusedertility disorder
Currículum VON:
Independen
Pharmacy (equ
mmunology, Un
RIENCE: pendent Grouporth‐Rhine We
2014, Pr
A VIDAD
NATALIA 4‐16359 cina apse@hotma
dicine
n working on 4
st stem cells. I o ascertain thee epiblast stem apolated to the
stem cells (iPS)fic cell‐replacem
g into somatic cell types are sf transcription fis very low andl stem cells (iNow trying to reg 2 Cell Stem Ce
cell (SSC) linesc manipulationtesticular transyet. One of mya human SSC lertility of pre‐pved prior to thehuman SSC linesed in this topic,
d on stem cell s (e.g. SSCs), th
Vitae:
t Group Leader
uivalent to Grad
niversitat Auton
p Leader, Heinristphalia Minist
roject Group Le
AYUDASCONVO
Turno d
ail.com
main topics rela
have assessed teir similarity to cells than to mhuman model
). I have investment therapy. 7
cells. iPS needstill not availablfactors. Howevd neurons do nNSCs) that can eprogram iNSCell and 1 Nature
s can be stablyn, thus represesplantation intoy main researchine will have mubertal patiente anticancer tres will be the pe, including 1 in
topics that canhus it fits into th
r, Heinrich‐Hein
de + Master) w
noma de Barcel
ich‐Heine Univery of Innovatio
eader, Max Plan
S RAMÓN YOCATORIA
de acceso g
ated to stem ce
the mechanismhuman embry
mouse embryon. 4 publications
tigated the me7 reports have
d to be differenle. In 2010, thever, the amounnot proliferateself‐renew. ThC in vivo in orde Protocols.
y derived in vitrenting a new so infertile miceh lines is focusemany implicatits in which speeatment and trerfect tool to stCell Stem Cell a
n improve the he Biomedicine
ne University (D
with Special Hon
lona (Barcelona
ersity (Düsseldon, Science and
nck Institute for
Y CAJAL A 2014
general
ells and their po
ms underlying thyonic stem cellsnic stem cells. Hs have been pu
chanisms undebeen published
ntiated into thee direct converst of generated. To avoid thiserefore an unlder to eliminat
ro and can be ource of cells e. Unfortunatelyed on decipherons in the treerm cannot beransplanted afttudy the mechaand 1 in Nature
medical treatm ANEP area.
Düsseldorf, Ger
nors, Universita
a, Spain).
orf, Germany).Research.
r Molecular Bio
SDD
SDE
DDC
SDP
otential use in r
he regulation ofs. Our results sHowever, the dublished in this
erlying reprograd in this topic, i
e required cell ion of fibroblasneurons is notlimitation, I himited numbere the transplan
converted to pfor transplantay, the culture cing the conditiatment of infecryopreserved
ter tumor elimianism underlyin.
ment of disease
many).
t de Valencia (V
medicine
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
regenerative m
f pluripotency ishow that humdata obtained ftopic, including
amming to pluincluding 1 Nat
types prior to sts into neuront enough for trhave been abler of neurons cantation step. 5
pluripotency unation. Furthermconditions to eons required toertility. For instd. In this scenaination, a proceng some types
es such as neur
Valencia, Spain
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
medicine:
in these two mman embryonic rom mouse epig 1 in Cell Stem
ripotency as aure Cell Biology
transplantations was accompliransplantation to directly coan be produce5 reports have
nder specific cumore, SSC linesestablish humano maintain SSCtance, some caario, patient‐spess that will reof male infertil
rodegenerative
).
urine stem iblast m Cell
new y and
n but ished since nvert d for been
ulture s can n SSC C self‐ancer ecific store ity. 7
(e.g.
(MEm ‐S(MFu ‐NFu ‐MFu ‐OFu TE‐M ‐Ju ‐O TH‐M ‐M ‐O IN‐D ‐Ju ‐NDe IN AW‐T‐F‐A‐D‐R CO RE‐ 3‐ 9‐ 3‐ 925Na
MDY
Münster, Germamployed as a sc
ep 2005‐Aug 20Münster, Germaunded by a Max
Nov 2004‐Feb 20unded by a rese
May 2000‐June unded by a rese
Oct 1998‐June 1unded by a rese
EACHING: May 2014
uly 2012, 3rd Ro
Oct 2011‐July 20
HESIS SUPERVISMay 2014, Doct
March 2014, Do
October 2013, M
NVITED EXTERNADec 2014, ANR 2
une 2014, CE11
Nov 2013, Call evelopment).
NVITED REVIEW
WARDED GRANitle: Dissecting unding organizAmount: 1.250.0Duration: 5 yearRole: Principal In
ONFERENCES: 2
ESEARCH ARTIC30 articles acce9 first authorsh3 corresponding9 papers have 5,4), 1 in Naturature Commun
MINISTERIO
E ECONOMÍACOMPETITIV
any). cientist accordin
009, Poany). x Planck Society
005, Guearch fellowship
2005, Predoctoearch fellowship
1999, Pregraduaearch fellowship
Habilitation
oyan Internatio
013, 3 h
SION: oral thesis: Ulf
octoral thesis: A
Master thesis: H
AL REVIEWER F2015 Program (
1 2014 Program
for Internatio
ER FOR PEER‐R
NTS AS PRINCIPAthe molecular ation: North‐Rh000 euros rs nvestigator
25 conferences
CLES: pted plus 2 repips g authorships pbeen publishedre (IF:38,5), 1 iications (IF:10)
A VIDAD
ng to the Germ
ostdoctoral fello
y postdoctoral f
uest scientist, Jop from the Span
oral fellow, Funp from the Span
ate researcher,p from the Span
for Privat Doze
onal Summer Sc
hours/week pe
Tiemann (Mag
Adele Marthaler
Hannah Flaßkam
FOR GRANT PRO(French Nationa
m (French Natio
nal Stem Cell
REVIEWED JOUR
AL INVESTIGATmechanisms thhine Westphali
including oral a
ports that are u
plus the 2 repord in journals wn Cell (IF:31,9).
AYUDASCONVO
Turno d
an Public Secto
ow, Max Planck
fellowship to pr
ohns Hopkins Unish Ministry of
dacio Irsicaixa (nish Ministry of
Universitat de nish Ministry of
entin, German a
chool: Stem Ce
r semester (4 se
na Cum Laude)
r (Magna Cum L
mp (Excellent).
OPOSALS: al Research Age
nal Research Ag
Research, Bre
RNALS: Stem Ce
OR: hat regulate hua Ministry of In
and poster pres
nder revision.
rts that are undith an impact f, 1 in Nature C
S RAMÓN YOCATORIA
de acceso g
or Labor Agreem
k Institute for M
romote scientif
University (Baltif Health (BEFI).
(Barcelona, Spaf Health (BEFI).
Valencia (Valef Education and
accreditation re
lls and Develop
emesters), Wes
).
Laude).
ency).
gency).
eakthrough Pro
ells, Nature Cel
man spermatognnovation, Scien
sentations.
der revision. factor higher thCell Biology (IF:
Y CAJAL A 2014
general
ment (TVöD).
Molecular Biome
fic cooperation
imore, USA).
ain).
ncia, Spain). d Culture.
equired for app
pmental Biology
stfälische Wilhe
oject (The Neth
l Biology, EMBO
gonial stem celnce and Resear
han 10, from w:20,7), 1 in Jou
SDD
SDE
DDC
SDP
edicine
with foreign co
plying to Profess
y, (Tehran, Iran
elms‐Universitä
herlands Organ
O Journal, BMC
l fate decisionsrch (Germany)
which 4 have bernal of Experim
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
ountries.
sorship position
n). Organizer an
ät (Münster, Ge
nization for He
C genomics and
s
een published imental Medicin
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
ns in Germany.
nd Lecturer.
ermany).
ealth Research
Scientific Repo
n Cell Stem Cene (IF:13,2) and
h and
orts.
ell (IF: d 1 in
No
ReÁreCo TítM
ReBehiAcUnDNStinvLeFeAnofendeanreFeleafie(Sasmfumpr(Mto
ReTRchM(MMstrempoAlFPdifFPpucoBiIm20co
MDY
ombre:
ferencia: ea Científicaorreo Electró
tulo: olecular mecha
sumen de laeing a moleculagh affinity antctivation Inducndergraduate RNA repair and tudent (MEC‐Covestigate the aeukemia, Clin Dellowship (MECnnual Rev Immf distinct mismndonuclease aceleterious impand lymphomas;epair/DNA deamellowship (MINEading scientist:eld of B cells anemin Immunols co‐author: to alfunction in Cnctional link bey long‐term goroviding new taMINECO‐Retos, o this goal.
sumen del CRAINING: BSc haracterization y Postdoctoral
MMR) proteins edical Researcudies on the imecently awardedy current Euroostdoc, I receivbert Einstein CP7‐PEOPLE‐201fferent SpanishPU Research Feublished a totaorresponding auomed & Pharm
mmunol, 2009; 011; PNAS, 201o‐authored revi
MINISTERIO
E ECONOMÍACOMPETITIV
ROA GORYC‐2014
a: Biomedicnico: sroa
anisms of DNA e
a Memoria: ar immunologistibodies. Such ced DNA DeamResearch Studethe mutagenic olaboración) anberrant expres
Dev Immunol. O). During the founol, Mol Medmatch DNA rectivity; PCNA‐ubact of aberrant ; and (iii) the pmination‐AID/lyECO) first, and to discern the nd allergy (JACI); (ii) as first authe characterizLL cells (Blood)etween autophal of uncoverinargets and theGobNavarra‐Sa
Currículum Vin Biology (20of activation‐in training continin the generath (CIMA, Univempact of DNA d two grants fropean FP7‐mobved 2 competitiCollege of Medi2 Internationalh programmes:ellowship (2002l of 24 articlesuthor articles (Jmacother, 2011;Med Clin, 200
10; PNAS, 2009;iew (Annu Rev
A VIDAD
MEZ, SERG4‐16399 cina [email protected]
editing and gen
st, I have alwaydiversification
minase (AID) pent at the U. ofenzyme AID, bnd PhD (MEC‐Fssion of Bcl2 in Once I got my Pollowing 6 yeard, Trends Genetpair (MMR) pbiquitylation roAID activity an
potential impacymphomagenea FP7‐Marie Crole of MLH1‐AI); and write a uthor: to elucidazation of cis‐ele; the identificathagy and BCL6 ng specific druggrapeutical stratalud), and my i
Vitae: 001) and PhD nduced cytidinenued at the Albtion of antibodersity of Navarrdeaminases in om MINECO‐Rebility‐IIF grant ive intramural icine, NY, USA l Incoming Fell Inncorpora‐To‐2006), and Un, which have aJACI, 2014; J Ex; Discov Med, 21); 10 co‐autho; DNA Repair, 2Immunol, 2008
AYUDASCONVO
Turno d
IO
nomic instability
ys been intrigueprocess in theromoting genof Salamanca. Sinboth in the phyFPU) Fellowshipmalignant B cePhD, I moved tors, my work wat*, Disc Med*, proteins in theole in recruitmed MMR in the t of AID in epigsis in Europe urie InternationATPase signalinbook about epate the role of ements that aretion of the Exo(British J Haemgable moleculategies for patiencorporation t
in Molecular e deaminase (Abert Einstein Cody diversity andra) as a Researthe molecular etos (145K, SAF(20K, PIIF‐2012Pilot Project gr(2010, 2011). Rowship (IIF) foorres Quevedo ndergraduate Rccumulated 46xp Med, 2012; 2011); 6 first‐auor papers (PNA2009; Leukemia8), all of them
S RAMÓN YOCATORIA
de acceso g
y through DNA
ed by the plaste germinal cenomic instabilitynce then, my rysiological funcps, allowed meells, and identifyo the lab of Proas published in Biomed Pharme mutagenic aent of error‐prpromotion of ggenetics. In latat CIMA in thnal Incoming Feng downstream igenetics of B cthe TF FOXP1 de critical for AID1‐exonuclease matol). In the fuar mechanisms ent care. I am to the recently
Medicine by AID) gene]. For ollege of Medicd prevention orch Associate inr mechanisms oF2013‐45787‐R2‐328177) to srants (10K & 1RESEARCH FELLr career reinteProgram (2012
Research Fellow61 cites, so far Trends Genet. uthor papers (PAS, 2013; Britisa, 2004; J Allergin prestigious
Y CAJAL A 2014
general
A deamination
ticity of B cells nters (GC) of sy and error‐proesearch interesction and malige to study the y 5 alternative of. Matthew D numerous artic
macother*, *as activity of AID one polymerasgenomic instabe 2011, I decidhe U. of Navaellowship laterof AID‐initiatedcells in allergy (during the engaD accessibility trole resecting Auture, the awaof DNA deaminconfident thatcreated Europ
the Universitythis work I reccine, NY, USA (f lymphoid man the Oncohemof B‐cell lymphR) and Gobiernostudy molecula5K) from the CLOWSHIPS: Curegration in Euro2) [by MINECO]wship (2000‐200scoring an h‐in2010); 3 correPNAS, 2010; PLsh J Haematol, gy Clin Immunojournals. More
SDD
SDE
DDC
SDP
to produce a trsecondary lymone DNA repast has centeredgnant transformclinical relevansplicing variantScharff (USA), cles and reviewcorresponding(i.e. MSH2/M
ses; RNF8/168 ility, and intracded to continuearra, funded by. During this timd lesions (J Exp (Ed. Springer), aagement of B co the Ig locus (AID lesions (PNrd of a RyC Felnases and errort the recent awean DeamiNET
y of Salamancceived the Extra(2006‐2011) onalignancies. Thematology Divisioomagenesis. PAo de Navarra (5ar mechanisms Cancer Center arently, I am abope. Previously]; Postdoctoral 01) [all three byndex of 10 (ISI sponding authooS ONE, 2010; 2013; Blood, 2ol, 2003); 1 editover, my publi
SECRETARÍA DEDE INVESTIGACDESARROLLO E
SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
SUBDIRECCIÓN DE RECURSOS HPARA LA INVEST
remendously dmphoid organs air. I learned td on the role omation of GC B nce of AID SNPts of AID; with funded by a S
ws (5 PNAS, DNg author) charaMSH6‐mediatedmediation to rclonal evolutione my primary rby an Inncorpome, I was able Med); initiate and a review acells in the GC r(J Immunol); thNAS); and reveallowship wouldr‐prone DNA reward of my firsT Consortium w
ca, Spain (200aordinary Gradn the role of DNen I joined theon (2011‐preseARTICIPATION 56K, GNS‐106/2s of lymphomaand Center for bout to finish a y, I was awardeResearch Felloy MEC]. KEY PUWeb of Sciencor reviews (SemPNAS, 2008; P2012; J Immuntorial (Genet Rication as corre
E ESTADO IÓN INNOVACIÓN
ENERAL CNOLOGÍA
NERAL IÓN
ÉCNICA
GENERAL HUMANOS TIGACIÓN
diverse repertoiis triggered bythis as a Volunf DNA deaminacells. The awa
Ps in atopic astpublications in panish PostdocA repair, PLoS cterizing (i) thed sensoring; Prepair DSBs); (iin of leukemias research about ora‐Torres Queto contribute: new projects oabout AID and Mreaction (Bloode description oaling in B cells a tremendouslypair in oncogenst 2 research gwill highly contr
1‐2006) [Molede Award in BioNA mismatch r Center for Apent), to continuIN PROJECTS: 2014), in additiogenesis. DuringEpigenomics atwo‐year Euroed fellowships owship (2006‐2UBLICATIONS: I ce). These inclumin Immunol, 2NAS, 2008; Clinol, 2012; Mol Res Int, 2011); aesponding auth
ire of y the nteer ation, ard of thma, JACI, ctoral ONE, e role MS2‐i) the (CLL) DNA
evedo (i) as n the MMR ); (iii) of AID a new y help nesis, rants ibute
ecular ology. repair pplied e my I was on to g my at the opean from 008), have ude 3 2012; n Dev Med, and 1 hor in
TrimascamSum
MDY
rends in Genetmmunology ands delivered lectuareer with stayentorship expeupervisor in theembers of the
MINISTERIO
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a Memoria: of my research cof Chemistry anperior Council in and in the wcterize immun
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02 when I join ton J. Pascual V). They are a ‐2004) I performcific antibodies
y after my mastory of M.‐Pilasensors for pesunder the direic (2009‐2011).AIMR) at Tohoearch Centers and Technologyscience. I joinedsition, I was woof research I hong others). In logy and nanotd to develop anunctional tissue
aceutical assaysmaceutical induesponses to extar requirementors, and immuno
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the group of PrVila (IIQAB) (noreference in immed a M.S. in Bs, modify prote
ster�s degreer Marco at thesticides residueection of profe. After my postoku University Initiative (WPy (MEXT). Thed the group of orking in the intave recently p2011, I started technology withn understandines with microsc
s and could be ustry. Engineerternal stimuli, ts. My idea is totechnology.
y Department e Nanobiotechnsors and immuam the leader
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a step toward red tissues havemonitoring theto import this t
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re to control eleotubes scaffoldrogel scaffoldsbryo bodies inIn this area of no Lett., amongbes tracks. Caping an electroccells using polyspatially long‐r
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Marco and FrancAdvanced Chetry and in biolwhere I learnedop and optimiz
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cisco Sanchez Bmistry of Catalogical and artd how to synthee an enzyme‐li
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goal of producited with biosee microenvironmy future rese
esearch Institu(Nb4Dg) led byotechnology in rect responsible My main proje2014). We are scaffolds. Weechanical propeher maturationng research onn nanotube gee recently publther project, webes are alignee for innovatingreaction, chromration gradientsparticipate andd as a Ph.D. stu
Baeza lonia, ificial esize, inked
same IC) in 2004‐an on I was ohoku f the evant nd in m cell f high main . This s and btain
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SECRETARÍA DEDE INVESTIGACDESARROLLO E
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Currículum V
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mpelling evidenn and survival tng metabolism,aling pathwaysidentifying andre studying inte
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Vitae:
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increasing burapeutic strateglay a central roetabolites to schinery, thus conce has shownthrough mecha are coordinates on mitochondd characterizinegration of sig
Parkinson�s sis as well as noo carry out thisogression of thin real time wilmeasurement
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rden in develogies. A commonole in neurons bserve as precurontributing to n that the metanisms that are ed through a cdrial activity ang new mechannaling and me
disease and ovel molecular s proposal is dhe selected neull be employedts of mitochondas well as otheAdditionally, thon of mitochondng to study ancell signaling has endowed uay to develop n
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oped countriesn feature to mby supplying enrsors of neurotcell death duritabolic programnot yet fully unomplex netword its subsequenisms of regultabolism in the
Friedreich�s atargets for theevised. It encourodegenerativ, including extrdrial respirationr parameters, he use of cell bdrial metabolisd target neuropathways in neus with the expnew therapeutic
Madrid
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ataxia. Ultimatrapeutic purpoompasses the uve disorders unacellular flux ann and substratesuch as mitochbiology, biochem in the brain ogenerative diseurodegeneratpertise and thec strategies to t
edical School (B
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Oxford, Oxford
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ng the molecunerative diseasg intracellular cnd other intracnt or in the evmitochondria
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Boston, EEUU)
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ular mechanismses is mitochoncalcium, maintacellular messenvent of accumumay contribut
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uncover meta
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ez‐Cassina A, [.
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Palomo GM, Ma
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Cassina A, Lim F
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Anderson P, Bio
, Diaz‐Nido J. Jo
Journal of Biol
na A, Garrido J
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a A, Diaz‐Nido J
J. Neurochemi
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Ormö M, NilssoAvila J. Journal o
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g E, Danial NN,
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, Watkins SM, H
al NN, Neuron,
2011, 18(10):1
0, 40(5):687‐68
es in Experimen
ochemical and
ournal of Neuro
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JJ, Bhat RV, Dia
llana B, Wando
J, Lim F, Wade‐
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on Y, Radesäteof Biological Ch
s e internacionanacionales
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272‐284
En prensa en T
012, 531(2):182
Hotamisligil GS,
2012, 74(4):71
1015‐1019
88
ntal Medicine a
Biophysical Res
oscience Resea
ry, 2009, 284(5
az‐Nido J, Wand
osell F, Diaz‐Nid
‐Martins R. Mo
nal, 2007, 50(1
esearch, 2006, 8
er AC, Jerning Ehemistry, 2003,
ales
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rends in Cell Bi
‐187 (*: AGC &
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9‐730
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search Commu
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5):3001‐3011
dosell F. Journa
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lecular Therapy
):181‐188
84(4):755‐767
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Glutamrecursor alpha‐s a nutrient is etabolized threhydrogenase ennant, Durán pes of gliomasndings showed ., Mol. Cell 20TORC1. ConveTORC1. Finally,nd is activated b
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DUCATION ANDDT: October 20
octorate, Decemaster (DEA), Mraduation, Augu
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mine, the most ketoglutarate (further undersrough glutamin(GDH. GLS is rand Gottlieb, N. On the other that glutamine012). Inhibitionrsely, enhance, cell growth anby glutamine anfindings positioaKG sensed bvation of mTOe stability of Hán and Gottliebo PHD inactivatn. In agreemenf HIF. Therefored forming a link
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e in combination of glutaminod glutaminolysnd autophagy, tnd leucine via goned aKG as any the cell? On RC1 by glutamHIF, the cellular, Biochem. Soction. Importantnt with this rese, PHD proteinsbetween gluta
Vitae:
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jects, comprisinthe response oeen the increasurán and Hall, Eno acid in the carboxylic acid observation thconsists of twhe expression er 2010). Inhibitential amino acon with leucine olysis prevents sis or a cell petwo processes glutaminolysis an intracellular mthis lead, my sinolysis (Duránr coordinator oc. Trans. 2009). ly, loss of PHD sult, PHD inhibs act as generalminolysis and t
Européen de Ch
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ancer cells
ng the study ofof cell signalingsed consumptioEMBO Rep 2012blood, plays a cycle, for nuclehat cancer cellswo deaminatiolevel by sevetion of GLS precid leucine direactivates mTO the Rag‐depeermeable aKG controlled by mand aKG producmessenger for nstudies also sun et al., Oncogeof the responseImportantly, oactivity during ition blocks th metabolic senthe mTORC1 pa
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ce, Autorisation
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minolysis and a
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f fundamental to nutrients aon of glutamine2). particularly imeotides and fors are particulaon steps catalral oncogenes,vents malignanectly binds and ORC1 by enhancendent lysosomanalogue stimumTORC1, are rection upstreamnutrients availauggest that proene 2013). PHDe to hypoxia. Pour work showeamino acid stae response of sors in the cell,athway.
ie (Pessac, Fran
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ntesis (CSIC / U
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autophagy in ca
SDD
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bioenergetics ovailability in cae in cancer cells
portant role in other amino arly dependent ysed by gluta and its activint transformatioactivates GDH cing glutaminolymal translocatioulates lysosomegulated by glut of Rag (Durán ability and sugglyl hydroxylaseDs are considerPHDs also requed that amino aarvation does nmTORC1 to am detecting scar
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of redox procesancer cells. As as and the over‐
n cell growth aacids. The impoon this amino
aminase (GLS) ity correlates won and slows ce to stimulate aysis and aKG pon and subseqal translocatiotaminolysis. Thet al., Cell Cyclgest new interees (PHD) are thred the oxygenuire aKG for thacid starvation not activate HIFmino acids andrcity not only of
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ring and functiohes by performalysis.
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PhD in Biochemmy research wcterization. I alHealth, Bethesd the Extraordition that was s
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ll movements in, I have designFellowship, Postnt from Cancer ition, I have march career.
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deadliest form ownstream of % of melanomatic disease is insight into the mic approaches. or (MC1R), I shthe MC1R (4 fir
n, UK) and theient samples, aAF‐driven melaget of UVR in mthor publicatioomotes resistaninhibitors usedked by MEK inh(4) Oncogenic ility (second‐au
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eld of cancer gme Consortium y next‐generatidrive the diseahesis of 'aborteed chromosomame Trust Sangened the osteosan acquired soma (Nat Genet 45Curie grant (FPcancer genomeovery in the fiela common evenpresent anotheesearch article
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unction and dis
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genomics. First,(ICGC), at Centon sequencing se (Nature 475ed apoptosis' toal rearrangemeer Institute at Carcoma, blood atically during 5:923‐6), and ATP7‐PEOPLE‐2012s. The results od of cancer gennt in human tur mechanism bpublished in th
e �Retrotransd to the undersrotranspositionminary results o
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tific career hase. ns in the genomcharacterized rate in several impact journals
, in 2010, I jointre for Genomi data analysis u5:101‐105; Natuo explain 'chronts (Tubio & EsCambridge (UKcancers, breascancer develop
ATF7IP in acute 2‐IEF) to analyzobtained withinnomics: a new umours. Becausby which tumohe journal Scien
position Subgrostanding of the n) of the canineof this research
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ses and 4 Natio
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journals Publisabetes, Internamedicine, FAS
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virus (HCV) andnate immune echanism of reecrete HCV RNAontrol of HCV inechanism invoKR). The resulticrobe and Jou
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GENERAL HUMANOS TIGACIÓN
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nce 2013 I amOCAPS (FP7‐31uman samples evastating disea
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mpairs fear extiew neurons geonsolidation and
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We postulate thowever, little israin.
here are not avesign epi‐drugsgnaling molecuepression, and A
sumen del Cducation 8/2003 to 12/200/2003 to 06/200/1995 to 06/20
Work experience6/2013 to prese6/2013 to prese4/2013 to 05/204/2011 to 03/204/2009 to 03/204/2008 to 03/201/2008 to 03/20
MINISTERIO
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a: Biomedicnico: robe
genetic link bet
a Memoria: : I obtained a pursued my Phd the epigenetscience Institutcognitive impa
m a senior rese16265). I study and mouse moases. I am also
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archer on neuthe epigeneticodels. I also sea a Research As
D students. I am
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tic events can lgy to inhibit exGF2‐dependent he adult mousotential target t
mentia is aging. s essential. Ressociated with aracterized yet7 signaling couthe role of IGF
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Vitae:
y and Biophysiceuroscience (Molecular Biology
archer (BIOCAPr with Prof. A. Fincipal Investigostdoct, ENI‐GoMBO Postdoctoostdoct, ENI‐Goostdoct, UIC, US
AYUDASCONVO
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d depression w
ology (2001) any and Biophysichizophrenia. A(2008‐2013). Thted with norma
roepigenetics ac mechanisms aarch for biomasociate Profess
m part of the �media. I have tw
ead to excessivxcessive fear. I manner. Similase hippocamputo treat Alzheim
The most sevecent studies inAD. These data. In this contexuld be a candidF2/IGFBP7 signa
/IGFBP7 signalliGFBP7 signalinsignaling in blonaling could be
cs (Ph.D.), UIC, .Sc.), USC, Spaiy (B.Sc.), USC, S
PS, FP7‐316265)Fischer (AG 179ator (DFG grantettingen, Germral Fellow (ALF ettingen, GermSA
S RAMÓN YOCATORIA
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ith Alzheimer¿s
nd a Master inics (2008) at thAfterwards, I mhere, I focusedal ageing, psych
at the Instituteassociated to parkers and thersor at the PhD
�Red Gallega
wo scientific bl
ve fear and cershowed in a marly, I showed us. In additionmer¿s disease (A
ere form of demn humans havea suggest a relaxt, IGFBP7 is dedate for the linaling and the a
ing to treat disng and the assood or CSF (e.ge used as a ther
USA n Spain
), IBI‐VIGO, Spa9/1‐1), DZNE‐Got, AG 179/1‐1),
many 652‐2008), EN
many
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n Neurosciencehe Univ. of Illinmoved to Goetd on the genomhiatric disorder
e of Biomedicapsychiatric, neurapeutic targetsProgram in Ne
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rtain psychiatricmouse model ththat fear extinn, we have shAD).
mentia is AD. The shown that PTationship betwe‐regulated in bnk between PTassociated mole
seases such as sociated epige. miRNAs) coulrapeutic target t
ain oettingen, Germ ENI‐Goettinge
I‐Goettingen, G
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(2005) at the nois at Chicagottingen (Germame‐environments and neurodeg
al Research of urodegeneratives for diagnosis,euroscience and
edicamentos (R
cia� and �El
c disorders suchat IGF2 facilitaction‐induced hown recently
he search for bTSD and depreeen PTSD and doth PTSD and ATSD and depresecular (eg. epig
PTSD, depressinetic mechanisd be a potentiato treat such br
many n, Germany
Germany
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DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
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Vigo under the and autoimm, prognosis andd Clinical Psych
REGID)�. More
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biomarkers in oession are also depression withAD as shown byssion with the genetic) mecha
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ENERAL CNOLOGÍA
NERAL IÓN
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GENERAL HUMANOS TIGACIÓN
ago de Compong the neurostas a postdoc aie, epigenome)eases.
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Action. Compth, 2013.
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and presented
. I am author oftions:
C et al. Psychop
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HY, Agis‐Balboa
C* and Fischer A
Agis‐Balboa RC,
C* et al. J Alzhe
gbemenyah HY*
C et al, EMBO J,
N, Agis‐Balboa
nbenesi F*, Zov
C et al, PNAS, 20
riu B, Maloku E,
C et al, PNAS, 20
Balboa RC et al.
Balboa RC, et al,
m part of the Dce using diverse
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f several resear
pharmacology, 2
boa RC & Spuch
a RC. Neurobiol
A. CMLS, 2013
et al, J Neurosc
eimers Dis, 2013
*, Agis‐Balboa R
, 2011.
RC, et al, J Alzh
voilis F*, Burkh
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, Agis‐Balboa R
006.
. PNAS, 2006.
, PNAS, 2005.
Divulgacción AGe media.
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Turno d
ch Fellow, UIC, ist in Health Scit, USC, Spain
r the Best Poste
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m organised by
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2014.
h C. Molecular
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(*, Correspond
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3 (*, Correspon
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of the Alzheime
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er. UIC, USA. 08
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Brain. 2014.
ing author).
nding author).
O J, 2011 (*, Equ
11.
Havan S, Agis‐B
phr Res, 2007.
cian Association
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contract. IBI‐Vig
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Balboa RC, et al,
n of Communic
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Goettingen (5.0
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PNAS, EMBO J, J
n).
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SECRETARÍA GEDE CIENCIA, TECE INNOVACIÓN
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pigenetics: From
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sumen de laver disease encetabolism (IEMrrhosis and end
uring my M.Sc.chnique to isorahuetes, 2001evelopment forelective prolifer
or my postdoctver disease (ALUFAs) such as ae found out thaUrtasun, 2009; U
y second postdCasp8) and its roat death recep012; Hatting, 20f JNK during acund then providever disease (Scheatment for acu
or my independecent results suompound functcrease in a signillions of peopl
sumen del Coon after I finis
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tled �Intraspleught practical a
My postdoctora
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a: Biomedicnico: cube
ion of Jnk1 and
a Memoria: compasses a wiM) or chronic livd‐stage hepatoc
and later my Polate hepatocyt1). Next, we ar transplantatioration of transp
oral investigatiLD) (Cubero, 20arachidonic aciat reactive oxygUrtasun, 2012).
doctoral has focole in death recptors in hepatoc015) and its theute and chroniced evidence thahaefer, 2015; Cute liver failure
dent career, I aggest that (1) ttion of Jnk1 annificant mannee around the w
Currículum Vhed graduated
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enic transplantaand theorical clal experience b
natomy and Phr Diseases at Mthe Spanish Mitocyte isolation
A VIDAD
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d Jnk2 during ac
ide spectrum over disease suchcellular carcino
Ph.D. studies I tes with the vieimed to purifyon into hyperbplanted cells (Cu
ions I first focu006; Cubero, 2d (AA) to the mgen (ROS) and n.
cused on the stceptor‐mediatecytes and immuerapeutic potenc liver injury (Cuat JNK1 in hemaCubero, 2015).e might have be
im to unmask the oxidative stnd Jnk2 in hepr our understaworld could be b
Vitae: in the Univers
ab, granted wir. Paloma Magaof bilirubin UDPpanish FISS (ISCmetabolism, s
ation of hepatolasses at UCM. began at Trinity
hysiology undeMount Sinai Scnistry of Sciencn (both fetal an
AYUDASCONVO
Turno d
FRANCISCO
mail.com
cute and chroni
f injury includinh as alcoholic livma (HCC).
became strongew of transplay hepatocyte sbilirubinemic raubero, 2005; Cu
used on the con2009). Our resumechanism whenitrogen specie
tudy of molecued apoptosis (Lune cells have dntial (Malato, 20ubero, 2010; Cuatopoietic cells Furthermore, een misinterpre
the compoundress response ipatocytes deternding of key mbenefited from
idad Complute
th a Fellowshianto, at the SerP‐glucuronosyl CIII), we focuseduch as the Crig
ocytes in an exp
y College Dubli
r the Supervisihool of Medicce and Educationd adult), I exp
S RAMÓN YOCATORIA
de acceso g
JAVIER
ic liver disease
ng acute liver faver disease (AL
gly interested innting them in suspensions (Aats (Cubero, 20ubero, 2007).
ntext of Kupffeults unveiled aereby KC mediaes (RNS) can ind
ular mechanismLiedtke, 2011) adifferent roles 012; Kaldenbacubero 2011). Wis crucial not owe have very
eted (Cubero, 2
and distinct fuis essential for rmines the fat
molecular mechtherapies that
nse Madrid (UC
p from the Regrvice of Experimtransferase thd on hepatocytgler‐Najjar synd
perimental mo
in where I cou
ion of Prof. Gaine as a postdon (Beca MEC),perimentally ap
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ailure such as dLD), non‐alcoho
n fetal hepatocorder to resto
Arza, 2001) and001; Bustaman
er (KC) and hepa synergism beate ECM remodduce a protectiv
ms of cell death.and later in NASin chronic liverch, 2014). My mWe first identifieonly for liver regrecently found015; Gastroent
unctions of Jnkthe modulatione of cancer ceanisms involvemodulate the f
CM), I started m
gional Governmmental Surgeryhroughout fetae transplantatidrome type I.
del of type I Cr
uld finish my P
abrielle McKeedoctoral fellow under the auspproached the
SDD
SDE
DDC
SDP
drug‐induced livolic steatohepat
cyte isolation. Tore liver functiod used them ate, 2006). Fina
atic stellate ceetween ethanoeling (Cubero, ve mechanism i
We first investSH (Hatting, 20injury and tum
main focus durined Jnk1 in HSC ageneration but d that the currterology, In Rev
1 and Jnk2 in dn of JNK during ells. These viabd in essential afunction of the
my predoctoral
ment of Madrid in Puerta de Hl developmenton as an alternMy doctoral th
rigler‐Najjar syn
hD papers and
. Later, I joinefirst and thenpices of Prof. Sstudy of the pa
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ver injury (DILI)titis (NASH) wh
Thus we workeon impaired byat the most aally, we formul
ells (KC), and thol and polyunsa2008; Cubero, in HSC in early s
tigated the act013). Furthermomorigenesis (Cung the past yeaas a profibrotic also for the prorent dogma of vision).
different forms g different formble projects haaspects of liver JNK genes.
l stage as a stud
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ndrome�. Dur
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d Dr. Natalia Nn as a recipienScott Friedman.athophysiology
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ENERAL CNOLOGÍA
NERAL IÓN
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GENERAL HUMANOS TIGACIÓN
) or inborn‐erroich may progre
d on optimiziny IEM (Sierra, 2appropiate staglated a strateg
heir role in alcoaturated fatty 2012). Futhermstages of liver i
ivation of caspaore, we have shbero, 2013; Arsrs has been thekinase (Zhao, 2ogression of chJNK inhibition
of liver injury. ms of DILI and (2ve the potentidisease. There
dent‐collaborat
period, we beg. We focused mancial support opic liver transing cum laude,
ing this stage,
sly acquire teac
Nieto�s lab, int of a postdoc Using my expey of alcohol‐ind
ors of ess to
g the 2000; ge of gy for
oholic acids more, njury
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Very 2) the ial to efore,
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ow (2012‐2014)rincipal Investigabio), and took s Secretary twoongresses, manapers indexed ieviewer for sev
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AYUDASCONVO
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w York, I was as Biology (NYCSby Prof. Trautwmodels of liver oral theses of 5classes per weesociation for tn invited as Inv of a doctoral tth in CNIO. Mostinguished Dissome as senior e German Rese
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prestigious Live
been several yethis time I haeover, I have cI have receivedhe Liver (EASL) to CNIC (Madriadrid). Furthere submitted ovas Oral Presennding author. Aon (DFG). I am a
SDD
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ars investigatinave actively colcollaborated wid the Glaxo SmConference anid) in 2013 undmore, I have beer 40 proceedtations. In totalso, I have writta member of th
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DIRECCIÓN GENDE INVESTIGACCIENTÍFICA Y TÉ
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ng the functionllaborated in tith the Teachin
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ENERAL CNOLOGÍA
NERAL IÓN
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GENERAL HUMANOS TIGACIÓN
nd the postdoc
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W Hetzer. Cell. echanism to prstability openiotentially proteuring the last yes taxanes, comodels and patirogram controll. Cancer Cell, in
y research goavision, analyzeesponses. To acancer biology, onsequences of
sumen del Cstudied Biologyolecular procesf Barcelona. SupDr. Neus Agelvolving redund
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ursuing to furtharn innovative SKCC (New YorLoS Biology, 20berrations comNPCs) produce
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�checkpoints�human cells. Mymultiple pathwaedundancy giviV, et al. Cance
tdoctoral reseagregation in huV, et al. PLoS Bsegregation to 2014; Kirsty Mrevent structurng new avenuects against canears I have alsomonly used inient tumor samled by the mastn press, Februar
al as an indepe the contributihieve this, I wilto elucidate
f deregulation i
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her study errorgenome editinrk, USA) as a po009) and focusemon in humanan anaphase i
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� that safeguay work revealeays involving acing a rational r Res. 2007).
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Minton. Nat Reval and numericues of researchcer. o participated in the clinics. Thmples (Domingter regulator Gry 2015) allowi
endent investigion of their fail take a multi‐dhow nuclear n cancer.
Vitae: rsity of Barcelog cancer I did medoctoral fellowowed that non‐by several kina
replication che
versity of Barcethe University ontrolling fidel
‐free chromosong methods to costdoctoral resed my researchn cancers suchinhibitory signa
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O, VERONIC
c.org
Cells and Conse
stability (CIN) ae not complete
rd genome inted different resctivation of Chkfor specific ca
pplied genomave participatedI have shown t
me integrity (Rov Mol Cell Biolcal chromosomh to understan
n the study of hese studies hgo‐Domenech JATA2 that driveng me to gain e
gator is to studlure to genomdisciplinary apppores and th
ona (Spain) supmy PhD studyingwships from thetumor cells actases that cance
eckpoint inhibit
lona in 2007. TMedical Centeity of mitosis du
ome segregatiocreate conditioearcher in 200h on the cell div as aneuploidyal in interphas
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equences in Can
and aneuploidyely understood.
egrity. During mponses of tumk1 and p38 kinancer treatmen
e‐editing methd in the study that nuclear poodriguez‐Bravo l. 2014). My we alterations annd the intricate
how cancer celhave uncoveredJ, Vidal S, Rodes aggressiveneexpertise in can
dy the molecume instability anproach building he mitotic che
pported by theg cell cycle chee Catalan Govetivate robust cer cells lack. T
tors (Cancer Re
To gain expertiser of Utrecht (uring human ce
on in human ceonal knock out 8. During the lavision control my and CIN. Use that ensures
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ncer
y are a hallmark. I have focuse
my PhD I studieor and non‐tumnases to ensurent combination
hods to precisof Plk1 kinase re complexes (V, et al. Cell. 20
work uncoverednd revealed NPe NPC‐checkpo
lls acquire chemd new mechanriguez‐Bravo Vess and survivancer biology and
lar and celluland the consequon my expertiseckpoint monit
e "Extraordinaryckpoint mecharnment (FI, 200heckpoint mechis work gave
es. 2006 and 20
se on cell cycle UMC, The Netell division (J. C
ells, chromosomhuman cells (cast years I havemechanisms thsing genome‐eds proper speed
SDD
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k of cancer, howd my research
ed ATR/ATM‐inmor cells to repe robustness ofs (Rodriguez‐B
sely dissect mroles in cytokiNPCs) ensure p014) (Highlightd mitotic timingPCs deregulatiooint network th
motherapy resisisms of chemo
V et al. Cancer l to chemotherd translational o
r mechanisms uences for canse in cell, molector faithful ch
y College Awarnisms in the Sc02‐2005) and frhanisms in resa rational for
07) and was re
control mechantherlands) as aell Biol. 2009).
me instability (CKO), I joined Dre worked on Plat ensure mitoditing I discoved of the next m
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estigation. 91:85gy. 178:1529‐1f Pathology. 176 46:836‐850. 2044. 2010 ‐603. 2009 al of Pathology. 62:777‐85. 20Cytology and H8 24. 2008 01. 2008 ogy, 158:496‐50ology. 25:262‐7gical Chemistry.‐72. 2006 gation. 85:885‐9necological Path27. 2005 46:475‐82. 200569‐77. 2004
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sumen del ChD in Science, master in Biologyegree in Biology
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novel platform allows modifyinmplex gene netwhPSCs.
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initiation modcterizing differen vivo, throughe our understangenetic screens
of Zoology anderland, 1998 rland, 1996
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Geneva‐Switze
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I acquired a sracterization o
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solid backgrounof remote enha
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onzalez, F. *, Zhducible genom
ndrey, G., Monetween topolog
onzalez, F., GeoNA repair genes
onzalez, F., Bouev Genet 12, 23
onzalez, F., Barelmonte, J.C. (2roc Natl Acad Sc
onzalez, F., Dub59.
pitz, F., Gonzaleuster. Cell 113,
pitz, F., GonzaleoxD complex se
atents ub. No.:WO/20tle: "Generatio
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alez, F. *, and mology 546, 21
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Huangfu, D. (15‐250.
D. *, Lelli, K., Vman pluripoten
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ua Belmonte, J
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Spitz, F. (2007)
boule, D. (2003
C., Vogt, T.F., Destral regulator
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2014). The iCR
Verma, N., Li, Qnt stem cells. Ce
alez, F., Noordgenes collinear
D., Stadtfeld, Mramming to a pl
.C. (2011). Met
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). Transgenic a
). A global cont
Duboule, D., anry module from
nt stem cells by
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Q.V., and Huangell stem cell 15,
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nalysis of Hoxd
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d Zakany, J. (20m evolutionary i
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for Rapid Gen
gfu, D. (2014). A, 215‐226.
eleu, M., Tronombs. Science 34
Jasin, M., and e. Cell reports 3
ng induced plur
N., Vassena, R., by transient ex
d gene regulati
fines a chromos
001). Large scannovations. Ge
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of. Denis Dubo
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and Duboule,
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working periodAfter my bached soil samples. tryptophan synudies I worked CS) performing r. Within the Pstidine kinases
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s of collagen ty566, NC1, NC2, Ignacio Fita innd virulence in
d during the las. TCS are key rresponses. I hontributions in t its cognate rephorylation in d the first crysturthermore, I srecognition betyears of researtill many questfungi. All this tivity, as TCS ar
Ciencia y Tecnorado (tesina) ennsayos enzimátal de dos años de Riverside (Es. Como becariael Instituto des sistemas de ddos meses en sachusetts en Wdo por una hists. Desde Diciente Rubio en elnuevos estudide varios NCs.boratorio del Ddiando la maqa cristalina de ón con el Dr. M
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ype IV chains 1, NC3, NC4 andn the Institute n Mycoplasma
st twelve yearsregulators of bhave studied ththe field solvinesponse regulathistidine kinasetal structure ofsolved structurtween a HK witrch, I have acqtions left behinstructural knowre absent in hu
logía de los alimn Químicas en eticos (ELISA) pa(2001‐2002) eEE.UU). Duranta FPI, en 2003 e Biomedicina dos componentel laboratorioWorcester (EE.tidina quinasa yembre 2007 hal Instituto de Bios estructurale. En Mayo 201Dr. Ignacio Fitauinaria de mola fosfatasa MGMichael T. Laub
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mentos (2000) el Departamenra la determin
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por la Universidto de Química ación de plaguo del Dr. Micho realizacé estsis doctoral en CSIC. El objetiviante una aproVan den Berg emis estudios dde la respuestacontratada CIBValencia, CSIC. Cinios no colagen contrato postamento de Biolcoplasma genita en virulencia. ecnológico de
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ells control: new
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how a single murol. 2005, Neongenital/neuronditions. Seconall (Acta Neuroutic avenues fo
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d other radial‐glar surface is auropathic/degeurface in dise
my training, as wf research. By of the ependyentify additiona
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ly established a
ol of Disease.20thol.2012), andhe impact factoropathology. In
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Selected publicaBrown L, Wolf J
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ales R, Casad
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my current poswo‐color supereate Prof. SW Hulty of 1000. Wol, 2013).
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stdoc with Profresolution STEDHell (Max Plance since upgrad
dy dendritic spiwas able to prscience, 2014). am currently in
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on making stem
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anford). I deven brain slice culvity (Tønnesenen, Behav Brain
ine analysis plaalyt. Chem. Lu
Neuroscience) irain slices, whiphys J, 2011). Thx physiological
ptical techniqu changes in spin imaging studiepine morpholog
gy, brain slices.
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arro, Basque Ce retreat of Hellers in Neurophoe Day Meeting,n Institute, UnivRE annual meetaux Neurosciencational League Ascience Day, LuStemCell annua
SUPERVISING EShort practic Short prSupervising Short practicSupervising
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hip ellowship Oral Presentatiog cost grants du
science, Zamudck Inst. Biophysg, Bordeaux, France bridge, UK France ordeaux, Francy meeting, Bud
agio, Italy
M2 students onfor M2 studentKahina KourdaM2 students onGeraldine Louv
man, French, Sp
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cells, Parkinson
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dio, Spain s. Chem.), Tegeance
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