MOTIC VM600 Virtual Microscope MOTIC VM600 Virtual Microscope

Development of Motic’s New Model;Development of Motic’s New Model;Features & Improvements, Model Features & Improvements, Model Strategy, and Model Competition Strategy, and Model Competition

Motic International Dealer MeetingMarch 2009

Topics CoveredTopics Covered

1. Motic VM Introduction: Hardware & Softwares

2. Application solutions: a. Clinical Diagnosis/b. Consultation, Researchc. Education

3. VM System Operation & software

4. Competitive Analysis

VM600-4： Digital Slide Scanner

VM： Digital Slide View software

1 、 DPCC（ Digital Pathology Digital Pathology Consultation & Communication Consultation & Communication Platform Platform ）

2 、 DSS（ Digital Slide Server Digital Slide Server System System ）

Motic Products Solution

www.moticpathology.com

www.motic.com/dssweb

4

Motic VM Components (Hardware & Scanning software))

Scanning

Scanning Process Demo：

Digital Slide View Demo

Motic Pro 285 CCD

1. Motic 285A ： 2/3 " , 1360 x 1024, 6.45m x 6.45m

MCAM285 Technical Data

　 Item MCAM285

Sensor Size 2/3"CCD

Resolution 1.4 mega pixels, 1360 X 1024 pixels

Pixel Size 6.45m x 6.45m

Frame Rate 15 fps / second

Shutter Electronic

Dynamic Range >44db S/N

Scanning System Progressive

Minimum Illumination ≈3Lux

USB Interface USB2.0(480Mbit/sec

Voltage DC 5V± 5%

Operating Current ≈260mA

Power Consumption ≈1.3W

Operating Temperature 0℃-50℃Storage Temperature 0℃-60℃Relative Humidity 40%-80%

OS recommended WINDOWS2000 / WINXP / VISTA

Objective: 20x；Specimen ： 10mmx10mm； Scanning Method: Standard； Speed ： About 4 min

Scanning Speed

VM600 Stage Configuration

•X - 272mm ； Y - 196mm ； Z - 93mm ;

•Travel range of 80mm by 24mm

•Stage Accuracy: 1.5625um for x/y –axis,; 0.015um for z-axis;

•Relocation Accuracy: <1um

Motic VM600 Recommended PC Specifications

Workstation System:•Windows XP Professional •Intel Core(TM) 2 processors•4GB RAM•300GB disk storage

•22 “ Monitor(or larger Optional)

Workstation System:•Windows XP Professional •Intel Core(TM) 2 processors•4GB RAM•300GB disk storage

•22 “ Monitor(or larger Optional)

Motic VM Scanning Methodology

1. High Precision Auto –Focus every Image , high quality

2. Standard ： Build Scanning model , good quality with faster

scanning speeds

3. ROI （ Region of Interest ） : Scan whole slide with low magnification(2x or 4x)

first, then scan ROI with higher magnification . Small Digital slide Size(<10M), useful and convenient for pathology or educational applications (Motic only feature)

4.Multilayer Focus: Multilayer focus and amalgamation each tiled

image . Very high quality ,especially for thick glass slide (but may be too slow for most applications)

Multilayer Focus Scanning

Multi-Layer Amalgamation

Living specimen

FreezesTissue

Traditional Pathology WorkflowTraditional Pathology Workflow

Fix, Dehydrate, Embedding….

Histo-processing Slide Staining

Slides

Surgery Center Pathology Center

Pathologist Center

Pathology Diagnosis

Tissue specimen

Pathology Education

Digital Slides

Digital Pathology Solution: Adjusting Standard Digital Pathology Solution: Adjusting Standard WorkflowsWorkflows

Living specimen

Fix, Dehydrate, Embedding….

Histo-processing Slide Staining

Tissue specimen

Surgery Center Pathology Center

Freezes Tissue

Pathologist Center

Pathology Diagnosis &Analysis

Slide

Image Analysis

Workflow Management

Remote-Consultation

Education

•Information Workflow, including Digital Slides…• Integrated Patient records (HIS/PACS…)•Education & Clinical •Remote-Consultation•Image analysis

Future Digital Pathology DirectionsFuture Digital Pathology Directions

Microscope

MOTIC’s Digital Development Makes the MOTIC’s Digital Development Makes the VM600 The Next Logical Progression …VM600 The Next Logical Progression …

Digital PathologyMicro+Camera

VM Application SolutionsVM Application Solutions

VM600 Digital Slide ApplicationsVM600 Digital Slide Applications Educational Educational ((Cell Morphology, Histology, Pathology, etc.)) Digital Slides Classroom Teaching Remote Teaching and Learning Virtual (Web) Teaching Lab for Images view and conference

Clinical Diagnosis(Clinical Diagnosis(PathologyPathology)) Digital Images Data and workflow Management Remote Consultation Digital Slides Conference Aided Diagnosis

ResearchResearch Digital Slides Data TMA Image analysis Pharmaceuticals

VM Educational ApplicationsVM Educational Applications

Digital slides Education System for Pathology and Digital slides Education System for Pathology and Histology TeachingHistology Teaching

Classroom Teaching 1. Digital Slides reduce concerns about slide making, loss, breakage or fading; 2. Archive and share critical slides; 3. Built-in Digital Slide information management to reduce teacher prep time for course development and dedicate more time to viewing

Digital slides Testing 1. Manage digital slides to create a test library as an effective means for distributing testing materials; 2. Auto testing

Digital Slides gallery( Web view) 1. Anywhere , anytime access via internet on web, Pre-learning and Review ; 2. Improving the teaching level and learning effectively;

Motic VMMotic VM

IE ViewIE ViewDSS Server DSS Server

workstation

IE ViewIE View

Motic Digital Slides Server Software SystemMotic Digital Slides Server Software System(DSS)

Lan/Internet

Web-Based

View by annotation , convenient for teaching and learning

Motic Digital Slides Server SystemMotic Digital Slides Server System(DSS)Web-Based

Incorporating VM600 with Motic Net as Incorporating VM600 with Motic Net as an effective teaching tool..an effective teaching tool..

Education (VM600 with Motic Net)

For Pathology Diagnosis (Secondary) & Consultation

Motic VM Feature: Observe slide by Motic VM whiling or after scanning the slide ,it is the best way for beginning of diagnosing training

Digital Pathology Consultation & digital slide Communication Platform

LAN or Internet（ ADSL）LAN or Internet（ ADSL）

Motic VMMotic VM

Remote ExpertsRemote Experts

On business or at homeOn business or at home

LAN or Internet（ ADSL）LAN or Internet（ ADSL）

DPCC PlatformDPCC Platform

Consultation station

Remote Consultation CenterRemote Consultation Center

MoticMotic DPCC Platform Web AddressDPCC Platform Web Address

http://www.moticpathology.com

HIS

PIS

Patient Information Info Management

Workflow

DICOM

Digital Slides

ReportRemote　Consultation

Internet)

Conference

Motic VM

Digital Pathology Information WorkflowDigital Pathology Information Workflow

Competitive AnalysisCompetitive Analysis

Market Sector CompetitorsMarket Sector Competitors

1. Zeiss Mirax 2. Olympus Bliss HD or .slide3. Aperio 4. Hamamatsu NDP5. Nikon Coolscope6. Claro 7. DMetrix ……

Zeiss

Mirax DESK(1-slide) Mirax SCAN(300-slide)Mirax MIDI(12-slide)

Objective: Plan-Apochromat 20x/0.8Scan camera: SONY DFW-X710 or others (1/3“inch, 1024 x 768 pixels, cell size

4.65 x 4.65 µm ) 

MIRAX Viewer - the virtual microscopeMIRAX MFM - fluorescent slide viewerMIRAX TMA - a powerful tool for high throughput tissue microarray evaluationIH-Lab - software for fast evaluation of immunohistochemistry stained samplesHistoQuant - quantitative and qualitative analysis applicationMIRAX E-School - teaching material authoring tool with exam moduleMIRAX 3D - an application for 3-dimensional reconstruction of serial slidesE-Consult – teleconsultation softwareMIRAX DB - database program for efficient data managementToxicoPath-LIS - application for the management and administration of toxicopathology research

Zeiss (3DHISTECH,Hungarian company)

Olympus

Dot slide(1-slide/50-slide)

Objectives : 2x PLAPON, 10x, 20x, 40x UPLSAPO, optional, e.g. 100x oilIllumination: brightfield with 100 W halogen lamp house, optional: fluorescence, polarisationDigital CCD camera: 2/3” CCD camera, 6.45 μm x 6.45 μm pixel size

Software functions and modules.View images locally, zoom, crop and rotate images.Net Image Server software for remote access to virtual slides with dotSlide software.Conferencing module for simultaneous and synchronised viewing of virtual slides, conference access control and user management, minute taking tool, chat function.TMA module to acquire individual images of TMA cores

Bacus: Bacus Laboratories,inc., a wholly-owned subsidiary of Olympus America . Founded in 1994, is a leader and innovator in the field of VM.

NDP: 210-slide

Hamamastu

Objective lens: 20X, NA 0.7 CCD: TDI sensor,4096 x 64 pixel , Line scanning

Software: Developed by other company

Distributed now in the USA through the

Olympus network, approx cost $120K

Aperio

120-slide

1 -slide 1-slide(Oil)

5-slide

Objective lens: PLAN-APO 20x / 0.75CCD: Line 3-CCD, 1040 x 1 pixel

NikonCoolScope

CCD:2/3-inch. (total number of pixels: 5.24-mega pixels;effective 5.07-mega pixels)

Dmetrix

.Objective : Array Micro lens (80)

.The fastest scanning system

Toco: 1-slide VS0201AS1 : 20-slide VS0801AS1: 80-slide

Claro(Japan)

Objective: Carl Zeiss Aplan 20x, 40xCamera: 1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x 960)

Clarient: formed in 1996 to develop and market the ACIS(R) Automated Cellular Imaging System, in cancer diagnostics Sells Its ACIS Instrument Business to Carl Zeiss for $12.5 Million

Following the acquisition of Trestle and of Clarient's equipment business, Carl Zeiss has become the leading provider of solutions for telepathology, digital slides and computer- supported diagnostics with more than 500 installed systems.

Following the acquisition of Trestle and of Clarient's equipment business, Carl Zeiss has become the leading provider of solutions for telepathology, digital slides and computer- supported diagnostics with more than 500 installed systems.

In marketing a clinical version of the system, Carl Zeiss MicroImaging said it is collaborating with the Danish diagnostics company Dako, a manufacturer of reagents for tissue-based cancer diagnosis.

Clarient/Trestle/Dako

Motic’s Strategic Positioning: Motic’s Strategic Positioning: 1. Natural Digital progression for Motic into Virtual slide making market

2. Offer “single-source” complete and easy integrated with VM hardware and software

3. 4. Package Applications by combining VM Digital slide with Motic Net

5. Highest Resolution Sony CCD

6. Different scanning methods; ROI slide for remote consultation

7. Value-Alternative to customer

Motic: Value-Based alternative to easy and Motic: Value-Based alternative to easy and efficient digital slide creation and integration!efficient digital slide creation and integration!