Kirubel Asfaw

Momand et al

p53.free.fr

Master control of cell cycle

It is a transcription factor.

Responds to cellular stresses by activating growth arrest or apoptosis

p53.free.fr

p53.free.fr

Cell survival

Cell cycle progression

p53.free.frJones et al

MDM2 overexpression blocks p53-mediated cell-cycle arrest and apoptosis.

Analysis of 3000 tumor samples shows that MDM2 is amplified in 7% of these tissues.

Momand et al

Wikepedia.org

SNP309 polymorphism was detected in 232 (68%) of 343 familial breast cancer cases

Wasielewski et all

No MDM2 gene amplification was observed in the presence of mutated p53 gene

Pollock et al