Flexible Control for Single-Use Cell CultureThe mPath controller architecture provides powerful process control for the unique needs of single-use bioprocessing. Emphasizing robustness, ease-of-use and flexibility, mPath controllers combine the robustness of manufacturing with the flexibility of process development. The architecture, based on programmable logic controllers (PLCs), outperforms microcontroller based embedded systems typically seen at this scale. When integrated with Pall bioreactors, mPath control towers easily handle process development (PD), seed applications and small-scale manufacturing. Flexible options for single-use sensors, variable speed pumps, networking and interfaces allow customization to individual process needs. Six precision mass flow controllers and three biocontainer bag hangers with integrated load cells track process inputs accurately. With advanced features designed for single-use, mPath controllers put fewer limits on your processes and your creativity.

BIOTECH

mPath™ Benchtop Bioreactor Control Towers

USD3220a

1

2

Features and Benefits

Features Benefits

Capable of accessing data anywhere on any networked device including laboratory workstations, desktop computers, or remote devices such as laptops, mobile phones and tablets

Operates as either a standalone network or integrated with site IT systems compatible with multiple network security approaches (e.g. virtual private network [VPN]) and password protection to protect bioreactors from unauthorized access

Intuitive visual displays for easy interaction with bioreactors to calibrate components, set critical parameters and fine tune process control

Advanced trending capability including creation of custom trends of any process variable for both historic and live processes. Overlay and compare trends from multiple batches on one graph

Database centric design supports naming, logging and exporting batches for traceability and data analysis

Full alarm customization to alert for process or safety critical events

User-definable recipes including scheduling, version control and retirement for recipes no longer in use. Recipes can be multi-phased with user-defined transitions between each phase

Compliance capability – designed for operation following 21 CFR Part 11/ Annex 11 regulations

Control Tower Color coded illumination ring around the front face of the controller allows identification of operating state from a distance

Individual LED indicators for each connection on the connector panel identify problems during set up and operation

mPath Link Software Highly visible color and textual alerts which indicate alarm severity on all software interfaces

Historical alarm logs to review equipment and process performance

Accurate gas mixing for two gas streams enabling accurate parameter control and complex gas control regimes, each gas within the mix delivered by a dedicated TMFC – Primary gas mix: N2, O2, Air and CO2 – Secondary gas mix: CO2 and Air

Calibrated flow rates up to 1 L/min for each TMFC

Onboard regulators ensure accuracy of TMFCs even with higher input pressures

Onboard pressure sensors, combined with alarming capability enable notification of empty gas cylinders or biocontainer bag overpressure

Fast fill button – quick and safe inflation of biocontainer bags with air

Accurate delivery of feeds and titrants without compromises, standard variable speed pumps enable smoother process control and feed profiles for less process variability – 8 mm maximum tubing outside diameter (OD) – 14 - 211 rpm (control requiring speeds less than 14 rpm achieved through pulse width modulation [PWM])

Removable pump heads for easy cleaning and serviceability

Removable biocontainer bag hangers with integrated load cells allow space efficient execution of weight based feed profiles and accurate tracking of titrant delivery

Extensive human factors research to determine optimal placement of connections and control tower elements

Flexibility in operation – choose when and where to view data, choose how to design processes

Compact design to limit bench space requirements – small form factor and biocontainer bag hangers remove the need for scales and bottles

Elevated from bench for cleanability

Control Software – mPath LinkThe mPath control tower is designed for use with the mPath Link server and software - a supervisory control and data acquisition (SCADA) software package

Advanced AlarmingMultiple notification modalities to ensure response to process critical events

Gas HandlingMore flexibility in gas control – six oxygen-rated thermal mass flow controllers (TMFCs) pre-calibrated for process gases

Optional Liquid HandlingMore accuracy in liquid delivery – three variable speed pumps, integrated load cells and biocontainer bag hangers

Ergonomics and SpaceDesigned with people in mind to simplify the use and maintenance of bioreactor controllers

3

Specifications

Item mPath Control Tower

Weight < 20 kg

Dimensions 230 mm (W) x 600 mm (D) x 450 mm (H) (H = 590 mm with hangers installed)

Gas Requirements Air, nitrogen, oxygen and carbon dioxide Minimum supply pressure 2.5 bar (36.3 psi) Maximum supply pressure 6.0 bar (87.0 psi)

EMC Directive 2014/30/EU BS EN 61326-1: 2013

Low Voltage Directive (LVD) 2014/35/EU BS EN 61010-1: 2010

Machinery Directive 2006/42/EC BS EN ISO 12100: 2010

RoHS (Restriction of Hazardous Substances) Directive All components RoHS compliant (2011/65/EU)

IP (Ingress Protection) Rating Designed and tested - IP 54 (IP54 IEC 60529)

Electrical Data Voltage universal input: 100 – 240 V AC Input frequency: 50/60 Hz

Power Consumption 360 W maximum

Electrical Power Cables USA, UK and European

Operating System Microsoftu Windowsu Embedded Compact

Operating Conditions Laboratory environment Temperature range +5 °C (+41 °F) to +40 °C (+104 °F) Up to 90% relative humidity Non-condensing

Storage Conditions Temperature range -20 °C (-4 °F) to +50 °C (+122 °F) Up to 90% relative humidity Non-condensing

Item mPath Link Server PC

Memory (RAM) 16 GB

Central Processing Unit (CPU) 1 x Intelu i3-8100 3.60 GHz

Storage 1 TB

Software/Operating System Ignitionu, Windows 10 LTSC, MySQLu Standard

Software Details

Software License Specification

Windows 10 LTSC Win 10 IoT Ent 2019 LTSC MultiLang ESD OEI Value

Windows MSSQL Microsoft SQL Serveru IoT 2019 Standard 4 Core (ESD)

Ignition v8.1 Ignition Perspective License (unlimited) Ignition OPC UA Server Module Ignition Tag Historian License Java embedded

Corporate HeadquartersPort Washington, NY, USA+1-800-717-7255 toll free (USA)+1-516-484-5400 phone

European HeadquartersFribourg, Switzerland+41 (0)26 350 53 00 phone

Asia-Pacific HeadquartersSingapore+65 6389 6500 phone

Visit us on the Web at www.pall.com/biotechContact us at www.pall.com/contact

Pall Corporation has offices and plants throughout the world. To locate the Pall office or distributor nearest you, visit www.pall.com/contact.

The information provided in this literature was reviewed for accuracy at the time of publication. Product data may be subject to change without notice. For current information consult your local Pall distributor or contact Pall directly.

© Copyright 2021, Pall Corporation. Pall, , Allegro, iCELLis, mPath, and Xpansion are trademarks of Pall Corporation. ® indicates a trademark registered in the USA. TM indicates a common law trademark. uCrucial is a trademark of Micron Technology Inc.; Ignition is a trademark of Inductive Automation, LLC.; Intel is a trademark of Intel Corporation; Microsoft and Windows are trademarks of Microsoft Corporation. MySQL is a registered trademark of Oracle Corporation. Samsung is a trademark of Samsung Electronics Co Ltd.

USD3220a/GN21.07879 9/21

Hardware Details

Component Name Component information

Motherboard BCM MX310HD (rev.1.0)

Memory (RAM) 16 GB Crucialu CT8G4SFS8266 M8FD

CPU Intel i3-8100 3.60 GHz

CPU (FAN) DYNATRON K199 (i3-i7)

Storage Media Samsungu 860 QV0

PSU XP ALM85US19C2-8

Ports 5 x USB 2 x Ethernet HDMI

* mPath Link software can be installed on any end user server as long as that server meets, at a minimum, the same specifications as the mPath Link server. Please contact Pall for further details.

Ordering InformationThe mPath control towers are available for use with Pall benchtop bioreactors, including:

■ Allegro™ XRS 25 rocking bioreactor

■ Xpansion® multiplate bioreactor system

■ iCELLis® Nano bioreactor system

Please contact your sales representative at bioreactors@pall.com or www.pall.com.