90 Abstracts/Lung Cancer 13 (1995) 81-104

Mucoepidermoid lung tumors. Two new cases and a review of the literature Voog E. Mermuche Y, Bailly C. Rebattu P Deporlemenl d%mrom~e Palhologique, CentmLeon-Beranl. 28, Rue Loennec. 69373 Lyon Cede-x 08. Bull Cancer 1995:82.208-IO

Muco epidennoid tumors of Ihe lung are rare tumors. derived from the minor salivary gland tissue of the proximal trachea bronchial tree We distinguish high grade and low grade malignity ,umors Authors are presenting fwo case reports of mucoepidemmid tumors of the lung with avelyaggressivebehavioranda review ofthe lilerature. Altention is drawn ,o the difTicul, diBeren,ial diagnosis with adenosquamous carcinoma of ,he lung

Preoperative staging in non-small cell lung cancer without lymphadenopathy on computed tomogram Cha SI. Kim CH. Park JY. Jung TH. Chang BH. Kang DS Depnmn~w ,J lnrerno, A/ed,c,nc, .Scboo, o, .A,<~,,cmc, K,,unppook \bmnnl 1 ~n,vrr.\/(,: 7&-u Tuberc Rcspnr DIS 1994.4 I 616-23

o*,PcIII.c.s Carelul e\a,uauon about mcdlas,mal m\ol\cmcn, 1s m~ponan, III the managemen, ofpallcnfs w,h nowsmall ccl1 lung cancer lnvawe stagmg pmadure such as mednsunoscop) IS adxated bxwsc of ,he unrcltabd~ly of nomnvasne slaglog mclhods such as CT. MRI We compared dt,Tcrcnccs be,wccn pre- and pa,opcn,nc s,agmg lo non-small cell lang cancer \rl,hou, I)mphadcnopa,h> on CT scan and anvestngalcd ,hc melhods ror more accura,e prcopcranc slagmg .A,<,,ho<l.r md R<w,r (I, Records of a total of 4 I pa,~co,s nl,h pre- opera,,\c T , ,N,M, nowsmall cell luog caoccr vcw rcuwcd and ,hc h,s,ologx ,,pes or ,umors vcrc squamous cell carunoma I” 32 cases. adcoocarc~nonu no 6 casts and large cell carc~oonva to 1 ascs T\rcnt> four cases were ccn,ral lcs~oos and sc~cn,ccn cases uere pcnphcral ICSIO.~. (2, Among the 32 casts w,,h prmperalwc T: . 2 casts wcrc tdcnuf,cd pos,opera,wcly as T , w,h tmasnon orchcs, wall and among 6 cases w,h preoperalw T. . l case was ldcnwicd pos,opera,~\el~ as T . w,h ,n\as,on oraor,a and &monar! arfcrxs (3) Ancr rhc operallon or15cascswlhT. . ScasccsucrcN and 1 cascsr\crcN. oonowa,nch Ancr Ihc opera,,o;ofh cases w,h T, . 2 casts uac N, and 1 cases w;e N, postopcrauvely Preqeratirc T , shoucd o,ore mlralhoraczc &mph node rnc,a~,asc~ and hlghcr N,M, m~oI\.cmc., rauo ,han prcoperatnc T,. , )4) Complclc surgical ~s~c,~oos wc done lo 14 out of4 I casts lncomplctc rcscc,,oo were done I” all postopcmlnc N: ,“mors (‘rmclu.w,n lnvawe s,ag,ng proccdura such as mcdms,mosmp\ should be conszdercd ,n the case orprcopcranc T , nowsmall cell lung caoccr cvcn though mcd,as,mal I!mphadcnopa,h! 1s ,101 rccogmxd on ,hc CT scan oflhc chcs,

Carcinoma of the lung in HIV-positive patients: Findings on chest radiographs and CT scans White CS. Haramatl LB. Elder KH. Karp J. Belani CP Deporlmenl o/ Rodrolom Unrvers,rv of Mmyland Med System. 22 S Greene St., Ro/lrn& MD 2/20/. A I f&n,genol ,995,164- 593-7.

Ob]ecrwe Several recent clmncal studies have described an assoc,a,,on between HIV seroposltwiry and lung cancer The purpose orlhns s,udy was 10 describe the spec,mm ofimaging ,iodmgs in HIV- postwe patems who had proved carcmoma of ,he lung In particular. we attempled lo define the role of CT in dmgooslog HIV-associated lung cancer Macenols ondblelhods The s,udy popularion consisled of 23 HIV-pos~lwe pa,wn,s from two ioslilulions who had lung cancer daagnosed between 1989 and 1993 All palienls had bolh ches, radio- graphs and CT SCIIOS. The group included I9 men and four women wth a mean age or42 years. The dlagnasisofluog cawerwas confirmed by bronchoscopy in eight paueols, by pleural fluld aspuafmn or pleural bnopsy m seven, by percutaneous needle biopsy ofa lung lesion m three. by bmpsy of an entmthoraac sile in four, and by ,horaco,omy lo one Two thoraoc radiologists retmspeaively evaluated the chesl mdwgmphs and CTscaos lo ldcntlfy parenchymal masscs. lymphadenopathy, pleural dwease, chcs, wall or medmsunal mvasion, and metaaatic lessons Rerulrs: FiAeen (65%) of the 23 patients had a central or peripheral o,assor nodule. Eagb, (35%) hadextenswe pleural dwase, efither as an &a,ed nnding or in combination with other abnormaht~es CT szans showed the mabgoan, lesion uoderlymg Ihe extensave pleural disease m all hut one case. All patnents wilh extensive pleural disease had adeoocarcmoma. No patient m the study was considered a candIdale for resection on the bans of chnical and radmlogic evaluation Concluston. Lung cancer in HIV-positive pa,ien,s ~lrested mostol?en on chest radwgmphs asa caral or peripheral massor nodule. Fxensive

pleural disease in the absence of an apparen, primaly lesion was the second nwstc~rnrn~n major manifesation. Loogcaocertberefore merits serious conslderalion in Lhe diffcrenlial dmgoosls of extenswe pleural disease in HIV-posilive patients. CT was most useful in evaluatmg malignant lesions associated with extensive pleural disease

Clinical study of birpenem to the secondary infections of lung cancer Havashl I. Sakorai M. Ichik, M. Shmtani I. De~+~tmenl oflnterncd Medrcme, Concerlnslilule Hosp~lal, 1-37-I Kmu~ikebukum: Toshrma- ku. Tokw 170 Chemolheraov (laoan) 1994~42. Suool4:706-7.

Cl&al investigation xv& ,iof,,ed oo’biapen’km @PM). a new carbapenem BIPM was admiostered to 2 lung cancer patienu with respiratory tmc, iofeclions (lung abscess and pneumonia), a, a daily do& of600 mg. The clinical response was excellen, in I and good in 1. Neither clinical side effects nor ahnomml laboralow findings were observed during or after administration of BIPM. -

Brain metastasis from lung cancer Nieder C. Niewald M, Nesde U. Walter K, Schnabel K Deportment o/ Rodrolherqv, Unrvers#ry Hospital, 66121 HombwgiSam Radio1 Onml 1994;28:403-7.

Our analysis included 150 palienu who were treated by whole-bran irradiation beween I983 and 1993. All of lhem received 10 x 3 Gy over 2 weeks. In 12 cases surgical resection ofbrain memaases preceded radiotherapy. 49 patients had primary smaIl-xll lung canceriSCLC), and 81 non-small cell lune cancer (NSCLC). The Others had mixed tumors The evaluation of&b CT-scans showed a significantly di&eo, average number of brain metastases (SCLC 4 oh?,.. NSCLC 2 me,.) and a smaller surrounding edema in ,hc case of SCLC. Diameter of melrlsmses and total cerebral tumor volume were distributed equally. The interval between primary lumor and development of brain metastases, presence of extracerebral melastases and Karnofsky performance status were also disuibuted equally, but SCLC patients were significantly younger The local remission rafe was dependent on hinolob as well as on the diameler ormelastases. In 44% oral1 cases a comolete or partial remission was found (SCLC 60%. adeno-ca 39%. q&now&a21% p=O.M)7). However.aRer mul,,varia,eaoalysis. bi~ology was no, found 10 be a prognosttc factor for survival. Surgical tmmnt aim bad no ioflueoce on UK snvival. Patieo,s’ age. Kamofsky- pxfommoce status, extracerebral memstases and ,he diameter of bram metastases were the only prognostic ractors. Mean survival was 123 days (median 69 days). The survival of pahents with extracerebral m~ta~tases and a Kamofsky-performance status ~70 was very poor. Therefore, theyshouldbcueaedooly in lhecaseofdisahlingsymploms. when application ofmrtiwstem~ds has failed. For Ihe majority ofpatienls radiotherapy with 10 x 3 Gy seems 10 be appmpriale

Carcinosarcomn of the lung Della Pooa C. Roao G, Mass&a F. Robustellmi M, Rossi G. Riul A Diviwm ofThoracic Surnerv. E. Mcmdlr Remnol Howibd, Vm Zubrm 33, 2303dSond,do. Ra&lOocol 1994:28373-5.

Belween January 1979, and December 1990. 1242 patients wi,h primary lung cancers were observed in our Dwision. Among these, 3 (0.2% - I male and 2 females, mean age 53 yrs.: range 40-75 yrs.) had a postoperative diagnosis of carcinosarcoma of the lung. Stage I was foundin 2 patienu, andslagell disease(Nl) in I. The resectionincluded lobectomy in 2 patients and wedge resecuon in 1. Postoperatively. lhe padents did no, receive any adjwan, ,rea,men, As ofDecember 1993. only one patient (pT2NO) is alive and who”, endence ofdisease a, 36 months from surgery. with the other two patients showing short pmtoperatwe survivals (3 and 7 months).

Accordance of clinical versus pathological stage (pTNM) in patients with surgically treated non-small cell lung caocer Wdma, S ,,qw,,,w,, o,Tborncrc .S’u,gm, Ihwe,r,lv .2lrd,~nl (‘cnrrr. %o/mko 7, 61105 I./uhljnna. Radml Oncol I994.2R 337-40

In a group of 35” pa,,co,s wi,h non-small cell carcinoma or Ihc lung, who were sub,mcd 10 opcrallon durmg the perwd from Ma? I983 to J&z ,987 a, ourmsututio~. ,hcagrccmc~, b&cn ,hc prcopcra,nc. ,hc ,n,raoocerauve and Ihc I)a,holomcal TNM s,as (4,h cd 1 rtas examined .The preoperalwe &age & Idcn,ncal wilh Ibe patbologaca,