Multicomponent Reaction (MCR) · point of view, thus, the reaction above is an extremely useful and eco-friendly MCR. Thus, MCR is a strong synthetic methodology to enable condensation

Please inquire for pricing and availability of listed products to our local sales representatives.2

Multicomponent reaction (MCR) is a synthetic methodology in which three or more reactants come together in a single reaction vessel to form a new product. The characteristic aspect of MCRs is that the final products contain almost all portions of substrates, generating almost no by-products. That makes MCRs an extremely ideal and eco-friendly reaction system. Target compounds can be obtained in one pot with much fewer steps. Therefore, MCRs have been paid much attention in various research fields, such as discovery of lead compounds in medicinal chemistry, or combinatorial chemistry.

There have been a number of reports on MCRs so far, and typical examples are described as below.

1. Strecker reaction (Three-component reaction: 3CR)

This reaction was reported by A. Strecker in 1850, and is extremely famous as the synthesis of a-amino acids. This reaction is an MCR which comprises three components, aldehydes, hydrogen cyanide, and ammonia as substrates, and is recognized as the world’s first MCR.1)

2. Hantzsch dihydropyridine synthesis (3CR)

This reaction was reported by A. R. Hantzsch in 1881, and is the best-known three-component MCR, which affords 1,4-dihydropyridine derivatives using b-keto esters, aldehydes, and ammonia.2) For an example, a calcium channel blocker, “Nifedipine”, is also synthesized by this reaction.3)

3. Biginelli reaction (3CR)

In 1891, an Italian chemist, P. Biginelli has reported the three-component MCR using b-keto esters such as ethyl acetoacetate (A0649), aromatic aldehydes such as benzaldehyde (B2379), and ureas (or thioureas) in the presence of acid catalyst (Brönsted or Lewis acids), affording dihydropyrimidinone derivaties.4) Dihydropyrimidinones have been paid much attention because of their various bioactivities such as anti-inflammatory or anti-bacterial activities. For an example of pharmaceuticals developed by using the reaction, several anti-tubercular agents have been reported as below.5)

4. Passerini reaction (3CR)

In 1921, an Italian chemist, M. Passerini et al. have reported the three-component reaction using carboxylic acids, aldehydes, and isonitriles, affording a-acyloxy amides.6) The Passerini reaction also has been applied into pharmaceutical research, for example, Hulme et al. have reported the library synthesis of novel norstatine derivatives bearing benzimidazole moieties.7)

Multicomponent Reactions (MCR)

Strecker Reaction (Amino Acid Synthesis)

R H

O NaCN, NH3

R CN

NH2

R COOH

NH2H3O+

+ +

Hantzsch Dihydropyridine Synthesis

R3 H

OR2O

O

OR1

NH3

NH

R3

R2O

O

R1

OR2

O

R1

2

MeO2C

O+

CHO

NO2

NH3+

NH

MeO2C CO2Me

NO2

Nifedipine

+ R4

NH

NH

R5

XR3

H O

O

R1 O

R2O

NR5

NR4

X

R3

R1

O

R2O+

H+

Biginelli reaction

(X = O or S)

NH

NHEtO2C

O

Examples of Anti-tubercular Agents using Biginelli Reaction

NN

F

NH

NH

O

NO2

NH

O

Passerini Reaction

+ +R2 CHO R3 NCR1 COOH R1 O

HN

O

R3

R2O

R1 COOHCHO

BocHN R2

NHBoc

CN

+ +CH2Cl2, rt, 18 h R1 O

HN

OBocHN R2

O

NHBoc

Passerini Products

10% TFA / CH2Cl2, rt, 24 h

R1 O

HN

OH2N R2

O

NH2

Et3N / MeOH (1 : 3), rt, 2 h

Acyl Migration

HO

HN

HN R2

O

NH2

OR1

10% TFA / DCE,MW, 100°C, 20 min

R1 NH

O R2

OH

NH

N

NH

O

OH

NH

N

NH

O

OH

NH

N

MeO

NH

O CH3

OH

NH

N

NH

O CH3

OH

NH

N

NNH

O

OH

NH

NHN

Ph

NH

O

OH

NH

NPh

CH3

3

Multicomponent reaction (MCR)

Please inquire for pricing and availability of listed products to our local sales representatives.

5. Gröbcke-Blackburn-Bienaymé reaction 8) (3CR)

This reaction is a three-component MCR using aldehydes, isonitriles, and a-aminoazines such as 2-aminoimidazole or 2-aminopyridine in the presence of acid catalyst. The reaction is applicable for the synthesis of fused nitrogen-containing aromatic compounds as below.

6. Kabachnik-Fields reaction (3CR)

In 1952, M. I. Kabachinik et al. have reported the three-component MCR using aldehydes, amines, and dialkyl phosphites in the presence of acid catalyst (Brønsted or Lewis acids), affording a-aminophosphonates.9) In recent years, much attention has been paid to a-aminophoshonates since they can be considered as structural analogues of the corresponding a-amino acids and transition state mimics of peptide hydrolysis. Thus, a-aminophoshonates have been applied into several research areas, such as development of renin inhibitors or HIV protease inhibitors.10)

7. Ugi reaction (4CR)

This reaction is the four-component MCR reported by I. K. Ugi et al. in 1962 for the first time.11) It enables one-pot condensation of four components (aldehydes, amines, isonitriles, and carboxylic acids), thus, it can be said that the Ugi reaction is the most versatile among MCRs. For an example of applications using this reaction, Fukuyama et al. have reported the synthesis of a marine tunicate, Ecteinascidin 743, which has extremely potent antitumor acitivity, using the Ugi reaction as a key step below.12)

Other examples of MCR

・MCR using p-toluenesulfonylmethyl isocyanide (TosMIC) (3CR)

p-Toluenesulfonylmethyl isocyanide (TosMIC) (T1046) is a synthetic reagent, developed by Leusen et al., and has both an isonitrile group and a tosyl group (leaving group) in one molecule.13) Different from other isonitrile compounds with odor character, TosMIC is an odorless and solid compound. Because of its easy-handling property, TosMIC has been widely used for the synthesis of nitrogen-containing aromatic heterocyclic compounds, such as oxazoles.14) TosMIC also has been used for MCRs, for example, Tsoleridis et al. have reported the synthesis of quinoxaline derivatives via the three-component condensation of o-phenylenediamines, aromatic aldehydes and TosMIC.15)

・MCR using benzynes (3CR)

Recently, there also have been several reports on MCRs using benzynes. For example, Yoshida et al. have reported the three-component MCR using in situ generated benzynes, imines, and carbon dioxide, affording benzoxadinones.16)

Recently, much attention has been paid on organic synthesis using carbon dioxide as a carbon source from the ecological

+ +H+

Gröbcke-Blackburn-Bienaymé Reaction

R2 CHO R3 NCN

NH2

R1 NR1

N

NHR3

R2

N

N

NHBn

N

N

NS

NHBn

N

N

NHBn

N

+ +

Kabachnik-Fields Reaction

R1 H

OR2 NH2 OR3

OR3

PH

O

OR3OR3

P

O

R1

HNR2

+ +

Ugi Reaction

R1 H

O

R2 NH2 R3 NC R4 COOH NH

N R4

O

R3

R1

R2

O

+

CH3 CHO +MeOH, reflux

Ugi Products

OO

OMOM

Me

NH2

OTBDPS

MeO NC

OMe

MeBnO

I

BocHN

CO2H

+ +

OO

OMOM

Me

N

TBDPSO

CH3

NH

O

MeO

O

NHBoc

OMe

Me OBn

I

(Y. 90%)

OO

OAc

Me

N

N

OMe

HO Me

S

OH

O

NHMeO

HO

Me

OH

H

Ecteinascidin 743

R1

R2

NH2

NH2

ArCHO

T1046 (TosMIC)

CH3 S

O

O

CH2NC+ +

N

NR1

R2

Ar

Toluene, reflux, 4 h

Base

R1 R2 Ar Base Quinoxaline (Y. %)

H phenyl DABCO

DBU

91H

H H 2,4-dimethylphenyl

phenyl

4-chlorophenylH H

Me Me

Me Me 2-methylphenyl

DABCO

DABCO

DBU

81

84

86

85

Entry

1

2

3

4

5

point of view, thus, the reaction above is an extremely useful and eco-friendly MCR.

Thus, MCR is a strong synthetic methodology to enable condensation of various substrates in one pot, however, in some cases, reactions require long times for completion or result in undesired side reactions even after optimization of reaction conditions such as solvents or Lewis acid catalysts. For resolving these problems, there have been some successful reports on accelerating MCRs. For example, Shaabani et al. have reported the ionic liquid promoted Gröbcke-Blackburn-Bienaymé reaction.17) As indicated in the table below, in the case of using ionic liquids as solvents, reactions proceed smoothly to afford the desired products in excellent yields. On the other hand, the yield of product is poor even in the prolonged reaction time (Entry 2’). Moreover, as indicated in Entry 1, the ionic liquid can be reused for the same reactions, maintaining the high yields.

Ionic liquids can be generally recovered and recycled, which can help to reduce the waste of traditional solvents which are rarely reused. In addition, ionic liquids have attracted much attention as excellent solvents due to their low volatility. Judging from these points, this reaction can be regarded as a more eco-friendly reaction example.

TCI offers a variety of aldehyde, amine, carboxylic acid, b-keto ester, urea & thiourea, and dialkyl phosphite compounds readily available in MCRs. For aldehyde, amine, and carboxylic acid compounds, typical products selected are listed judging from reports on MCRs so far. In addition, benzyne precursors, Lewis acids, and ionic liquids used in MCRs are also listed in this brochure.

References1) A. Strecker, Ann. 1850, 75, 27.

2) A. Hantzsch, Ber. 1881, 14, 1637.

3) R. Alajarin, J. J. Vaquero, J. L. G. Navio, J. A-Builla, Synlett 1992, 297; R. Alajarin,

P. Jordan, J. J. Vaquero , J. A-Builla, Synthesis, 1995, 389; B. M. Khadilkar, A. A.

Chitnavis, Ind. J. Chem. 1995, 34B, 652; B. M. Khadilkar, V. G. Gaikar, A. A.

Chitnavis, Tetrahedron Lett. 1995, 36, 8083.

4) P. Biginelli, Ber. 1891, 24, 1317; P. Biginelli, Ber. 1891, 24, 2962.

5) A. R. Trivedi, V. R. Bhuva, B. H. Dholariya, D. K. Dodiya, V. B. Kataria, V. H.

Shah, Bioorg. Med. Chem. Lett. 2010, 20, 6100; V. Virsodia, R. R. S. Pissurlenkar,

D. Manvar; C. Dholakia, P. Adlakha, A. Shah, E. Coutinho, Eur. J. Med. Chem.

2008, 43, 2103

6) M. Passerini, Gazz. Chim. Ital. 1921, 51, 181.

7) A. Y. Shaw, F. Medda, C. Hulme, Tetrahedron Lett. 2012, 53, 1313.

8) K. Gröbke, L. Weber, F. Mehlin, Synlett, 1998, 661; C. Blackburn, B. Guan, K.

Shiosaki, S. Tsai, Tetrahedron Lett. 1998, 39, 3635; H. Bienaymé, K. Bouzid,

Angew. Chem. 1998, 110, 2349; H. Bienaymé, K. Bouzid, Angew. Chem. Int. Ed.

1998, 39, 2234.

9) M. I. Kabachnik, T. Y. Medved, Dokiady Akademii Nauk SSSR, 1952, 83, 689; E.

K. Fields, J. Am. Chem. Soc. 1952, 74, 1528.

10) S. Shibuya, YAKUGAKU ZASSHI 2004, 124, 725; M. C. Allen, W. Fuhrer, B. Tuck,

R. Wade, J. M. Wood, J. Med. Chem. 1989, 32, 1652; M. K. Manthey, D. T. C.

Huang, W. A. Bubb, R. I. Christpherson, J. Med. Chem. 1998, 41, 4550.

11) I. Ugi, Angew. Chem. Int. Ed. 1962, 1, 8.

12) A. Endo, A. Yanagisawa, M. Abe, S. Tohma, T. Kan, T. Fukuyama, J. Am. Chem.

Soc. 2002, 124, 6552.

13) A. M. V. Leusen, Org. Synth. 1977, 57, 102.

14) O. Possel, A. M. V. Leusen, Heterocycles, 1977, 7, 77; A. M. V. Leusen, O. H.

Oldenziel, Tetrahedron Lett. 1972, 23, 2373.

15) C. Neochoritis, J. Stephanidou-Stephanatou, C. A. Tsoleridis, Synlett 2009,

302.

16) H. Yoshida, H. Fukushima, J. Ohshita, A. Kunai, J. Am. Chem. Soc. 2006, 128,

11040.

17) A. Shaabani, E. Soleimani, A. Maleki, Tetrahedron Lett. 2006, 47, 3031.

+TMS

OTfR

Ar H

NMeCO2 R

O

MeN

O

Ar

+

KF

18-Crown-6

THF, 0 °C

Ar = 2,4,6-trimethyphenyl

Reaction time (h) Product

Benzyne Precursor

Benzyne Precursor

TMS

OTf

TMS

OTf

F

TMS

OTf

OMe

TMS

OTf

15O

MeN

O

Ar

O

MeN

O

Ar

FO

MeN

O

ArF

O

MeN

O

Ar

OMe

O

MeN

O

Ar

(Y. 82%)

(Y. 63%, 4 : 1)

63and

(Y. 73%)

(Y. 44%)

46

60

+ +rt, 3 h

Yield (%)Entry

R2 CHON

NH2

[bmim]Br

N

NR2

HNR1

[bmim]Br = N

N

(CH2)3CH3

CH3

Br

R1 R2

1

2

3

4

5

Ph

Ph

4-CH3C6H4

4-O2NC6H4

4-Pyridyl

Br

Me

Me

Me

Me

NC

98 (95, 92, 90, 85)a

98

99

92

97

a The same ionic liquid is used for each of the five runs.

2'ｂ PhMe 25

b Ionic liquid is not used. Reaction time is 12 h.

R1



Aldehydes・・・・・・・・・・・・・ 6

Amines・・・・・・・・・・・・・・・ 7

Carboxylic Acids・・・・・・・・・・ 8

b-Keto Esters・・・・・・・・・・・・ 8

Isonitriles・・・・・・・・・・・・・・ 10

Ureas・・・・・・・・・・・・・・・・ 10

Thioureas・・・・・・・・・・・・・・ 11

Dialkyl Phosphites ・・・・・・・・・ 13

Diketone Compounds ・・・・・・・ 13

Isatins・・・・・・・・・・・・・・・ 13

Benzyne Precursors・・・・・・・・・ 14

Lewis Acids ・・・・・・・・・・・・・ 14

Ionic Liquids・・・・・・・・・・・・ 15

The list of productsWe introduce our products according to their structure and applications.


AldehydesC

OCH3

O

H

A0479 25g 100g 500g

o-Anisaldehyde [135-02-4]

C

OCH3

O

H

A0478 25mL 100mL 500mL

m-Anisaldehyde [591-31-1]

C

O

H

OCH3

A0480 25mL 500mL

p-Anisaldehyde [123-11-5]

C

O

H

B2379 500g

Benzaldehyde [100-52-7]

C H

O

Br

B0836 25g 100g 500g

2-Bromobenzaldehyde [6630-33-7]

C

O

H

Br

B0548 25g 100g 500g


C

O

H

Br

B0549 25g 250g


C H

O

Cl

C0561 25g 500g

2-Chlorobenzaldehyde [89-98-5]

C

O

H

Cl

C0124 25g 100g 500g


C H

O

Cl

C0125 25g 100g 500g


C

Cl

F

H

O

C1465 1g 5g

2-Chloro-4-fluoro-benzaldehyde [84194-36-5]

H

O

C0352 25mL 500mL

trans-Cinnamaldehyde [14371-10-9]

C

O

H

CN

C0443 5g 25g

4-Cyanobenzaldehyde [105-07-7]

C

O

H

C0880 25mL 100mL

Cyclohexanecarboxaldehyde [2043-61-0]

Cl

Cl

C

O

H

D1666 25g 500g

2,3-Dichlorobenzaldehyde [6334-18-5]

C

O

H

OH

OH

D0564 25g 100g 500g

2,4-Dihydroxybenzaldehyde [95-01-2]

O

OC

O

H

B2019 1g 5g

3,4-Ethylenedioxybenzaldehyde [29668-44-8]

O C

O

H

F0073 25g 500g

Furfural [98-01-1]

OH

C

O

H

H0197 25g 100g 500g

3-Hydroxybenzaldehyde [100-83-4]

C

O

H

OH

H0198 25g 100g 500g

4-Hydroxybenzaldehyde [123-08-0]

O

CH3

CH3H

I0101 25mL 500mL

Isobutyraldehyde [78-84-2]

C

C

O

H

H

O

I0153 25g 250g

Isophthalaldehyde [626-19-7]

C

O

H

N0002 25mL 100mL 500mL

1-Naphthaldehyde [66-77-3]

C

O

H

N0003 5g 25g

2-Naphthaldehyde [66-99-9]

C

O

H

NO2

N0130 25g 100g 500g

2-Nitrobenzaldehyde [552-89-6]

NO2

C

O

H

N0129 25g 500g


NO2

C

O

H

N0559 25g 100g 500g


F

F

F

F

F

C

O

H

P0746 5g 25g

Pentafluorobenzaldehyde [653-37-2]

C

O

H

B0242 5g 25g 250g

4-Phenylbenzaldehyde [3218-36-8]

O

OCH

O

P0456 25g 500g

Piperonal [120-57-0]

H3C

CH3C

H3C

C

O

H

P0847 5mL 25mL

Pivalaldehyde [630-19-3]

N C H

O

P0425 25g 100g 500g

2-Pyridinecarboxaldehyde [1121-60-4]

N

C

O

H

N0090 25mL 100mL 500mL


N

C

O

H

I0143 25mL


C

C

O

H

O

H

T0010 25g 100g 500g

Terephthalaldehyde [623-27-8]

S C

O

H

T0725 25mL 100mL 500mL

2-Thiophenecarboxaldehyde(stabilized with HQ) [98-03-3]

C

CH3

O

H

T1073 25mL 500mL

p-Tolualdehyde [104-87-0]

C

CH3

O

H

T0259 25mL 100mL 500mL

p-Tolualdehyde [104-87-0]

Please inquire for pricing and availability of listed products to our local sales representatives. 7


C H

O

CF3

T1281 25g

2-(Trifluoromethyl)-benzaldehyde [447-61-0]

C

O

H

CF3

T1091 5g 25g 250g

4-(Trifluoromethyl)-benzaldehyde [455-19-6]

C

OCH3CH3O

OCH3

O

H

T2651 5g 25g

2,4,6-Trimethoxybenzaldehyde [830-79-5]

C

O

H

CH3

CH3

CH3

T1368 25mL

2,4,6-Trimethylbenzaldehyde [487-68-3]

O

NC

O

H

O0453 200mg 1g

4-Formyloxazole [118994-84-6]

C H

O

OCH3

OCH3

CH3O

T0059 25g 100g 500g

3,4,5-Trimethoxybenzaldehyde [86-81-7]

Amines CH2NH2

A0219 25mL 500mL

Allylamine [107-11-9]

NH

N

NH2

A0850 5g 25g

2-Aminobenzimidazole [934-32-7]

N

N NH2

A0989 5g 25g

2-Aminopyrazine [5049-61-6]

NH

N

NH2

A1859 5g 25g

3-Aminopyrazole [1820-80-0]

N NH2

A0411 25g 100g 500g

2-Aminopyridine [504-29-0]

N

N NH2

A0412 25g

2-Aminopyrimidine [109-12-6]

S

N N

NH2

A1060 5g 25g

2-Amino-1,3,4-thiadiazole [4005-51-0]

S

N

NH2

A0633 25g 100g 500g

2-Aminothiazole [96-50-4]

NH

N

NNH2

A0432 25g 500g

3-Amino-1,2,4-triazole [61-82-5]

CH3NH2

A0445 25mL 100mL 500mL

Amylamine [110-58-7]

NH2

A0463 500g

Aniline [62-53-3]

CH2NH2

B0406 25mL 500mL

Benzylamine [100-46-9]

NH2

Br

B0541 25g 250g

2-Bromoaniline [615-36-1]

CH3 C

CH3

NH2

CH3

B0709 25mL 100mL 500mL

tert-Butylamine [75-64-9]

CH3 NH2

B0707 25mL 500mL

Butylamine [109-73-9]

NH2

C0494 25mL 500mL

Cyclohexylamine [108-91-8]

NH2

C0887 25mL 500mL

Cyclopentylamine [1003-03-8]

O CH2NH2

F0091 25mL 100mL 500mL

Furfurylamine [617-89-0]

CH3

CH3NH2

I0095 25mL 500mL

Isobutylamine [78-81-9]

NH2

CH3

CH3

I0165 25mL 500mL

Isopropylamine [75-31-0]

NH2

P0085 25mL 100mL 500mL

2-Phenylethylamine [64-04-0]

N CH2NH2

A1161 25g 250g

2-Picolylamine [3731-51-9]

HC CCH2NH2

P0911 5mL 25mL

Propargylamine [2450-71-7]

NH2

I

NO2

I

D4736 5g 25g

2,6-Diiodo-4-nitroaniline [5398-27-6]

CH2NH2

CH3

M2726 1mL 5mL

2-Methylallylamine [2878-14-0]

NH2

NH2

P0168 25g 100g 500g

1,2-Phenylenediamine [95-54-5]



Carboxylic AcidsCH3 OH

O

A2035 300mL

Acetic Acid [64-19-7]

C

O

OH

C

O

CH3

A1075 5g 25g

2-Acetylbenzoic Acid [577-56-0]

OH

OCH2

A0141 25g 500g

Acrylic Acid (stabilized with MEHQ) [79-10-7]

C

O

OH

NH2

A0497 25g 100g 500g

Anthranilic Acid [118-92-3]

O

OC

O

HO

B3764 5g 25g

1,4-Benzodioxane-6-carboxylic Acid [4442-54-0]

C

O

OH

B2635 25g 500g

Benzoic Acid [65-85-0]

OH

OBr

B0531 25g 500g

Bromoacetic Acid [79-08-3]

C OH

O

Br

B0552 25g 100g 500g

2-Bromobenzoic Acid [88-65-3]

ClCH2 C

O

OH

C2123 25g 500g

Chloroacetic Acid [79-11-8]

O

OH

C0353 25g 100g 500g

trans-Cinnamic Acid [140-10-3]

OH

ONC

C0439 25g 500g

Cyanoacetic Acid [372-09-8]

C

O

OH

C0470 25g 500g

Cyclohexanecarboxylic Acid [98-89-5]

CH C

O

OH

D0869 25g 100g 500g

Diphenylacetic Acid [117-34-0]

C

F

OH

O

F0112 25g

4-Fluorobenzoic Acid [456-22-4]

H OH

O

F0513 300mL

Formic Acid [64-18-6]

O

OHH

O

G0366 25mL 500mL

Glyoxylic Acid (ca. 50% in Water, ca. 9mol/L) [298-12-4]

C

OH

OH

O

H0206 25g 500g

2-Hydroxybenzoic Acid [69-72-7]

C

O

OH

I

I0053 25g 100g 500g

2-Iodobenzoic Acid [88-67-5]

C OH

O

NO2

N0155 25g 500g

2-Nitrobenzoic Acid [552-16-9]

C C C OH

O

P0610 5g 25g

Phenylpropiolic Acid [637-44-5]

C

C

O

OH

O

H

P0281 25g 100g 500g

Phthalaldehydic Acid [119-67-5]

NH

N

C

O

OH

P1862 1g 5g

Pyrazole-3-carboxylic Acid [1621-91-6]

OH

OHS

M0052 25g 500g

Thioglycolic Acid [68-11-1]

C

O

OH

CF3

T1145 5g 25g

4-(Trifluoromethyl)-benzoic Acid [455-24-3]

b -Keto EstersCH3 O

CH2

O O

A1981 25g 500g

Allyl Acetoacetate [1118-84-9]

CH3 OCH3

O O

A0811 25mL 500mL

Amyl Acetoacetate [6624-84-6]

CH3 O

O O

A1080 25mL 100mL 500mL

Benzyl Acetoacetate [5396-89-4]

CH3 O

O O

CH3

CH3

A0815 25mL

sec-Butyl Acetoacetate [13562-76-0]

CH3 OC(CH3)3

O O

A0816 25mL 100mL 500mL

tert-Butyl Acetoacetate [1694-31-1]

CH3 O CH3

O O

A0795 25mL

Butyl Acetoacetate [591-60-6]

O

OO

O

OCH3

CH3

O0073 5g 25g

Diethyl Oxalacetate [108-56-5]

CH3 O O CH3

OOO

O0229 1g 5g

Diethyl 3-Oxopimelate [40420-22-2]



CH3 O CH3

OO

A0649 25g 500g

Ethyl Acetoacetate [141-97-9]

O CH3

O O

B0097 25g 100g 500g

Ethyl Benzoylacetate [94-02-0]

ClO CH3

OO

C0911 25g 500g

Ethyl 4-Chloroacetoacetate [638-07-3]

O CH3

O O

N Cl

F

Cl

E0811 5g 25g

Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate [96568-04-6]

(CH3)3C O CH3

O O

D1891 5mL 25mL

Ethyl 4,4-Dimethyl-3-oxovalerate [17094-34-7]

OO CH3

OO

CH3

O

CH2

E0489 25g 500g

Ethylene Glycol Monoacetoacetate Monomethacrylate (stabilized with BHT) [21282-97-3]

O CH3

O O

F

F0435 1g 5g 25g

Ethyl (4-Fluorobenzoyl)-acetate [1999-00-4]

CH3O CH3

OO

CH3

E0882 5g 25g

Ethyl Isobutyrylacetate [7152-15-0]

O

OCH3 Cl

O

E0484 5g 25g

Ethyl Malonyl Chloride [36239-09-5]

O CH3

OO

CH3O

M1380 25g

Ethyl 4-Methoxybenzoyl-acetate [2881-83-6]

O CH3

O O

O2N

N0513 5g 25g

Ethyl 4-Nitrobenzoylacetate [838-57-3]

CH3O CH3

OO

O0216 10g 25g

Ethyl 3-Oxoheptanoate [7737-62-4]

CH3 O CH3

OO

K0030 25mL 500mL

Ethyl 3-Oxohexanoate [3249-68-1]

CH3O CH3

O O

K0031 5g 25g

Ethyl 3-Oxovalerate [4949-44-4]

OCF3CF2

OO

CH3

P1062 5g

Ethyl 4,4,5,5,5-Pentafluoro-3-oxovalerate [663-35-4]

O CH3

O OF

F

F

F

E0759 25g

Ethyl (2,3,4,5-Tetrafluoro-benzoyl)acetate [94695-50-8]

O

Cl3C O

O

CH3

T1285 10g 25g

Ethyl 4,4,4-Trichloroacetoacetate [3702-98-5]

O

O CH3CF3

O

T0810 25g 100g 500g

Ethyl 4,4,4-Trifluoroacetoacetate [372-31-6]

CH3 OCH3

O O

A0916 25mL

Heptyl Acetoacetate [42598-96-9]

CH3 O CH3

O O

A0913 25mL

Hexyl Acetoacetate [13562-84-0]

CH3 O

O O

CH3

CH3

A0812 25mL 500mL

Isoamyl Acetoacetate [2308-18-1]

CH3 O

O O

CH3

CH3

A0814 25mL

Isobutyl Acetoacetate [7779-75-1]

CH3 O CH3

O O CH3

I0826 25g 500g

Isopropyl Acetoacetate [542-08-5]

O

CF3 O

O

CH3

CH3

T1530 25g

Isopropyl 4,4,4-Trifluoroacetoacetate [175230-50-9]

O

O

O

O

CH3

CH3

M0799 25g 100g 500g

Meldrum's Acid (=2,2-Dimethyl-1,3-dioxane-4,6-dione) [2033-24-1]

CH3 OOCH3

O O

A1583 25g 500g

2-Methoxyethyl Acetoacetate [22502-03-0]

O

OCH3

O

M2277 5g 25g

Methyl 3-Cyclopropyl-3-oxopropionate [32249-35-7]

O

ClCH3O

O

M2315 5g 25g

Methyl Malonyl Chloride [37517-81-0]

CH3 O

O O

NO2

N0875 5g 25g

4-Nitrobenzyl Acetoacetate [61312-84-3]

CH3 O CH3

O O

A0915 25mL

n-Octyl Acetoacetate [16436-00-3]

CH3 O

O OCH3

CH3

A0813 25mL

3-Pentyl Acetoacetate [13562-81-7]

CH3 O

OO

CH3

A0817 25mL 500mL

Propyl Acetoacetate [1779-60-8]

O

O CH3

O

F

F

E1018 5g 25g

Ethyl 4,4-Difluoro-acetoacetate [352-24-9]

Cl

O O

O CH3

E1059 1g 5g

Ethyl 3-Oxo-3-(4-chlorophenyl)-propionate [2881-63-2]

O

O

O

CH3

CH3

E1071 1g 5g

Ethyl 2-Benzoylpropionate [10488-87-6]

S

O

O

O

CH3

E1073 200mg 1g

Ethyl 3-Oxo-3-(2-thienyl)-propionate [13669-10-8]

O

O

O

NC

CH3

E1080 200mg 1g

Ethyl 3-(4-Cyanophenyl)-3-oxopropionate [49744-93-6]

O CH3

O OF

E1097 5g 25g

Ethyl (2-Fluorobenzoyl)-acetate [1479-24-9]

Br

O CH3

O O

E1117 1g 5g

Ethyl (4-Bromobenzoyl)-acetate [26510-95-2]

O

O

O

CH3

OCH3

E1120 1g

Ethyl (2-Methoxybenzoyl)-acetate [41607-95-8]



OCH2CH3

O O

CH3O

E1121 1g 5g

Ethyl (3-Methoxybenzoyl)-acetate [27834-99-7]

O

O

OCH3

CH3

E1125 1g

Ethyl (2-Methylbenzoyl)-acetate [51725-82-7]

O

O

O

CH3

E1126 1g

Ethyl 3-Cyclohexyl-3-oxopropionate [15971-92-3]

NH

CH3

O OF

F0963 200mg 1g

2'-Fluoroacetoacetanilide [5279-85-6]

NH

O O

CH3

O2N

N0990 200mg 1g

4'-Nitroacetoacetanilide [4835-39-6]

NH

O O

CH3

CF3

O0444 200mg 1g

4'-(Trifluoromethyl)-acetoacetanilide [351-87-1]

O

O

O

O

CH3CH3

R0165 5g 25g

Ethyl 2,4-Dioxovalerate [615-79-2]

O

OCH3CF3

O

T1245 5g 25g

Methyl 4,4,4-Trifluoro-acetoacetate [83643-84-9]

IsonitrilesCH2NC

B2185 1g 5g

Benzyl Isocyanide [10340-91-7]

C

CH3

CH3

CH3 NC

B1274 5mL 25mL

tert-Butyl Isocyanide [7188-38-7]

NC

C1438 1g 5g

Cyclohexyl Isocyanide [931-53-3]

CNO CH3

O

I0562 5g 25g

Ethyl Isocyanoacetate [2999-46-4]

NC

I0824 1g 5g

1-Isocyanoadamantane [22110-53-8]

NN

N

CH2NC

I0455 1g 5g

1-(Isocyanomethyl)-1H-benzotriazole [87022-42-2]

CH2 C

CH3

CH3

NCC

CH3

CH3

CH3

T1054 1mL 5mL

1,1,3,3-Tetramethylbutyl Isocyanide [14542-93-9]

CH3 S

O

CH2NC

O

T1046 5g 25g

p-Toluenesulfonylmethyl Isocyanide (= TosMIC) [36635-61-7]

NC

C2959 1g

Cyclopentyl Isocyanide [68498-54-4]

NC

NO2

N0982 200mg 1g

4-Nitrophenyl Isocyanide [1984-23-2]

CH3S

O

O

CN

T3157 1g 5g

a-Tosylbenzyl Isocyanide [36635-66-2]

Ureas NH

O

CH3 NH

CH3

O

A0101 25g

1-Acetyl-3-methylurea [623-59-6]

CH3 NH

NH2

O O

A0124 25g

Acetylurea [591-07-1]

CH2NH

NH2

O

A0237 25g 250g

Allylurea [557-11-9]

NH

NH2

O

B0449 25g

Benzylurea [538-32-9]

HO NH

NH

OH

O

D0767 25g 500g

1,3-Bis(hydroxymethyl)-urea [140-95-4]

NH

NH

Si(CH3)3(CH3)3Si

O

B1103 25g

N,N'-Bis(trimethylsilyl)urea [18297-63-7]

CH3 NH

NH2

OO

Br

CH3

B2842 25g

1-(2-Bromoisovaleryl)urea [496-67-3]

NH

NH2

O

Br

B2833 5g

(2-Bromophenyl)urea [13114-90-4]

NH

NH2

OBr

B2834 5g 25g

(4-Bromophenyl)urea [1967-25-5]

NH

NH2

O

CH3

B1831 25g

Butylurea [592-31-4]

O

NH

NH2Cl

C0173 25g

2-Chloroethylurea [6296-42-0]

Cl

SNH

NH

OO O

CH3

C1220 25g

1-(4-Chlorophenylsulfonyl)-3-propylurea [94-20-2]

Cl

SNH

NH2

OO O

C2266 5g

(4-Chlorophenylsulfonyl)-urea [22663-37-2]



NH

NH

NO

Cl

C0926 5g 25g

1-(2-Chloro-4-pyridyl)-3-phenylurea [68157-60-8]

O

NH

NH2

O

NC

C1101 25g 250g

Cyanoacetylurea [1448-98-2]

NH

NH2

O

C2034 25g

Cyclohexylurea [698-90-8]

NH

NH

O

CH3

O

NOCH3

CN

C2657 5g 25g

Cymoxanil [57966-95-7]

NH

NH

O

D0441 25g 500g

1,3-Dicyclohexylurea [2387-23-7]

CH3 NH

NH

CH3

O

D0534 25g 500g

1,3-Diethylurea [623-76-7]

NH

O

NH

CH3CH3

D0289 25g 500g

1,3-Dimethylurea [96-31-1]

NH

NH

O

C0031 25g 100g 500g

1,3-Diphenylurea [102-07-8]

O

NH

NH2CH3

E0192 25g 500g

Ethylurea [625-52-5]

OH

OHN

O

H2N

H0655 25g

Hydantoic Acid [462-60-2]

NH2NH

HO

O

H0700 25g

2-Hydroxyethylurea [2078-71-9]

O

NH

NH2HO

H0438 25g

3-Hydroxyphenylurea [701-82-6]

NH

N

HN

O O

HOCH2HN

O

HN

O

HN

NH

N

O O

CH2OH

I0665 25g 250g

Imidazolidinyl Urea [39236-46-9]

NHCH3

O

H2N

M0455 25g 500g

1-Methylurea [598-50-5]

NH

NH2

O

O2N

N0328 5g

Nitrourea [556-89-8]

NH

NH2

O

CH3(CH2)17

O0209 10g

N-Octadecylurea [2158-08-9]

CH3

SNH

NH2

OO O

T2890 5g

p-Toluenesulfonylurea [1694-06-0]

CH3

NH

NH2

O

T0802 25g

o-Tolylurea [614-77-7]

NH

NH2

OCH3

T0328 25g

p-Tolylurea [622-51-5]

NH

NH

OCl

Cl

Cl

T1015 25g 500g

3,4,4'-Trichlorocarbanilide [101-20-2]

CH2N NH(CH2)3

O

Si

OCH2CH3

OCH2CH3

OCH2CH3

U0048 25mL

1-[3-(Triethoxysilyl)propyl]-urea (40-52% in Methanol) [23779-32-0]

CH2N NH(CH2)3

O

Si

OCH3

OCH3

OCH3

T1915 25g 250g

1-[3-(Trimethoxysilyl)-propyl]urea [23843-64-3]

H2N NH2

O

U0073 300g

Urea [57-13-6]

NH

NH

OOCH3CH3O

B4483 1g 5g

1,3-Bis(4-methoxyphenyl)-urea [1227-44-7]

NH

NH

OFF

B4517 1g 5g

1,3-Bis(4-fluorophenyl)-urea [370-22-9]

NH

NH

OCF3CF3

B4518 200mg 1g

1,3-Bis[4-(trifluoromethyl)-phenyl]urea [1960-88-9]

NH

NH

OClCl

B4529 1g 5g

1,3-Bis(4-chlorophenyl)-urea [1219-99-4]

NH2NH

OCH3CH2O

E1171 200mg 1g

(4-Ethoxyphenyl)urea [150-69-6]

NH2NH

OF

F0950 1g 5g

(4-Fluorophenyl)urea [659-30-3]

NH2NH

OCH3O

M2575 1g 5g

(4-Methoxyphenyl)urea [1566-42-3]

NH2NH

OO2N

N0980 1g 5g

(4-Nitrophenyl)urea [556-10-5]

O

NH

NH2CHC

P2171 200mg 1g

2-Propynylurea [5221-62-5]

ThioureasCH3 N

HNH2

O S

A0117 25g

1-Acetyl-2-thiourea [591-08-2]

NH C NH2

S

A1403 5g

1-Adamantylthiourea [25444-82-0]

NH

NH

S

OHCH2

A0230 25g 500g

1-Allyl-3-(2-hydroxyethyl)-2-thiourea [105-81-7]



CH2NH

NH2

S

A0220 25g 100g 500g

1-Allyl-2-thiourea [109-57-9]

NH

NH2

SO

B0802 25g

N-Benzoylthiourea [614-23-3]

NH

S

NH

CF3

CF3

CF3

CF3

B3452 200mg 1g

1,3-Bis[3,5-bis(trifluoromethyl)phenyl]-thiourea [1060-92-0]

H3C NH

NH

CH3

S

D0301 25g 500g

1,3-Dibutylthiourea [109-46-6]

NH

NH

S

D0440 5g 25g

1,3-Dicyclohexylthiourea [1212-29-9]

H3C NH

NH

CH3

S

D0530 25g 500g

1,3-Diethyl-2-thiourea [105-55-5]

H3C NH

NH

CH3

SCH3 CH3

D0253 25g

1,3-Diisopropylthiourea [2986-17-6]

NH2S

NHNCH3

CH32HCl.

D0652 10g

S-[2-(Dimethylamino)ethyl]-isothiourea Dihydrochloride [16111-27-6]

NH

S

NH

CH3CH3

D0804 25g 100g 500g

1,3-Dimethylthiourea [534-13-4]

NH

NH

S

T0197 25g 500g

1,3-Diphenyl-2-thiourea [102-08-9]

NH

NH

S

CH3 CH3

D0802 25g

1,3-Di(o-tolyl)thiourea [137-97-3]

NH

NH

SCH3CH3

D0803 5g 25g

1,3-Di(p-tolyl)thiourea [621-01-2]

NH

NH

S

NH2

NH

CH3HCl.

E0419 5g

1-Ethyl-3-guanidinothiourea Hydrochloride [381670-29-7]

NH

NH2

SF

F0836 5g 25g

(4-Fluorophenyl)thiourea [459-05-2]

NH2NH

S

H2N

NH

G0234 25g 100g 500g

Guanylthiourea [2114-02-5]

NH

S

NH2CH3

M0619 25g 500g

N-Methylthiourea [598-52-7]

HN

S

NH2

N0071 5g 25g

1-(1-Naphthyl)-2-thiourea [86-88-4]

NH

NH

S

NH2

NH

P1167 5g

1-Phenyl-3-guanylthiourea [15989-47-6]

NH2

S

NH

P0237 25g 500g

1-Phenyl-2-thiourea [103-85-5]

H2N NH2

S

T2475 300g

Thiourea [for General Organic Chemistry] [62-56-6]

NH

CH3

NH2

S

T0657 25gt

o-Tolylthiourea [614-78-8]

CH3

NH

NH2

S

T0656 5g

p-Tolylthiourea [622-52-6]

NH

NH

SClCl

B4481 1g

1,3-Bis(4-chlorophenyl)-thiourea [1220-00-4]

NH

NH

SOCH3CH3O

B4482 1g

1,3-Bis(4-methoxyphenyl)-thiourea [1227-45-8]

NH2NH

SBr

B4484 1g 5g

(4-Bromophenyl)thiourea [2646-30-2]

NH

NH

SCF3CF3

B4611 1g 5g

1,3-Bis[4-(trifluoromethyl)-phenyl]thiourea [1744-07-6]

CH2NH C NH2

S

B4612 1g 5g

Benzylthiourea [621-83-0]

NH

NH

S

B4997 1g 5g

1-Benzyl-3-phenyl-thiourea [726-25-0]

NH2NH

S

Br

B4998 5g 25g

(3-Bromophenyl)thiourea [21327-14-0]

NH2NH

SCl

C2960 5g 25g

(4-Chlorophenyl)thiourea [3696-23-9]

H2N NH

S

C2966 200mg 1g

Cyclohexylthiourea [5055-72-1]

NH

F

NH2

S

Cl

C3137 1g 5g

(3-Chloro-4-fluorophenyl)-thiourea [154371-25-2]

NH2NH

S

Cl

C3168 1g 5g

(3-Chlorophenyl)thiourea [4947-89-1]

NH2NH

SF F

D4861 1g 5g

(2,4-Difluorophenyl)-thiourea [175277-76-6]

NH2NH

S

CH3

CH3

D4958 5g 25g

(2,6-Dimethylphenyl)-thiourea [6396-76-5]

NH2NH

S

F

F1055 1g 5g

(2-Fluorophenyl)thiourea [656-32-6]

H2N NH

SOCH3

M2593 5g 25g

(4-Methoxyphenyl)-thiourea [2293-07-4]

H2N NH

S

OCH3

M2597 1g

(2-Methoxyethyl)thiourea [102353-42-4]

NH

NH

S

CH3

M2786 1g 5g

1-Methyl-3-phenyl-thiourea [2724-69-8]

O2N

NH

NH2

S

N0995 1g

(4-Nitrophenyl)thiourea [3696-22-8]



NH2NH

S

N

P2272 5g 25g

(2-Pyridyl)thiourea [14294-11-2]

ONH

H2N

S

T3413 200mg

[(Tetrahydrofuran-2-yl)-methyl]thiourea [66892-25-9]

Dialkyl Phosphites CH2O P

O

H

OCH2

P1016 25g 250g

Dibenzyl Phosphite [17176-77-1]

P

O

CH3(CH2)3O O(CH2)3CH3

H

D0300 25g

Dibutyl Phosphite [1809-19-4]

P

O

CH3CH2O OCH2CH3

H

D0521 25g 100g 500g

Diethyl Phosphite [762-04-9]

CHCH2O P

H

OCH2CH

OCH3

CH3

CH3

CH3

D3417 25g 500g

Diisobutyl Phosphite [1189-24-8]

P OCH

H

OCH3

CH3CHO

CH3

CH3

P0629 25g 500g

Diisopropyl Phosphite [1809-20-7]

P

O

CH3O OCH3

H

D0786 25mL 500mL

Dimethyl Phosphite [868-85-9]

O P

O

O

H

D0907 25g 100g 500g

Diphenyl Phosphite (contains 5% Phenol at maximum) [4712-55-4]

Diketone CompoundsBr

CH3

OO

B4754 1g 5g

(4-Bromobenzoyl)acetone [4023-81-8]

NH

CH3

O O

Cl

C2984 200mg 1g

3'-Chloroacetoacetanilide [2415-87-4]

C C CC

OO

D4699 250mg 1g

Dibenzoylacetylene [1087-09-8]

C

O

C

O

F

F0989 200mg 1g

4-Fluorobenzil [3834-66-0]

CH3

F

OO

F0996 1g 5g

(4-Fluorobenzoyl)acetone [29681-98-9]

NH

CH3

O OF

F0963 200mg 1g

2'-Fluoroacetoacetanilide [5279-85-6]

NH

O O

CH3

O2N

N0990 200mg 1g

4'-Nitroacetoacetanilide [4835-39-6]

NH

O O

CH3

CF3

O0444 200mg 1g

4'-(Trifluoromethyl)-acetoacetanilide [351-87-1]

Isatins N

C

O

CH3

O

O

A2941 5g 25g

1-Acetylisatin [574-17-4]

N

O

O

CH2 CH CH2

A2943 1g

1-Allylisatin [830-74-0]

NH

Br O

O

B1566 25g 250g

5-Bromoisatin [87-48-9]

NH

Br

O

O

B2423 5g 25g


NH

O

O

Br

B2424 5g 25g


NH

O

O

Br

B3974 1g 5g


N O

O

CH3

Br

B4779 1g 5g

5-Bromo-1-methylisatin [2058-72-2]

NH

O

O

Cl

C1870 5g 25g

4-Chloroisatin [6344-05-4]

NH

Cl

O

O

C1871 5g 25g


NH

O

O

Cl

C2840 1g 5g


N

Cl

CH3

O

O

C3195 200mg 1g

5-Chloro-1-methylisatin [60434-13-1]

NH

O

O

Cl

Cl

D4039 1g 5g

4,7-Dichloroisatin [18711-13-2]

NH

O

O

F

F0551 5g 25g

7-Fluoroisatin [317-20-4]



NH

F

O

O

F0589 5g 25g

5-Fluoroisatin [443-69-6]

NH

O

O

I0080 25g 100g 500g

Isatin [91-56-5]

NH

O

OI

I0640 5g

5-Iodoisatin [20780-76-1]

NH

O

O

CH3O

M1362 5g 25g

5-Methoxyisatin [39755-95-8]

NH

CH3

O

O

M1703 5g 25g

5-Methylisatin [608-05-9]

N

CH3

O

O

M2706 1g 5g

1-Methylisatin [2058-74-4]

NH

O

O

CH3O

M2856 1g 5g

6-Methoxyisatin [52351-75-4]

NH

O

OO2N

N0572 5g 25g

5-Nitroisatin [611-09-6]

N O

O

P2279 5g 25g

1-Phenylisatin [723-89-7]

NH

O

O

CF3

T2457 1g 5g

7-(Trifluoromethyl)isatin [391-12-8]

NH

O

OCF3O

T2774 1g 5g

5-(Trifluoromethoxy)isatin [169037-23-4]

Benzyne Precursors NN

N

NH2

A1464 1g 5g

1-Aminobenzotriazole [1614-12-6]

Si(CH3)3

OSO2CF3CF3O2SO

(CH3)3Si

B3047 1g

3,3'-Bis(trimethylsilyl)biphenyl-4,4'-diyl Bis(trifluoromethane-sulfonate) [828282-80-0]

I

C

O

O. H2O

D2503 5g 25g

Diphenyliodonium-2-carboxylate Monohydrate [96195-89-0]

Si(CH3)3

OSO2CF3

OCH3

M1884 1g 5g

3-Methoxy-2-(trimethylsilyl)-phenyl Trifluoromethane-sulfonate [217813-03-1]

Si(CH3)3

OSO2CF3

OCH3

M1885 1g 5g

4-Methoxy-2-(trimethylsilyl)-phenyl Trifluoromethane-sulfonate [556812-41-0]

CH3

OSO2CF3

(CH3)3Si

M1883 1g 5g

2-Methyl-6-(trimethylsilyl)-phenyl Trifluoromethane-sulfonate [556812-44-3]

Si(CH3)3

OSO2CF3

CH3

M1882 1g 5g

4-Methyl-2-(trimethylsilyl)-phenyl Trifluoromethane-sulfonate [262373-15-9]

I OSO2CF3

Si(CH3)3

P1620 1g 5g

Phenyl[2-(trimethylsilyl)phenyl]-iodonium Trifluoromethane-sulfonate [164594-13-2]

OSO2CF3

Si(CH3)3

T2465 1g 5g

1-(Trimethylsilyl)-2-naphthyl Trifluoromethane-sulfonate [252054-88-9]

OSO2CF3

Si(CH3)3

T2466 1g 5g

3-(Trimethylsilyl)-2-naphthyl Trifluoromethane-sulfonate [780820-43-1]

Si(CH3)3

OSO2CF3

T2089 1g 5g 25g

2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate [88284-48-4]

OSO2CF3Si(CH3)3

OSO2CF3Si(CH3)3

CF3O2SO

(CH3)3Si

1,3,5-Tris[4-(trifluoromethanesulfonyloxy)-3-(trimethylsilyl)phenyl]benzene [847925-63-7]

T2467 1g

OCH3

CH3O

OSO2CF3

Si(CH3)3

D3883 1g 5g

4,5-Dimethoxy-2-(trimethylsilyl)phenyl Triflate [866252-52-0]

Lewis Acids O CH3CH3BF3 .

B0527 25mL 100mL 500mL

Boron Trifluoride - Ethyl Ether Complex [109-63-7]

BiCl3

B3546 25g 250g

Bismuth(III) Chloride Anhydrous [7787-60-2]

InCl3

I0778 5g 25g

Indium(III) Chloride Anhydrous [10025-82-8]



La3

3

S

O

CF3 O

O

T1293 5g 25g

Lanthanum(III) Trifluoromethanesulfonate [52093-26-2]

LiBr

L0210 25g 100g 500g

Lithium Bromide [7550-35-8]

NiCl2

N0850 25g 500g

Nickel(II) Chloride Anhydrous [7718-54-9]

RuCl3

R0074 1g 5g

Ruthenium(III) Chloride [10049-08-8]

Sc3

3

S

O

CF3 O

O

T1663 1g 5g

Scandium(III) Trifluoromethanesulfonate [144026-79-9]

TiCl4

T2052 100m 500mL

Titanium(IV) Chloride (14% in Dichloromethane, ca. 1.0mol/L) [7550-45-0]

TiCl4

T3238 100mL 500mL

Titanium(IV) Chloride (ca. 19% in Toluene, ca. 1.0mol/L) [7550-45-0]

xH2O.Yb3

3

S

O

CF3 O

O

T1610 5g 25g

Ytterbium(III) Trifluoromethanesulfonate Hydrate [54761-04-5]

ZnCl2

Z0014 25g 300g

Zinc Chloride [7646-85-7]

Ionic Liquids N

N

(CH2)3CH3

CH3

Br

B2193 5g

1-Butyl-3-methylimidazolium Bromide [85100-77-2]

N

(CH2)3CH3

CH3

Cl

N

B2194 5g 25g 100g

1-Butyl-3-methylimidazolium Chloride [79917-90-1]

N

(CH2)3CH3

CH3

PF6

N

B2320 5g 25g

1-Butyl-3-methylimidazolium Hexafluorophosphate [174501-64-5]

N

CH3

(CH2)3CH3

BF4

N

B2195 5g 25g 100g

1-Butyl-3-methylimidazolium Tetrafluoroborate [174501-65-6]

N

(CH2)3CH3

CH3

CF3SO3

N

B2337 5g 25g

1-Butyl-3-methylimidazolium Trifluoromethanesulfonate [174899-66-2]

CH3(CH2)3

(CH2)3CH3

N (CH2)3CH3

(CH2)3CH3

Br

T0054 25g 100g 500g

Tetrabutylammonium Bromide [1643-19-2]

CH3(CH2)3

(CH2)3CH3

N (CH2)3CH3

(CH2)3CH3

Cl

T0055 5g 25g 100g

Tetrabutylammonium Chloride [1112-67-0]

P

(CH2)3CH3

(CH2)3CH3

(CH2)3CH3CH3(CH2)3 Br

T1124 25g 100g 500g

Tetrabutylphosphonium Bromide [3115-68-2]

R5109E 20161021

Documents

Multicomponent Reaction (MCR) · point of view, thus, the reaction above is an extremely useful and eco-friendly MCR. Thus, MCR is a strong synthetic methodology to enable condensation