Multivitamin and Breast Cancer

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LOGO

Multivitamin And Breast CancerEXT.


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Introduction

breast cancer is the most commoncancer in women worldwideA few risk factors are preventablethrough reducing alcohol intake,increasing physical activity levels andmaintaining a healthy weight.

Some studies suggest the antioxidant

may prevent mammary cancers ?


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Risk factors

- Increasing age- Family history- Previous breast cancer and some

other breastconditions- Dense breast tissue as shown onmammogram- Gynaecological and reproductivehistory- Body size, diet and exercise


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Multi-vitamin supplements

antioxidant Prevent oxidative damage inbody cells.

antioxidant nutrients and non -nutrients include vitamins A, C,and E, selenium, lycopene, and

beta-carotene.


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Multi-vitamin supplements

Vitamin CVitamin EVitamin DVitamin B and folic acidMultivitamin


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Vitamin C

Vitamin C induces apoptotic effects onbreast cancer cellsLow plasma levels of vitamin C

associated with risk of breast cancerand mortality in breast cancersurvivorsrisk of recurrence and mortality was

reduced


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Vitamin E

Vitamin E is antioxidant and an anti-proliferating agent. tocopherols andtocotrienols.vitamin E does not against breast cancerlow plasma levels of vitamin Eassociated with a risk of breast cancer .vitamin E supplements may interfere

with the therapeutic effects of tamoxifen


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Vitamin D

Higher vitamin D may help preventbreast cancer or increase risk of cancer nuclear transcription factor thatregulates cell growth, differentiation,apoptosis and a wide range of cellularmechanisms central to the developmentof cancer,But vitamin D intakeIncrease breast density


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Post -menopausal breast cancer riskwas significantly associated with serum25(OH)-vitamin D levels

Vitamin D metabolites acts astherapeutic agents because1,25(OH)2Dhas been shown to inhibit theproliferation and metastasis of bothbreast and prostate cancer cells.


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Vitamin D deficiency may beassociated with poor outcomes in

breast cancer.vitamin D decreased estrogenreceptor-positive (ER+) breast cancer in mice. Vitamin D showed no benefitsfor estrogen receptor-negative (ER-)cancer .
http://www.empowher.com/condition/breast-cancerhttp://www.empowher.com/condition/cancerhttp://www.empowher.com/condition/cancerhttp://www.empowher.com/condition/breast-cancer


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Vitamin B and folate

In postmenopausal women higherb12 and folate prevent breast cancervitamin B12 deficiency may lead tobreast cancerHigher plasma levels of folate andvitamin B 6 may reduce the risk of breast cancer. And adequatecirculating levels of folate may beimportant for high risk of breastcancer because of higher alcoholconsumption.


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Research of this topic

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Berube S, Diorio C, Brisson J. Multivitamin-multimineralsupplement use and mammographic breast density. Am

J Clin Nutr. 2008 May;87(5):1400-4. PMID: 18469264

taking vitamin and mineralsupplements significantly increased thedensity of breast tissue, a strong riskfactor for breast cancer. Folic acid,often present in a potent form in multi-vitamins, may also accelerate tumorgrowth.


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Sylvie Brub, Caroline Diorio and Jacques Brisson Multivitamin-multimineral supplement use and mammographic breast densityAmerican Journal of Clinical Nutrition, Vol. 87, No. 5, 1400-1404,

May 2008

multivitamin-multimineralsupplement use was found to beassociated with higher mean breastdensity among premenopausal

women ,these findings do not supportany benefit from multivitamin-multimineral supplement use onbreast cancer risk


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Celine M. Vachon, Lawrence H. Kushi, James R. Cerhan, etal.Association of Diet and Mammographic Breast Densityin theMinnesota Breast Cancer Family Cohort 2000;9:151-160.

Results of this study suggest that increasedbreast density is associated with intakes of vitamins C and E are associated withincreased density, also among premenopausalwomen, and there was a linear trend of increasing breast density with increasingvitamin B 12 intake among postmenopausalwomen only



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PatriciaGMoorman,,MaryFRicciuti,RobertCMillikan and Beth , Vitaminsupplement use and breast cancerina North Carolina population,Public Health Nutrition:4(3),821827, Submitted 14 September 2000:

Accepted 12 December2000

Vitamin supplements do notsubstantially reduce the risk of breastcancer reductions in risk most likelywill be achieved through modificationof overall dietary patterns rather thanby supplementation with one or moremicronutrients


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http://www.reuters.com/article/2010/03/29/us-multivitamins-

cancer-idUSTRE62S4F520100329

a new study finds that older womenwho use multivitamins may be morelikely than non-users to develop

breast cancer. reported in theAmerican Journal of Clinical Nutrition


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conclusion

There is no good evidence that takingmulti-vitamin preparations increasesthe risk of breast cancer. However, the

best way to ensure an adequate intakeof vitamins is to eat a balanced diet richin fruit and vegetables.


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Patients may be advised to notconsume high-dose antioxidantsupplements during chemotherapy or

radiation therapy. Antioxidantconsumption via food sources and abasic multivitamin supplement are verysafe.


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Referrences

DorganJF,SchatzkinA. Antioxidant micronutrients incancer prevention. Nutr.Cancer 1991; 5:4368.http://cebp.aacrjournals.org/content/15/3/443.abstract http://jnci.oxfordjournals.org/content/95/5/373.short http://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htm JournaloftheNationalCancerInstitute,Vol.95,No.5,March5,2003 PlasmaFolate, VitaminB6, VitaminB12,Homocysteine,and Risk of Breast CancerGalan P, Briancon S, Favier A, Bertrais S, Preziosi P,Faure H, et al. Antioxidant status and risk of cancerin the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels? Br JNutr. 2005 Jul;94(1):125-32. PMID: 16115341
http://cebp.aacrjournals.org/content/15/3/443.abstracthttp://cebp.aacrjournals.org/content/15/3/443.abstracthttp://jnci.oxfordjournals.org/content/95/5/373.shorthttp://jnci.oxfordjournals.org/content/95/5/373.shorthttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://www.health.harvard.edu/newsweek/Higher-vitamin-D-may-help-prevent-breast-cancer.htmhttp://jnci.oxfordjournals.org/content/95/5/373.shorthttp://jnci.oxfordjournals.org/content/95/5/373.shorthttp://jnci.oxfordjournals.org/content/95/5/373.shorthttp://cebp.aacrjournals.org/content/15/3/443.abstracthttp://cebp.aacrjournals.org/content/15/3/443.abstracthttp://cebp.aacrjournals.org/content/15/3/443.abstract


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Multivitamin and Breast Cancer