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Muscle Physiology
Summer Prematriculation Program
Summer 2004
Rahul Dave’
(312) 996-7610
Rm 206 CMW
Muscles act in many organ
systems
Muscles need a signal to contract
Muscle Anatomy
MotorUnit
Nerve branch
Muscle
Main Nerve
SkeletalMuscle
Smooth Muscle
Cardiac Muscle 1
Cardiac Muscle 2
Intercalated Disc
3 Fiber Types
Fuel ATP Fatigues?
Fast White Glyc High Hard
Fast Red Oxid High Medium
Slow Red Oxid Low Easy
Motor Unit Size
Recruitment Order
Use
Fast White Large Third Power Lift
Fast Red Medium Second Jogging
Slow Red Small First Postural mm
Z-disc
H-zone
M-line
A-band I-ban
d
I-ban
d
Sarcomere Structure
Sliding Filament Theory
Brown Tropomyosin
Yellow Troponins
Blue Actin
Black Myosin Head Bind Site
Other Muscle Proteins
Pink Myosin
Smooth Muscle Structure
Muscle Structure
• Describe the hierarchy of organization in muscle
• Distinguish smooth, skeletal and cardiac muscle based on histology
• Understand and rationalize the differences between fiber types
• Know the skeletal muscle sarcomere structure cold.
Nerve-Muscle
Interface
Excitation-Contraction Coupling
Cross Bridge Cycle
Smooth MuscleNerve-Muscle Interface
E-C Coupling (Smooth)
G
Neurotransmitter
SR
IP3 PIP2
Ca2+
Crossbridge Cycle (Smooth)
Muscle Contraction
• Know each step in transmission across the neuromuscular junction
• Know each step in E-C Coupling for striated muscle
• Know each step in the cross-bridge cycle for striated muscle
• Know the differences between smooth and striated (skeletal + cardiac) muscle
Preload and Afterload
Preload
The force (load) a muscle exerts prior to contraction.
Pre-contraction
Afterload
Force muscle exerts during contraction.
After [the start of] contraction
Demonstration
Frank-Starling Law
Force-Velocity Curve
Exercise Physiology
These are all adaptations
• Learning new motor patterns
• Strength exercises: muscle hypertrophy
• Endurance exercises: changes in muscle metabolism
Muscle Diseases
Metabolism• Lactic Acidosis• Glycogen Storage Diseases
Muscle Function• Dilated Cardiomyopathy• Muscular Dystrophy• Malignant Hyperthermia
Neurologic• Hirschsprung’s disease• Myesthenia Gravis• Multiple Sclerosis• Parkinson’s Disease• Polio