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Page 1 of 2http://en.wikipedia.org/wiki/Myoglobinuria
Myoglobinuria
Classification and external resources
Urine from a person with rhabdomyolysis showing the
characteristic brown
discoloration as a result of myoglobinuria
ICD-10 R82.1
(http://apps.who.int/classifications/icd10/browse/2010/en#/R82.1)
ICD-9 791.3
(http://www.icd9data.com/getICD9Code.ashx?icd9=791.3)
DiseasesDB 23059
(http://www.diseasesdatabase.com/ddb23059.htm)
eMedicine ped/1535
(http://www.emedicine.com/ped/topic1535.htm)
MeSH D009212 (http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?
field=uid&term=D009212)
Model of helical domains in
myoglobin.
MyoglobinuriaFrom Wikipedia, the free encyclopedia
Myoglobinuriais the presence of
myoglobin in the urine, usually
associated with rhabdomyolysis or
muscle destruction. Myoglobin is
present in muscle cells as a reserve
of oxygen.
Contents
1 Causes
2 Diagnosis3 Treatment
4 External links
5 References
Causes
Trauma, vascular problems,venoms, malignant hyperthermia,
certain drugs and other situations
can destroy or damage the muscle,
releasingmyoglobin to the
circulation and thus to the kidneys.
Under ideal situations myoglobin will be filtered and excreted
with
the urine, but if too much myoglobin is released into the
circulation
or in case of renal problems, it can occlude therenal filtration
system
leading to acute tubular necrosis and acute renal
insufficiency.
Other causes of myoglobinuria include:
McArdle's disease
Phosphofructokinase deficiency[1]
Carnitine palmitoyltransferase II deficiency
malignant hyperthermia
Polymyositis
Diagnosis
http://apps.who.int/classifications/icd10/browse/2010/en#/R82.1http://apps.who.int/classifications/icd10/browse/2010/en#/R82.1http://apps.who.int/classifications/icd10/browse/2010/en#/R82.1http://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/Polymyositishttp://en.wikipedia.org/wiki/Venomhttp://en.wikipedia.org/wiki/Malignant_hyperthermiahttp://en.wikipedia.org/wiki/Myoglobinuria#Diagnosishttp://en.wikipedia.org/wiki/Myoglobinuria#Causeshttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/Musclehttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPGhttp://en.wikipedia.org/wiki/Myoglobinhttp://en.wikipedia.org/wiki/Urinehttp://en.wikipedia.org/wiki/Polymyositishttp://en.wikipedia.org/wiki/Malignant_hyperthermiahttp://en.wikipedia.org/wiki/Carnitine_palmitoyltransferase_II_deficiencyhttp://en.wikipedia.org/wiki/Myoglobinuria#cite_note-pmid18421897-1http://en.wikipedia.org/wiki/Phosphofructokinase_deficiencyhttp://en.wikipedia.org/wiki/McArdle%27s_diseasehttp://en.wikipedia.org/wiki/Renal_insufficiencyhttp://en.wikipedia.org/wiki/Malignant_hyperthermiahttp://en.wikipedia.org/wiki/Venomhttp://en.wikipedia.org/wiki/Physical_traumahttp://en.wikipedia.org/wiki/Myoglobinuria#Referenceshttp://en.wikipedia.org/wiki/Myoglobinuria#External_linkshttp://en.wikipedia.org/wiki/Myoglobinuria#Treatmenthttp://en.wikipedia.org/wiki/Myoglobinuria#Diagnosishttp://en.wikipedia.org/wiki/Myoglobinuria#Causeshttp://en.wikipedia.org/wiki/Oxygenhttp://en.wikipedia.org/wiki/Musclehttp://en.wikipedia.org/wiki/Rhabdomyolysishttp://en.wikipedia.org/wiki/Urinehttp://en.wikipedia.org/wiki/Myoglobinhttp://en.wikipedia.org/wiki/File:Myoglobin.pnghttp://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&term=D009212http://en.wikipedia.org/wiki/Medical_Subject_Headingshttp://www.emedicine.com/ped/topic1535.htmhttp://en.wikipedia.org/wiki/EMedicinehttp://www.diseasesdatabase.com/ddb23059.htmhttp://en.wikipedia.org/wiki/Diseases_Databasehttp://www.icd9data.com/getICD9Code.ashx?icd9=791.3http://en.wikipedia.org/wiki/List_of_ICD-9_codeshttp://en.wikipedia.org/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problemshttp://apps.who.int/classifications/icd10/browse/2010/en#/R82.1http://en.wikipedia.org/wiki/ICD-10_Chapter_Rhttp://en.wikipedia.org/wiki/ICD-10http://en.wikipedia.org/wiki/International_Statistical_Classification_of_Diseases_and_Related_Health_Problemshttp://en.wikipedia.org/wiki/Rhabdomyolysishttp://en.wikipedia.org/wiki/Urinehttp://en.wikipedia.org/wiki/File:RhabdoUrine.JPG
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encyclopedia
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After centrifuging, the urine of myoglobinuria is clear, where
the serum of hemoglobinuria after centrifuge
is pink to red.
Treatment
Hospitalization and IV hydration should be the first step in any
patient suspected of having myoglobinuria orrhabdomyolysis. The
goal is to induce a brisk diuresis to prevent myoglobin
precipitation and deposition,
which can cause acute kidney injury. Mannitol can be added to
assist with diuresis. Adding sodium
bicarbonate to the IV fluids will cause alkalinzation of the
urine, believed to reduce the breakdown of
myoglobin into its nephrotoxic metabolites, thus preventing
renal damage. Often, IV normal saline is all that
is needed to induce diuresis and alkalinize the urine.
External links
Overview (http://neuromuscular.wustl.edu/msys/myoglob.html) on
the Neuromuscular disease centerwebsite.
References
1. ^Toscano A, Musumeci O (October 2007). "Tarui disease and
distal glycogenoses: clinical and genetic update"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949577).Acta
Myol26(2): 1057. PMC 2949577
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949577). PMID
18421897
(https://www.ncbi.nlm.nih.gov/pubmed/18421897).
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