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Naïve phenotype Activated, central memory / reduced effector phenotype Activated, peripheral memory / enhanced effector phenotype Excessively activated, anergic / exhausted phenotype Epitope-specific T cells Vector yielding PD-1 lo central memory cells Vector yielding PD-1 hi peripheral memory / effector cells

Naïve phenotype

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Vector yielding PD-1 lo central memory cells. Vector yielding PD-1 hi peripheral memory / effector cells. Epitope-specific T cells. Naïve phenotype. Activated, central memory / reduced effector phenotype. Activated, peripheral memory / enhanced effector phenotype. - PowerPoint PPT Presentation

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Page 1: Naïve phenotype

Naïve phenotype

Activated, centralmemory / reduced effector phenotype

Activated, peripheralmemory / enhanced effector phenotype

Excessively activated, anergic / exhausted phenotype

Epitope-specific T cells

Vector yieldingPD-1lo central memory cells

Vector yieldingPD-1hi peripheral memory / effector cells