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NanoDESK INTERNATIONAL WORKSHOP ON SAFE IMPLEMENTATION OF
NANOMATERIALS IN PLASTIC INDUSTRY
Carlos Fito López
ITENE – Technical Coordinator
International Iberian
Nanotechnology Laboratory (INL)
October 18th 2017
Outline
1. Concept and Objectives
2. Overall view of the workplan and deliverables
3. Progress so far and main results
4. Summary comclusions
NanoDESK INTERNATIONAL WORKSHOP
1. Concept and objectives
NanoDESK INTERNATIONAL WORKSHOP
1. Concept and objectives
4
Project Objectives (Following SUDOE indicators)
• Promotion of the nanotechnology as KET to support the
development of new added value plastic materials
based on the use of engineered nanomaterials (ENMs)
• Ensure the technical viability and safety of process
and products based on the use of ENMs
Technical Objectives :
The project focused on the development of a set of web based applications to promote
investment and safe use of nanofillers in the plastic industry, including:
• A decision support system to assist companies, an in particular SMEs, in the selection
of nanofillers to meet the performance criteria of added value composites;
• A new information searching tool to assist companies in the identification of market
trends and nanotechnology applications;
• An interactive observatory on the safety of nanostructured polymer based materials;
• A set of computational modelling approaches (QSAR models) to support the
characterization of the toxicological profile of target nanofillers;
• A set of novel exposure estimation models to support SMEs in the evaluation of the
risk posed by the use of nanofillers in workers, consumer and
1. Concept and objectives
5
Project Concept
Mercado
• Nanotechnology has the potential to contribute
significantly to the future of plastic, promoting the
development of a new generation of smart and innovative
products.
• However, the current uncertainty about the effects of ENMs
on the environment and human health, and the consequent
lack of regulation, are a difficult barriers to overcome by
the plastic sector
1. Concept and objectives
6
Project Concept
Mercado
• The main outcome of the project will be the NanoDESK platform, with a preliminary version
expected in April 2018.
1. Concept and objectives
7Mercado
7
Membership
• Instituto Tecnológico del Embalaje,
Transporte y Logística (ES)
• ProtoQSAR 2000 SL (ES)
• Universitat Rovira i Virgili (ES)
• International Iberian Nanotechnology
Laboratory (PT)
• Centre National de la Recherche
Scientifique. Délégation Midi-Pyrénées.
Centre d'Elaboration de Matériaux et
d'Etudes Structurales (FR)
• Instituto Valenciano Seguridad y Salud
Trabajo (ES)
• Universidade do Porto. Faculdade de
Ciências
• Start-date: 01/06/2016
• End-date: 31/05/2019
• Budget: 799.375,84 €
• Funding scheme: FEDER
1. Concept and objectives
8
Main Results
Obj. Products GT Due
Dev
elo
pm
ent
of
a w
eb p
latf
orm
to
pro
mo
te t
he
use
of
ENM
s in
th
e P
last
ic In
du
stry
P1.1. Specification sheets of ENMs and nanocomposites GT1 11.16
P1.2. Computerized multicriteria decision tree GT1 03.17
P2.1. Data mining algorithms GT2 02.17
P2.2. Advanced web searching engine GT2 06.17
P3.1. NanoQSAR models. GT3 03.18
P4.1. Worker Exposure Estimation model GT4 02.18
P4.2. Environmental Exposure Estimation model GT4 03.18
P4.3. Consumer Exposure Estimation model GT4 06.18
P5.1. Polymer based nanocomposites safety Observatory GT5 06.18
P5.2. Strategic plan of the plastic sector GT5 07.17
P6.1. NanoDESK web Platform (beta) GT6 03.18
P6.2. NanoDESK web Platform (Complete version) GT6 01.19
9
Dissemination / communication
• Project Website
http://sudoenanodesk.europeanprojects.net/
1. Concept and objectives
2. Overall view of the work plan and
timetable
NanoDESK 1st Stakeholder´s day
2. Overall view of the workplan and timetable
11
Project activities
• GT1. Definition of the specifications and uses of
nanomaterials in the plastic industry
• Objective: description of 10 ENMs
• Results: data inventory and multicriteria
decision tree
• P1.1. Data sheets of ENMs and nanocomposites (11.2016)
• P1.2. Computerized Multicriteria Decision Tree (02.2017)
• GT2. Development of advanced tools for data searching
• Objective: development of advanced tools to retrieve
specific data on the physicochemical and
(eco)toxicological of ENMs
• Results: advanced-parameter search algorithm
• P2.1. Advanced-parameter search algorithms (02.2017)
• P2.2. Advanced Web Searching Engine (06.2017)
2. Overall view of the workplan and timetable
12
Project activities
• GT3. Optimization and development of QSAR models
• Objective: optimization and development of QSAR
models to predict toxicological properties
• P3.1. QSAR models covering 4 properties (03.2018)
• Results: set of 4 QSAR models to predict
bioaccumulation, genotoxicity, dermal and oral toxicity
• GT4. Development of exposure estimation models
• Objective: development and validation of models
to support the estimation of the exposure levels
and quantification of environmental release
• Results: set of 3 models to support risk assessment
• P4.1.Worker Exposure model implemented in web (03.2018)
• P4.2.Environmental exposure estimation model (02.2018)
• P4.3.Consumer Exposure estimation model (03.2018)
2. Overall view of the workplan and timetable
13
Project activities
• GT5. Development of the PNC Observatory
• Objective: development and implementation of
the NanoDESK PNC Observatory
• P5.1. Observatory web site (06.2018)
• P5.2. Strategic plan of the plastic sector (07.2017)
• P5.3. Consumer Exposure estimation model (03.2018)
• Results: Observatory on the safety of
nanostructured plastic material
• GT6. Development of the NanoDESK platform
• Objective: design and development of the NanoDESK
web platform, integration of tools and validation by
stakeholders.
• Results: Delivery of the NanoDESK platform (June 18)
• P6.1. Web platform NanoDESK – Beta (03.2018)
• P6.2. Web platform NanoDESK – Final (01.2019)
2. Overall view of the workplan and timetable
14
Scheduled events
Events Date Location
Join Workshop 15/11/2016 Sevilla (Spain)
1st NanoDESK Stakeholder´s day 28/03/2017 Valencia (Spain)
First NanoDESK International workshopOctober
2017Braga (Portugal)
Join Workshop on regulatory challenges
and risk assessment of ENMs
December
2017Madrid (Spain)
2nd NanoDESK Stakeholder´s dayMarch
2018Toulouse (France)
Join Workshop on nanotechnology
challenges
June
2018Valencia (Spain)
3rd NanoDESK Stakeholder´s daySeptember
2018Oporto (Portugal)
NanoDESK successful experiencesNovember
2018Barcelona (Spain)
Workshop on modelling approaches for
regulatory risk assessment
February
2019Tarragona (Spain)
Second NanoDESK international workshop April 2019 Toulouse (France)
Final NanoDESK dissemination event April 2019 Valencia (Spain)
International Networking workshop with
plastic manufacturersMay 2019 Braga (Portugal)
Channel Id Description
Social
networks
Lindkedin
@nanodesk
https://es-es.facebook.com/Invassat.gva
www.linkedin.com/groups/8596648
MultimediaProject
videos2
Other E-learning Webinars
3. Progress so far and main results
NanoDESK 1st Stakeholder´s day
3. Progress so far and main results
GT1. Specifications and uses of nanomaterials in the plastic industry
• Ag• Al2O3• CaCO3• Nanoclay• Sb2O5• SiO2• ZnO• CNT• Nanocellulose• TiO2• Graphene
NANOMATERIALS FORMULATION SUPPLIERS SPECIFIC PRODUCT
Silver nanoparticles (Ag NPs)
10nm
ON-Q* Catheters Halyard, formerly
AcryMed
SilvaGard®
Silver nanoparticles (Ag NPs)
15nm
powder, polymer-coated nanoparticles (25%
silver, 75% polymer)
SSNano Sky
Spring
Nanomaterials Inc
GACOMP (Polymer
dispersions)
Titanium dioxide nanoparticles
(TiO2 NPs)
Dry powder TiO2 min 97% (wt.), Al2O3 max
1.7% (wt.), C 0.2% (wt.)
Chemours Ti-Pure™ R-101
Aluminium oxide nanoparticles
(Al2O3 NP) 40nm
Dispersion in hexanediol diacrylate (HDDA),
30% NP content
BIK Nanobyk-3602
CaCO3-80nm CaCO3, +98% Pure, APS: 80 nm mKnano MKN-CaCO3-P080
Multiwall carbon nanotubes-
95nm diameter and 1.5um
lenght
Dry powder, 100 % NANOCYL NANOCYL® NC7000™
Montmorillonite
10 nm (thickness) / 42 nm
(interlayer distance)
Layered aluminosilicate (montmorillonite)
modified with an organic salt
(hexadecyltrimethylammonium bromide)
BYK additives Clay 1 – Cloisite
Sb2O5/SnO2 (85:15)
15nm
NanoArc® Antimony Tin Oxide nanopowder,
100% crystalline, non-porous, non-
agglomerated particles.
Nanophase
Nanoengineered
Products
NanoArc® Antimony Tin
Oxide nanopowder
Silica nanoparticles (SiO2 NPs)
20nm
25% by weight dispersion of surface-treated
particles in
Methoxypropylacetate/methoxypropanol
(MPA/MP)
BIK Nanobyk-3650
ZnO nanocrystals
45+/-5 nm
Colloidal suspension of ZnO nanoparticles in
diethylene glycol
ZnO concentration (%w): 1.0+/-0.2
Linari nanotech ZnO-DEG
Nanocellulose CNC / CNF Maine University CNF
Graphene - AVANVARE -
3. Progress so far and main results
GT1. Specifications and uses of nanomaterials in the plastic industry
GENERAL PRODUCT DESCRIPTION
Producer Nanocyl / Nanocyl SA rue de l'Essor, 4 5060 Sambreville Belgium
Product commercial
name
NANOCYL® NC7000™ (Registered in ECHA)
Webpage http://www.nanocyl.com/product/nc7000/
Core material Multiwall carbon nanotubes. Catalytic Chemical Vapor Deposition (CCVD)
process.
Commercial
formulation
Dry powder, 100 %
Polymers that typically
incorporate the NP
Thermoplastic polyurethane (TPU) / PA66 (PolyAmide 66) / PA12
(PolyAmide 12) / HDPE (High Density Poly Ethylene) / PP (PolyPropylene) /
LDPE (Low Density Poly Ethylene) / EVA (Ethylene Vinyl Acetate) / ABS
(Acrylonitrile Butadiene Styrene) / PC (Poly Carbonate)
Applications Products requiring low electrical percolation threshold such as high-
performance electrostatic dissipative plastics or coatings
Sectors Industrial - ESD parts / Electronic Packaging /Automotive / Aerospace /
Construction / Wind Power / Sporting Goods
MATERIAL DESCRIPTION
Identification CAS
number
- EC number 936-414-1
Material Type Multiwall carbon nanotubes
Molecular Formula C / Allotropic form of carbon
Chemical Composition Carbon purity 90 % / Other components < 10 %
PHYSICAL-CHEMICAL CHARACTERISTICS
Physical appearance Solid black
powder
Tubular shape Fine powder
Average NP size
In dry state (TEM) In suspension (hydrodynamic
diameter)
9.5 nm diameter / 1.5 µm in length Not available
Size dispersity Not available
Surface area 250 – 300 m2/g
Surface tension 59.6 mN/m
Zeta potential Not available
Solubility < 2 mg/L
Density At 20°C was obtained: D 20/4 = 1.988
Crystallinity -
NP shape Tubular shape
pH -
(ECO)TOXICOLOGICAL INFORMATION
DNEL (Derived No Effect Level) – long term exposure: 0.05 mg/m3
Acute toxicity Dermal Inhalation Ingestion Genotoxicity
LD50 rat >
2,000 mg/kg
LD50 rat > 5,000
mg/kg
Not mutagenic
(Ames test).
Sub-Chronic
toxicity
Dermal Inhalation Ingestion Intravenous
5 days, rat, LOAEC: 2
mg/m³
repeated dose, 90 days,
rat, LOAEC: 0.1 mg/m³
lung (multifocal
granulomatous
inflammation)
Oral, repeated
dose, 28 days, rat,
NOAEL: 0.5 mg/kg
No carcinogenic
response.
(2-year bioassay in
the peritoneal cavity
of the rat)
Acute ecotoxicity
in animal models
Aquatic
invertebrates
Aquatic vertebrates
(fish)
Soil invertebrates Algae
Daphnia
magna,
freshwater,
48h, EC50 >
100 mg/l
Danio rerio, 14 days,
EC50 > 100 mg/l
Desmodesmus
subspicatus,
freshwater, 72h,
EC50: 134 mg/l
Long term
ecotoxixity in
animal models
Daphnia
magna, semi
static, NOEC >
25 mg/l
Danio rerio, semi static,
EC10: 100 mg/l
In silico models
GT1. Specifications and uses of nanomaterials in the plastic industry
Mercadohttp://dsstool.sudoenanodesk.europeanprojects.net/
3. Progress so far and main results
3. Progress so far and main results
19
• GT2. Development of advanced tools for data searching
3. Progress so far and main results
20
• GT5. Development of the PNC Observatory
21
Proposed structure
3. Progress so far and main results
3. Progress so far and main results
22
• GT.T3. Communication activities
• Be informed by clicking on
http://sudoenanodesk.europeanprojects.net
4. Summary conclusions
NanoDESK 1st Stakeholder´s day
4. Summary conclusions
24
To conclude….
• According with the information described previously, NanoDESK will have a
direct impact on the plastic Industry, workers and consumers, providing the
industry with solutions to support the use of nanotechnologies in the near
term.
A close collaboration with the industrial partners is key to
ensure the application of the project results in a large
number of companies.
Selecting proper ENMs formulations
Designing of easy-to-use user interfaces of advanced
tool for risk assessment purposes
Delivery of the nanosafety observatory
A better understanding of the workplace, consumer and
environmental exposure will provide the stakeholders with
scientific and consensuated data to conduct regulatory
actions
Carlos Fito López
ITENE - Project Coordinator
Thank you for your
attention ¡
NanoDESK INTERNATIONAL WORKSHOP ON SAFE IMPLEMENTATION OF
NANOMATERIALS IN PLASTIC INDUSTRY