National Institute of HealthNational Institute of Health

Pathom Sawanpanyalert, MD, DrPHPathom Sawanpanyalert, MD, DrPHNational Institute of HealthNational Institute of Health

Department of Medical SciencesDepartment of Medical SciencesMinistry of Public Health, ThailandMinistry of Public Health, Thailand

Roles of the National Roles of the National Institute of HealthInstitute of Health

Serves as national reference Serves as national reference laboratories for clinical diagnoses and laboratories for clinical diagnoses and epidemiological studies of infectious epidemiological studies of infectious and non-infectious diseasesand non-infectious diseases

Conducts and co-ordinates research Conducts and co-ordinates research projects for prophylaxis and therapy projects for prophylaxis and therapy of infectious and non-infectious of infectious and non-infectious diseases or syndromes of national diseases or syndromes of national importance and for public welfareimportance and for public welfare

Research facilities for Research facilities for infectious diseasesinfectious diseases

Facilities and equipment: biosafety cabinets, autoclaves. CO2 incubators, microscopes (including scanning and transmission election microscopes), PCR machines, DNA sequencers, FACS machines, beta counters and biosafety level-3 containment laboratories for in vitro and in vivo experiments

Laboratory TestsLaboratory Tests

Serological testsSerological tests Isolation and characterizationIsolation and characterization PCR and other nucleic acid testsPCR and other nucleic acid tests Health profile testsHealth profile tests Special laboratory testsSpecial laboratory tests

Quality system complies with ISO Quality system complies with ISO 9001, ISO 15189 and ISO 170259001, ISO 15189 and ISO 17025

Health Research AreasHealth Research Areas

Infectious DiseasesInfectious Diseases Non-infectious DiseasesNon-infectious Diseases

1.1. Research for reference laboratory Research for reference laboratory testing services testing services

2.2. Research on public health problemsResearch on public health problems

3.3. Research and development on Research and development on diagnostic kits, drugs and vaccinesdiagnostic kits, drugs and vaccines

Infectious DiseasesInfectious Diseases HIV-1 Subtype E Vaccine DevelopmentHIV-1 Subtype E Vaccine Development Collaborates with the National Institute of Collaborates with the National Institute of

Infectious DiseasesInfectious Diseases Antiretroviral Drug Resistance SurveillanceAntiretroviral Drug Resistance Surveillance Collaborate with International Medical Center of Collaborate with International Medical Center of

Japan and NIIDJapan and NIID Diagnosis of Opportunistic FungiDiagnosis of Opportunistic Fungi Collaborate with Chiba University Collaborate with Chiba University Emerging and Re-emerging Diseases SurveillanceEmerging and Re-emerging Diseases Surveillance Collaborates with US CDCCollaborates with US CDC Tuberculosis DiagnosisTuberculosis Diagnosis Collaborates with Colorado State UniversityCollaborates with Colorado State University Antimicrobial Resistance Surveillance, supported by Antimicrobial Resistance Surveillance, supported by

WHOWHO Influenza and Avian Influenza Vaccine DevelopmentInfluenza and Avian Influenza Vaccine Development Leptospirosis Test Kit and Vaccine DevelopmentLeptospirosis Test Kit and Vaccine Development Dengue Haemorrhagic Fever SurveillanceDengue Haemorrhagic Fever Surveillance WHO Global Salmonella SurveillanceWHO Global Salmonella Surveillance

Non-infectious DiseasesNon-infectious Diseases

National neonatal Screening National neonatal Screening ProgrammeProgramme

Thalassemia ScreeningThalassemia Screening Biomonitoring of Toxic Biomonitoring of Toxic

SubstancesSubstances

Major emerging and Major emerging and Remerging Diseases under the Remerging Diseases under the laboratory-based surveillance:laboratory-based surveillance:1.1. Acute DiarrheaAcute Diarrhea

2.2. Acute Viral HepatitisAcute Viral Hepatitis

3.3. InfluenzaInfluenza

4.4. Fever or Fever with unknown originFever or Fever with unknown origin

5.5. Meningococcal MeningitisMeningococcal Meningitis

6.6. EncephalitisEncephalitis

7.7. Legionnaire’s DiseaseLegionnaire’s Disease

8.8. Hand-Foot-Mouth Disease and HerpanginaHand-Foot-Mouth Disease and Herpangina

9.9. Haemorrhagic Fever with Renal SyndromeHaemorrhagic Fever with Renal Syndrome

Roles in Thai NIH in Disaster Roles in Thai NIH in Disaster Management: Tsunami (December Management: Tsunami (December 2004)2004)

1.1. Laboratory-based surveillance of Laboratory-based surveillance of communicable diseases (post-communicable diseases (post-Tsunami)Tsunami)

2.2. Assist in victim identification (DNA Assist in victim identification (DNA matching)matching)

3.3. Provision of test kits for use in Provision of test kits for use in diagnosis and surveillance (post-diagnosis and surveillance (post-Tsunami)Tsunami)