Needlefree IV Connector Technology

Chosen by clinicians and infection control professionals more than twice as often as any other

Neutron®

Needlefree Catheter Patency Device

NanoClave®

Low Profile Neutral Displacement Connector

MicroClave® ClearNeutral Displacement Connector

Clear housingpermits visual confirmation of flush after use with medications or blood.

Straight fluid pathfor clearing blood and blood residual with low flush volumes.8

Minimal residual volume (also referred to as priming volume) allows for lower flush volumes.

Split-septuma preferred design feature for connectors.7

The patented technology in our complete line of needlefree IV connectors has been clinically proven to provide an effective barrier against bacterial transfer and colonization, helping you keep your patients safer from bloodstream infections.1,2

Common features of the line include:

> A single clinical protocol used with all patient populations, minimizing clinical training and in-servicing and providing maximum patient safety throughout the hospital.

> Highly efficient flushing ability, helping you to completely clear the connectors of blood and blood components with minimal flush volumes.

> A mechanically and microbiologically closed system, providing a safe and effective microbial barrier to help keep your patients safer from bloodstream infections.

> Industry preferred needlefree connector technology that has been chosen by clinicians and infection control professionals more than twice as often as any other.3

Neutron®

Needlefree Catheter Patency Device

Lower costs and enhance patient care by preventing blood reflux and

reducing central line occlusions.

NanoClave®

Low Profile Neutral Displacement Connector

Keep your delicate neonatal and pediatric patients safe while

effectively managing their fluids.

MicroClave® ClearNeutral Displacement Connector

Visualize connector flushing after blood draws or administration and lower

the risk of bloodstream infections.

Silicone Seal and Internal Cannula

Specifically designed to minimize contact between the connector’s external surface and the internal

fluid path upon luer activation, these needlefree connectors

minimize entry points for bacteria. Several studies have attributed this

feature to a significant reduction in bacterial contaminants

passed through the connector.4,5,6

One Market-Leading Technology. One Clinical Protocol.

Three ProvenInfection Control

All-Stars

Reducing catheter occlusions with the Neutron catheter patency device may provide real-time clinical benefits.

Avoid Delays in Critical Patient Care

Neutron may help avoid delays in therapy  of critical intravenous medications  (e.g.,

antibiotics and oncolytics), nutritional support, and blood products.

Avoid Patient Discomfort and Pain

Neutron may help avoid patient discomfort and pain caused by

unnecessary needlesticks, catheter restarts, and manipulating the IV site.

Avoid Unnecessary Costs

Neutron may help minimize unnecessary costs that add up

when treating an occlusion.

Help Reduce Risk of Infection

Neutron may help reduce the risk of infection by preventing thrombosis

and minimizing IV line manipulation.

Maintaining catheter patency and minimizing occlusions can be important steps in your efforts to enhance patient safety, improve patient outcomes, and reduce costs.But despite your efforts, central line occlusions, which are frequently caused by blood reflux,9 remain a significant issue that can result in delays in critical patient care, increased risk of infection, and increased healthcare costs. That’s why reducing the risk of catheter occlusions may help you decrease the need for expensive declotting agents such as tPA, and reduce the clinical costs associated with managing catheter occlusions.

Neutron’s breakthrough anti-reflux technology helps you stop occlusions before they start, while providing a safe and effective microbial barrier.Unlike other technologies, such as positive displacement needlefree connectors, Neutron is the only device FDA-cleared to prevent all forms of reflux into a catheter and is the first device to be cleared for all patient populations—including pediatrics and immunocompromised patients.

The Neutron Catheter Patency Device Reduces Reflux to Help You

Minimize Occlusions

Neutron: Better by Design

Because of an innovative design that incorporates a patented bi-directional silicone valve to help prevent reflux at all times, Neutron helps maintain catheter patency during times when traditional connectors have been shown to occlude most often.

Unlike other anti-reflux valves, Neutron’s patented technology provides the unique ability to absorb and physically compensate for pressure variations that typically result in blood reflux into a catheter.

During InfusionDuring Aspiration No Fluid Flow

During Reflux Challenge

The perfect choice for your delicate

neonatal and pediatric patients

NanoClave Low Profile Neutral Displacement Connector

Keeping Your Tiniest Patients

Safe From Infection while effectively managing their fluids.

MicroClave Clear Neutral Displacement Connector

The Clear Choice to Help You

Visualize Flushing and reduce the risk of bloodstream infection.

Ideal for a wide range of clinical applications and patient populations, MicroClave Clear is the optimal facility-wide needlefree IV connector.

MicroClave Clear combines proven Clave® technology with a clear

housing that lets you visualize connector flushing after blood draws

or administration.

> Does not require a change in clinical practice or technique

> Can be used on all peripheral, arterial, and central venous catheters

> Permits visual confirmation of connector flushing

> Utilizes proven infection control technology2,6

Visualize connector

flushing while reducing the

risk of hospital-acquired

bloodstream infections

at the same time.

Preventing infections and managing patient fluids are critical elements of neonatal infusion therapy. And NanoClave is here to help.

NanoClave is specifically designed to help keep your neonatal and pediatric

patients safe by minimizing flush volumes and providing a safe and effective

microbial barrier.

> Minimizes patient discomfort with small size and weight

> Minimal residual volume of only 0.02 mL allows for lower flush volumes

> Utilizes proven infection control technology2,6

Clinicians Around the WorldChoose ICU MedicalNeedlefree Connectors More than Any Other.We have been developing innovative connector technologies that improve patient and

caregiver safety while helping you improve outcomes for more than 30 years. From the

original Clave connector to the revolutionary Neutron Catheter Patency Device, connectors

incorporating the foundational split-septum and internal blunt cannula technology from

ICU Medical are chosen twice as often as any other connector technology.10,11

Make the most of our clinically preferred needlefree technology with made-to-order custom IV sets with no long-term contracts or minimum order requirements.

Our  low-cost, custom IV set program allows facilities to maximize efficiencies by:

> Avoiding burdensome assembly of multiple sets and unnecessary storage of extra components

> Designing patient-ready IV sets by choosing from thousands of clinically proven component options

> Customizing sets with color-coded IV components and accessories to improve IV line management and avoid medication mix-ups

©2014 ICU Medical Inc. | M1-1462 Rev. 01800.824.7890 | www.icumed.com

Learn how we can help you find the right needlefree connector to meet your unique clinical needs by calling 800.824.7890 or by visiting www.icumed.com/therightconnector.

1 Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011. 2 Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) at an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028. 3 Global Healthcare Exchange (GHX) Market Intelligence data. Connectors, Needleless, Parenterals, [92-100]. Q1-Q4 2012. Includes stand-alone needlefree connectors and ancillary direct access devices (two-piece, hemodialysis, non-swab-able, and non-patient contact connectors excluded). 4 J. Yebenes, M. Delgado, G. Sauca, M. Serra-Prat, M. Solsona, J. Almirall, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561 5 JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.; 36:181-189 6 Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007, Abstract 412. 7 Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010 8 Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1. 9 Gorski, Lisa A MS, RN, CS, CRNI. Central Venous Access Device Occlusions: Part 1: Thrombotic Causes and Treatment. Home Healthcare Nurse. 21:2 115-121, February 2003. 10 2011 GSX market data on single-sterile sales of standalone needleless connectors. February 27, 2012. 11 2011 GSX market data on single-sterile sales of extension sets with needleless connectors. February 27, 2012.