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NERVOUS SYSTEM
NERVOUS FUNCTIONS• Body’s master controlling and communicating
system• Three functions– Sensory input• Gathers information
from sensory receptors
– Integration• Processes and interprets
sensory input
– Motor output• Activates effector organs to cause a response
Nervous System Organization
ORGANIZATION
Two Principal Parts of the System• Central nervous system (CNS)– Brain and spinal cord– Integrating and command center• Interprets sensory input• Dictates motor responses
• Peripheral nervous system (PNS)– Nerves extending from brain and spinal cord– Carry impulses to and from the CNS
PERIPHERAL DIVISIONS
Two Functional Subdivisions of the PNS• Sensory division– “afferent division”– Nerve fibers conveying impulses to the CNS
• Somatic afferent fibers convey impulses from the skin, muscles, and joints
• Visceral afferent fibers convey impulses from visceral organs• Motor division– , “efferent division”– Nerve fibers conveying impulses from the CNS
ORGANIZATION
HISTOLOGY
• Nervous system consists mainly of nervous tissue• Highly cellular– e.g., <20% extracellular space in CNS
• Two principal cell types– Neurons
• Excitable nerve cells that transmit electrical signals
– Supporting cells• Smaller cells surrounding and wrapping neurons• “Neuroglia”
NEURONS• Nerve cells• Structural units of nervous system
– Billions are present in nervous system• Conduct messages throughout body
– Nerve impulses• Extreme longevity
– Can function optimally for entire lifetime• Amitotic
– Ability to divide is lost in mature cells– Cannot be replaced if destroyed
• Some (very few) exceptions• e.g., stem cells present in olfactory epithelium can produce new neurons
– Stem cell research shows great promise in repairing damaged neurons• High metabolic rate
– Require large amounts of oxygen and glucose
Neurons
Axon of anotherneuron
Axon of anotherneuron
Cell BodyCell BodyDendritesDendrites
AxonAxon
MyelinSheathMyelinSheath
Dendrites of another neuron
Dendrites of another neuron
Collins I4 lines
• Based on the diagram, what do you think each part does to receive and pass along an impulse toward the brain
Agenda11/3/11 – Day 1
• Take more notes• HW- vocab
NEURONS• Generally large, complex cells• Structures vary, but all neurons have the same basic
structure– Cell body– Slender processes
extending from cell body
– Plasma membrane is site of signaling
NEURON CELL BODY• Most neuron cell bodies are located in the CNS– Protected by bones of skull or vertebral column
• Clusters of cell bodies in the CNS are termed “nuclei”
• Clusters of cell bodies in the PNS are termed “ganglia”
NEURON CELL BODY• Major biosynthetic (control) center of neuron• Other usual organelles present except CENTRIOLES
-Why?• What do centrioles
do?
NEURON PROCESSES
• Extend from the neuron’s cell body
• Two types of neuron processes– Dendrites– Axons
NEURON PROCESSESTypical Dendrite• Short, slender, branching extensions of cell body– Generally hundreds clustering close to cell body– Most cell body organelles also present in dendrites
• Main receptive / input regions– Large surface area for
receiving signals from other neurons
– Convey incoming messages toward cell body
NEURON PROCESSESTypical Axon• Single axon per neuron• The axon forms from the narrowing of the cell body.
The region between the large cell body and the axon is the “axon hillock”
• Sometimes very short• Sometimes very long– e.g., axons controlling
big toe are 3 – 4 feet long
NEURON PROCESSESTypical Axon• Single axon may branch along length• “Axon collaterals” extend from neurons at ~ 90o angles• Usually branches
profusely at end– 10,000 or more
terminal branches is common
– Distal endings termed “axonal terminals”
NEURON PROCESSESTypical Axon• Conducting component of neuron• Generates nerve impulse• Transmits nerve
impulses away from cell body towards the
axonal terminals
NEURON PROCESSESTypical Axon terminal• Axonal terminals are secretory component of neuron• Sequence of events– Signal reaches terminals– Membranes of vesicles fuse with
plasma membrane– Neurotransmitters released– Neurotransmitters interact
with either other neurons or effector cells• Excite or inhibit
VocabularyEither in flash card form OR in list• CNS
• PNS• Neuron• Stimulus• Afferent division• Efferent division• neuroglia
• Amitotic• Dendrite• Cell body• Axon• Axon terminal• Ganglia• Nuclei (in terms of
clusters)
Collins I2 lines
• What is the difference between the PNS and the CNS?
Agenda11/4/11 -- Day 2
• Remember quiz 11/9• Take notes• Complete labeling and coloring of neuroglia• HW-complete ALL vocab terms
MYELIN SHEATH
• Whitish, fatty covering the axons of many neurons
• Protects and electrically insulates fibers• Increases speed of nerve impulse transmission– Some axons and all dendrites are unmyelinated
MYELIN SHEATH• In PNS, Schwann cells Continually wrap around the axon
of a neuron– Result is many concentric layers of plasma membrane
surrounding the axon– Thickness depends on number of wrappings
• Nucleus and most of cytoplasm exist as a bulge external to the myelin sheath
Myelin sheath and schwann cells
Node of Ranvier
Schwann Cells
MYELIN SHEATH• Adjacent Schwann cells on axon do not touch
each other– Gaps in sheath occur at regular intervals • “Nodes of Ranvier”
– Axon collaterals can emerge at these nodes
MYELIN SHEATH
• In CNS, there are both myelinated and unmyelinated axons
• Oligodendrocytes, not Schwann cells, form CNS myelin sheaths– Numerous processes that can coil around
numerous (up to 60) axons at once
NEUROGLIA
• “Nerve glue”• Six types of small cells associated with neurons– 4 in CNS– 2 in PNS
• Several functions– Supportive scaffolding for neurons– Electrical isolation of neurons– Neuron health and growth
CNS NEUROGLIA
• Astrocytes• Microglia• Ependymal cells• Oligodendrocytes
CNS NEUROGLIAAstrocytes
• Anchor neurons to capillary blood supply• Facilitate nutrient delivery to neurons– (blood astrocyte neuron)
CNS NEUROGLIAMicroglia• Small ovoid cells; thorny looking• Transform into macrophage– Phagocytize microorganisms, debris– (Cells of immune system cannot enter the CNS)
CNS NEUROGLIAOligodendrocytes• Wrap processes tightly around thicker neuron
fibers in CNS– Makes “Myelin sheath”– Insulating covering
CNS NEUROGLIAEpendymal Cells• Line central cavities of brain and spinal cord• Many are ciliated– Beating helps circulate cerebrospinal fluid cushioning brain
and spinal cord
PNS NEUROGLIASchwann cells• Surround and form myelin sheaths around larger
neurons of PNS– Functionally similar to oligodendrocytes
PNS NEUROGLIA
• Satellite cells– Surround cell bodies of PNS ganglia
HW- Vocab Terms
• Myelin sheath• Schwann cells• Nodes of ranvier• Oligodendrocytes• Neuroglea• Astrocyte• Microglia• Ependymal cell• Satalite cell
MYELIN SHEATH
• White matter– Regions of the brain and spinal cord containing
dense collections of myelinated fibers
• Gray matter– Regions of the brain and spinal cord containing
mostly nerve cell bodies and unmyelinated fibers
NEURON CLASSIFICATION
• Structural classification based upon number of processes– Multipolar neurons– Bipolar neurons– Unipolar neurons
• Functional classification based upon direction nerve impulse travels– Sensory (afferent) neurons– Motor (efferent) neurons– Interneurons (association neurons)
NEURON CLASSIFICATION
Structural Classification• Multipolar neurons
– Three or more processes– Most common neuron type
in humans• (> 99% of neurons)
• Bipolar neurons– Two processes – axon and
dendrite– Found only in some special
sense organs • e.g., retina of eye
– Act as receptor cells
• Unipolar neurons– Single short process– Process divides into proximal
and distal branches• Distal process often associated
with a sensory receptor– “Peripheral process”
• Central process enters CNS– Most are sensory neurons in
PNS
Classification of neurons by shape
NEURON CLASSIFICATIONFunctional Classification• Sensory (afferent) neurons– Transmit impulses toward CNS
• From sensory receptors or internal organs
– Most are unipolar– Cell bodies are located outside
CNS• Motor (efferent) neurons– Carry impulses away from CNS
• Toward effector organs– Multipolar– Cell bodies generally located in
the CNS
• Interneurons – a.k.a., association
neurons– Lie between motor
and sensory neurons in neural pathways
– Shuttle signals through CNS pathways where integration occurs
– > 99% of neurons in body
– Most are multipolar– Most are confined
within the CNS
NEUROPHYSIOLOGY
• Neurons are highly irritable– Responsive to stimuli
• Response to stimulus is action potential– Electrical impulse carried along length of axon– Always the same regardless of stimulus– The underlying functional feature of the nervous
system
ION CHANNELS
Plasma membranes contain various ion channels• Passive channels (leakage channels)– Always open
• Active channels (gated channels)– Ligand-gated channels
• Open when specific chemical binds
– Voltage-gated channels• Open and close in response to membrane potential
– Mechanically-gated channels• Open in response to physical deformation of receptor
– e.g., touch and pressure receptors
MEMBRANE POTENTIALS• A voltage exists across the plasma membrane– Due to separation of oppositely charged ions
• Potential difference in a resting membrane is termed its “resting membrane potential”– ~ -70 mV in a resting
neuron– Membrane is
“polarized”
MEMBRANE POTENTIALS
• Neurons use changes in membrane potentials as signals– Used to receive, integrate, and send signals
• Changes in membrane potentials produced by– Anything changing membrane permeability to ions– Anything altering ion concentrations
• Two types of signals– Graded potentials
• Short-distance signals– Action potentials
• Long-distance signals
MEMBRANE POTENTIALS
Graded Potentials• Short-lived local changes in membrane potential– Either depolarizations or hyperpolarizations
• Cause current flows that decrease in magnitude with distance
• Magnitude of potential dependent upon stimulus strength– Stronger stimulus larger voltage change– Larger voltage change farther current flows
MEMBRANE POTENTIALSGraded Potentials• Triggered by change in neuron’s environment– Change causes gated ion channels to open
• Small area of neuron’s plasma membrane becomes depolarized (by this stimulus)
• Current flows on both sides of the membrane– + moves toward – and vise versa
MEMBRANE POTENTIALSGraded Potentials• Inside cell: + ions move away from depolarized area• Outside cell: + ions move toward depolarized area– (+ and – ions switch places)
• Membrane is leaky– Most of the charge is quickly lost through membrane– Current dies out after traveling a short distance
MEMBRANE POTENTIALS
Graded Potentials• Act as signals over very short distances• Important in initiating action potentials
MEMBRANE POTENTIALS
Action Potentials• Principal means by which neurons communicate– Brief reversal of membrane potential
• Total amplitude of ~ 100 mV (-70 +30)
– Depolarization followed by repolarization, then brief period of hyperpolarization
– Time for entire event is only a few milliseconds
• Events in generation and transmission of an action potential identical between neurons and skeletal muscle cells
ACTION POTENTIALS
ACTION POTENTIALS
• Not all local depolarizations produce action potentials
• Depolarization must reach threshold values– Brief, weak stimuli produce sub threshold
depolarizations that are not translated into nerve impulses
– Stronger threshold stimuli produce depolarizing events
ACTION POTENTIALS
• Action potential is all-or-nothing phenomenon– Happens completely or doesn’t happen
• Independent of stimulus strength once generated– Strong stimuli generate more impulses of the
same strength per unit time– Intensity is determined by number of impulses per
unit time
ACTION POTENTIALS
Multiple Sclerosis (MS)• Autoimmune disease mainly affecting young
adults• Myelin sheaths in CNS are gradually destroyed• Interferes with impulse conduction– Visual disturbances, muscle control problems,
speech disturbances, etc.
• Some modern treatments showing some promise in delaying problems
SYNAPSE• Nerve impulse reaches axonal terminal• Voltage-gated Ca2+ channels open in axon– Ca2+ enters presynaptic neuron
• Neurotransmitter is released via exocytosis– Vesicles fuse with axonal membrane
• Neurotransmitter binds to postsynaptic receptors• Ion channels open in
postsynaptic membrane– Result is excitation or
inhibition
SYNAPSE
• Binding of neurotransmitter to its receptor is reversible
• Permeability affected as long as neurotransmitter is bound to its receptor
• Neurotransmitters do not persist in the synaptic cleft– Degraded by enzymes associated with postsynaptic
membrane– Reuptake by astrocytes or presynaptic terminal– Diffusion of neurotransmitters away from synapse
NEUROTRANSMITTERS• More than fifty neurotransmitters identified• Most neurons make two or more– Can be released singly or together
Classification by Structure• Acetylcholine (ACh)• Biogenic amines• Amino acids• Peptides• ATP• Dissolved gases
Classification by Function• Excitatory/Inhibitory• Direct/Indirect