NeSSI Compatible NeSSI Compatible Spectroscopic Flow CellsSpectroscopic Flow Cells

Mike DoyleMike DoyleAxiom Analytical, Inc. Axiom Analytical, Inc.

Unique Requirements of Unique Requirements of Spectroscopic Process AnalysisSpectroscopic Process Analysis

Use of broad spectrum optical radiationUse of broad spectrum optical radiation

Need to couple to complex remote instrumentsNeed to couple to complex remote instruments

Need to produce SPC plots from large arrays of Need to produce SPC plots from large arrays of datadata

Comparison Of Four Forms Of Process Comparison Of Four Forms Of Process Molecular SpectroscopyMolecular Spectroscopy

Mid-IR Near-IR UV-Visible Raman

Applicable Sampling Methods

ATR - liquids Transmission - gases

TransmissionDiffuse reflectance

Transmission ATR

Raman Scattering

Band Types FundamentalsFundamentals Overtones (CH, OH, Overtones (CH, OH, etc)etc)

ChromophoresChromophores FundamentalsFundamentals

Calibrations EasyEasy Often TediousOften Tedious Case dependentCase dependent Case dependentCase dependent

Optics Chemically sensitiveChemically sensitive ResilientResilient Resilient Resilient Resilient Resilient

Fiber-Optic Coupling Short Distances OnlyShort Distances Only OKOK OKOK OKOK

Sample Fluorescence

OKOK OKOK OKOK Problematic Problematic

Background Radiation

OKOK OKOK OKOK ProblematicProblematic

Referencing OKOK OKOK OKOK ProblematicProblematic

Applicability of Various Sampling MethodsApplicability of Various Sampling Methods

SampleType

Mid-IR ATR Mid-IRTransmission

NIR & UV-VisTransmission

NIR DiffuseReflectance

UV-Visible ATR

Raman

Clear Fluids Yes Some Cases Yes No Yes Yes

Scattering Fluids

Liquid Phase Only

No Some Cases Some Cases Liquid Phase Only

Yes

Powders No No Some Cases Yes No Yes

Bulk Solids,Scattering

No No Some Cases Yes No Yes

Bulk Solids,Clear

No No Some Cases No No Yes

Gases No Yes Yes No No Some Cases

Spectroscopic Methods Appropriate to the Spectroscopic Methods Appropriate to the NeSSI PlatformNeSSI Platform

Samples Type – Clear liquidsSamples Type – Clear liquids

Methods:Methods: Near-IR: TransmissionNear-IR: Transmission UV-Visible: Transmission and ATRUV-Visible: Transmission and ATR Raman: BackscatterRaman: Backscatter Mid-IR: ATR ?Mid-IR: ATR ?

The NeSSI Platform ObjectivesThe NeSSI Platform Objectives

Standardize and simplify systems for process analysisStandardize and simplify systems for process analysis

Provide a system of miniature, interchangeable sample Provide a system of miniature, interchangeable sample handling componentshandling components

Analyzer systems close to the sampling pointAnalyzer systems close to the sampling point

Short lines, fast responseShort lines, fast response

Modular assemblyModular assembly

Axiom Product Overview – Fluid AnalysisAxiom Product Overview – Fluid AnalysisNear-IR and UV-Visible TransmissionNear-IR and UV-Visible Transmission

Established ProductsEstablished Products FPT-850 Transmission ProbesFPT-850 Transmission Probes FCT Series Cross-Line Sampling SystemsFCT Series Cross-Line Sampling Systems FFV-300 Series Transmission CellsFFV-300 Series Transmission Cells FST-500 Unistage Transmission SamplerFST-500 Unistage Transmission Sampler

Most Significant DevelopmentMost Significant Development Permanent Welded-in Metal SealsPermanent Welded-in Metal Seals

Recent DevelopmentsRecent Developments Self Cleaning ProbesSelf Cleaning Probes Small Diameter ProbesSmall Diameter Probes Polymer Melt Transmission ProbesPolymer Melt Transmission Probes NeSSI Compatible FFV Transmission CellsNeSSI Compatible FFV Transmission Cells

Established ProductsEstablished Products FPT-850 Transmission ProbesFPT-850 Transmission Probes FCT Series Cross-Line Sampling SystemsFCT Series Cross-Line Sampling Systems FFV-300 Series Transmission CellsFFV-300 Series Transmission Cells FST-500 Unistage Transmission SamplerFST-500 Unistage Transmission Sampler

Most Significant DevelopmentMost Significant Development Permanent Welded-in Metal SealsPermanent Welded-in Metal Seals

Recent DevelopmentsRecent Developments Self Cleaning ProbesSelf Cleaning Probes Small Diameter ProbesSmall Diameter Probes Polymer Melt Transmission ProbesPolymer Melt Transmission Probes NeSSI Compatible FFV Transmission CellsNeSSI Compatible FFV Transmission Cells

FFV Series Transmission CellsFFV Series Transmission Cells

Variable or fixed pathlengthsVariable or fixed pathlengths

FFV-320NSI Transmission CellFFV-320NSI Transmission Cell

FFV-320-NSI Transmission CellFFV-320-NSI Transmission Cell

Tunable Laser Spectra of Isopropanol with Tunable Laser Spectra of Isopropanol with Pathlengths from 1 to 7.5 mmPathlengths from 1 to 7.5 mm

Comparison of FTIR and Tunable Laser SpectraComparison of FTIR and Tunable Laser Spectra(1 and 2 mm pathlengths)(1 and 2 mm pathlengths)

Product Overview – Fluid AnalysisProduct Overview – Fluid AnalysisAttenuated Total Reflectance (ATR)Attenuated Total Reflectance (ATR)

Established ProductsEstablished Products Direct-coupled ATR Probes – Including diamond tipped probesDirect-coupled ATR Probes – Including diamond tipped probes ATR Flow Cells – Process and lab Tunnel CellsATR Flow Cells – Process and lab Tunnel Cells Fiber-coupled UV-Visible Tunnel CellsFiber-coupled UV-Visible Tunnel Cells

New DevelopmentsNew Developments Fiber-coupled Mid-IR ATR ProbesFiber-coupled Mid-IR ATR Probes Integrated ATR Sampling SystemsIntegrated ATR Sampling Systems UV-Visible ATR Probes (in development)UV-Visible ATR Probes (in development) NeSSI Compatible NeSSI Compatible UV-Visible Tunnel CellsUV-Visible Tunnel Cells

FNL-120 UV-Visible ATR CellFNL-120 UV-Visible ATR Cell

Fiber-coupled UV-Visible Tunnel CellFiber-coupled UV-Visible Tunnel Cell

FNL-120EL Extended Length UV-Visible FNL-120EL Extended Length UV-Visible Tunnel CellTunnel Cell

FNL-120NSI UV-Visible ATR CellFNL-120NSI UV-Visible ATR Cell

FNL-120UV-NSI UV-Visible ATR CellFNL-120UV-NSI UV-Visible ATR Cell

FNL-120EL Spectrum of 50% FNL-120EL Spectrum of 50% Red Food DyeRed Food Dye

Product Overview Product Overview Raman ProbesRaman Probes

Established ProductsEstablished Products Modular Raman Probes for Lab Applications – RFP-400 SeriesModular Raman Probes for Lab Applications – RFP-400 Series Robust Process Probes – RFP-500 SeriesRobust Process Probes – RFP-500 Series

Recent DevelopmentsRecent Developments Self-cleaning Raman ProbesSelf-cleaning Raman Probes Multi-pass Raman SamplingMulti-pass Raman Sampling NeSSI Compatible Raman Cells (Single- and Multi-pass)NeSSI Compatible Raman Cells (Single- and Multi-pass)

RFP-400 Series Lab Raman ProbesRFP-400 Series Lab Raman Probes

Multipass Raman Probe DesignMultipass Raman Probe Design

NeSSI Multipass Raman CellNeSSI Multipass Raman Cell

Raman Spectra of Isopropanol: Raman Spectra of Isopropanol: Black = single pass, Red = Black = single pass, Red = multipass, Blue = black X 8.4multipass, Blue = black X 8.4

Raman Spectra of Toluene: Raman Spectra of Toluene: Black = single pass, Red = multipass, Black = single pass, Red = multipass, Blue = Black X8.0Blue = Black X8.0

NeSSI Sampling System ExampleNeSSI Sampling System Example

NeSSI Compatible Spectroscopic Cells from NeSSI Compatible Spectroscopic Cells from Axiom Analytical, Inc.Axiom Analytical, Inc.

Currently AvailableCurrently Available

FFV Series Transmission Cells (Near-IR, UV-Visible)FFV Series Transmission Cells (Near-IR, UV-Visible) FNL-120 UV-Visible ATR CellFNL-120 UV-Visible ATR Cell

In DevelopmentIn Development Raman Cells (Single- and Multi-pass)Raman Cells (Single- and Multi-pass)

Possible DevelopmentPossible Development Diffuse Reflectance Cells (For turbid liquids)Diffuse Reflectance Cells (For turbid liquids) Mid-IR ATR CellsMid-IR ATR Cells

Axiom Analytical, Inc.Axiom Analytical, Inc.

Engineering for the Engineering for the UnexpectedUnexpected