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Nestlé Science & Research
Nutrition &Life SciencesNutrition &
Life Sciences ProcessingProcessing
Quality&
Safety Sciences
Quality&
Safety Sciences
Consumer Perception & Preferences
Consumer Perception & Preferences
Consumer Perception &Preferences
Nutrition & Life Sciences Processing
Quality & SafetySciences
Dr Bruce German
Disclaimer
This presentation contains forward looking statements which reflect Management’s current views and estimates. The forward looking statements involve certain risks and uncertainties that could cause actual results to differ materially from those contained in the forward looking statements. Potential risks and uncertainties include such factors as general economic conditions, foreign exchange fluctuations, competitive product and pricing pressures and regulatory developments.
Goals of 1st INS Are People all the same in response to diet, health and disease risk
Are there methods that can assess health status, predict the trajectory of health and act to prevent disease
D:\Documents\...\Human Plasma_1 27/05/2003 09:50:06 Human Plasma No1, LCrun, manual injection of 5 ultargetfsms4e5 RT: 0.0000 - 21.9416
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9.471310.85746.6989 20.332917.476415.20531.0502 9.93107.5684 18.459913.9725 21.16212.3065 5.1317 8.53594.88222.8708
NL:1.57E7TIC F: MS Human Plasma_1
Human Plasma_1#10-709 RT: 2.03-21.93 AV: 644 NL: 7.48E4T: FTMS + p ESI Full ms [ 150.00-2000.00]
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218.8295366.1756204.1230195.0877 334.0986231.1161 279.1591254.1598 263.2043 298.1259235.1110188.1645 339.0539178.0896 319.0878 352.0739
328.9980288.1362246.1698 274.1217 307.1323175.2444157.7074
Consensus from 1st INS
Humans differ Genetically AND by Lifestyle choices
The Tools to measure Metabolism in individuals exist but are not yet brought to practice
But do we need to assess Health?
Now:
More and More Humans are suffering from Health problems due to Metabolic imbalances
Goals of 2nd INS
Assemble the world’s scientific leaders in the regulation of Energy Metabolism
Discuss the solutions that could solve the problems of Obesity, Diabetes and Metabolic Disorders
Consensus from 2nd INS
Metabolic Diseases are being driven by a combination of inappropriate environmental factors (diet-lifestyle) on a background of genetic susceptibility
The consequences of metabolic disorders will be devastating to many aspects of public health
The regulation of metabolism and the basis dietary choices lie in the brain
Next
What is the role of Diet in Brain Functions?
Goal of 3rd INS Assemble the world’s scientific leaders in the regulation of Brain Mechanisms and Functions
How does the brain react to food and can food alter the functions and slow the deterioration of these functions during aging
• The human brain is an astonishing engine that demands massive fueling
• Our senses of taste, smell, touch, vision and hearing when activated by food ‘light up’ most of our brain
Consensus from 3rd INS
• We are beginning to understand the important role of food in fueling the brain and the important role of the brain in choosing food
• The potential of good diets to improve brain functions are greater than we previously thought
• The potential of bad diets to deteriorate brain functions are worse than we previously thought
Next
• How does diet effect the cellular mechanisms and processes of Cancer?
Consensus from 3rd INS
Goals of the 4th INS
• What are the causes of the developmentof cancer
• What solutions are emerging
• How can nutrition help
Concensus of the 4th INS
The Cell cycle is ‘checked’ at multiple points
• Damage to cellular check points are critical to cancer development
• Damage can be from toxins, pathogens, radiation even inflammation
• Therapies are increasingly targeted to specific damage sites
• Nutritional demands of the cancer patient are unique
DNA Damage
Goals of the 5th INS
• How are our cellsfueled
• What fuels ouroverall development
• What determineshuman performance and recovery
Session 1 The Powerhouse
• The membrane is a nano battery
• All cells fuel themselvesby using the charge of their nanobatteries to make ATP
• The process of makingATP from a nanobatteryuses a molecular stepper motor
Session 1 The Muscle
• The muscle cell requiresstimulation: Use it or Lose it
• Muscle Development and Degradation are active processes
Session 2 The Controls• Muscle is controlled by Nuclear
Receptors• Exercise turns these Nuclear
Receptors on• Drugs targeting these receptors mimic
exercise in animal models
Session 2 The Problems• The Environment in
which children growup is changing
• Exercise and physical playopportunities are shrinking
• The consequencescould be prolongedin overall health of the population
Session 2 Bones• Bones store Calcium• Bone is stimulated by exercise• Nutritional Status and Exercise are
critical to build and retain bonesthrough life
Session 3 Performance• Peak performance is limited by our
heart’s ability to deliver oxygen –stroke volume
• All people and all ages benefit fromexercise training with important physiological benefits
Session 3 Limits• Human achievements continue to
improve but by smaller increments• Thermal regulation is a key to
endurance performance
Session 3 in Practice• Optimal diet and exercise depends
on the specific event• The margin of victory in elite events
is very very small• Every little bit helps - sometimes
Session 4 Sarcopenia• The balance of muscle building and
destruction changes with age• Inactivity is devastating to the
balance of muscle • Timing of eating is important as well
Session 4 Nutrition• Exercise and Nutrition interact in the
protection of muscle during aging• Muscle is conspicuously protective
of metabolic health physiologicalhealth and cognitive health
Consensus from 5th INS
Exercise/Physical Activity is highly beneficial to human health at all ages
Inactivity is devastating to human health at all ages
Nutrition can enhance the benefits of exercise
But:
Nutrition’s ability to prevent the damage of inactivity is limited
Nestle’s Research Assets
Nestlé Research Centre: leading-edge science
Nestlé's global R&D network
External partners: pushing frontiers of science and its
application
Thank you