Neuropathology

Dr. Cahyono KaelanDept. of PathologyFaculty of Medicine MakassarINDONESIA

Peripheral NerveMotor Unit General reaction of MUSegmental demyelinationAxonal degeneration + MF atrophyNerve regeneration + Reinnervation of MFReaction of MF

Disease of the PN-Imflamatory NeuropathiesInfection PolyneuropathiesHereditary motor and Sensory neuropathiesAcquired Metabolic and toxic neuropathiesTraumatic NeuropathyTumor of PN

Imflamatory NeuropathiesGuillain Barre SyndromeAcute demyelinating polyradiculopathyImmune mediated neuropathyChronic Polyradiculopathy

Infection Polyneuropathies1.Leprosy

2. Diphteria

3. Varicella- Zoster Virus

Acquired MetabolicPeripheral Neuropathy (DM)Peripheral Neuropathy (Nutition def. Vit. B1Peripheral Neuropathy MalignancyPeripheral Neuropathy - Alcoholic

Tumor of Peripheral NerveSchwannomaNeurofibromaMalignant SchwannomaNeurocutaneous Syndrome ( Phakomatoses)NeurofibromaTuberous SclerosisVon Hippel Lindow

Tumor of Peripheral NerveSchwannoma :Cellular area (Padat Antoni A) + Verucay bodyMyxoid region (Loses ) Antoni B

SchwannomaClinical features :Acustic Neuroma ( Cereello-pontine angle) acustic pendengaranTinnitus & Hearing loss

Vestibular - Keseimbangan

NeurofibromaClinical features :Dikulit ( lobe2)Cutaneus neurofibromaSoliter or flexiformMalignant neurofibroma Von Recklinghausen (recurrent)

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