Neurotechnologies and Brain Computer Interface · 2018. 7. 2. · 3 Biographies & contacts ABOUT THE AUTHORS Jérôme Mouly Dr. Marjorie Villien As a Technology & Market Analyst,

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Neurotechnologies and brain computer interface

Market and Technology analysis

2018

강태영oic

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Abbott, Ad-tech, Advanced Brain Monitoring, AdvaStim, AIST, Aleva Neurotherapeutics, Alphabet, Amazon, Ant Group, ArchiMed, Artinis Medical Systems, Atlas Neuroengineering, ATR, Beijing Pins Medical, BioSemi, Biotronik, Blackrock Microsystems, Boston

Scientific, Brain products, BrainCo, Brainscope, Brainsway, Cadwell, Cambridge Neurotech, Caputron, CAS Medical Systems, CEA, Circuit Therapeutics, Cirtec Medical, Compumedics, Cortec, CVTE, Cyberonics, Deep Brain Innovations, Deymed, Dixi Medical,

DSM, EaglePicher Technologies, Electrochem Solutions, electroCore, Elmotiv, Endonovo Therapeutics, EnerSys, Enteromedics, Evergreen Medical Technologies, Facebook, Flow, Foc.us, G.Tec, Galvani Bioelectronics, General Electric, Geodesic, Glaxo Smith

Klein, Halo Neurosciences, Hamamatsu, Helius Medical, Technologies, Hitachi, iBand+, IBM Watson, IMEC, Integer, Integra, InteraXon, ISS, Jawbone, Kernel, LivaNova, Mag and More, Magstim, Magventure, Mainstay Medical, Med-el ElektromedizinischeGeraete, Medtronic, Micro Power Electronics, Micro Systems Technologies, Micromed, Microsoft, MindMaze, Mitsar, MyBrainTechnologies, Natus, NEC, Nemos, Nervana, Neurable, Neuralink, NeuroCare, NeuroElectrics, NeuroLutions, NeuroMetrix,

Neuronetics, Neuronetics, Neuronexus, Neuropace, Neuros Medical, Neuroscan, NeuroSigma, NeuroSky, Neurosoft, Neurostar, Neurowave, Nevro, Nexeon, Nexstim, Nielsen, Nihon Kohden, Nirox, Nonin Medical, Nuvectra, Olympus, Ornim, Oscor,

Pacesetter, Panasonic, Paradromics, Philips, Plexon, PMT Corporation, RetroSense, Rhythm, Ripple, Rythm Dreem, Samsung, SceneRay, Second Sight Medical, Sensomedical, Setpoint Medical, Shimadzu, Siemens, Sony, Sorin Group, Soterix Medical, SPR

Therapeutics, Stim Wave, Teijin, Thync, Toyota, Verily, VieLight, Vygon, Ximedica, Ybrain,

And many more !!

LIST OF COMPANIES MENTIONED IN THIS REPORT

©2018 | www.yole.fr | Neurotechnologies and brain computer interface

240+ slides of market and technology analysis

Information gathered through direct discussions with technology developers, end-users and key opinion leaders

http://www.yole.fr/http://www.yole.fr/

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Biographies & contacts

ABOUT THE AUTHORS

Jérôme Mouly

Dr. Marjorie Villien

As a Technology & Market Analyst, Dr. Marjorie Villien is member of the Medical Technologies business unit at Yole Développement (Yole). She is a dailycontributor to the development of these activities with a dedicated collection of market & technology reports as well as custom consulting projects.After spending two years at Harvard and prior Yole, Marjorie served as a research scientist at INSERM.Marjorie Villien is graduated from Grenoble INP and holds a PhD in physics & medical imaging.

Jerôme Mouly serves as a Technology & Market Analyst specialized in microtechnologies for biomedical & medical imaging applications at Yole Développement(Yole). Since 2000, Jérôme has participated in more than 100 marketing and technological analyses for industrial groups, start-ups and institutes related tosemiconductor & medical technologies industry. Jérôme holds a Master of Physics from the University of Lyon.

KnowMade’s team realized the patent analysis:

Dr Coralie Le Greneur

Dr Coralie Le Greneur works for Knowmade in the field of Biotechnology and Life Sciences. She holds a PhD in Molecular Biology from the University of NiceSophia- Antipolis (France). She also holds the International Industrial Studies Diploma in Patents from the CEIPI, Strasbourg (France).

Dr. Brice Sagot

Dr. Brice Sagot is COO and cofounder of Knowmade. He is leading the Biotechnology and Life Sciences department. He holds a PhD in molecular biology from theUniversity of Nice Sophia-Antipolis, France.

http://www.yole.fr/http://www.yole.fr/mailto:[email protected]:[email protected]:[email protected]:[email protected]

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OBJECTIVES OF THIS REPORT

• Explain the challenges linked to neurotechnologies, and their current/ future applications

• Offer a technical and economic segmentation of the neurotechnologies field: neurosensing, neurostimulation, andbrain computer interface (BCI)

• Deliver an overview of neurotechnologies’ main players and their respective technologies

• Furnish market data and forecasts for the period 2017 - 2035, and market dynamics for each segment

• Provide neurotechnology roadmaps and an overview of the latest innovations in each segment

• Understand the most active companies through a comprehensive patents list for neurostimulation andneurosensing


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WHO SHOULD BE INTERESTED BY THIS REPORT?

o Pharmaceutical and medical device companies:

• To understand what is state of the art inneurotechnology

• To identify the different players across the supplychain

• To get a list of selected players in the field ofneurotechnology both in the market and indevelopment

• To understand behavior evolution and identifynew business models

• To identify competitors and targets forcollaborations or M&A

o Equipment & Material suppliers:

• To understand the technical evolution ofneurotechnology devices.

• To identify business opportunities and prospects

o R&D players:

• To understand new challenges inneurotechnology

o Medical devices outsourcing companies:

• To have a broad overview of all neurotechnologyapplications & markets

• To identify new markets

• To monitor and benchmark potentialcompetitors

• To understand behavior evolution

• To identify the key challenges linked to hardwarein the field of neurotechnology

o Financial & Strategic investors:

• To understand the potential for neurotechnologydevices in the consumer and healthcareindustries

• To know the latest trends within the industry

• To get a list of players in the field ofneurotechnology and their activities


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TABLE OF CONTENTS

• Executive Summary 10

• Introduction 55

• How does the brain work?

• Neurological disorders

• Brain Initiative

• Scope of the report

• Segmentation of the Neurotechnology Market 67

• Technological and behavioral/economical criteria

• Segmentation

• Market Analysis 71

• Mergers and acquisitions

• Fundraising analysis

• Market data and forecasts 2017-2023

• Neurotechnology ecosystems

• IOMT in the neurotechnology business

• Roadmaps

• Forecasts 2017-2035 using the model of the DNA sequencing history

• Neurosensing 90

• Main players and market share

• Market data and forecasts 2017 – 2023: system level and electrodes level, bytechnology and by application

• EEG value chain

• Main technologies and roadmaps

• Patent landscape by KnowMade

• Company profiles

• Neurostimulation 153

• Main players and market share

• Market data and forecasts 2017 – 2023 by technology (DBS, SCS, VNS, TMS,TDCS, etc.) and by application (clinical, research, consumer)


• Patent landscape by KnowMade


• Brain Computer Interface 204

• Main players

• Market data and forecasts 2017 – 2023 by applications



• Supply Chain Analysis 227

• General Conclusions 233

• Annex - Patent Landscape Methodology 238


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INTRODUCTION TO NEUROTECHNOLOGY

How does the brain work? (1/2)

Most of the technologies

aiming at interacting with the brain target the electrical

signaling pathway of the

neurons

• The brain is made of a lot of different types of cells:

• Neurons : electrically excitable cells that receive, process, and transmit informationthrough electrical and chemical signals

• Microglia : immune system

• Oligodendrocytes : provide support and insulation to axons

• Astrocytes : variety of tasks, from axon guidance and synaptic support, to thecontrol of the blood brain barrier and blood flow

• The axon of the neuron is responsible for conveying an action potential fromthe cell body to the axon terminus. An action potential is an electrical signalresulting from a sudden, transient change in membrane potential.


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How does the brain work? (2/2)

Electrical events propagate the signal within a neuron and

chemical processes

transmit the signal from one

neuron to another

• When an action potential reaches an axon terminal it triggers the release of neurotransmitters into the synaptic cleftwhich diffuses and binds receptors on the postsynaptic neuron.

• Sufficient binding will cause the postsynaptic neuron to “fire”.

• There are two kinds of neurotransmitters :

• Excitatory neurotransmitters stimulate the brain.

• Inhibitory neurotransmitters calm the brain and help create balance.


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Neurological disorders

Up to 1 billionpeople, nearlyone in six ofthe world'spopulation,suffer fromneurologicaldisorders

- 10 20 30 40 50 60 70 80 90

100

Mill

ions

people

affect

ed

Worldwide prevalence of most neurological disorders

(in millions people affected)

Trauma Infections DegenerationPsychiatric disorders

Tumors VascularNon-

psychiatric disorders

350M 1,140M

Source: WHO


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Scope of the report

Scope:

Neurotechnologies directly interacting

with patients

Not included in the scope of this report are neurotechnologies based on medical imaging

systems not directly interacting with the patient (MRI, MEG, PET, etc.), cochlear implants and

retinal prosthesis.

Included in this report are neurotechnologies which directly interact with/touch the patient,

such as neurosensing technologies (EEG, ECoG, NIRS, etc.), neurostimulation (DBS, VNS, TDCS,

etc.) and brain computer interfaces.


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SEGMENTATION OF THE NEUROTECHNOLOGY MARKET

Invasive Non invasive Invasive Non invasive

Electrical Light Magnetic Ultrasound

Sensing

Clinical

Electro-corticography,

Neural probes

Electro-

encephalography

Near infrared

spectroscopy

Stimulation

Neurostimulation Optogenetics

Transcranial

magnetic

stimulation

Focused

ultrasounds

Transcranial direct

current stimulations

Near Infrared stimulation

ConsumerVagus nerve

stimulation

ActuationClinical

Brain computer interface

Consumer

Invasiveness

Technology

Technological

criteria Behavioral

criteria

: Technologies not available in clinics yet

Segment 2 : Neurostimulation

Segment 1 : Neurosensing

Segment 3 : Brain Computer Interface

Aim

of th

e

syst

em

Use

rs


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NEUROTECHNOLOGY ECOSYSTEM

Medical device

outsourcing

manufacturers

Brain computer

interfaceNeurostimulation

Neurosensing

Electrode

manufacturers


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CONTENT OF THE REPORT

Introduction


14


Market analysis and segmentation


15


Neurosensing


16


Neurostimulation


17


Brain Computer Interface


Documents

Neurotechnologies and Brain Computer Interface · 2018. 7. 2. · 3 Biographies & contacts ABOUT THE AUTHORS Jérôme Mouly Dr. Marjorie Villien As a Technology & Market Analyst,