ADIPOFILL’IN™

BIO-CONTROLLED LIPOFILLING

NEW DATA AS A BREAST VOLUME ENHANCER

ANTI-AGING / ANTI-WRINKLE

• L-ornithine, an amino acid obtained by biotechnology from vegetable starch, encapsulated in a Ionosome™

• Ionosome benefits:

- Resistent delivery system

- Penetration to target adipocytes

- Higher efficacy

• Lipofilling action :

‐ Reverses age-related lipoatrophy to reduce the appearance of structural aging (face, hand)

‐ Plumps up body (breast, buttock)

Adipofill’in™ - A lipofilling-like alternative

INCI name

Water (and) Propanediol (and) Ornithine (and) Phospholipids (and) Glycolipids

L-ornithine

• Ionosome™: new generation of delivery system

Polysaccharide-coated encapsulation: hydrophobized polysaccharides (stearoyl inulin) inserted in the phospholipid membrane = protective coating

Adipofill’in™ - Ionosome™ delivery system

Lipophilic side

Hydrophilic

side

C18

IONOSOME™

C18

C1

8C18

Hormesis concept - Hot trend

• Hormesis = vaccin-like activity : homeostatic and adaptative beneficial response of cells to microstress exposure in order to correct a physiological imbalance.

The word “hormesis” comes from the greek root “hormeticos”, which means ”stimulation”

• Concept launched by Givenchy with Vax’in (2010)This vaccine-like serum is formulated with a unique complex

capable of generating micro-stimuli, which encourage the skin'scells to produce their own age-defying protein HSP70

Lipohormesis™ - New proprietary concept

• Lipohormesis™ = hormesis applied to adipose tissue → growth stimulation

• Various stresses in the adipose tissue are able to stimulate its expansion through the activation of Hypoxia Inducible Factor (HIF-1α ), a transcription factor.

• This explains the obesity vicious circle. As the fat tissue increases, some areas are in hypoxic conditions (lack of oxygen). To correct the situation, cells activate the HIF-1α that induces fat tissue expansion to compensate lack of space and oxygen.

Activation of adipocyte anabolism

Adipofill’in™: lipohormesis inducer

Reduction of the appearance of structural aging

Breast volume enhancement

New results

NEW

Clinical study

on breast volume

Why and how to enlarge breast?

Why?

Breast = seduction asset

→ Source of complex for many women with small size cup

How?

• Push up bra ≠ Non permanent

• Surgery procedures:

Lipofilling (fat injection) and silicone implant

≠ Invasive and painful

Silicone implant

Fat injectionFat injection

Push up bra effect of Adipofill’in™

• Breast consists of 80% adipose tissue whichconfers its shape and volume.

• Adipose tissue growth = ↗ breast volume

• Lipofilling or lipomodelage effect

By stimulating adipose tissue growth, Adipofill’in™ mimics a breast lipomodelage .

Breast volumizer clinical study

Protocol

• 20 women (18- 36 years old) having a bra cup size A (preferably) or B (maximum), stable weight for at least 3 months and regular menstrual cycles.

• Twice daily application of a cream with 2% Adipofill’in™ on a split breast vs. a placebo, by massage until complete penetration.

• 2 months application

• Measurement of the breast volume using the in vivo Fringe Projection method before and after the treatment

• Self-assessment during the study

Tested formula:

Water; Dicaprylyl Carbonate ; Glyceryl Stearate Citrate (and) Polyglyceryl-3 Stearate (and) Hydrogenated Lecithin; Glycerin, Water (and) Propanediol (and) Ornithine (and) Phospholipids (and) Glycolipids; Lysolecithin (and) Sclerotium Gum (and) Xanthan Gum (and) Pullulan; Sodium Phytate; Tocopherol (and) Helianthus Annuus (Sunflower) Seed Oil; Fragrance.

After 56 days application

of Adipofill’in™

Before treatment (D0)

A D27, 75% volunteers had a significant positive effectA D56, 100% volunteers had a significant positive effect

+3%*

Up to 7%

Adipofillin’in™ enlarges breast volume with high efficacy.

Breast volumizer clinical study

*p<0.05

Lipofilling

effect of

Adipofill’in™

Breast volumizer clinical study

The breast volumizer action of Adipofillin’in™ is perceptible from14 days and is even more after 27 days.

Summary

↑ Breast volume

↑HIF-1α

↑Adipogenesis

↑Lipogenesis

↓Lipolysis

↑Adipose tissue

Lipomodelage of Adipofill’in™

Cosmetic permanent push up bra effect

In vivo study

In vitro studies

Tolerance studies

• Skin Irritation (single patch test) (concentration tested: 4%)

• Eye Irritation (HET CAM) (concentration tested: 4%)

• Sensitization (HRIPT) (concentration tested: 4%)

• AMES test in progress (pure product)

• Phototoxicity in progress (concentration tested: 4%)

Excellent Safety Profile.

Product information

INCI name

Water (and) Propanediol (and) Ornithine (and) Phospholipids (and) Glycolipids

Appearance

Off-white to light yellow aqueous suspension

Recommended dosage

0.5 - 2%

Product information

Formulation

Add below 40⁰C

Optimum pH

4.5 - 6.0

Applications

• Anti-aging skin care

• Anti-wrinkle skin care

• Eye contour care

• Correcting care

• Lip care

• Breast volume enhancer

• Buttock volume enhancer

• Anti-aging treatment for hands

• Men’s care

THANK YOU!

2017-08-29