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New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
ORGANIZED BY
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard
in collaboration with
Indian Pharmaceutical Association (Delhi Branch)
Monday, 16th November 2015
Venue:
Auditorium, Faculty of Pharmacy, Jamia Hamdard, New Delhi-62
2
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
ORGANIZING COMMITTEE
3
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
The history of Jamia Hamdard began with the establishment of a small unani clinic in the year 1906 by
Hakeem Hafiz Abdul Majeed, a practitioner with the vision of making the practice of Unani medicine a
scientific discipline. In 1972, Hamdard College of Pharmacy was setup with the objective of providing
and training in all branches of Pharmacy, which was given the Deemed University status in the year 1989.
Currently, Jamia Hamdard is engaged in imparting high quality teaching and research in the disciplines of
Pharmacy, Science, Medicine, nursing, management, Information technology, Allied Health Sciences,
Islamic studies etc. In recognition of its excellent and academic achievements, Jamia Hamdard has been
accredited with 'A' Grade by National Accreditation and Assessment Council (NAAC).
The Department of Pharmaceutical Chemistry is one of the core Department, engaged in research related
to drug development and discovery. The Department was formally established in 1986 with the M.
Pharm. (Pharmaceutical Chemistry) and Ph.D. programme. The University started two year M Pharm
(Pharm Analysis) course in the academic year 2006. The courses are approved by the All India Council
for Technical Education (AICTE) and Pharmacy Council of India (PCI). Current areas of research can be
broadly classified into following categories: Anticancer, Drug Designing, Antimalarial, Anticonvulsant,
Anti-inflammatory, Natural Chemistry, Hepatoprotective drugs, etc. The Department is well equipped
with modern wet laboratories along with analytical instruments like NMR (Bruker Avance-400MHz), IR
(Bruker alpha-T spectrophotometer), Mass (Waters SYNAPT UPLC-MS/MS) etc. The Department has
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New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
about 58 national and 202 international publications in various reputed journals with an average impact
factor of 2.0 during last five years. The Department has also received research grants to the tune of more
than Rs. 2.5 crores from various funding agencies like UGC/ ICMR/ AYUSH/ AICTE/ DST/ DBT. The
students are well placed in various industries (Ranbaxy Research Laboratories-Diachi, Sun-Pharma,
Nicolas Piramal, Jubiliant Organosys, Dabur etc) and Academic and Research Institutions through
Placement cell.
Owing to the advent of computer aided drug design and discovery, nanotechnology, stem cell research,
molecular diagnostics, translational medicine, reverse pharmacology etc., pharmaceutical research has
attained new heights. Advances in assay and instrument technology have provided the means necessary to
address the evolving needs of drug discovery. In order to provide proper direction and to channelize
future pharma research and keeping the recent developments in mind, the seminar provides the right
platform. The seminar will serve as a platform for interaction between young scholars and scientists from
academia and industry with experienced scientists from various institutions. Eminent research
personalities have been enlisted as resource persons. The outcomes of the seminar will direct the future
foci to move ahead in diverse research areas for the benefit of mankind.
The recent trends highlighting innovative and interesting topics will be discussed under the main theme of
conference.
1. Antibiotics Resistance
2. Traditional therapies and natural products
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New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
3. Innovations in Drug formulations
4. Drug discovery, pharmacology and toxicology
5. Frontiers technology of drug discovery
6. Instrumentation in Drug discovery
7. Current trends in Medicinal Chemistry
Program-Schedule
09:00–
10:00am
Registration
10:00-
10:05am
Quran recitation
10:05-
10:10am
Bouquet presentation
10:10-
10:20am
Welcome Address by the Dr. M. Mumtaz Alam, Convener
10:20-
10:30am
Pharmacy week introduction by Prof Farhan J Ahmad, IPA
10:30-10:35am Address by the Prof Asghar Ali, Dean, Faculty of Pharmacy
2nd One Day National symposium on
New Horizons in Drug Discovery and Development
16 November 2015
6
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
10:35-
11:00am
Keynote address by Dr. Syed Tanvir Ali, Plant Head, Quantum Natural
11:00-
11:05am
Vote of thanks by Prof. Anees A Siddiqui, Head, Department of Pharmaceutical
Chemistry
11:05-
11:10am
National Anthem
11:10-
11:30am
High Tea
Auditorium : Scientific Session-I
Chairman – Prof Anees A Siddiqui
Co-chairman –Dr Javed Ali; Dr. S. E. Haque
11:30 –
12:15pm
Invited Lecture by Dr. Asif: Scientist, ICGEB, New Delhi
Title: “Understanding biology of cell organelles in malaria parasite and development
of new anti-malarials”
12:15 –
01:00pm
Invited Lecture by Dr. Rahul Jain: GM, Kusum Healthcare
Title: “Smart drug delivery system”
01:00 –
02:00pm
Lunch with Poster Presentation
Auditorium: Scientific Session-II
7
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Chairman -Prof Divya Vohora
Co-chairman –Dr. Sayeed Ahmad
02:00 –
02:30pm
Invited Lecture by Dr. Suhail Parvez: Associate Professor, Jamia Hamdard
Title: “Ion channel electrophysiology: An emerging technique in drug discovery”
02:30 –
03:00pm
Invited Lecture by Dr. Ziaur Rahman: Associate Professor, Mangalayatan University,
Aligarh
Title: “Polymorphism: Current trends in Medicinal Chemistry”
03:00 –
03:30pm
Invited Lecture by Ms. Priyamvada Jain: Pharmaceutical Quality Advisor, YES
Pharma Services
Title: “An introduction to regulatory affairs and current trends in formulation
development”
03:30 –
04:00pm
Oral Presentations
04:00 –
04:15pm
Tea
Scientific Session-III: Training Session
04:15 –
05:00pm
Pharmacological Screening: by Dr. Abul K Najmi, Assistant Professor, Pharmacology,
Jamia Hamdard
Chromatographic separation of Natural Products: by Dr. Showkat R Mir, Assistant
8
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Professor, Pharmacognosy, Jamia Hamdard
NMR Technique: by Dr. M. Shaquiquzzaman, Assistant Professor, Pharm Chemistry,
Jamia Hamdard
Nanoformulations: by Dr. Gaurav Jain, Assistant Professor, Pharmaceutics, Jamia
Hamdard
05:00–
05:15pm
Invited Lecture by Tijjani Salihu, Jamia Hamdard
Title: “Protein Chemistry”
05:15–
05:20pm
Address by Prof. C. L. Kaul
05:20–
05:35pm
Awards distribution for Best Poster (04; one in each category) and Best Oral
Presentations (01) by Prof. R. K. Khar, President IPA
05:35–
05:40pm
e-Poster Award distribution by by Prof. R. K. Khar, President IPA
05:40–
05:50pm
Closing remarks by Prof. R. K. Khar, President IPA
05:50–
06:00pm
Certificate distribution
9
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Poster Presentation: List of Presenting Author along with title and Abstract number
Presenting Author Title of the Abstract Abstract No AasiyUlErum Integration of Novel drug delivery system in traditional Unani therapies D-16 A.K. Najmi
Alleviation of DOX induced nephrotoxicity by benazepril, quercetin and Bombyxmori B-1
Abdullah Adverse Effects of NewerAnti-Diabetic Drugs in Treatment of Type II Diabetes Mellitus
B-2
Abidin L Natural boons for arthritis and their molecular targets D-11 Ahsan Ahmed Khan Synthesis and Anticonvulsant activity of Semicarbazone derivatives of
some naturally occurring compounds C-15
Afrin Salma The role of DprE1 inhibitors for the management of anti-tubercular activity
B-3
Akhtar Wasim Molecular docking in Medicinal Chemistry C-20 Aqil M. Utility of Terpenes in Transdermal delivery of an Anti-hypertensive agent A-6
Arya Ashwani Recent Advances in understanding of the Schizophrenia B-4 Asif Husain New Benzimidazole derivatives: Synthesis and in-vitro anticancer activity C-23 Chanda Ranjan Syntheses, characterization and neuropharmacological evaluation of some
novel 3-(2-furanyl)-4,5-dihydro-5-substituted phenyl isoxazoles C-2
Choudhary Deepika Structure based designing and ADME-T studies of butenolide derivatives as potential agents against Receptor ICAM-1: A drug target for cerebral malaria
C-3
Deepanshu Sharma Role of Cyclin dependent kinase (CDK) Inhibitor in Cancer: An overview B-6 Dinesh K. Mehta Antifungal evaluation of 2-amino-5-(2-nitrophenyl)-1, 3, 4-thiadiazole C-4 Divya Vohora Effect of Phosphoinositide-3 Kinase inhibitors in inflammatory diseases:
The light at the end of the tunnel B-12
Farah Khan Natural mineral compound Jade in ash form [JAF] modulates the humoral innate immune response.
B-16
Farah Iram Anticancer activity of New 1-(1H-Benzo[d]imidazol-2-yl)ethanone derivatives C-6
Geetika Ganjoo Role of Carvedilol compared to other β-Blockers in acute Myocardial infarction B-7
Gita Chawla Ketoprofen: An update ofchemistry and chemical modifications to reduce the gastrointestinal side effects. C-24
Hinna Hamid Development of Novel benzimidazole based GSK-3β inhibitors C-12 Presenting Author Title of the Abstract Abstract No
10
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Hooda Anil Recent advances of Nano-carrier on Herbal Drugs D-1 Iqbal Zeenat Development and validation of a RP-HPLC method to simultaneously
detect lactone and carboxylate form of Topotecan along with Thymoquinone: Application to nanoparticulate system
A-7
Jaspreet Kaur Anxiolytic activity of polyphenol fraction of peel extract of Punica granatum Linn in Mice D-2
Joon Nisha Herbal Emulgens D-3 Joon Ritu Phytosomes: A step ahead in the field of Phytomedicine D-8 Juveria Usmani Pathophysiology of Peptic ulcer and treatment with current therapy B-8 Kamran J Naquvi HPTLC Quantification of thymol in different extracts and volatile oil of
Safoof-e-Muhazzil D-4
Khan Mohemmed Faraz
Pyrazole derivatives in the treatment of cancer C-27
Mahfuz Alam Synthesis and antimicrobial activity of 3,5-substituted phenyl-3,3a,4,7-tetrahydro-2H-pyrazolo[3,4-c]pyridazines
C-25
Mandeep Kaur
Drug Discovery: Novel Technologies C-8
Manisha Pahal
Stroke: A sudden loss of brain function B-9
Md Arman Arif Long term antihypertensive efficacy and safety of the oral Direct Renin Inhibitor (DRI) ALISKIREN
B-10
Md Azhar Iqbal Design and synthesis of Novel Benzimidazole based fused heterocyclic derivatives as potential anticancer agents C-1
Md Jahangir Alam Synthesis, in vitro studies and molecular docking of novel Pyrazole derivatives as potential TNF-α inhibitor and anti-inflammatory activity
C-7
Mohammad Ashif Khan
Novel development and conventional technique for solubility enhancement: Melt-Sonocrystallization A-1
Mohd Javed Naim Synthesis of some New Thiazolo [2, 3-a] Pyrimidine derivatives as Anti-inflammatory and anti-microbial agents C-9
Mohd. Vaseem Ismail
Impact analysis of Merger and acquisition in Pharmaceutical industry B-18
Mujeeb M Supercritical carbon dioxide assisted extraction of solasodine from Solanum nigrum Linn D-6
Presenting Author Title of the Abstract Abstract No Nasa Praveen Liquisolid: A novel technique of enhancing drug solubility of poorly A-2
11
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
aqueous soluble drugs Nazim Hussain Anticancer activity of Methanolic extract of Cordia dichotoma bark D-15 Neha Mallick Stabilization of superparamagnetic iron oxide nanoparticles- Development
and in vitro localization study for magnetic drug targeting applications A-10
Parminder Nain Anti-atherogenesis and anti-hyperlipidemic activity of Emblica officinalis leaves extract in albino rats fed with high fat diet
B-11
Pooja Verma Hypertension & its treatment including Herbal drugs D-7 Rahmat Ali Development of non-purine Xanthine oxidase inhibitors as structural
analogues of Febuxostat for management of Gout and Hyperuricemia C-10
Reena Sheoran Nanotechnology in Cancer diagnostics and therapeutics A-3
Rina Das Synthesis of 2-amino-5-(2-nitrophenyl)-1, 3, 4-Thiadiazole using Ultrasound Irridation Technique. C-11
Sadaf Ali Suvorexant: An overview C-13 Sajal Chhabra In-Silico studies of Pyridazine derivatives as COX-2 Inhibitors C-16 Sandeep Kumar Benzimidazole as anticancer agent C-22 Sandhya Bawa Hitches of Gout: As Xanthine Oxidase Inhibitors C-21 Seemi Siddiqui RP-HPLC Method for Estimation and Stress Degradation Study of
Paclitaxel C-28
Sharma R. K. Densitometric validation and optimization of Polyphenols in Phyllanthus maderaspatensis Linn by High-Performance Thin-layer Chromatography D-13
Sharma Anjali Floating drug delivery system A-4
Shilpa Parmar Gliptins- a new class of oral anti-diabetic agents C-17 Siddiqui N Druggability issues with bioactive leads from herbal medicines D-12 Sindhwani G. Plant tissue culture: A revolutionary technique in advancement of Herbal
Drug D-9
Soni Singh Production and Optimization of Astaxanthin by Phaffia rhodozyma under Submerged Fermentation D-14
Soodan S Nutraceuticals as alternative medicines D-10 Sushama Talegaonkar
Functionalized bioceramic nanoparticles of Risedronate for synergistic targeting to bone A-8
Swarna Dabral
Monitoring and Reporting of adverse drug reactions in In Patient Department (IPD) in Mahant Indresh Hospital, Dehradun, Uttarakhand.
B-13
Presenting Author Title of the Abstract Abstract No Syed Ehtaishamul Haque
Effect of Resveratrol and Black tea extract on Cellular architecture of Rats myocardium B-19
12
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Talha Jamal Efficacy and Tolerability of Meloxicam, a COX-2 preferential Nonsteroidal anti-Inflammatory Drug
C-18
Teena Sharma Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Poorly water Soluble Drugs A-5
Waseem A. Siddiqui Amelioration of hyperglycemia, hyperlipidemia and oxidative damage in streptozotocin-induced type 1 diabetic rat model B-17
Yadav Mamta Influence of nano-technology on Herbal Drugs D-5 Zameer S.
Letrozole and Anastrazole (But not Exemestane) impairs spatial learning and memory by modulating Hippocampal DICKKOPF-1 and sclerostin in female mice
B-14
Zulphikar Ali Synthesis & docking studies of quinoxaline clubbed 1,3,4-oxadiazole derivatives as non-ulcerogenic anti-inflammatory agents
C-19
Oral Presentation: List of Presenting Author along with title and Abstract number
Presenting Author Title of the Abstract Abstract No Ashwini Dinodia Angina pectoris: An overview OB-5 Mohd Akhtar Antidepressant like effect of Irbesartan in unpredictable chronic mild
stress induced depression in mice OB-15
Neelima Shrivastava Recent development in the discovery of benzimidazole as anti-cancer agent and their synthetic approaches OC-26
Ozair Alam
Design, synthesis, molecular docking and molecular dynamics of pyrazoline derivatives as potential anti-inflammatory agents
OC-5
Saima Amin Polymeric nanoparticles for oral delivery of Cilnidipine. OA-9
Syed Shafi Anti-malarial and anticancer activities of spiroisoxazoline analogues of artemisinin OC-14
13
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
Best Oral and Poster Presentation:
Best Oral Presenter: Dr. Ozair Alam, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
Jamia Hamdard, New Delhi-110062 (OC-5)
Best Poster Presenter in Category-A: Mr. Praveen Nasa, Department of Pharmaceutical Education &
Research, B.P.S. Mahila Vishwavidyalaya, Khanpur Kalan, Sonipat, (Haryana), India (Poster no: A-2)
Best Poster Presenter in Category-B: Zameer S, Department of Pharmacology, Faculty of Pharmacy,
Jamia Hamdard, New Delhi-110062 (Poster no: B-14)
Best Poster Presenter in Category-C: Sandeep Kumar, Department of Pharmaceutical Chemistry,
Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062 (Poster no: C-22)
Best Poster Presenter in Category-D: Nahida, Department of Pharmacognosy, Faculty of Pharmacy,
Jamia Hamdard, New Delhi-110062 (Poster no: D-12)
Dr. Ozair Alam & Mr. Praveen nasa receiving awards for Best Oral Presentation and Best Poster
Presentation
14
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
CONFERENCE AT A GLANCE:
INAUGURATION
VALEDICTORY
SCIENTIFIC SESSION:
15
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
AWARDS DISTRIBUTION:
16
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch
17
New Horizons in Drug Discovery & Development-2 16TH November, 2015
Organized by: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard. In collaboration with: IPA, Delhi Branch