New Products Fall 2017 - Peptides International · by two species of mosquito of the genus Aedes: ... Dengue virus is caused by one of four closely related virus serotypes of the

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Peptides International, Inc.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USD

New Products 2017

RECOMBINANT PROTEIN PRODUCTSPlease Note: Peptides International is offering dozens of new recombinant proteins this year! Due to space constraints, the following is only a representative sampling. For a complete list of the thousands of available products, please visit our website or utilize the contact information below.

ENZ-1017 Cathepsin-D Mouse Recombinant Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extra-

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cellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.

CHI-003 Chikungunya E2 RecombinantChikungunya is an infection caused by the chikungunya virus which is passed to humans by two species of mosquito of the genus Aedes: A. albopictus and A. aegypti. Animal res-ervoirs of the virus include monkeys, birds, cattle, and rodents. The features of the disease are a sudden onset of fever 2-4 days after exposure. The fever typically lasts 2-7 days,

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while the associated joint pains usually last weeks or months but sometimes years. The mortality rate is a little less than 1 in 1,000. The disease has occurred in outbreaks in Asia, Europe and the Americas since 2004. CHIKV is a single-stranded positive-sense RNA genome, 11,800 nts long which encodes 2 open reading frames. The nucleocapsid is tightly enveloped by a host-derived lipid bilayer (envelope) supporting the virus-encoded envelope proteins. 80 glycoprotein spikes are C- terminally anchored within the viral envelope. The structural polyprotein is translated from a viral sub genomic mRNA, while as the 5 structural proteins (capsid, E3, E2, 6K, E1) are translated as a single polyprotein, from which capsid (C) is cleaved off to encapsidate. The envelope polyprotein precursor E3-E2-6K-E1 is translocated to the endoplasmatic reticulum. Polyprotein is processed by host signalases, result-ing in E3, E2 & E1 forming viral hetero-trimeric spikes. The viral spikes majorly contains E2 and E1 facilitate cell receptor recognition, cell entry thru pH-dependent endocytosis and support viral budding.

CHM-029 Chemokine (C-X-C Motif) Ligand 16CXCL16 is a type I membrane protein, which contains a non-ELR motif-containing CXC chemokine domain in its extracellular region. Human and Mouse CXCL16 share a 70% a.a. sequence similarity within their chemokine domains and 49% overall a.a. sequence identity. Functional CXCL16 can be dropped from the cell surface as an approximately

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35kDa soluble protein. CXCR6 is the functional receptor for CXCL16. CXCL16 functions as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), proposing that CXCL16 may be involved in pathophysiology such as atherogenesis. In addition, CXCL16 induces a strong chemotactic response and calcium mobilization. CXCL16 binds to CXCR6/Bonzo.

CHM-024 VEGF Co-regulated Chemokine 1, His Tag Human RecombinantCXCL17 Human, His is a secreted molecule with a size and predicted 3-dimensional fold-ing pattern similar to that of chemokines CXCL8/IL8 and CXCL14/BRAK. CXCL17 is con-stitutively generated by airway and intestinal epithelium. CXCL17 induces the chemotaxis of quiescent, but not LPS-activated peripheral blood monocytes and dendritic cells, and it

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also binds these cells specifically. The expression of CXCL17 is increased in endothelial cells when they are induced to form tubes in vitro. CXCL17, CXCL1/GRO and CXCL8/IL8 which have roles in angiogenesis, show signifi-cantly correlated expression with that of VEGF in primary lung, breast and esophageal tumors. Therefore, CXCL17 is suggested to have a role in tumor angiogenesis. The mature Rat CXCL17 shares 82%, 71% amino acid sequence identity with mouse, human CXCL17, respectively.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDDengue virus is caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, and each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hy-perendemicity) can occur. In cell culture experiments and mice Morpholino antisense oligos have shown specific activity against Dengue virus.

DEN-041 Dengue Antigen for Rapid Test RecombinantDengue Antigen for Rapid Test has over 90% sensitivity and specificity over 90% to detect both dengue IgM and IgG.

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1200DEN-039 Dengue-2 Envelope Hydrophobic Domain Recombinant

Recombinant Dengue 2 Envelope Hydrophobic Domain, e.coli derived, contains 225 amino acids (228-485) from dengue 2 envelope. The protein is fused to a His tag at C-terminal and purified by standard chromatography techniques.

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1200DEN-042 Dengue Multiple Epitopes 10 Recombinant

The rapid test prepared by this antigen has over 90% sensitivity and specificity of over 90% to show quick and strong signal for both dengue IgM and IgG. Conjugate gold sus-pension buffer, blocking reagent and running buffer den- epi-10 comes with the order.

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DEN-043 Dengue Multiple Epitopes 13 RecombinantRecombinant Dengue Multiple Epitopes 13 is genetically designed dengue multiple epi-topes epi-13 designed especially for lateral flow product, they are selected from dengue genome. The rapid test prepared by this antigen has over 90% sensitivity and specificity over 90% to show quick and strong signal for both dengue IgM and IgG. Conjugate gold suspension buffer, blocking reagent and running buffer den- epi-13 comes with the order.

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HOR-017 Endothelin-3 Human RecombinantEDN3 interacts with endothelin receptor B, on the surface of cells. Throughout embryonic development, EDN3 takes part in neural crest cells that migrate from the developing spinal cord to specific regions in the embryo, where they give rise to many different types of cells. EDN3 and EDN3R are necessary for the forma-

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tion of nerves in the large intestine (enteric nerves) and melanocytes (produce melanin). Mutations in the EDN3 gene is linked with Waardenburg syndrome, type IV that is characterized by changes in skin, hair, and eye coloring. Mutations in the EDN3 gene is linked with Hirschsprung disease that causes se-vere constipation or intestinal blockage

ENZ-997 Glutathione S-Transferase MU 5 Human Recombinant, ActiveGlutathione S-transferase mu 5 (GSTM5) belongs to the glutathione s-transfer-ase (GST) family of proteins. There are 8 families of GST proteins, specifically α, κ, mu, ω, π, σ, θ and ζ, each of which is comprised of proteins which have various

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5200functions throughout the cell. GSTM5 belongs to the mu class of enzymes which function in the de-toxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. GSTM5 has an imperative role in de-toxification. GSTM5 conjugates reduced glutathione to a large number of exogenous and endogenous hydrophobic electrophiles.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDENZ-996 Glutathione S-Transferase α 4 Human Recombinant, Active

Glutathione S-transferase A4 (GSTA4) is a member of the GST superfamily. The GSTA4 enzyme is involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. GSTA4 shows an especially high activity with reactive carbonyl compounds such as alk-2-enals. GSTA4 is

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extremely effective in catalyzing the conjugate addition of reduced glutathione to 4-hydroxynonenal, which is an important product of peroxidative degradation of arachidonic acid and a frequently used biomarker for oxidative damage in tissue. The GSTA4 enzyme is expressed at a high level in the brain, placenta, and skeletal muscle and much lower in the lung and liver.

ENZ-873 Glutathione S-Transferase α 1 Mouse RecombinantMembrane-bound and cytosolic forms of GST are encoded by 2 separate su-pergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione.

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ENZ-881 Hexosaminidase A Human Recombinant, SF9HEXA is the α subunit of the lysosomal enzyme beta-hexosaminidase which, combined with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules having N-acetyl hexosamines term-inus. The two subunits composing Beta-hexosaminidase, α and β, belong to the

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glycosyl hydrolases family and are encoded by distinct genes. α subunit gene mutations can cause Tay-Sachs disease (GM2-gangliosidosis type I).

CHM-330 IP-10 Human Recombinant (CXCL10)CXCL10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-γ-induced protein (?-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-?. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for

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monocytes and T cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of this chemokine has been determined under 3 different conditions to a resolution of up to 1.92A.

CYT-144 Interleukin-12 Mouse RecombinantIL-12 is a heterodimeric cytokine that stimulates the production of IFNγ from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells. It is an initiator of cell-mediated immunity.

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CHM-026 I-TAC (CXCL11) Mouse RecombinantCXCL11 is a small cytokine belonging to the CXC chemokinen family that is also called Interferon-inducible T-cell α chemoattractant (I-TAC) and Interferon-γ-inducible protein 9 (IP-9). I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small

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intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TACchemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells.The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDENZ-491 Lactate Dehydrogenase A Human Recombinant

LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglo-binuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-

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genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential.

ENZ-825 Lipocalin-1 Human RecombinantLipocalin-1 (LCN1) belongs to the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins, which bind to various hydrophobic ligands. LCN1 pro-tein is the principal lipid binding protein in tears and is overproduced in response to numer-ous stimuli including infection and stress. LCN1 is a marker for chromosome aneuploidy as well as an autoantigen in Sjogren’s syndrome.

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CHM-031 LIX Mouse Recombinant (CXCL5)CXCL5 is a small cytokine belonging to the CXC chemokine family that is also known as epithelial-derived neutrophil-activating peptide 78 (ENA-78). It is produced following stimu-lation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-α.

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2700Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II IFN. This chemo-kine stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. The gene for CXCL5 is encoded on four exons and is located on human chromosome 4 amongst several other CXC chemokine genes. CXCL5 has been implicated in connective tissue remodelling.

MAL-004 Malaria Falciparum MSP1 RecombinantPlasmodium falciparum is a protozoan parasite, one of the species of Plasmodium that cause malaria. Malaria parasites are members of the Apicomplexa. Apicomplexa are char-acterized by a set of organelles found in some stages of the parasite’s life cycle. These organelles, collectively known as apical organelles because of their localization at one end

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of the parasite, are involved in interactions between the parasite and host. In particular, the apical organelles have been implicated in the process of host cell invasion. In the case of Plasmodium, three distinct invasive forms have been identified: sporozoite, merozoite, and ookinete.

MAL-003 Malaria Vivax MSP1 RecombinantMerozoite surface antigen is a protein located on the outside of the merozoite, playing an imperative role in immune reaction. About 45% cases of malaria are infected by Plasmo-dium vivax (Pv). Pv. MSP1 has to be used with Plasmodium falciparum (Pf) together for ELISA and rapid diagnostic test, Pf and vivax infection takes about 95% of Plasmodium caused infection.

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CHM-285 Monocyte Chemotactic Protein-2 Canine Recombinant (CCL8)CCL8 is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precur-sor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large clus-

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ter of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many differ-ent immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDENZ-764 Matrix Metallopeptidase 10 Human Recombinant

MMP10 which is a part of the matrix metalloproteinase (MMP) is activating procollage-nase. MMP10 is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP10 takes part in the breakdown of extracellular matrix in normal physiological pro-cesses, like embryonic development, reproduction, and tissue remodeling, as also in

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disease processes, such as arthritis and metastasis. The majority MMP’s are secreted as inactive proproteins that are activated when cleaved by extracellular proteinases. MMP10 encodes an enzyme which degrades proteogly-cans and fibronectin.

ENZ-720 NAA30 HumanN-α-acetyltransferase 30 (NAA30) is catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. NAA30 catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. In addition, NAA30 is essential for the lysosomal localization and function of ARL8B. The disease Eastern equine encephali-tis has been associated with NAA30.

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HOR-015HOR-014HOR-018

Procalcitonin Canine RecombinantProcalcitonin MouseProcalcitonin Porcine

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5200Procalcitonin is a peptide hormone mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock.

PRO-1938 Protein-c Receptor Human Recombinant 5 µg 20 µg

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PRO-2438 Protein-c Receptor Human Recombinant, Sf9 2 µg 10 µg

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5200Protein-c Receptor Human Recombinant is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The PROCR protein is an N-glycosylated type I membrane protein which enhances the activation of protein C. PROCR gene mutations are linked with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. In addition, PROCR may have a role in malarial infection and has been linked with cancer.

CHM-032 Thymus Expressed Chemokine (CCL25) Human Recombinant, His Tag 5 µg20 µg

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2700ENZ-1011 Tissue Plasminogen Activator Human Recombinant, Sf9 1 µg

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1100ENZ-1023 Tissue Plasminogen Activator (311-562 a.a.) Human Recombinant 2 µg

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CODE PRODUCT QTY USDENZ-1023 Tissue Plasminogen Activator (311-562 a.a.) Human Recombinant 2 µg

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tPA Human, Sf9 is a secreted serine protease which converts the proenzymeplasminogento plasmin, a fibrinolyticenzyme. Plasmino-gen is synthesized as a single chain which is cleaved by PLAT into the two chain disulfide linked plasmin. This enzyme plays a role in cell migrationand tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

ZKV-006 Zika Ectodomain Recombinant Zika Ectodomain is a glycosylated protein, produced using baculovirus vec-tors in insect cells and its MW is approximately 45kDa. The Zika Ectodomain is a recombi-nant protein of the ectodomain of the envelope protein from the Suriname Zika virus strain. > 90.0% as determined by SDS-PAGE

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ZKV-007 Zika Envelope F.Length The E.Coli derived Recombinant Zika Envelope protein 40-400 a.a. having an M.W. of 38kDa and is a full length protein without a C-terminal hydrophobic region. The Zika En-velope full length protein is fused to a 6xHis tag at C-terminus and purified by proprietary chromatographic technique.

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ZKV-008 Zika Envelope Domain-3 The E.Coli derived Zika Envelope Domain-III is a non-glycosylated polypeptide chain having a molecular mass of 11 kDa and fused to a His tag at N-terminus. Zika Envelope protein solution contains PBS and 45mM arginine..

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ZKV-0097 Zika Envelope N Zika Envelope N protein is a peptide partially derived from zika envelope N terminal contain-ing 270 amino acids, having an M.W. of 30kDa and the Isoelectric point is 6.37. The Zika Envelope N protein is fused to a 6xHis tag at C-terminus and purified by proprietary chro-matographic technique.

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ANT-008 Zika NS1 Paired Antibody/Mouse Anti Zika NS1 PairedZika NS1 conjugation antibody and Zika NS1 capture antibody are used to develop rapid test for Zika NS1 rapid test. Please note that when ordering for example: 100 µg antibody we ship 50 µg from each of the antibodies (100 µg in total).

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1200Zika virus (ZIKV) belongs to the family Flaviviridae and the genus Flavivirus, it is transmitted by daytime-active Aedes mosquitoes, such as A. aegypti and A. albopictus. The Zika virus is related to the dengue, yellow fever, Japanese encephalitis, and West Nile viruses. Much like the other flaviviruses, Zika virus is enveloped and icosahedral and has a nonsegmented, single-stranded, positive-sense RNA genome. Zika fever is an infection, which often causes no symptoms or only mild ones, like a mild form of dengue fever, and it is treated by rest. As of February 2016, there has been mounting evidence that Zika fever in pregnant women can cause abnormal brain devel-opment in their fetuses by mother-to-child transmission, which may result in miscarriage or microcephaly, however it is not yet known whether Zika virus causes microcephaly. Furthermore, a connection has been established with neurologic conditions in infected adults, including Guillain–Barre syndrome.


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDFKK-3877-PI FK18

H-Phe-Phe-Phe-Glu-Arg-Leu-Glu-Ser-Asn-Asn-Tyr-Asn-Thr-Tyr-Arg-Ser-Arg-Lys-OH (M.W. 2371.62) C107H155N31O31

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180720

Novel Neuropeptide Shown to Have Neuroprotective Effects by Increasing Phosphorylation of AktS. Xiong, et al., Neurochem. Intl., 1 (2017).

RGD-3750-PI H-dPEG®4-Glu[dPEG®

4(cyclo (Arg-Gly-Asp-d-Phe-Lys))]2 (M.W. 2060.35) C92H150N22O31For In Vitro Assays of Integrin αvβ3/αvβ5 Expression in Tumor TissuesR. Gao, et al., Med Princ Pract., 24, 244 (2015). Y Zheng, et al., Bioconjugate Chem, 25,1925 (2014).

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TSP-3873-PI H-Phe-Ile-Arg-Val-Val-Met-Tyr-Glu-Gly-Lys-Lys-OHFIRVVMYEGKK(M.W. 1369.70) C64H104N16O15S

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CD47 Binding Peptide Derived from Thrombospondin 1; Inhibitor of Angiogenic ResponsesS. Kaur, et al., J. Biol. Chem., 285, 38923 (2010).

TSP-3874-PI H-Phe-Ile-Arg-Gly-Gly-Met-Tyr-Glu-Gly-Lys-Lys-OH FIRGGMYEGKK(M.W. 1285.54) C58H92N16O15S Control Peptide for CD47-Binding Peptide 7N3 (TSP-3873-PI)S. Kaur, et al., J. Biol. Chem., 285, 38923 (2010).

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PLT-3409-v L17E Cytosolic Delivery Peptide L17E, L17

0.5 mg vial 300

Ile-Trp-Leu-Thr-Ala-Leu-Lys-Phe-Leu-Gly-Lys-His-Ala-Ala-Lys-His-Glu-Ala-Lys-Gln-Gln-Leu-Ser-Lys-Leu-NH2 (M.W. 2859.4) C134H220N38O31 [1898254-09-5] Peptide for Transport to CytoplasmaM. Akishiba, et al., Nature Chemistry, 9, 751 (2017). (Original)

RGD-3993-PI Mal-PEG3-Glu[cyclo (Arg-Gly-Asp-d-Tyr-Lys)]2PEG3 = 11-amino-3,6,9-Trioxaundecanoic acid(M.W. 1690.79) C74H107N21O25Dimeric RGD Peptide for Click Chemistry

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2801100

Semaglutide is a glucagon-like peptide (GLP-1) analogue and a GLP-1 receptor agonist. Not only does it have a half-life of up to one week, it has been used in type 2 diabetes research for its ability to stimulate insulin production while suppressing glucagon secre-tion in a glucose-dependent manner. Semaglutide has an increased albumin affinity and exhibits a three-fold decrease in GLP-1 receptor affinity when compared to liraglutide.1 Recent studies in patients with type 2 diabetes suggest that semaglutide may also have an improved cardiovascular outcome in those patients who are at risk for a cardiac event.2

1. J. Lau, et al., J. Med. Chem., 58, 7370 (2015). 2. S.P. Marso, et al., N. Engl. J. Med., 375, 1834 (2016).

GLP-3875-PI SemaglutideH-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys[(AEEA)2-ϒ-Glu-N-(17-Carboxy-1-Oxoheptadecyl)]-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH(M.W. 4113.67) C187H29N45O59 [910463-68-2]

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Glucagon-like peptide-1 (GLP-1) Analog Shown to Stimulate Insulin & Suppress Glucagon Secretion in a Glucose-Dependent MannerBolar Exemption applies. This is a FDA-regulated product. It is the responsibility of the customer to ensure that they are complying with Federal rules. PI cannot be liable for infringement of rights made by the user.S.P. Marso, et al., N. Engl. J. Med., 375, 1834 (2016). J. Lau, et al., J. Med. Chem., 58, 7370 (2015).C.F. Gotfredsen, et al., Diabetes, 63, 2486: (2014).


Phone: 502-266-8787 Fax: 502-267-1329



CODE PRODUCT QTY USDTED-3880-PI Teduglutide

(Trifluoroacetate Form) H-His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH (M.W. 3752.08) C164H252N44O55S [197922-42-2]

1 mg5 mg

4251675

Bolar Exemption applies. This is a FDA-regulated product. It is the responsibility of the customer to ensure that they are complying with Federal rules. PI cannot be liable for infringement of rights made by the user.Glucagon-like Peptide 2 Analog Used to Treat Short Bowel SyndromeP. Jeppesen, et al., Gut, 54, 1224 (2005). P. Jeppesen, Therap. Adv. Gastroenterol., 5, 159 (2012).

VAS-3878-PI [Arg8]-VasopressinH-[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Arg-Gly-NH2 (M.W. 1084.25) C46H65N15O12S2 [113-79-1]

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70280

Peptide Antidiuretic Hormone Originating from Hypothalamus; Plays Role in OsmolalitT. Tsuji, et al., J. Physiol., 10.1113/JP274025 On-line acceptance 4-12-17. P.J.Duncan, et al., J. Physiol., 593, 1197 (2015).F.Jean-Alphonse, et al., J. Biol. Chem., 289, 3960 (2014). C.Y.Jiang, et al., J. Neurophysiol., 111, 991 (2014).

ENZYME INHIBITORS & SUBSTRATES PRODUCTSSAC-3839-PI Ac-Pro-Arg-Asn-Lys-Acc-NH2

Ac-PRNK-Acc-NH2(M.W. 755.84) C34H49N11O9

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200800

Specific Substrate for Tryptases βI and βIIThe substrate has the following kinetic constants for βI tryptase: kcat of 17.84 ± 0.40s-1, km of 14.5 ± 1.9 μm, kcat/Km of (1.23 ± 0.15) × 106 s−1 m−1. The substrate has the following kienetic constants for βII tryptase: kcat of 16.84 ± 0.27s-1, km of 8.9 ± 0.9 μm, kcat/Km of (1.89 ± 0.17) × 106 s−1 m−1. J.B. Harris, et al., JBC, 276, 34941 (2001).

SAC-3836-PI Ac-Pro-Arg-Thr-Lys-Acc-NH2Ac-Pro-Arg-Thr-Lys-Acc-NH2 (M.W. 742.84) C34H50N10O9

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Specific Substrate for Tryptases βI and βIIThe substrate has the following kinetic constants for βI tryptase: kcat of 18.34 ± 0.33 s-1, km of 23.4 ± 2.3 μm, kcat/Km of (0.78 ± 0.07) X 106 s−1 m−1. The substrate has the following kienetic constants for βII tryptase: kcat of 18.67 ±0.30 s-1, km of 14.7 ± 1.4 μm, kcat/Km of (1.27 ± 0.12) X 106 s−1 m−1.

SAC-3837-PI Ac-Leu-Gly-Pro-Lys-Acc-NH2Ac-LGPK-Acc-NH2(M.W. 655.76) C32H45N7O8 Specific Substrate for Thrombin

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The substrate has the following kinetic constants for: kcat of 3.2 +/-0.4 s-1, km of 95 +/- 30 μm, kcat/Km of 0.018 +/- 0.003 s−1 m−1.


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Phone: 502-266-8787 Fax: 502-267-1329



ILP-3851-PI Leupeptin (synthetic)Acetyl-l-Leucyl-l-Leucyl-l-Argininal Hemisulfate Monohydrate(M.W. 426.56 • 49.04) C20H38N6O4 • 1/2 H2SO4 [103479-89-7]Inhibitor for Serine and Cysteine ProteinaseS. Kondo, et al., Chem. Pharm. Bull., 17, 1896 (1969). A. Sarin, et al., J. Immunol., 154, 5806 (19954). J.P. Montenez, et al., Toxicol. Lett., 73, 201 (1994). A. Sarin, et al., J. Immunol., 153, 862 (1994).

25 mg100 mg

150482

UBX-3876-PI Ubenimex (Bestatin) HCl Salt [(2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutanoyl]-L-Leucine (M.W. 308.38 · 36.46) [65391-42-6]Inhibitor of Aminopeptidases, LAP3; Potent, Irreversible Inhibitor of Leukotriene A4 (LTA4) Hydrolase

1 mg 5 mg

25 mg

3166

230

L. Örning, et al., The Journal of Biological Chemisty, 266,1375,(1991). J. F. Evans and S. Kargman, FEBS Letters, 297, 139, (1992).

MCA-3206-v Ubiquitin-MCA Met-Gln-Ile-Phe-Val-Lys-Thr-Leu-Thr-Gly-Lys-Thr-Ile-Thr-Leu-Glu-Val-

50 μg vial 200

Glu-Pro-Ser-Asp-Thr-Ile-Glu-Asn-Val-Lys-Ala-Lys-Ile-Gln-Asp-Lys-Glu-Gly-Ile-Pro-Pro-Asp-Gln-Gln-Arg-Leu-Ile-Phe-Ala-Gly-Lys-Gln-Leu-Glu-Asp-Gly-Arg-Thr-Leu-Ser-Asp-Tyr-Asn-Ile-Gln-Lys-Glu-Ser-Thr-Leu-His-Leu-Val- Leu-Arg-Leu-Arg-Gly-Gly-MCA MCA: 4-Methyl-Coumaryl-7-Amide(M.W. 8721.9) C388H636N106O119S Food Intake Suppressor / Insulin Secretion SuppressorL.C. Dang, et al., Biochemistry, 37, 1868 (1998). (Original) S.C. Johnston, et al., EMBO J., 18, 3877 (1999).

D.E. Mason, et al., Biochemstry, 43, 6535 (2004).

TOOLS FOR PEPTIDE SYNTHESISACC-9001-PI Fmoc-Acc-Resin

Fmoc-7-Aminocoumarin-4-Acetic Acid-Rink Amide AM ResinHelpful Tool in Substrate Library SynthesisJ.L. Harris, et al., PNAS, 97, 7754 (2000).

1 g5 g

7503000

FAC-1960-PI Fmoc-Acc-OH Fmoc-7-amino-4-carbamoylmethylcoumarin; 7-(9-Fluorenylmethyloxycarbonylamino)-Coumarin-4-Acetic Acid(M.W. 441.44) C26H19NO6 [378247-75-7] G.B. Fields and R.L. Noble, Int J Pept Protein Res., 35, 161 (1990).

1 g5 g

7503000

FGP-1917-PI Fmoc-Gly-Pro-OH N-α-(9-Fluorenylmethyloxycarbonyl)-Glycinyl-Proline(M.W. 394.43) C22H22N2O5 [212651-48-4]

1 g5 g

135450

MMP-5039-PI Mob-S-Mercaptoproprionic Acid4-Methoxybenzyl-S-Mercaptoproprionic Acid(M.W. 226.3) C11H14O3S

0.25 g1 g

150316


Phone: 502-266-8787 Fax: 502-267-1329




SPECIALTY PRODUCTS AND TECHNOLOGIESNAY-Y192-v Prorenin (314-337) (Human) Antiserum

(Rabbit)50 μl vial 350

NAY-Y480-v PSA (53-92) (Human) Antiserum(Rabbit)

50 μl vial 350

NAY-YK091 Glucagon-HS ELISA 1 Kit 950


Phone: 502-266-8787 Fax: 502-267-1329




Phone: 502-266-8787 Fax: 502-267-1329




BIOLOGICALLY ACTIVE PEPTIDES PRODUCTSPAB-AF683 Amyloid β-Protein (1-42, O-Acyl Isopeptide)

26-O-acyl isoAβ1-42, iAβ42, (1-25): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly (26-42): Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala (M.W. 4514.0) C203H311N55O60S [753459-14-2]pH Click Peptide for Amyloid β-Protein (Human, 1-42)Ester bond between Gly25 α-carboxyl group and Ser26 β-hydroxyl group

2 mg Inquire

PAB-4492-v Amyloid β-Protein (Human,11-40) Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val (M.W. 3151.6) C143H228N38O40S [338458-53-0] Endogenous Truncated Amyloid β-Protein

0.5 mg vial 150

P. Seubert, et al., Nature, 359, 325 (1992). (Original) J.T. Huse, et al., J. Biol. Chem., 277, 16278 (2002). (Biochem.; β’-Cleavage)K. Liu, et al., Acta Neuropathol., 112, 163 (2006). (Pharmacol.) J.D. Barritt and J.H. Viles, J. Biol. Chem., 290, 27791 (2015). (Pharmacol.)H. Cai, et al., Nat. Neurosci., 4, 233 (2001). (Biochemistry)

PAB-4493-v [Pyr11]-Amyloid β-Protein (Human,11-40) Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val(M.W. 3133.6) C143H226N38O39S [192377-94-9] Endogenous Truncated Amyloid β-Protein

0.5 mg vial 150

P. Seubert, et al., Nature, 359, 325 (1992). (Original) K. Liu, et al., Acta Neuropathol., 112, 163 (2006). (Pharmacol.)J.D. Barritt and J.H. Viles, J. Biol. Chem., 290, 27791 (2015). (Pharmacol.)

PCT-4495-v Caloxin 2A1 Val-Ser-Asn-Ser-Asn-Trp-Pro-Ser-Phe-Pro-Ser-Ser-Gly-Gly-Gly-NH2(M.W. 1478.5) C64H91N19O22 [350670-85-8] Selective Plasma Membrane Ca2+-Pump Inhibitor

0.5 mg vial 100

J. Chaudhary, et al., Am. J. Physiol. Cell Physiol., 280, 1027 (2001). (Original) M.M. Szewczyk, et al., Pflügers Arch., 456, 255 (2008). (Review)

PCT-4494-v Candidalysin Candida albicansEcel-III62-92K Ser-Ile-Ile-Gly-Ile-Ile-Met-Gly-Ile-Leu-Gly-Asn-Ile-Pro-Gln-Val-Ile-Gln-Ile-Ile-Met-Ser-Ile-Val-Lys-Ala-Phe-Lys-Gly-Asn-Lys (M.W. 3310.1) C153H266N38O38S2 [1906866-53-2] Fungal Cytolytic Peptide Toxin

0.5 mg vial 280

D.L. Moyes, et al., Nature, 532, 64 (2016). (Original) A.P. Mitchell, Nature, 532, 41 (2016). (News & Views)U. Hofer, Nature Rev. Microbiol., 14, 268 (2016). (Research Highlights)

PDF-4497-s β-Defensin-1 (Mouse) mBD-1 Asp-Gln-Tyr-Lys-Cys-Leu-Gln-His-Gly-Gly-Phe-Cys-Leu-Arg-Ser-Ser-Cys-Pro-Ser-Asn-Thr-Lys-Leu-Gln-Gly-Thr-Cys-Lys-Pro-Asp-Lys-Pro-Asn-Cys-Cys-Lys-Ser(M.W. 4070.6) C168H266N52O54S6 (Disulfide Bonds Undetermined) Antimicrobial Peptide

0.1 mg vial 250

K.M. Huttner, et al., FEBS Lett., 413, 45 (1997). R. Bals, et al., Infect. Immun., 66, 1225 (1998).

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New Products Fall 2017 - Peptides International · by two species of mosquito of the genus Aedes: ... Dengue virus is caused by one of four closely related virus serotypes of the