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New solid-state NMR methods in controlled release
Staffan Schantz
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AstraZeneca R&D
Biologics Small Molecules Immuno - therapies
Protein engineering
Neuroscience Infection
& Vaccines
CV- Metabolism
Respiratory, Inflammation
& Autoimmunity Oncology
Core Therapy Areas Opportunity-focused
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Can we determine domain sizes using NMR?
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Hydroxypropyl cellulose
0 10 20 30
Ethanol
70
80
90
100
Ethyl cellulose
0
10
20
30
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Domain sizes in MR-coatings NMR – Nuclear Magnetic Resonance
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Domain sizes in MR-coatings NMR – Nuclear Magnetic Resonance
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Domain sizes in MR-coatings NMR – Nuclear Magnetic Resonance
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
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RT/60%r.h. for 4 weeks on silicon
The results are in good agreement with SANS (Marucci et al.
2015).
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RT/60%r.h. for 4 weeks on silicon
EC/HPC free film (slow drying)
EC/HPC free film (intermediate drying)
EC/HPC free film (fast drying)
EC/HPC/MCC coated pellets
EC/HPC/API coated pellets
Domain size HPCc [nm]
294 216 154 156 134
Domain size ECc [nm]
145 107 76 86 66
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RT/60%r.h. for 4 weeks on silicon
0
50
100
150
Wat
er p
erm
eabi
lity,
m2 /s
Films made at decreasing time for the phase separation to
occur
A B
C D
Cast film
Faster film formation kinetics give smaller domains with higher
connectivity (Marucci 2013).
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Dr Maria Baias Dr Aaron Rossini
Thanks to… Dr Judith Schlagnitweit Dr Mingxue Tang
Dr Sara Richardson Prof Lyndon Emsley
AstraZeneca R&D Mölndal, Sweden
http://weizmann.academia.edu/MariaBaias
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