New Therapeutic Approaches Aimed at Eliminating Persistent

HIV Reservoirs in InfectedIndividuals ReceivingAntiretroviral Therapy

Tae-Wook Chun, Ph.D.Laboratory of Immunoregulation

National Institute of Allergy and Infectious DiseasesNational Institutes of Health

Department of Health and Human Services

Potential Strategies for Eradication of HIV

Early initiation of antiretroviral therapy

Use of immune-modulating agents

Addition of newer classes

of drugs

Use of virus “purging” agents

Use of HIV-specific killing agent

Potential Strategies for Eradication of HIV

Early initiation of antiretroviral therapy

Use of immune-modulating agents

Addition of newer classes

of drugs

Use of virus “purging” agents

Use of HIV-specific killing agent

Potential Strategies for Eradication of HIV

Early initiation of antiretroviral therapy

Use of immune-modulating agents

Addition of newer classes

of drugs

Use of virus “purging” agents

Use of HIV-specific killing agent

Potential Strategies for Eradication of HIV

Early initiation of antiretroviral therapy

Use of immune-modulating agents

Addition of newer classes

of drugs

Use of virus “purging” agents

Use of HIV-specific killing agent

Potential Strategies for Eradication of HIV

Early initiation of antiretroviral therapy

Use of immune-modulating agents

Addition of newer classes

of drugs

Use of virus “purging” agents

Use of HIV-specific killing agent

Persistence of HIV in Gut-Associated LymphoidTissue despite Long-Term Antiretroviral TherapyTae

Persistence of HIV in Gut-Associated Lymphoid

Tissue despite Long-Term Antiretroviral Therapy

Chun et al.

Effect of Raltegravir Intensification on Immunologic and Virologic Parameters of HIV-Infected, Aviremic Individuals

Buzon et al., Nature Medicine, 16 (4): 460-5, 2010

Changes in Levels of Cell-Associated Unspliced HIV RNA in Infected Individuals who Underwent Intensification of ART

Yukl et al., personal communication