Nitric Oxide - Probiotics€¦ · Nitric Oxide: The Molecule of Life 4 Dedication This book is dedicated to my medical staff at Elan Vital Medical Center and our clients worldwide,

Nitric Oxide:the molecule of life

Noni and the Nitric Oxide Link

By Dr. Abbas Qutab

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Acknowledgments

I’d like to thank Dr. Tom Burke, Dr. Harry O. Eidenier, Jr. and Dick Simonian, Esq. for their ongoing support and friendship. Also Brian Thayer of Dream Builders, for making this dream a

together.

Nitric Oxide: The Molecule of Life

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Dedication

This book is dedicated to my medical staff at Elan Vital Medical Center and our clients worldwide, who have allowed us to create wellness strategies for achieving optimal health. It is a constant joy for me to witness and be a part of their improvement and well being.

Foreword

Studies of the effects of nitric oxide in people have been accelerating since its discovery in the late 1980’s. Its broad range of biologic effects is hard to envision for a molecule with so short a half-life. As a gas, it’s here and then it’s gone. Yet Dr. Abbas Qutab has gracefully woven a tale showing where nitric oxide is a participant in many different organ systems and medical conditions. How he was able to gleam this information from many thousands of medical research publications is, quite frankly, amazing. This synopsis, remarkably, doesn’t talk down to the reader by using sophisticated, sometimes unintelligible medical terms. Rather it takes the reader from commonly understood conditions such as pain and coronary arteries, which virtually everyone understands, to a simple explanation of how the presence or absence of nitric oxide can make a difference in people’s health. You have to be impressed that he was able to capture the important, positive messages that sometimes are buried in the medical literature. I hope that those who read this book come away as impressed as I was in this description of why Noni, via nitric oxide, may be so helpful for so many different conditions.

By Dr. Thomas Burke

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“The WORLD should read this book…. (all) at once!”

Anonymous

Table of Contents

Acknowledgments ......................................................................3Dedication ..................................................................................4Foreword ....................................................................................5Introduction ................................................................................9Extracts on Noni Create Nitric Oxide ......................................13Nitric Oxide: The Molecule of Life .........................................17 What is nitric oxide? ....................................................18 What does nitric oxidedo in the body? .........................18 Where does nitric oxide come from? ............................18 Do nitrates/nitrites lead to peroxynitrites? ..................22

Health Benefits of Nitric Oxide ...............................................25 Nitric oxide and the heart ............................................25 Nitric oxide and blood pressure ...................................27 Nitric oxede and pain relief .........................................28 Nitric oxide and seual function ....................................32 Nitric oxide and fertility ...............................................33 Nitric oxide and weight loss .........................................33 Nitric oxide and energy ................................................34 Nitric oxide and exercise/sports ...................................36 Nitric oxide and inflammation .....................................36 Nitric oxide and digestion ............................................38 Nitric oxide and the immune system ............................39 Nitric oxide and the prevention of cancer ....................40 Nitric oxide and insomnia ............................................41 Nitric oxide and diabetes .............................................42 Nitric oxide and the brain ............................................44 Nitric oxide and wound and fracture healing ..............46 Nitric oxide and trauma ...............................................48

Final Thoughts .........................................................................51End Notes .................................................................................54Bibliography ............................................................................56About the Author ......................................................................59


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INTRODUCTION

It must have been three or four years ago now, that one of my favorite patients, whom I will call “Sonny” showed up in my office for his regular checkup. “I’ve stopped all my meds,” Dr. Abbas,” he said, a little sheepishly, but with a determination in his eye. This big bear of a man, charming and jovial, had fought a long-standing war with high blood pressure. We were mostly winning this battle, with the normal medications, and the contribution of his rigid discipline (most of the time) when it came to diet and exercise. Sonny always has a joke and a smile for us when he comes in to the clinic, and often brings gifts of fresh fruit or vegetables -he’s a great guy. As you can imagine, I was a bit appalled at this news that he no longer took the drugs that I counted on to protect him, but he eagerly told me what he was taking instead. “Nitric oxide, doc. Extracts of the Noni tree - it’s something to do with creating nitric oxide in the body. I heard about it from a friend of mine who takes it for her arthritis- she hasn’t felt this well in years. So I gave it a try. Go on, take my blood pressure.” He grinned and pulled up his sleeve in anticipation. To my surprise, his blood pressure was normal. He hadn’t seen 120 over 80 for at least five years without medication. Sonny explained that he had now been taking this Noni extract product for three months, and had been off


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his medications for one month. I insisted he come back monthly for a while, so I could monitor this situation, and each time he came into my office, his blood pressure remained normal. He was taking no drugs at all, just this proprietary blend of extracts of Noni fruit. He was thrilled and proud of his discovery. And I was completely intrigued. This launched my investigation into the humble Noni tree, with its strange little ugly fruit. I read everything I could get my hands on, and discussed it with many colleagues, many of whom brushed it off as another scam or possible placebo effect. Now, while it is true that placebo effects are powerful, they just don’t normalize blood pressure problems as severe as Sonny’s. And they don’t reverse illnesses as crippling as the fibromyalgia that

had been plaguing Nancy, another of my patients. The change in her wellbeing since she started to take a proprietary blend of Noni extracts has been almost miraculous. In my study, I learned this proprietary nutraceutical creates nitric oxide in the body. Nitric oxide, known as NO, has been extensively proven in thousands of studies to

aid every system and cell in the body, and has shown dramatic results when used by patients suffering from a wide variety of complaints. I have been recommending the proprietary blend of Noni extracts to my patients for several years, now, with wonderful results. Nitric oxide, which has become a sort of celebrity molecule, has been the subject of thousands of scientific papers in the past decade. It is a small, simple molecule, composed of

“Nitric oxide has been extensively proven in thousands of studies to aid ev-ery system and cel-lin the body...”

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one atom of oxygen and one of nitrogen. It was best known as a toxic gas and an ingredient in air pollution until 1987, when it was first shown to be produced by various cells throughout the human body and to help cells communicate with each other. I spoke at great length with scientists who were researching Noni, its nitric oxide effect, and I found myself wanting to help spread the word. I now travel extensively, lecturing to both doctors and laypeople on the benefits of this proprietary blend of Noni extracts that have such a high nitric oxide effect. I must emphasize that I make no money whatsoever from the sale of any Noni extract or nitric oxide products. It is simply that I have never before found a product that I could so wholeheartedly endorse, and I wish to extend the benefits I see so regularly in my practice to people all over the world.



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EXTRACTS OF NONICREATE NITRIC OXIDE

By now there certainly aren’t many people interested in health and healing who haven’t heard of Noni. Typing “Noni” into Google brings up six or seven million websites where this topical fruit tree is referenced. Since the middle of the 1990’s, Noni, or Morinda citrifolia, has catapulted onto the worldwide stage and grown exponentially, with sales now estimated at about one billion dollars annually. This shrubby evergreen tree, with its small, foul-smelling fruit has been called the “Ancient Cure from Paradise,” the “Painkiller Tree,” and the “Aspirin of the Ancients.” In Australia it has been called “Cheesefruit” from the overwhelming smell. It grows wild throughout the Southeast Asian countries, but its original home was Polynesia, Micronesia and the Hawaiian Islands. Polynesians have successfully used this health-promoting plant and its fruit for thousands of years, yet they readily admit to not knowing how or why it works. Southeast Asians have always used all parts of the Noni tree medicinally-the bark, root, leaf, fruit and flower. Researchers have explored the Noni fruit, leaves, and roots to try to ascertain the exact ingredient or ingredients that promote health. Noni is high in Vitamin C and other vitamins, amino acids (the building blocks of protein), minerals, and contains several other compounds including the antioxidant carotenoids, and bioflavonoids. It is also has potassium, which is a consideration for anyone suffering from kidney disease or insufficiency. Although it has less potassium content than orange juice or tomato juice, you still may want to be aware of this. This list of constituents alone do not adequately explain the benefits patients all over the world are experiencing from taking Noni, considering they naturally occur in many nutritious plant foods.


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Determined to solve this puzzle, scientists began to notice a correlation between the success stories of patients using Noni and the benefits of having enough nitric oxide in the body. Due to its importance in the human body, a vast amount of research was being conducted on the properties of nitric oxide. It seemed possible that nitric oxide (NO) was the mechanism at work- perhaps Noni caused a nitric oxide effect in the people who took it. Research was undertaken in 1999 and 2000, by Dr. Thomas Burke and his researchers at Integrated Systems Physiology, an independent lab in Denver, Colorado. They conducted in-vitro experiments which tested diluted Noni juice on endothelial

cells, the cells that line the inner surface of blood vessels. That was the answer for which everyone had been searching- the Noni juice did indeed create nitric oxide! This suddenly helped to explain the enormous improvements patients were having drinking this humble tropical juice. The shrubby little tree that had the weight of the collective voice of generations was finally being confirmed in the scientific arena. Having isolated at least one of the main

mechanisms by which Noni works in the body, this advanced Noni product is now available on the market. This product has been available internationally, now, for three years. And the reports of health improvements are pouring in from around the world. There is now even a test that can show you how well the proprietary blend of Noni extracts is generating NO in your own

In vitro testing yielded great finds about nitric oxide

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system. Baltimore Laboratories in Monroe, CT, has created a test which reliably indicates nitric oxide levels in the body. This quick and easy saliva test measures within 30 seconds, and in early trials, showed increases in nitric oxide by-products of up to 400% in people who had taken two droppers-full three times a day for only four days. So what is nitric oxide anyway? What does it do for us, and where does it come from?



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NITRIC OXIDE:THE MOLECULE OF LIFE

Nitric oxide (NO) helps maintain, defend, and repair every cell of the body. That’s quite a statement. But the fact that it is one of the most important molecules to human life is, without a doubt, one of the major discoveries of this century. Scientists knew that NO was produced in bacteria, but no one realized its importance in higher animals such as mammals. This discovery caused quite a sensation in the late 1980’s. By 1992 it was named “The Molecule of the Year” by Science magazine. In 1998 it brought the Nobel Prize for Physiology or Medicine to three scientists, Robert Furdhgott, Luis Ignarro and Ferid Murad, for their discovery of the signaling properties of NO. The scientific literature on NO is growing exponentially, and to date, in 2006, there are more than 70,000 scientific papers published regarding some aspect of nitric oxide and its beneficial role in patient care. But the most important fact in all this is that it brings better health to millions around the world. Most people have never even heard of nitric oxide, known as NO. NO is not nitrous oxide, the laughing gas that some dentists use to sedate their patients. It is not nitric acid, a highly corrosive acid which is used in the making of explosives and fertilizers. And it is not nitrogen dioxide, a poisonous air pollutant, a component of acid rain. Nitric oxide may be a simple molecule, made up of one part nitrogen, and one part oxygen, but scientists and researchers around the globe have been astonished by the seemingly limitless list of functions of nitric oxide in the body. “In my 25 years of research, I have never seen a molecule [NO] that so pervasively influences normal and abnormal body functions,” said Dr. Solomon Snyder, the director of neuroscience at Johns Hopkins Medical School. 1

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WHAT DOES NO DO IN THE BODY? Although it is a highly reactive gas, NO is however the most important “signaling” or “messenger” molecule in our body. This means that although it has only a short life of a few seconds, in that time it instigates processes involving an extensive array of physiological functions that control blood circulation, inflammation, learning and memory, digestion, and penile erection. One of NO’s broadest functions is in controlling blood pressure by dilating (relaxing and widening) blood vessels, which improves blood flow and helps prevents the clotting of the blood. This holds profound implications for the treatment of cardiovascular disease. It may have been what led Sonny to my office three years ago. It is also a powerful tool to help patients with impotence problems, as it can initiate and maintain erection by dilating blood vessels. This explains the mechanism of Viagra. Plentiful studies in the laboratory have shown that nitric oxide is also vitally important to the immune system. It fights and kills bacteria, viruses, fungi, parasites, and cancer cells, or stops their ability to multiply. It also acts like a neurotransmitter, relaying messages between nerve cells. More of its roles are continually being isolated and identified, and research into the potential clinical applications of nitric oxide is still in its infancy. The possibilities seem endless. Across the board it is truly an important and busy molecule!

WHERE DOES NO COME FROM? Let me tell you a little about where NO comes from. The primary way that nitric oxide is created is from L-arginine, one of


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the essential amino acids, which are building blocks of protein. The essential amino acids are called that because the body cannot create them from other compounds, but must get them from food, such as meat and fish. Then various enzymes are needed, plus oxygen, to release nitric oxide from L-arginine. The biochemistry depends on the action of one of a family of enzymes, called nitric oxide synthases or NOS, which converts L-arginine to another amino acid, L-citrulline, forming nitric oxide in the process. But nitric oxide is also created from substances known as nitrates and nitrites found in plants such as green leafy vegetables, and Noni, as we now know, has proven to be high in these substances. Proprietary extracts of the Noni tree contain large amounts of nitrates and nitrites, which are then converted into nitric oxide by normal stomach acid. 2 3 This NO protects us by killing almost all the bacteria that have been swallowed in our food. But in addition, the nitric oxide diffuses through the stomach wall and enters the red blood cells, or binds to proteins and is carried to all parts of the body. For thousands of years, humans have used nitrates to preserve meat from bacterial spoilage. Now, you may think of nitrates and nitrites in a negative way, having heard that they seem to be harmful chemicals added to foods such as bacon, sausage, and smoked meats. But strangely enough, it appears that nitrates may have been blamed incorrectly. Recent research shows that there is a healing potential instead; nitrates are an aid to cardiovascular health through their conversion into nitric oxide. A study published in Harvard’s “Heart Letter” in 2004 found that nitrates and nitrites

“...Nitric oxide is the most important ‘signaling’ or ‘mes-senger’ molecule in our body.”


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(through nitric oxide’s action) keep arteries relaxed and more flexible, which in turn keeps blood pressure low, and prevents strokes and heart attacks. 4 Other studies carried out by the National Institutes of Health, the University of Alabama and Wake Forest University 5 have confirmed these findings, that nitrate, a common salt, can dilate blood vessels and improve blood flow. In an article published in the November 2003 issue of Nature Medicine, researchers reported that nitrite is easily converted into nitric oxide, suggesting that nitrates and nitrites may in fact be a source of nitric oxide for the body’s needs. 6

Since nitric oxide, from nitrates and nitrates, dilates blood vessels, this may help to explain why some people feel a bit faint, or get headaches after eating smoked meats with nitrates. But I don’t suggest you start eating lots of hot dogs- those high fat little guys made from questionable meats will never be a health food! There is a much better source of nitric oxide, and it is from a proprietary blend of Noni extracts. So, since nitric oxide is released from arginine, why not just eat lots of protein that is high in L-arginine, or take arginine supplements? Internet ads and gyms across America are abuzz with the arginine - nitric oxide link. And the truth is L-arginine is indeed a good source of nitric oxide, and most Americans probably get enough in the protein that we regularly eat to make our own nitric oxide. But there are a few good reasons why taking a substance which releases nitric oxide directly, from nitrates and nitrates, is preferable. First, there are several co-factors that are necessary in order to form nitric oxide in your cells. Secondly, the environment around the cells making nitric oxide must not be too acidic or too alkaline. If one or more co-factors is missing or not in adequate supply, and/or the cell environment is too acidic or too alkaline, then


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nitric oxide will not be created, or not at optimum levels. Exercise also plays a part in creating the optimum amount of nitric oxide from L-arginine. In people who are sedentary, or those whose chronic illness or overweight issues limit their ability to exercise, nitric oxide is not produced in optimal quantities. Another factor to consider when ensuring a good supply of NO is the fact that L-arginine has other roles to play in the body besides its ability to generate nitric oxide, primarily in the metabolism of protein, for muscle growth. Its other functions include detoxifying ammonia in the body (a by-product of energy production) and promoting the secretion of several hormones, including insulin, and growth hormone. Since creating NO is not L-arginine’s only job, it seems preferable to take a plant substance that directly generates NO. And finally, there is the herpes link. People who suffer from either herpes Type 1, the oral form that causes cold sores, or herpes Type 2, the genital form, need to be aware that L-arginine can actually “feed” the herpes virus, which needs arginine to replicate. Those patients are regularly urged to avoid the L-arginine-rich foods, and to eat L-lysine foods or take lysine supplements, which may reduce herpes outbreaks, or limit them. This is due to the fact that L-lysine competes with L-arginine in the body, so the supplementation of L-lysine can tip the balance in its own favor. This ameliorates herpes outbreaks, especially the oral form. L-arginine has not been

Exercise is key in creating nitric oxide


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conclusively proven to worsen herpes Type 2 symptoms, but its general connection to herpes has been shown in many trials. And further, with regard to the herpes issue, recent detailed studies have shown that nitric oxide actually inhibits the replication of the herpes virus7, which is good news for those who take the proprietary blend of Noni extracts.. This herpes link may seem small to those of you who have never had cold sores, or aren’t familiar with this nasty virus. But unfortunately herpes is especially prevalent in humans. In fact, over 100 million people here in the U.S. alone are afflicted with the virus, in conditions such as cold sores, genital herpes, and shingles, its painful cousin. So, eating a big steak or downing L-arginine capsules isn’t

always the answer. However, the proprietary blend of Noni has a large amount of nitrates and nitrites which can be converted into nitric oxide when they reach the hydrochloric acid in the stomach. This nitric oxide can then pass through the stomach wall, rapidly diffusing through the body. This method of getting nitric oxide is faster and relies on no other conditions for its creation, giving you

nitric oxide quickly when and if it is needed.

DO NITRATES/NITRITES LEAD TO PEROXYNITRITES, THE DAMAGING FREE RADICALS? In my lectures I am often asked if taking a product high in nitrates and nitrites might lead to damaging levels of peroxynitrites,

“...The proprietary blend of noni has a large amount of nitrates and nitrites that can be con-verted intonitricoxide...”

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which are a type of free radical. In a nutshell, no. This is because the amount of nitrates and nitrites in the proprietary blend of Noni extracts, while high, is not immediately converted to nitric oxide. Contents of the stomach break down fairly slowly. Also, the NO diffuses through the stomach lining and enters the blood vessels where it attaches to amino acids and proteins, and while attached to these proteins the nitric oxide cannot react with oxygen to form peroxynitrite. Peroxynitrite is only created when nitric oxide is released as a gas from the proteins and then interacts with oxygen. Finally, the body, through an additional mechanism of NO, has a safety valve to protect it from peroxynitrites. There is a powerful antioxidant molecule, called glutathione, also generated by NO, which can mop up peroxynitrites. There is absolutely no way that ingestion of plant substances such as the proprietary blend of Noni extracts would lead to the formation of peroxynitrites.



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HEALTH BENEFITSOF NITRIC OXIDE

Now that you know a little about the many functions nitric oxide has in the body, let’s talk a little about what nitric oxide can do for specific health problems that you or someone in your family may be experiencing.

NO AND THE HEART NO helps to prevents heart disease. Heart attacks happen when blood can’t circulate through the coronary arteries in the heart resulting in the death of a part of the heart muscle- it simply dies and scars over from a lack of oxygen. This happens partially because of narrowing of the arteries caused by cholesterol build-up. But heart attacks can also be due to blood clots forming in these narrowed arteries caused by inflammation, leading the artery to clog up just like plumbing in the sink. Dr. Robert Vogel, professor of medicine at the University of Maryland Medical Center described this condition in a very picturesque way; that the clogged “endothelial lining had the texture of Velcro”, promoting this condition called atherosclerosis. Atherosclerosis consists of plaques containing cholesterol and lipids on the walls of the arteries. To some degree it naturally occurs with aging, but there are many other risk factors; high blood pressure, smoking, diabetes, high cholesterol, and/or a family history of heart disease. As well as a heart attack, atherosclerosis can lead to stroke, and eye and kidney problems. With this build up of plaque lining the artery walls, the endothelial cells lose their capacity to produce nitric oxide. Inactivity and poor diet also weaken the endothelial cells, as can high blood sugar from diabetes. When these fragile endothelial

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cells are damaged, they can not create as much nitric oxide.8 By taking a substance high in nitrates and nitrates such as the proprietary blend of Noni extracts, nitric oxide helps to prevent heart disease in several ways. It dilates the arteries, making them wider, so more blood, more oxygen and nutrients can get through to the heart muscle. It also helps prevent clotting by preventing the platelets in the blood from sticking together, as well as preventing them from sticking to the vessel wall. NO has also been shown to reduce arterial plaque once formed. Nitroglycerin, that well-known “under the tongue” medication, works to ease chest pain by the release of nitric oxide. This drug has been in use for well over 100 years, but until researchers in 1988 discovered nitric oxide’s function with regard to dilating dilate blood vessels, no one knew how it worked. Interestingly, Alfred Nobel, of the Nobel Prize fame, made his fortune in nitroglycerine, which is also involved in the creation of dynamite. When he died, his heirs were astounded to learn that he had left the bulk of his fortune to create the Nobel prizes that are have become so prestigious. Ironically, the man whose name became synonymous with the most destructive weapon the world had yet seen, dynamite, went on to establish these coveted awards for intellectual achievement and peace. Furthering this irony, in Nobel’s later years he suffered a heart condition which caused him to have severe angina pain, and his doctor recommended he take small doses of nitroglycerine! He refused, unwilling or unable to believe that the explosive substance he knew so well could help, not harm, the human body. John P. Cooke, M.D., director of vascular medicine at Stanford University’s medical school, states, “NO is the body’s own form of nitroglycerin. In fact, heart patients would not need to take nitroglycerin if their vessels were making enough NO. I


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sometimes tell heart patients to think of a healthy endothelium as a lifelong supply of nitroglycerin.”9

Large efforts are currently being made in the pharmaceutical industry, to find more powerful and selective heart drugs based on this new awareness of nitric oxide and its role in blood vessel maintenance and health. However, it seems that a natural substance, such as the proprietary blend of Noni extracts is the superior answer, without the side effects so common to pharmaceutical drugs.

NO HELPS TO REDUCES HIGH BLOOD PRESSURE According to recent figures supplied by the American Heart Association, about 65 million Americans age 20 and older have high blood pressure, or nearly 30%. Of these, 63% are unaware of the condition. High blood pressure or hypertension means that the heart has to pump harder to push blood through narrowed vessels. High blood pressure is also a frequent cause of, and risk factor for, stroke, heart disease (including heart attack), and kidney failure. Once again, nitric oxide helps relax the muscles in the walls of the vessels, thereby helping to lower blood pressure. NO, via the extracts of the Noni tree, can be a useful adjunct to help these millions of people in normalizing their blood pressure along with, of course, the diet and exercise of a healthy lifestyle.

Remember my patient, Sonny, who had struggled with high blood pressure for so long? He is one of thousands around the world who have discovered that a proprietary blend of Noni extracts can achieve what

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drugs, diet and exercise could not.

NITRIC OXIDE AND PAIN RELIEF An enormous number of people regularly suffer from pain, dramatically reducing their quality of life. A 2005 USA Today/ABC News/Stanford University Medical Center poll showed that 19% of American adults, or almost 1 in 5, suffer from chronic pain and 44% have acute or short-term pain. These were attributed to medical injury or to joint pain, heart disease or cancer.10

When you are in pain, it is hard to think about anything else. Nothing else seems to matter much- all you can think about is being pain-free. Or finding a way to live with it somehow. So how does pain work and what happens in the body? Pain may be anything from unpleasant to agonizing, but it does have a function; it is actually a necessary survival instinct. It is the reflex that makes you whip your hand away from that hot stove in a reaction that seems faster than thought. It is the instinct that forces you to avoid using a muscle that needs to rest after an injury. In this regard, pain has a positive outcome. But when chronic pain from inflammation or an injury continues unabated, it seems to have no rhyme or reason. We just want it to stop. All pain, indeed all sensation, results from the functioning of the nervous system, that incredibly complicated web of nerves and cells and messengers that communicates sensory information. From the brain to every cell in the body, the nervous system handles the messages for such sensations such as cold, touch, and heat, and of course pain, from bruises, sprains, and from other more chronic sources such the inflammation of arthritis. Many drugs are prescribed for pain relief. Scientific research shows that the pain relieving effects of the medications like morphine, aspirin, and oxycontin are due to the release of Nitric Oxide.11 Take tennis elbow, for example. An interesting


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Australian study recently proved that the pain of chronic tennis elbow is relieved by topical application of nitric oxide.12 This is great news for all the people who have suffered from this difficult-to-treat injury. Taking a proprietary blend of Noni extracts, or even applying it topically, can help pain sufferers without the harmful side effects and possible addiction so often caused by pain killers. During my lectures I ask that people email me with the results of taking the proprietary blend of Noni extracts. Cassandra, an Australian model, wrote me of her experience of pain from an injury. “I am a black belt martial arts champion and I had a bad fall training for the Olympics about eight years ago,” she wrote. “I damaged my neck and teeth and I have to say I have had no neck or back pain since I started using a proprietary blend of Noni extracts! I am feeling so great. Today I don’t know what to do with out this product.” Then there is the case of Lene Jensen of Scandinavia. She told me that her ex-fiancée gave her a spray bottle of the proprietary blend of Noni extracts early in 2006. He had told her that it could help all kinds of conditions, and had pain relieving qualities. She reported, “The next morning when I should start on the product I woke up with a very bad toothache. I don’t know why but I grabbed the spray and sprayed it on my bad tooth. In 2-3 minutes the pain disappeared 100%. This is WILD!”

“Taking a proprietary blend of noni extracts, or even applying it topically, can help pain sufferers without the harmful side effects and possible addiction sooften caused bypain killers.”

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Eric Mortensen, of Denmark, wrote me the following email: “Hello, my name is Eric Mortensen: In two days the proprietary bland of Noni extracts cured me of terrible stress, a bad headache migraine and sleeplessness. In five to nine days it helped my back pains, eczema on two fingers that no doctors or other health specialists had been able to cure for several years. During the last 3 years I have taken 12 strong headache pills each day to relieve awful headache pains and pressure in my forehead. “To sleep I have had to take one or two sleeping pills. Without these pills I could not sleep. Since day two on the proprietary blend of Noni extracts I have not taken one single pill, and all the above mentioned pains and problems are gone by the wind. Now 14 days later I feel much younger in every part of my body. I focus much better, I remember much better and it is easier to concentrate. I need to say that my sex life has improved a lot. I feel that I have got much more energy here, and have become more sensitive. My fiancé has exactly the same experience. “Beside this I can really feel that my legs have much better blood circulation and today and I can walk and walk where I before got acid in my legs when I walked too fast.” Another wonderful testimonial came in at the last minute, and almost didn’t make the book. But it was so exciting I held up the presses to get it in. Listen to this, sent in an email to me from Claus B. Henriksen, of Denmark: “I realize that I may be too late for a testimonial for Dr. Qutab’s book, but I find my wife’s personal experience so interesting that I want to tell you about it. “My wife has MS and the past six months she has encountered increasing spasms in her legs, particularly in her


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right leg, from the thigh to under her foot. These spasms are either involuntary, or triggered by movement, touching, laughter or coughing. Three times a day she takes three full droppers full of the proprietary blend of Noni extracts. It has improved her circulation and her lower extremities are not as cold as they used to be. But it has made no different to the violent pain caused by the spasms. “About three weeks ago she decided to distribute/rub some drops of the extract on the muscles that spasms and the result is staggering. For up to three hours she experiences almost no spasms. “Because of her experience a dear friend of ours, who also has great pain, but in connection with her menstruation, decided to rub some drops on her lower abdomen, which gave her great pain relief. “Furthermore she was very unfortunate two days ago, getting a second degree burn on two fingertips, touching a very hot plate on our electric stove. Obviously she experienced a violent pain and skin on her fingers turned white. For five hours she kept the fingers in ice cold water, but the pain continued. I suggested that she tried the proprietary blend of Noni extracts. And guess what. The pain disappeared almost completely. Again for about three hours. She kept applying it regularly and today, her fingers almost look as if nothing had happened. No visible scars, though the affected area is a little reddish and the skin a little tight. “This information may not be new to you or the doctors on the medical board, but I find it significant and would like to make a comment. I believe that the above gives basis for considerations of a special lotion with a much stronger concentration. Whether this would bring relief for a period longer that three hours I do not know, but maybe it is possible to produce a lotions that has a


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slower and long term release of the active ingredient.” What an incredible story.

NITRIC OXIDE AND SEXUAL FUNCTION One of the hottest topics surrounding nitric oxide and its uses in the body is with regard to sexual health. Research is beginning to show that smokers, or those with atherosclerosis, high blood pressure, or diabetes may have less nitric oxide in their bodies, which can lead to impotence. Since the discovery that it is nitric oxide which dilates blood vessels in the penis to initiate and maintain erections, pharmaceutical companies have jumped to create drugs to make use of this fact. Prolonging the vasodilation effect of nitric oxide is the mechanism by which medications like Viagra, Levitra and Cialis help millions of men with erectile dysfunction or impotence. However, the proprietary blend of Noni extract releases nitric oxide to aid in sexual health without the side effects related with those medications. On a recent lecture tour in the UK, I again asked for people’s experience of using the proprietary blend of Noni extracts. Marjorie Beauchamp, from England sent me a short, amusing email: “This product, the blend of Noni extracts that I have been taking… it’s a powerful Aphrodisiac ... I won’t reveal more ... my husband and I can only say WOW, WOW, WOW!” I think her point is well made.

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NO IMPROVES FERTILITY Nitric oxide has other beneficial effects in the sexual arena- it holds important functions with regard to fertility. After the sperm reaches the egg, it releases nitric oxide, killing and preventing the other competing sperm from entering the egg. Nitric oxide also helps the women’s fertility by keeping their ovaries youthful and extending the reproductive age. Taking a substance that increases the nitric oxide effect such as the proprietary blend of Noni extracts can help maintain reproductive health and vitality in both sexes.

NO AND WEIGHT LOSS Within the cells of your body are the tiny mitochondria, the sites where food and oxygen is miraculously turned into energy for you. These microscopic parts of cells are actually major

powerhouses. In addition to generating almost all of the energy you use, and controlling your cellular metabolism, the mitochondria are where all your fat is burned- both dietary fat and stored fat. Research suggests that nitric oxide not only stimulates

Fertility improves withnitric oxide


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the creation of new mitochondria13, but also may make each individual mitochondrion larger, which helps them to burn even more fat and therefore, could help you to lose weight. Many of my patients and the people who come to hear my lectures on the effects and benefits of nitric oxide have told me about the weight they have lost on the proprietary blend of Noni extracts. Many of them were taking it for other complaints, but noticed the weight loss as a side bonus! Beverly Morrison, one of my patients in my clinic in Massachusetts, had been trying for years to lose some weight, but could never get it off, or keep it off. She wrote of her experience: “After a five-year struggle with excess weight I lost 15 pounds in 60 days. I decided to have a mini-body cleanse supervised by Dr. Abbas Qutab, followed by a daily regimen of Noni juice and a nitric oxide supplement (the proprietary blend of Noni extracts). I took two droppers full three times a day and also two tablespoons of Noni juice. The mini cleanse provided the metabolic boost that my system needed and the nitric oxide gave me the sustained energy to increase physical activity. Months later, I am delighted that I have kept the weight off and exercise daily for at least 30 minutes.”

NO AND ENERGY “I just have so much more energy.” I hear this statement more than any other from the folks who approach me after lectures, or write to me, after trying the proprietary blend of Noni extracts. With our lives getting busier and busier, and everyone pushing to achieve more in each day, more energy seems to be a great gift. You know how you usually feel so much better after

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a brisk walk? This is due to the generation of nitric oxide in your body. Exercise increases NO, and taking a substance that increases NO increases your energy to exercise, and so forth. Taking the proprietary blend of Noni extracts to increase NO and exercising is a great combination! NO, as we have seen on the section regarding cardiovascular health, causes blood vessels to dilate, which keeps blood flowing to all tissues. Blood carries oxygen, glucose (a type of sugar) and other nutrients. Once oxygen, glucose and nutrients enter the cells, the highly efficient mitochondria generate energy for all bodily functions. A deficiency of NO of course then leads to less than normal blood flow, which then decreases the delivery of glucose and oxygen to cells and organs. So by that same reckoning, the optimum availability of NO can lead to higher energy levels for normal daily activity, plus more specifically for exercise regimes and sportsmen. Frazer Goodman, a jazz musician in Australia wrote to me with these comments: “Wow, for me the proprietary blend of Noni extracts has given me much more energy and also I feel strengthening in my legs and a sense of wellbeing. I notice also that my stress level especially under the heat has been more tolerable. It’s been amazing.” Bryan Prettyman, here in the US, said the following: “My daughter has more energy and is not falling asleep in class and getting all of her homework done now in school. She has more energy during basketball games as well and is healing from a sprained ankle much faster. Rachael, a friend of mine, said she felt more energy within two days, less stress and a better overall mood. She has also noticed her skin tone changing. Another friend, Mark, tells me he lost 5 lbs in a week and has more energy.

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“As for me, I have way more energy, less stress, better mood, and think I am much more clear and focused. My back hurts less as well. I have also noticed a stronger sexual drive. Lots of good things happening.”

NO AND EXERCISE/SPORTS Lasse Rouhiainen, from Finland, really noticed the effects on his exercise routine and sports: “I’m normally quite healthy, but I have noticed some amazing effects that the proprietary blend of Noni extracts gives me. I sleep better and less hours than before. I take it before and after going to the gym or doing sports and it really helps a great deal! I truly believe this product will help make peoples’ lives better.”

NITRIC OXIDE REDUCES INFLAMMATION There is an extraordinary number of people globally who suffer from inflammatory disorders: In the USA alone the figures are:

Nitric oxide inhibits inflammation in blood vessels by blocking the inflammation that occurs in damaged endothelial cells. If these cells become damaged or dysfunctional NO production is impaired which leads to more inflammation and

Inflammatory Diseases in the United States

Arthritis (all types) - 70 millionAllergies - 39 millionAsthma - 17 millionCardiovascular Disorders - 60 million


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tissue damage- a very vicious cycle. From there it is an easy step to the many other inflammatory diseases that haunt our society today; hypertension, obesity, high cholesterol, diabetes, arthritis, lupus, and many other syndromes. For these millions of people who suffer from inflammatory disorders, a heightened nitric oxide effect from a substance such as the proprietary blend of Noni extracts could be extremely beneficial. Henrik Lundin, an ice hockey player in Sweden, wrote to me that he feels stronger, and his inflammation from previous injuries has been reduced, since regularly taking the proprietary blend of Noni extracts. This is what he said: ”When I used to play ice hockey, (I stopped playing as professional in 2002) I always had problems with the upper part of my feet, especially in the beginning of every ice hockey season. I always tied my skates hard on the upper part of the skates to balancing better on the ice. I always got inflammation after a few days of training, causing me to try everything from warm feet baths, using Tiger Balm and various drugs a lot. Sometimes it was so bad that I could not train with my team for many days. “In November 2005 I spoke to a friend who was playing ice hockey in my hometown who invited me to come and train with a 2nd league team in Sweden. I continued the training with this team and of course inflammation hit my feet again. At the same time a friend sent me the proprietary blend of Noni extracts which I took for two days and my feet were cured. It must be that product that cured my inflammation- that this product helped me with my inflammation is great, but even better is that I feel stronger, full of energy and more clear-minded than I did before.” Eczema, that itchy unpleasant skin disorder, is also


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considered an inflammatory disease. Martin Florian Toby, from Denmark, wrote me an email after taking the proprietary blend of Noni extracts, very pleased that his eczema was so improved: “I was introduced to this proprietary product by a friend. After using it for two weeks twice a day, the eczema on my face disappeared. For six years I had suffered from this eczema so today I’m very happy. My children also had a very bad cold and flu that also disappeared in the same period.” Fibromyalgia is another painful inflammatory illness that you may have heard of. It involves widespread pain, especially in specific tender points in muscles, plus a long list of symptoms including fatigue, irritable bowel syndrome (constipation or diarrhea), chronic headaches, sleep disorder, and dizziness. I recently received an email from a woman in Sweden, Karin Clizbe, who has found great relief using the proprietary blend of Noni extracts. Here’s what she said; “I have fibromyalgia and also Morbus Dercum [a rare syndrome which includes fatigue and painful swellings of the fatty tissue] and have lots of pain and other problems. I have started to take the proprietary blend of Noni extracts and am sleeping in a better way. I start to feel an inner peace combined with more and new energy! With my best regards from Sweden, Karin Clizbe.”

NITRIC OXIDE IMPROVES DIGESTION NO is heavily involved in the processes of your digestive tract. It regulates blood flow to the gut, which helps you digest your food, and keeps the lining of the gut whole and undamaged to protect you from invaders such as bacteria, viruses, fungi, and parasites. It also actively is able to kill off those invaders by its action. NO also helps to keep the intestines moving properly.

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This is called peristalsis, and is what makes food move smoothly along the intestinal tract being absorbed as nutrients, and finally being expelled as waste. It also helps to control the relaxation of muscle along the intestinal walls, and the function of the valves, called sphincters at the bottom of the esophagus, at the bottom of the stomach where it joins the duodenum, and the ileocecal valve where the small intestine meets the large. So people who suffer from spasms of these valves, or those with IBS, Irritable Bowel Syndrome, may benefit from a heightened level of NO in the body. Once again, many of the people taking the proprietary blend of Noni extracts find that they have improved digestion reduced constipation. It seems to be one of the first things to improve, along with a general sense of wellbeing and improved energy.

NO AND THE IMMUNE SYSTEM Another main function of nitric oxide in the body is its contribution to the immune response. NO acts as a powerful weapon against infections. It acts as a signaling molecule between immune cells, and is produced in white blood cells, such as macrophages, which are large cells which destroy invaders. Macrophages use the toxic effects of NO, in large quantities, to kill invading viruses, bacteria, fungi, and parasites. Studies show that viruses, including HIV, multiply less rapidly when exposed to nitric oxide, and that NO can destroy invading organisms that are hard to kill by any other method.

“Nitric oxide acts as a powerful weapon against infections. It acts as a signaling molecule between immunecells.”

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As we saw earlier in the section on NO and digestion, various pathogens (bacteria and viruses) can enter our bodies through the digestive tract with our food intake. By taking the proprietary blend of Noni extracts, nitric oxide is released in the stomach which can kill the bacteria and other pathogens that may have been swallowed in our food.

NO AND THE PREVENTION OF CANCER Key players of your immune system, your white blood cells, use nitric oxide to defend against cancerous tumors. Several scientific studies show that nitric oxide can inhibit cancer cells, and there is much research being conducted with an eye to creating drugs that will release nitric oxide releasing agents as a tumor defense mechanism.14 15 16

An exciting study was conducted by researchers from the University of Hawaii led by Annie Hirazumi. Mice with the deadly Lewis Lung Carcinoma were treated with Noni extract, and subsequently their life span was significantly increased between 105%-123%. The experiment was repeated on a different lot of mice with similar results. The researchers concluded that the Noni juice “...seems to act indirectly by enhancing host immune system involving macrophages and/or lymphocytes.”17 18

Another cancer trial published in the cancer journal, Angiogenesis, looked at the effects of Noni juice on tumors; it was found that Noni was highly effective in reducing both the growth rate and the proliferation of malignant tumors.19

Cancer is one of the leading causes of death in America today, and one in four Americans will have some form of cancer in his or her lifetime. So logically it makes sense to increase nitric oxide in our bodies to help prevent various cancers. And we can do that by taking the proprietary blend of Noni extracts.


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NO AND INSOMNIA Insomnia is an increasingly common and debilitating problem for many people. They may have difficulty falling asleep, may wake up often during the night, wake too early, or feel that their sleep is just not refreshing. Unfortunately, according to the National Sleep Foundations nationwide polls, 58% of adults experience symptoms of insomnia a few nights or more per week, 29% experience it every night or almost every night, and 68% report that sleepiness interferes with their concentration and makes handling stress on the job more difficult. Frighteningly, 19% report that they have dozed off while driving during the past year. So insomnia is becoming a chronic problem that has a major impact on how people function during the day. It can cause irritability, poor judgment, and as you can see, can increase the risk of accidents. It can also worsen existing medical problems and lead to new ones, since so much physical and mental rejuvenation takes place when we are sleeping. Once again, adequate levels of nitric oxide may help- it has been shown that nitric oxide plays an important part in the initiation and continuation of good sleep. Various studies have concluded that when nitric oxide formation is suppressed or interfered with, normal sleep mechanisms are also suppressed.20 21

Tony Ejem, a fashion photographer from Canada, found relief from his insomnia within days of taking the proprietary blend of Noni extracts, and he emailed me about his experience.

Nitric oxide is important for good sleep

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“When I was introduced to the proprietary blend of Noni extracts by a friend, I was very excited. After my first two bottles arrived I started to take the recommended dose right away. I had suffered for many years with severe insomnia -not being able to sleep without taking strong sleeping pills every night. “I have been involved in sports for all my life (martial arts, tennis, downhill skiing, windsurfing etc.) on the competitive level. I was injured many times over the years and had to deal with a lot of pain in my lower back and my neck. In the last five years I have had to take some strong painkillers to be able to function on a daily basis. “Lately I started to experience even more stiffness in my neck along with very painful migraine headaches as a result of long hours I have to spend working on the computer as a professional photographer. I went through a body cleansing for the first three days on the product. I went to bed on day four and slept for very first time without any pills. This has not changed since then. My back and neck pain decreased 60% in three weeks and my headaches are gone. “I started to share the product with some of my friends and heard many wonderful testimonials in almost every case. I believe I will get stronger and get even better quality of life as I continue to use this product every day.”

NO AND DIABETES According to the American Diabetes Association, there are approximately 20 million Americans who have diabetes, which is around 7% of the population. And the percentage has been growing, unfortunately, in parallel with the increase in obesity which plagues our society. Research has consistently shown that people suffering diabetes have a reduced amount of nitric oxide in their bodies.


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In both Type 1 and Type 2 diabetes blood and urine tests show reduced levels of nitrates and nitrites, which indicate a lessened ability to generate NO. This leads to poor circulation, including heart disease, kidney problems, damage to the retinas of the eyes, loss of feeling in fingers and toes (peripheral neuropathy), and slower or otherwise impaired wound healing. The reason why NO is under produced in diabetics is not completely understood by scientists and researchers at this point. One possibility may be that diabetes leads to an accumulation of acid molecules, which is called acidosis, in the body. This is due to the fact that the main dysfunction in diabetes is a reduced ability to process sugar into energy. The result is too much acid in the body. Acid cells tend to suppress the production of nitric oxide, or use up available stores of nitric oxide.22

Another possibility for NO underproduction is that diabetics may have less NO in their systems due to a destructive process caused by the diabetes itself, which causes oxygen radicals to destroy or inactivate NO at an accelerated rate.23 Or it may be the fact that those with diabetes seem to be less able to generate nitric oxide from L-arginine. It may even be that low L-arginine intake in the diet or lack of exercise leading to low oxygen in the body may contribute to the diabetic’s reduced NO state. Or it may be all of the above factors combined. In any event, many people with diabetes struggle with many health issues. One is relating to the nervous system. Diabetics tend to experience a loss of sensation, a phenomena that is caused directly by an abnormality in nerve function. The damage to nerves, leading to a loss of nerve function, is in great part due to poor circulation caused by decreased production of, or loss of, NO. One example of this is in the diabetic patient’s digestive track. NO’s role as an important signaling molecule makes it vital


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to the messaging system which controls smooth muscle cells. This regulates the movement of food through the digestive track, called intestinal motility, or peristalsis. It is the reduced levels of NO in these patients that may be the cause of nerve dysfunction in the stomach, called gastroparesis, that delays or stops stomach emptying. The unpleasant and uncomfortable result for the diabetic is nausea, vomiting, bloating, and weight loss. They need increased levels of available NO to bring greater blood flow, with essential oxygen and nutrients, to those vulnerable nerve cells.

Since diabetics have a lessened ability to generate NO from L-arginine, simply adding more arginine-rich foods to the diet does not help. It is powerful new knowledge that the proprietary extracts of Noni can, without depending on L-arginine, directly supply high levels of nitric oxide to the diabetic patient. Finally, if that wasn’t enough for the diabetic patient, nitric oxide also mimics insulin action in moving glucose out of the blood and into cells.24 One could speculate that perhaps nitric oxide intake via the proprietary blend of Noni extracts might lead to a lessened need for as much drug usage for the control of blood sugars. I look forward to hearing from more diabetic patients in the future.

NO AND THE BRAIN Research on nitric oxide’s role in the brain is currently

Noni extracts can supply nitricoxide to diabetics

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revealing some of the most exciting advances of knowledge in biology. NO is distributed everywhere throughout the brain, and may have an involvement in almost all of its normal physiological functions. It is unlike any known neurotransmitter; unstable, and seems to be produced when needed by neurons. As we have seen earlier, acting as a messenger between cells is one of its primary functions throughout the body, but this is especially true in the brain, where there is more of the enzyme that creates NO, nitric oxide synthase, than in any other organ of the body.25

Many studies are being conducted with regard to NO’s brain and nervous system connection, and researchers are suspecting that NO may turn out to be the molecule that is at the basis of learning and memory. Simply put, a cell in the brain is responsible for releasing a chemical messenger called glutamate, which stimulates another cell, a receptor cell, with this chemical to release nitric oxide. If it is strongly stimulated, the receptor sends back an NO molecule to tell the sender that the message was received, and asks it to send an even stronger message next time. This cycle is known as “long term potentization”, a fascinating and normal path that creates memory. NO is also certainly involved in behavior, as it is the neurotransmitter found in a number of nerve pathways within brain regions that regulate the emotions. In a very interesting study conducted at Johns Hopkins University, mice were specially bred without the gene that enables them to make nitric oxide in the brain cells. These mice turned out to exhibit dramatically more sexual and aggressive behavior than normal mice. Because this behavior was heightened, it appears that removing the gene causes a loss of social inhibition. One of the co-researchers of this study, Dr. Solomon Snyder, director of the Department of Neuroscience at Johns Hopkins, said, “… nitric oxide may be the neurotransmitter that puts a brake on our social behavior.

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The highly aggressive behavior in mice whose brains cannot make nitric oxide appears to be the most pronounced change in aggression ever associated with a neurotransmitter.”26 27

In this same study, it was noted that there were emotional changes to these altered mice, with regard to fear. When confronted with a situation that would cause a normal mouse to be hesitant, the study mice acted fearlessly. The findings could, of course, have significant implications for studying human aggressive and violent behavior, but much more research is needed. As well as looking at NO’s involvement in normal brain function, scientists are also investigating its involvement in pathology or disease. Problems in the brain that seem to be related in some way to nitric acid production are schizophrenia, multiple sclerosis, and strokes. Since nitric oxide can prolong cell life, it may be an effective way to treat certain diseases where cells die prematurely, such as Parkinson’s disease and Alzheimer’s disease. I regularly recommend that my patients take the proprietary blend of Noni extracts, and it is wonderful for me to see them feeling better. I often see improvements in brain function such as learning and memory. How exciting it is that this source of beneficial nitric oxide has been discovered and made available to all of us.

NO AND WOUND AND FRACTURE HEALING For wounds or fractures to heal properly, there must be an adequate supply of NO, which regulates cell division and proliferation necessary for tissue repair, as well as ensures that cells mature, and collagen is synthesized.28

Let me explain just a little of how this works. When NO stimulates cell division, one cell becomes two, two cells become


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four, etc. There are 10 to 20 growth factors that are involved in this process, and several of these simply can not complete their function with out nitric oxide. Besides NO’s importance to cell proliferation, it is also involved in making sure that each new cell is identical to its parent.

As cells proliferate, they must become mature cells capable of responding to external signals. If there is not an adequate supply of NO for these processes, normal maturation does not occur, so a cell cannot recognize, process and transmit information from outside of the cell to the cell interior. The bottom line is that wound healing cannot occur.

Nitric oxide also protects the wound while it is healing, by effectively reducing the number of dangerous cells including bacteria and fungi which may infect the wound. In this way nitric oxide may promote the health of certain cells and tissue. An interesting study with wounds of diabetic patients found not only that nitric oxide production is reduced in those with non-healing wounds, but that healing would only occur when that deficiency of NO was corrected. There proved to a critical level of nitric oxide production that is essential for healing.29

NO is also involved in the healing of bones. Researchers at the Orthopedic Research Institute, at the University of New South Wales in Australia found that after a fracture, NO activity was found in the broken area, rising to a peak on the 15th day after the break. They double checked this finding, wishing to ascertain the dependence of healing on the nitric oxide, by

“Work with nitric oxide is creating promising methods of treating bone fractures and also bone diseasessuch asosteoporosis.”

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using an inhibitor of NO. A significant decrease in healing was observed in the rats that had been given the inhibitor. These results show for the first time that NO is generated in the body when a fracture takes place and that supplementation of NO can reverse the slowness or inhibition of healing produced by NO inhibitors.30

Studies testing substances that increase the amount of NO have shown an increase in bone mass in experimental animals, and early evidence suggests that the same applies in humans. Work with NO is creating promising methods of treating bone fractures, and also bone diseases such as osteoporosis.31 32

NO AND TRAUMA As you’ve seen throughout this book, nitric oxide has powerful benefits for many chronic disease conditions common to man. But it also offers benefits for acute problems such as trauma treatment, as well. NO is used in the intensive care hospital setting to give significant improvement to patients in respiratory distress, and it even saves lives. In another example, treating Down’s syndrome babies with nitric oxide before and after cardiac surgery gives much better results than using simple oxygen.



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FINAL THOUGHTS Research into all the potential clinical applications of nitric oxide is still in early days, but is extremely promising, and has come a long way in a relatively short time. With NO’s involvement in so many aspects of physiological function, everything from blood pressure to sexual health, this unstable gas, this tiny simple molecule, is one of the bright stars on the horizon for drug companies around the world. They are in a race to create drugs that will treat a whole gamut of human disease. Some of these will hopefully be useful and indeed beneficial in extreme circumstances. But unfortunately, in too many instances pharmaceutical companies look for a synthetic drug that they can patent, which usually comes with a host of side effects, some dangerous, as I am sure you are only too aware. But those of us who know about Noni, and its proprietary blend of extracts, are in a fortunate position. We can ingest a natural, gentle plant substance which generates healthful levels of nitric oxide in our bodies, to benefit from the numerous protective and healing qualities of NO. Research is essential for the ongoing understanding of nitric oxide’s functions in the body, but for our purposes, as consumers, sometimes it is more powerful to hear the accounts of other peoples’ experiences with a product. As I plowed through the hundreds of testimonials that I have received, one stands out in particular. Anita Granoe of Norway praises the nitric oxide effect in so many health areas that I couldn’t decide where to put it in this book! So here it is: “I can’t praise the proprietary blend of Noni extracts enough. After I started on these drops I have got my inner peace back, I feel much more fresh and with much more energy, but in a relaxed way.

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“Many hours in front of a PC screen each day means that I often feel dizzy and have headache, but this has almost disappeared now. I have not needed to take any pain relief pills since I started on the drops. “Besides this I feel that my quality of sleep has been much, much better. Before I almost never felt rested but now I wake up fresh and fit each day. I sleep more hours in a deep sleep. Before I had a light sleep and often woke up. “When my daughter became ill with a very high fever, I gave her the drops, and the day after, believe it or not, she was free from fever. “I have tried a lot of health products before but NEVER discovered an effect that comes near to the proprietary blend of Noni extracts. At last a product that really keeps what it promises. I can give my warmest recommendations!” As a busy doctor working with health problems every day, so can I!

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END NOTES1Talan, Jamie. “The healing powers of nitric oxide.” Montreal Gazette. Sep 26, 1993, C5.

2Ruddell, WSJ, et al. “Nitrite and thiocyanate in gastric juice.” Gut. May, 1976;17(5):401.

3

4

5Leary, Warren E. (2003) “Study Finds That Nitrites in the Body Greatly Aid Blood Flow.” New

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8Mott, Gregory. “For Your Heart, Just Say NO.” The Washington Post: Sept 10, 2002, 2

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clinical trial.” Am J Sports Med. 2003; 31:915–20.

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Vol. 299. no. 5608, 838 – 839.

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Iss 2, 143 – 149.

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i4 pR1048.

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BIBLIOGRAPHYArticles and StudiesGuo, FQ, et al. “Identification of a plant nitric oxide synthase gene involved in hormonal signaling.” Science 302, 10/03/2003; 100-3

Del Rio, LA, et al. “Nitric oxide and nitric oxide synthases activity in plants.”Phytochemistry 65(7), 4/2004, 783-92.

McKnight, GM, et al. “Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans” Gut 40(2), 2/1997, 211-4.

Hirazumi, A, et al. “An immunomodulatory polysaccharide rich substance from the fruit juice of Morinda citrifolia (Noni) with anti tumor activity.” Phytother Res.(5), 8/13/1999; 380-7.

Zaragoza, Saura, et al. “An antiviral mechanism of nitric oxide: inhibition of a viral protease.” Immunity(1), 1/1999, 21-8.

Sanders, SP. “Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line.” J Virol. 72(2), 2/1998, 934-42.

Moncada, S, et al. “The discovery of nitric oxide as the endogenous nitrovasodilator.” Hypertension 12(4), 1988, 365-372.

Ignarro, LJ. “Nitric oxide as a unique signaling molecule in the vascular system: a historical overview.” J Physiol Pharmacol.53(4), 2002, 503-514.

Gong, L, et al. “Nitric oxide signaling: systems integration of oxygen balance in defense of cell integrity.” Curr Opin Hematol. 11(1), 2004; 7-14.

Snyder, SH, Bredt, DS. “Biological roles of nitric oxide.” Scientific American 266(5), 1992, 68-71.

Nathan, CF, Hibbs, JB. “Role of nitric oxide synthesis in macrophage antimicrobial activity.” Curr Opin Immunol.3(1), 1991, 65-70.

Kanner, J, et al. “Nitric oxide as antioxidant.” Arch Biochem Biophys 289 (1), 1991, 130-136.

Welch, G, Loscalzo, J. “Nitric oxide and the cardiovascular system.” J Card Surg 9(3), 1994, 361-371.

Kranz, JC, Jr, et al. “Mechanism of action of organic nitrates.” J Pharmacol Exp Ther 70, 1940 323-327.

Hishikawa, K, et al. “Role of L-arginine-nitric oxide pathway in hypertension.” J Hypertens. 11(6), 1993, 639-64.


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Gornik, Heather, Creager, M, “Arginine and endothelial and vascular health.” The Journal of Nutrition. v134, 10/2004, p2880S(8).

Paoloni, JA, et al. “Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial.” Am J Sports Med 31, 2003, 915–20.

Moncada, Salvador, Higgs, Annie. “The L-arginine-nitric oxide pathway. (Review Article), The New England Journal of Medicine v329 n27, 12/30/1993, p2002(11).

Bratasz, Anna, et al. “Generation of nitric oxide as a predictive parameter in medicine.” Current Topics in Biophysics 26(1), 2002, 129-136.

Furchgott RF, Zawadzki JV. “The obligatory role of endothelial cells in the relaxation of arterial smooth muscle.” Nature 288, 1980, 373-6.

Palmer, RMJ, et al. “Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.” Nature 327, 1987, 524-6.

Ignarro, LJ. “Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.” Acad Sci (USA)84, 1987, 9265-9.

Moncada, S, et al. “Nitric oxide: physiology, pathophysiology and pharmacology.” Pharmacol Rev 43, 1991, 109-42.

Petros, A, et al. “Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock.” Lancet 338, 1991, 1557-8.

Younos, C et al. “Analgesic and Behavioral Effects of Morinda Citrifolia, Planta Medica 56, 1990, 430-434.

Bai, T. R. et al. “Effect of an Inhibitor of Nitric Oxide Synthase on Neural Relaxation of Human Bronchi.” Am. J .Physiol., 264, 5/1993, L425-L430.

Barinaga, M. “Is Nitric Oxide the Retrograde Messenger?” Science, 254, 11/29/1991, 1296-1297.

Bredt, D. S., et al. “Cloned and Expressed Nitric Oxide Synthase Structurally Resembles Cytochrome P-450 Reductase.” Nature, 347, 10/25/1991, 768-770.

Edelman, GM, Gally, JA. “Nitric Oxide: Linking Time and Space in the Brain.” Proc. Natl. Acad. Sic., USA. 89, 12/1991, 11651-11652.

Holloway, M. “Unlikely Messengers: How Do Nerve Cells Communicate?” Scientific American. 267, 12/1992, 52+.

Koshland, D. E. “The Molecule of the Year.” Science 258, 12/18/1992, 1861.

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Koshland, Daniel E. “NO News is Good News.” Science 258, 12/18/1992, 1862-1865.

Lancaster, J. R. Jr. “Nitric Oxide in Cells.” American Scientist 80, 5-6/1992, 248-259.

Murray, R. K., et al. “Nitric Oxide is the Endothelium Derived Relaxation Factor and is Also an Important Compound in the Nervous System.” Harper’s Biochemistry, 1993, pp 657-658.

Schuman, E. MD, Madison,V. “A Requirement for the Intercellular Messenger Nitric Oxide in Lone Term Potentiation.” Science 254, 12/6/1991, 1503-1506,.

Snyder, S. H., D. S. Bredt. “Biological Roles of Nitric Oxide.” Scientific American 266, 5/1992, 68-71+.

Snyder, S. H. “Nitric Oxide: First in a New Class of Neurotransmitters.” Science 257, 7/24/1992, 494-496.

Stroh, M. “The Root of Impotence: Does Nitric Oxide Hold the Key.” Science News 142, 7/4/1992, 10-11.

Young, S. “The Body’s Vital Poison.” New Scientist 137, 3/13/1993, 36-40.

BOOKSIgnarro, Louis. “NO More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse-- Heart Disease and Stroke.” St. Martin’s Press. 2005, New York.

Ignarro, Louis. “Nitric Oxide: Biology and Pathobiology.” Academic Press. 2000, New York.Solomon, Neil, “Noni Juice: How Much, How Often, For What.” Pride Publishing. 2000, Oren, Utah.

Elkins, Rita, “The Noni Revolution: Today’s Tropical Wonder That Can Battle Disease, Boost Energy and Revitalize Your Health.” Woodland Publishing. 2002, Salt Lake City, Utah.

Navarre, Isa. “Getting Started with Noni” Direct Source Publishing. 2004, Vineyard, Utah.

Byrd, Edward. “The Nitric Oxide Revolution: Transform Your Physique in 21 Days.” Medical Research Institute. 2005, San Francisco.

Butler AR, Nicholson, R. “Life, Death and Nitric Oxide.” Royal Society of Chemistry. 2003, Cambridge, UK.

Hukkanen, Mika, et al. “Nitric Oxide in Bone and Joint Disease.” Cambridge University Press. 1998, Cambridge, UK.

Vincent, Steven. “Nitric oxide in the Nervous System” Academic Press. 1995, London.


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About the AuthorDr. Abbas Qutab is the founder of Elan Vi-tal Medical Centers located in Boston and Worcester, Massachuetts. Since they first opened in 1989, these clinics have been the choice of many thousands of people around the world seeking complementary and alternative medicine treatments.

Dr. Qutab holds degrees in medicine, oriental medicine and chiropractic, and has a Ph.D. in Ayurvedic medicine. He is one of the very few physicians in the United Sates who has been awarded an honorary Sc.D. from the World Health Organization Charted University for his work in promoting alternative medicine. Dr Qutab travels extensively and has taught thousands of physicians in the United States and Europe on how to integrate alternative medicine into their practices.

Dr. Qutab is board-certified in naturopathic medicine and has received several leadership awards for promoting complementary medicine. He is on the advisory board of the Congressional Health Care Reforms Committee in Washington, D.C. and in 2003 received the Physician of the Year award. Dr. Qutab has also extensively researched nitric oxide and all of its functions in the body. He has co-authored several books on Ayurvedic medicine.

Documents

Nitric Oxide - Probiotics€¦ · Nitric Oxide: The Molecule of Life 4 Dedication This book is dedicated to my medical staff at Elan Vital Medical Center and our clients worldwide,