National License: Infectious disease

PAGE 9NMLE step I: Infectious Diseases

NL: Infectious disease III Viral infections.. (MED26)Encoded and printed by Maymaykung269 Med34KKU

Proof and pictured by Waen32 MED34

Herpes Simplex Virus

Clinical manifestation skin lesion vesicle genitalia

Herpes simplex virus 2 Type I orolabial (cold sore) Type II genital sexual activity

Herpes simplex Type I : Herpes labialisHerpes simplex Type II: Genital herpes

giemsa (Tzanck test) Multinucleated giant cell herpesvirus clinical diagnosis

Herpesvirus spinal ganglion reactivate

Herpes simplex Acyclovir Oral 3 () complication immunocompromised host Normal host HSV self-limited immunocompromised host spread organ Herpes simplex encephalitis Herpes Temporal lobe Temporal lobe Acyclovir IV formVaricella Zoster Virus

Skin lesion dermatome Varicella zoster Acyclovir 5

immunocompromised host acyclovir visceral complication Herpes zoster meningitis pneumonia Post herpetic neuralgia Herpes Nerve immune Flare up spinal ganglia Tricyclic antidepressants Epstein - Barr virus

Blood smear lymphocyte atypical lymphocyte Epstein - Barr virus Infectious mononucleosis lymph node exudative phayryngitis maculopapillar rash erythema maginatum

Complication EBV CNS complication meningitis encephalitis hemolytic anemia EBV B cells antibody RBC autoimmune hemolytic anemi (AIHA) spleen rupture airway obstruction

interprete lab total white count atypical lymphocyte 90% Hepatitis

EBV oncogenic virus Lymphoma ALL-3 Burkitts lymphoma nasopharyngeal cancer

Steroid Ab Supportive treatment

HSV-8

Kaposi sarcoma HIV

Cutaneous Kaposis sarcoma

Visceral Kaposi sarcoma

Parvovirus B19

Skin lesion (Erythema infectiosum), immune RBC Bone marrow pure red cell aplasia Ab Parvovirus immunoglobulin Immune Influenza virus

(Influenza) upper respiratory tract symptoms

Influenza virus mucociliary respiratory tract dysfunction bacterial on top S. aureus, S. pneumoniae H. influenzae COPD Influenza vaccine post-bacterial on top

Influenza aspirin Reyes syndrome ( liver failure encephalopathy influenza aspirin) aspirin

Complication influenza myocarditis, pericarditis, myositis Guillain-Barr Syndrome 1 encephalitis

influenza antiviral amantadine prophylaxis vaccine influenza vaccine COPD, , 65 vaccine amantadine Influenza type A emerging Avian influenza virus (H5N1)

Enterovirus

encephalitis Rash URI symptom GI symptom complication encephalitis confusion, , drowsiness cranial nerve palsy neurological manifestation

Diagnosis PCR JE virus

JE virus Arboviruses virus

JE transmission 5-15 N/V neuro coma Brain lesion involve thalamus imaging thalamus clinical encephalitis expose cranial nerve palsy conjugate eye

JE encephalitis Mortality rate 1 3 motor weakness, paralysis, seizure, blindness, ataxia, extrapyramidal movement 75% abnormal behavior change CSF profile WBC count , protein , sugar EEG Delta wave CT diffuse white matter lesion basal ganglia, thalamus pons diagnosis IgM titerDengue virus

Arboviruses (Dengue hemorrhagic fever) 3-7 (virus Petechiae ) shock

Dengue Hemorrhagic fever hypovolemic shock () Dengue shock syndrome (DSS) Dengue virus reservoir host CBC Hct 20% Platelet 100,000/mm3 aspirin blood pressure shock plasma vaccine Dengue convalencense rash

Rabies virusRabies virus Rhabdoviridae (Rabies encephalitis) incubation period (2-16 -) connective tissue NMJ peripheral nerve 3 1 (prodomal period) 2-10 2 (acute neurologic phase) 2 1. (Furious rabies) 3 5 2. (Dumb rabies) 3 3 - 7

cerebral cortex, cerebellum, hippocampus dorsal spinal ganglia degeneration axon myelin sheaths spinal cord posterior horn Negri body cytoplasm Negri body Hippocampus Ammon,s horn Rabies virus envelope detergent vaccine