NORSC Presentation. What is iPRD? Founded in 2008 at the University of Leeds Established to...
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NORSC Presentation. What is iPRD? Founded in 2008 at the University of Leeds Established to support chemical companies of all sizes by providing solutions
What is iPRD? Founded in 2008 at the University of Leeds
Established to support chemical companies of all sizes by providing
solutions for product and process development. Research focus
driven entirely by challenges in chemical manufacturing Developing
technologies to improve products and product manufacture: Working
with a diverse range of industries: RobustnessProcess Efficiency
(throughput, waste, energy) Quality ControlEnvironmental &
worker safety issues Product CostSustainability (raw materials,
supply chain) ConstructionAgrochemicalWaste RecoveryDyes &
Pigments (textiles) Personal CareElectronicsMineral ProductsEnergy
& Renewables PharmaceuticalSecurity PrintingAutomotiveFine
& Speciality Chemicals
Slide 3
John Blacker Chris Rayner Professor of Organic Chemistry >20
years experience of working with a wide range of industries
(pharma, cosmetics & power generators!) Director of 3
chemistry-based SMEs (pigmentation, carbon capture) Frans Muller
Prof. of Chem. Process Engineering 17 years experience in
industrial product development (AZ, Syngenta) Focused on the
interaction between process and equipment Expert in Scale up,
mixing, modelling and computer simulation. Management Team Steve
Marsden Professor of Organic Chemistry >30 industrial research
collaborations Secondment in the speciality chemicals industry
examining the challenges in technology transfer between
Universities & industry. Professor of Process Chemistry 19
years experience in the fine chemicals industry (ICI) Technical
Director at Piramal Healthcare. Research interests include
catalysis Inventor on 25 patents Kevin Roberts Brotherton Professor
of Chemical Engineering World expert in the formation and
processing of crystalline solids Application in Process R&D
(PAT) Industrial Fellowship at AstraZeneca Philip Kocienski FRS
Professor of Organic Chemistry New methodology for the synthesis of
biologically active targets >30 years consulting experience with
pharmaceutical and agrochemical industries
Slide 4
Integration of Expertise at iPRD Expertise at Leeds throughout
the product development process Industrial R&D uses integrated
teams of chemists and chemical engineers to solve problems in a
holistic manner iPRD working model reflects the industrial approach
Route design Process design Isolation design Formulation design
Product Concept/ candidate Synthetic chemistry Catalysis Separation
sci/eng Crystallisation Particle Science Physical organic chem.
Reaction engineering
Slide 5
Expertise Chemistry and Process Catalysis Crystallisation/
Particle Science Process Engineering Formulation
Slide 6
Process Laboratory Industry-standard development and scale-up
facilities and procedures 4.8m investment by Yorkshire Forward/EU
(ERDF) 650m 2 refurbished laboratory space Unique facility in
academia worldwide non-aqueous solvent handling capabilities
Projects executed by industrially-experienced scientists Dedicated
laboratory manager and technician On-site mechanical and electrical
workshops Safety training for all staff and students Access to all
University analytical facilities Specialist services provided by
professional partners: iPOS (Agilent Centre of Excellence):
http://www-old.hud.ac.uk/ipos/http://www-old.hud.ac.uk/ipos/
ParticlesCIC (Particle Characterisation):
http://particlescic.org/http://particlescic.org/
Slide 7
Batch Manufacture Remotely-controlled 20 and 50 L reactors
with: 5 L addition vessel 20 L distillate receiver 1 m 2 condenser
variable speed agitator motor pitched bladed agitator ATEX rated
(temperature, gas apparatus) Operational temperature range: -20 to
160 o C Integrated PAT: Temperature sensors (Tr, Tj, condenser,
BOV) Coolant flow meters for vessel jackets and condensers Rotation
sensors on agitator to monitor agitation rate Reaction monitoring
via IR, pH and conductivity probes FBRM (LasenTech) probe for
crystallisation monitoring
Slide 8
Flow Manufacture Flow Reactors Syrris-Afrika Microreactor
2*800ml high pressure cascade CSTR Variable residence time static
mixer 40-200ml/min Oscillating baffled reactor High pressure
fixed-bed catalyst flow reactor Semi-continuous microwave
Mercury-lamp photoreactor Flow Work-up and isolation Continuous
liq-liq extraction Lab-scale thin film evaporator Short-path
continuous distillation Rotary drum filter
Slide 9
Process Development Technologies Specialist equipment available
to aid all aspects of process development: Small-scale parallel
reactors (solubility/reaction screening) Continuous reaction and
work-up assessment High pressure reaction vessels Calorimetry and
Process Safety Crystallisation and Isolation Development 100 m
Slide 10
Current Projects TSB Immobilised Catalyst Project for purer,
lower cost products in more intensive process iPRD, AstraZeneca,
Pfizer, Reaxa, Cambridge Uni TSB Mild, selective extraction of
chemicals from seaweed iPRD, Bd Ayre Products, Critical Processes,
The Body Shop, Independent Cosmetic Advice, Higgins Consultancy
IMI/EUGreen Chemistry for the 21 st Century 20 academic and
industry collaborators across Europe including Durham, York,
Manchester, Leeds TSB Control of crystal growth for integrated
primary and secondary manufacturing iPRD, AstraZeneca, Pfizer,
Syngenta, Avantium TSB Mild, selective extraction of chemicals from
fruit iPRD, Critical Processes, Higgins Consultancy EPSRC
Phosgene-free synthesis of isocyanates for fine chemicals iPRD,
Pfizer
Slide 11
Avoiding going through the mill Pharmaceuticals/agrochemicals
are typically isolated as large crystals of variable size (primary
manufacture) Processing to the appropriate size for formulation by
milling, granulation, or micronisation (secondary manufacture) is
energy intensive & wasteful Leeds technology facilitates
real-time measurement of crystal growth TSB High Value
Manufacturing award - 1.6m project (590k @ Leeds) with Syngenta,
Pfizer, AstraZeneca, Avantium to investigate effects of crystal
growth modifiers on control of crystal size Aim: avoid secondary
manufacture (safer, cheaper, more active products) 100 m
Slide 12
Strategic process and manufacture related R&D using Leeds
and other expertise, public-private funding via individual or
collaboratively funded projects Contract work in process
development, testing and small scale manufacture Students trained
in process R&D Professional development courses Industrial Club
Consultancy and advisory service Industry Offering
Slide 13
Process Design Process Understanding Process Measurement
Technology Design Process Optimisation Bulk ManufactureData
Analysis Physical & Chemical Analysis Renewable Feedstocks
Product Isolation Continuous Processing Materials Safety Analysis
Catalysis Green Chemistry Scale-Up Risk Assessment Understanding
Impurities Process Modelling Waste Stream Reduction & Recycling
PAT Process Understanding Reaction Screening Improving Energy
Efficiency Understanding Bulk Properties Our Research and
Consultancy Services include:
Slide 14
iPRD has an excellent track record of delivering high quality
contract research and consultancy projects All services tailored to
meet clients commercial needs Contracts managed by University KT
professionals (confidentiality, IP) Our experts have a diverse
skill set but a common focus: application of research expertise to
commercial business situations Contract & Consultancy
Services
Slide 15
iPRD Industrial Club iPRD hosts two meetings per year
Brainstorm cross-industry challenges Identify potential areas for
collaboration Showcase iPRD projects and activities Annual Research
Symposium Symposium topics: Green Chemistry Crystallisation
Intensive Processing Process Optimisation Process Modelling (March
2012) Current Members:BakhuPfizerYPTChiralQuest
AstraZenecaEscubedSyngentaLonzaDyeCat BromChemGSKScientific
UpdateDr ReddysDeDietrich
Slide 16
Joint Chemistry/Chemical Engineering activity High quality
students recruited from both disciplines Unique courses to Leeds
University Student bursaries from EPSRC and Industry (3.5k) Get
Involved in Training Scientists for Process Industries Course
Material: Industry-led lectures and workshops Industry-sponsored
laboratory projects for student training Use of large scale
laboratories where appropriate (25 and 50 L reactors) TitleDuration
MSc in Chemical Process Research and DevelopmentOne year Integrated
MSc and PhD (Centre for Doctoral Training) in Chemical Process
Research and Development Four Years MSc in Pharmaceutical Process
Engineering also available
Slide 17
Summary: Acknowledgements: Prof. John Blacker, Prof. Steve
Marsden, Prof. Kevin Roberts, Prof. Xue Wang, Prof. Jonathan
Williams, ERDF, Yorkshire Forward, EPSRC, TSB What is iPRD?
Research Facilities and Infrastructure Working with the Chemical
and Chemical-Using Industries Strategic Process and
Manufacturing-Related R&D Research Collaborations iPRD
Industrial Club Student Training and Professional Development
Knowledge Transfer Partnerships Contract Research and Consultancy
Services