November 16, 2018

Announcements

Saint Francis Opens New Care Center in Glastonbury

Smilow Cancer Hospital at Saint Francis opened a new Care Center in Glastonbury, CT with a ribbon cutting ceremony last week. The new location at 31 Sycamore Street will provide convenient care to our patients east of Hartford. We are grateful to the Savings Bank of Manchester Charitable Foundation, Inc., for their funding support of the new Center.

News Center

Scott Gettinger Named Thoracic Oncology Program DART Leader

I am pleased to announce that Scott Gettinger, MD, Associate Professor of Medicine (Medical Oncology), has been named the Disease Aligned Research Team Leader for our Thoracic Oncology Program. Scott is an outstanding clinician, researcher, and clinical trialist, who has led many of our lung cancer clinical trials, including breakthrough immunotherapy trials. "Scott's leadership will focus the thoracic oncology program on the next wave of clinical and translational research, helping to ensure we have the most innovative treatment options for our patients. I look forward to continuing our work together," said Roy S. Herbst, MD, PhD. In his role as Associate Director for Translational Research, Dr. Herbst will continue to oversee the DART organization for Yale Cancer Center and Smilow Cancer Hospital, as well as the Yale SPORE in Lung Cancer.

Dr. Gary Soffer Joins Integrative Medicine Program

Gary Soffer, MD, Assistant Professor of Clinical Pediatrics, will begin seeing patients at Smilow Cancer Hospital who have been referred for a consultation in Integrative Medicine. In addition to his clinical training in pediatric allergy and immunology, Dr. Soffer will be training with the University of Arizona Center Fellowship in Integrative Medicine in Tucson and has completed a 200 hour

certification as a Mindfulness Instructor. He established Mind Body Medicine, an organized mindfulness group while in medical school at the Sackler School of Medicine at Tel Aviv University, and completed an Integrative Medicine Elective Rotation at Assaf HaRofeh Hospital and at the University of

Thermal Ablation Effective in Early-Stage Lung Cancer

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Stephen Huff Never Smoked a Day in His Life. At 28, He Was Diagnosed With Lung Cancer.

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Local Consolidative Therapy vs Observation in Limited Metastatic NSCLC

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Arizona. He will see patients on Friday afternoons in Smilow on NP 8 and can be referred to directly through EPIC.

Yale Cancer Center Innovation Awards Announced

I am very excited to announce the recipients of our Yale Cancer Center Innovation Awards. Through the generous support of an anonymous donor, Yale Cancer Center has been able to launch 13 ground-breaking scientific projects covering the full gamut of cancer research. The esteemed group of recipients represent the diverse scientific interests of our Center and hails from numerous academic departments across the University and multiple Cancer Center Research Programs. The selection process culled out the most exceptional awards for funding from more than 100 strong applications, which were each reviewed and scored by at least two internal reviewers in an NIH-style study section format. I am hopeful that this represents just the first of many such award cycles, and aim to repeat a similar process annually to continue advancing innovative scientific discoveries at Yale Cancer Center. Congratulations to:

Joseph Contessa, MD, PhD

Project Title: Targeting TRIM16 Mutations in Osteosarcoma

Sarah Mougalian, MD

Project Title: Text Messaging to Improve Adherence in Early Stage Breast Cancer

Lucia Jilaveanu, MD, PhD

Project Title: Regulators of Metastatic Dormancy in Melanoma Cells with Central Nervous System Tropism

Daniel DiMaio, MD, PhD

Project Title: Oncogene Discovery in Unexplored Sequence Space

Mandar Muzumdar, MD

Project Title: Targeting Pancreatic Endocrine-exocrine Interactions for Cancer Prevention and Therapy

Akiko Iwasaki, PhD

Project Title: Exploring the Innate Mechanisms Underlying Cancer Immune Surveillance

Selling a Lifestyle: Men, Women, and Gender in Cigarette Advertising

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Herbst Highlights Next Steps With Immunotherapy in Lung Cancer

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Yale Study Shows Immunotherapy Drug Helps Patients with Metastatic Melanoma

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Carla Rothlin, PhD & Sourav Ghosh, PhD

Project Title: Overcoming Barriers for Effective Brain Tumor Immunotherapy

Farren Isaacs, PhD

Project Title: Elucidating Complex Cancer Pathways by Multiplex Precise Genome Engineering

Mustafa Khokha, MD

Project Title: Regulating β-catenin Nuclear Translocation to Treat Cancer

Claudio Alarcon, PhD

Project Title: Uncovering the Role of Epitranscriptomics in Cancer Initiation and Progression

Rachel Perry, PhD

Project Title: Prevention of Colon Adenocarcinoma by Liver-Targeted Mitochondrial Uncoupling

Aaron Ring, MD, PhD & Bryce Nelson, PhD

Project Title: An Open-Source Proteomic Platform for Single-Cell Dissection of the Tumor Microenvironment

Richard Kibbey, MD, PhD, Principal Investigator

Project Title: High-Resolution, High-Throughput Metabolic Mapping of Cancer Susceptibility and Resistance Pathways

Notables

Craig Crews, PhD, Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry, has been awarded one of two prestigious, five-year, renewable American Cancer Society Research Professorships. Dr. Crews' $400,000 grant will be used to further investigate the use of PROTACs. The aim is to use PROTAC technology to go after cancer causing proteins that are not currently ''pharmaceutically vulnerable'' to expand

Yale Cancer Center Investigators Show Recommended, but Underused Treatment for Rare Blood Cancer Saves lLves

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Yale Cancer Center Finds Patients Choose Cancer Care Based on Hospital Affiliations

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Latest Posts:

Smilow Cancer Hospital welcomes Dr. Nicholas Blondin! Dr. Blondin will care

the number of drug target proteins, leading, it is hoped, to the development of new anti-cancer therapeutics.

Our Head & Neck Cancers Program held a very successful cancer screening at ESPN Headquarters in Bristol on November 6. The team screened 123 employees and referred 15 to Yale Medicine/Yale Cancer Center specialists for follow-up care. For the first time, with the assistance of Deb Kieslich, operations manager for otolaryngology, the team connected ESPN employees in need of a referral with "on-the spot" appointments with our Yale specialists.

Special thanks to Joseph Mendes, PA-C, for coordination of the day, the physicians and screeners, and the Breast Center, Screening & Prevention, and Colorectal teams for hosting fantastic educational tables.

The Head & Neck Cancers Team at ESPN Headquarters

for patients at Smilow Cancer Hospital in New Haven and the Smilow Cancer Hospital Cancer Care Center in Trumbull.

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The Onco-dermatology Clinic at Smilow Cancer Hospital serves the dermatologic needs of cancer patients including very dry skin, itching, rashes, nail and hair changes, skin infections, cancer involvement of the skin, radiation dermatitis, and other changes.

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West Haven, Connecticut Mayor Nancy R. Rossi (far right) participated in the West Haven Breast Cancer Awareness Program (WHBCAP) check presentation to the Breast Center and Cingari Family Boutique at Smilow Cancer Hospital. I

The Developmental Therapeutics Research Program is proud to welcome Lohith Gowda, MD, MRCP. Dr. Gowda is an Assistant Professor in the Department of Medicine (Hematology). As a recent trainee, Dr. Gowda has worked on offering curative intent treatment options for patients with hematologic neoplasms. His initial research as a fellow in Hematology was focused on discovery of a new compound that targets P38 MAPK-Tie2 pathway in myeloid disorders. This compound has now been studied in clinical trials and has shown encouraging results.

Subsequently, Dr. Gowda worked on developing a protocol that involves transfusing novel red cell product in transfusion dependent hematologic malignancies. This work has received FDA approval to begin clinical trials (NCT03056378). Another area of research focus has been to educate patients on appropriate therapeutic decisions that they need to make in an era of increasing drug choices. To facilitate this, Dr. Gowda has developed a predictive model for haploidentical transplant recipients. Currently, he is working on validating his findings with colleagues in Europe.

As a new faculty member at Yale, Dr. Gowda looks forward to developing a clinical trial portfolio for patients opting to receive a stem cell transplant. He envisions this initiative will help foster collaborations with our translation teams to offer mechanistic based individualized therapies.

Yale Cancer Center welcomes Candice van Emmenes to our team. Candice will serve as the Human Resources General (HRG) for Yale Cancer Center, effective December 1. Candice joined Yale in 2015 and has been a HRG for the Yale School of Public Health, Department of Genetics, and Environmental Health and Safety. Please join us in welcoming Candice to the Cancer Center.

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Struggling with how to tell your child about your diagnosis? Our Parenting At a Challenging Time Program can help.

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Smilow Cancer Hospital joins the International Neuroendocrine Cancer Alliance in raising awareness of neuroendocrine tumors (NET) for our patients and their physicians who are working hard to care for this difficult disease. We recently held a symposium to share more information

Tara Sanft, MD, Director of the Survivorship Clinic at Smilow Cancer Hospital, participated in the AtlanticLIVE Cancer Summit earlier this week to discuss cancer survivorship and concerns of cancer survivors with the attendees.

Dr. Fadlo Khuri, President of the American University in Beirut, professor of medicine at the Faculty of Medicine and Medical Center, and an internationally known oncologist in lung cancer, presented the Paul Calabresi Memorial Lectureship on Tuesday, lecturing on No Man is an Island: Raising Cancer Care in the MENA Region. The lecture was hosted by Dr. Roy Herbst and attended by Dr. Calabresi's family, including his brother, the Honorable Guido Calabresi, and his sons, Dr. Peter Calabresi and Steven Calabresi, and his daughter, Janice Maggs.

The Honorable Guido Calabresi, Dr. Fadlo Khuri, and Dr. Roy Herbst

Development Update

When Elisabeth von Trapp, a member of the family whose story inspired The Sound of Music, comes to town for a concert, it's a big deal. Von Trapp has visited Old Lyme to sing four concerts at Saint Ann's Episcopal Church over the last several years. When von Trapp came to Old Lyme this past October, she was doing a concert in support of Old Lyme resident Eleanor Robinson who is suffering from non-small cell lung cancer and all proceeds from the concert were donated to Yale Cancer Center and the research that Dr. Sarah Goldberg is doing towards treatment of the disease. The evening raised over $4,500 to support lung cancer research at Yale Cancer

on NET.

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Our Prostate and Urologic Cancers Program at Smilow Cancer Hospital gives our patients access to a collaborative approach to cancer care, and physician expertise to provide personalized treatment for prostate, bladder, kidney, testes, penis, and urethra cancers.

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In honor of #LungCancerAwarenessMonth, listen to an interview with Dr. Roy Herbst, Chief of Medical Oncology and

Center.

Employee Profile: Donna Durmazlar

The North Pavilion's 8th floor in Smilow Cancer Hospital is an outpatient oncology and infusion center, and typically hosts patients who are receiving treatment for solid tumor cancers or are seeing the provider on that floor. As the Manager of Clinical Operations, it is Donna Durmazlar's responsibility to make sure the floor is running efficiently. From helping a provider who is

running behind get back on track, to ensuring the front desk staff and medical assistants are fully staffed each day, to helping out in crisis situations such as a Code Blue, Donna is always there to ask: 'how can I help?'

In addition to managing the 8th floor, Donna is also the covering manager for the 7th floor and the Phase 1 Unit front desk. To stay on top of all issues, she and other practice and floor managers meet each morning. This morning huddle gives everyone the opportunity to raise and resolve issues,

an expert in the treatment of lung cancer, on Yale Cancer Answers. Email your questions to canceranswers@yale.edu

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Thank you to the Clinton, CT Little League for their generous donation to the Breast Center at Smilow Cancer Hospital, in partnership with Viglione Heating & Cooling Inc. in East Haven. The players raised funds through raffles and auction prizes during a special game, where the ceremonial first pitch was thrown by a breast cancer survivor whose great grandson was playing in the game! Coincidentally, all of the team members were born at Yale New Haven Children's Hospital 11 years ago when Smilow Cancer Hospital was under construction! Thank you all for your

review coverage for call-outs, and review the census for each floor.

"Smilow is great in that there are strict processes in place to ensure a steady clinic flow and make it as easy as possible for our patients," says Donna. "Patient needs are always our first priority."

In her seven years with Smilow, Donna has come full circle. She first started as a temp on the 8th floor, working at the front desk checking in patients. Soon, she was hired full time and worked her way up. And now seven years later, she is manager of the same floor. What is most bittersweet is when she still sees the same patients coming in for appointments that she did as a temp at the front desk.

"It is rewarding when you see a patient leaving and they tell you they are in remission. So many patients stop by my office and say 'thank you,' and this is what makes you do everything possible to make their experience better."

#OOTB Thanks Insil Kim!

YCC #OUTOFTHEBLUETHANKS recently recognized Insil Kim, a Clinical Research Coordinator, for her continued commitment to the Head & Neck Cancers DART team and the Brain Tumor team, along with their study patients. When one of her study patients had to reschedule their mid-week appointment to that Friday, Insil canceled her previous request for that day off in order to be here for the patient. Insil is always willing to do what it takes to move a patient forward

support!

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Meet Dr. Veronica L.S. Chiang, Professor of Neurosurgery and Director of our Gamma Knife Center. Our Gamma Knife Center recently celebrated its 20th anniversary and treated its 5,000th patient! When the Center opened in 1998, it predominantly treated inoperable or high surgical risk neurosurgical conditions. Not only has the number of Gamma Knife cases increased, but the type of patients they treat have also changed over the years. With improved cancer survival, more patients with brain metastases need Gamma Knife treatment to keep their disease under control. Gamma Knife has become first line treatment for brain metastases.

through a trial, to assist her peers, and to respond to sponsor requests. Thank you, Insil!

Yale Cancer Center's #OUTOFTHEBLUETHANKS program is a staff recognition initiative to show appreciation to employees who have exemplified an above-and-beyond effort or an outstanding contribution to the team. All nominations should be submitted to the Director's Office c/o Anna Raso.

Funding Opportunities

NCCN Foundation 2019 Young Investigator Award (YIA) Request for Proposals

Through the YIA Program, the NCCN Foundation invites proposals from early career investigators with innovative ideas and an interest in improving the quality, effectiveness, and efficiency of care provided to cancer patients. Yale will nominate one candidate to apply for the award.

Internal Application Deadline: November 25, 2018

Learn More >>

Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R21/R01)

This R21 NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of pain target discovery and validation projects

Application Deadline: November 27, 2018

Learn More >>

Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional)

The purpose of this FOA is to promote the discovery of strong candidate biomarkers and endpoints for pain that can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials.

Application Deadline: November 27, 2018

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Analytical and/or Clinical Validation of a Candidate Biomarker for Pain

The overarching purpose of FOA is to promote the validation of strong candidate biomarkers and endpoints for pain that

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Liz DeLuca returned to Smilow Cancer Hospital to honor her husband's wishes and support the nurses who cared so well for him, and who provide care to all of our patients on a daily basis. Through the Frederick A. DeLuca Foundation, Liz is providing educational grants to our nurses, enhanced training opportunities, and more patient education. We are grateful for her support!

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can be used to facilitate the development of non-opioid pain therapeutics from discovery through Phase II clinical trials.

Application Deadline: November 27, 2018

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NIH Clinical and Translational Science Award (CTSA) Program SPIRiT Call for Proposals

SPIRiT, the Sharing Partnership for Innovative Research in Translation, is pleased to announce a new funding program that supports pilot research projects representing collaborations between investigators from at least two of the SPIRiT sites.

Application Deadline: November 30, 2018

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Breast Cancer Alliance Education and Outreach Grant

This grant supports programs directly related to outreach and case managerial breast cancer services, including education, counseling, biopsies and mammograms for the underserved.

Application Deadline: November 30, 2018

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YCC 2018 Class of '61 Cancer Research Award

This annual Award recognizes significant accomplishment in cancer research at Yale University by a young member of the faculty, coupled with the expectation for future outstanding contributions to our understanding of the causes of cancer and to the development of novel cancer treatments.

Nomination Deadline: November 30, 2018

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YCC K12 Calabresi Immuno-Oncology Training Program (IOTP) Scholar Awards

We are pleased to solicit applications for the Yale Cancer Center K12 Calabresi Immuno-Oncology Training Program (IOTP) Scholar Awards for junior faculty to enhance research skills beyond the training provided during graduate and postgraduate training. Successful applicants are required to demonstrate a strong commitment to a career in cancer immunology. The two-year IOTP curriculum includes didactic and practical training in basic, translational and clinical aspects of cancer immunology research. The program also

Follow Yale Cancer

Center on Twitter

"It's simple: quitters win!" says Dr. Steven Bernstein. Today is the #GreatAmericanSmokeout@americancancer. "Smokers don't be discouraged-stopping is hard. People often have to try a few times. Keep at it!"

The Great American Smokeout @americancancer is today! "Quitting #tobacco use is the most important step people can take to improve their health," says Dr. Lisa Fucito. Contact the Tobacco Treatment Service at Smilow Cancer Hospital

To test #immunotherapy to treat #bloodcancers like #CML and #MDS, Dr. Amer Zeidan received a grant from @LLSusa. His team was one of 80 worldwide to receive more than $42 million in research dollars from the organization.

Thank you to Dr. Fadlo Khuri @AUB_Lebanon for your insightful presentation on cancer care in the MENA region at our 12th annual Calabresi Lectureship

As part of the #GreatAmericanSmokeout attend the new 'Selling Smoke' exhibit opening on 11/13 and learn about free #tobaccocessation resources

Dr. Adam Boruchov and Dr. Thomas Prebet host the 3rd annual hematologic malignancies symposium in Hartford today to discuss the newest advances in #leukemia#lymphoma#multiplemyeloma.

includes a required research component (either clinical or bench research, or a combination thereof). Applicants are required to identify a mentor and a provide a research and mentorship proposal.

Application Deadline: December 1, 2018

Learn More >>

Instructions to Apply >>

Marsha Rivkin Center for Ovarian Cancer Research

Every year, the Rivkin Center funds promising research in ovarian cancer, selecting researchers and studies through a highly competitive process.

• Pilot Study Program: To support investigator-initiated projects in all areas of ovarian cancer research. Application Deadline: December 3, 2018

• Scientific Scholar Awards: To assist promising laboratory and clinical scientists, who have novel ideas and fresh approaches to scientific challenges, in pursuing a career as an independent investigator in ovarian cancer research.

Application Deadline: December 3, 2018 Learn More >> Damon Runyon Physician-Scientist Training Award This Award is designed to encourage and recruit outstanding U.S. Specialty Board eligible physicians to pursue cancer research careers. Application Deadline: December 3, 2018 Learn More >> Lion Heart Fund for Cancer Research Yale investigators are encouraged to submit proposals of innovative, high-potential projects requiring pilot funding. Projects may be in any area of breast cancer research - basic, translational, clinical, outcomes and population science are all welcomed from any discipline or group of disciplines. A committee, comprised of scientific/medical experts from Yale Cancer Center and dedicated Lion Hearts, will review the proposals and choose those to be funded. Funding will be $50,000 for a one-year project. Application Deadline: December 4, 2018 Learn More >> Emerging Global Leader Award This FOA is designed specifically for applicants proposing to serve as the lead investigator of an independent clinical trial,

New #cancer research @JCO_ASCO by Dr. Harriet Kluger shows #immunotherapy can help treat patients with #melanoma that has spread to the brain.

How do many patients choose

#cancercare? New research by

@DanielBoffa@SocSurgOnc finds patients choose based on hospital affiliations.

Exciting that #headandneckcancer research presented #ESMO18 by @BarbaraBurtness made world-wide headlines!

Calendar

Surgery Grand Rounds/Samuel Clark Harvey Memorial Lecture

November 16; 7:30AM

LMP 1094

Improving Outcomes in Pancreas Cancer

Jeffrey Drebin, MD, PhD

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Yale Cancer Answers

November 18; 7:30PM

WNPR

Cellular Therapy Research and Clinical Trials

Michael Hurwitz, PhD, MD

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YCC Hematology Special Seminar

November 19; 1PM

SHM I-116

Disseminated Intravascular Coagulation

Elizabeth Federici, MD

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a clinical trial feasibility study, or a separate ancillary study to an existing trial, as part of their research and career development. Application Deadline: December 4, 2018 Learn More >> Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium This FOA, issued by the NCI, is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. Application Deadline: December 7, 2018 Learn More >>

NCI Research Specialist Award (R50) This award encourages the development of stable research career opportunities for exceptional scientists who want to pursue research within the context of an existing cancer research program, but not serve as independent investigators. Letter of Intent Due: December 11, 2018 Learn More >> The NCI Predoctoral to Postdoctoral Fellow Transition Award The purpose of this Award (F99/K00) is to encourage and retain outstanding graduate students recognized by their institutions for their high potential and strong interest in pursuing careers as independent cancer researchers. Internal Deadline: December 13, 2018 Learn More >>

Administrative Supplements to Cancer Center Support Grants to Strengthen NCI-Supported Community Outreach Capacity through Community Health Educators of the National Outreach Network The purpose of this administrative supplement is to support a strengthening of community outreach capacity by working through the National Outreach Network (NON). Application Deadline: December 15, 2018 Learn More >> Alex's Lemonade Stand Foundation Grants The innovative grant program funds crucial research that can make a real and important difference for children with cancer.

• Epidemiology Grant: To support the research of investigators who have a specific focus on the epidemiology of childhood cancer, early detection of

Yale Cancer Biology Institute Research Seminar

November 19; 3PM

Hope 110

Genomic Engineering Approaches for Studying Chromosome Arm-Level Aneuploidy in Squamous Cancers

Alison Taylor, PhD

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YSM Pathology Seminar Thesis Defense

November 20; 9AM

TAC N-107

Digital Precision Immuno-Oncology: The Tumor Microenvironment and Human Melanoma Immunotherapy Response

Pok Fai Wong, MBBS

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YCCEH Seminar

November 20; 11:30AM

Brady Auditorium

Hematopoietic stem cells in stress, disease and aging

Emmanuelle Passegue

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YCC Chalk Talk

November 20; 1PM

BCMM 206/208

Vision for a Thriving YCIO

Miriam Merad, MD, PhD

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Yale Cancer Answers

November 25; 7:30PM

WNPR

Organ Transplant for Cancer Patients

Sukru Emre, MD

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Yale Cancer Biology Institute Research Seminar

November 26; 3PM

childhood cancer, or the prevention of childhood cancer. Application Deadline: December 17, 2018 Earliest

• Young Investigator Grant: To fill the critical need for startup funds for less experienced researchers to pursue promising research ideas, as well as encourage and cultivate the best and brightest researchers of the future and lead to long-term research projects.

Application Deadline: December 17, 2018 Learn More >>

Pediatric Immunotherapy Discovery and Development Network (PI-DDN) (U54 and U01) This FOA is associated with the Beau Biden Cancer MoonshotSM Initiative that is intended to accelerate cancer research. The purpose is to establish centers of collaborating investigators with the goal of identifying and advancing research opportunities for translating immunotherapy concepts for children and adolescents with cancer toward clinical applications. Application Deadline: December 17, 2018 Learn More >> Administrative Supplements to Cancer Center Support Grants to Strengthen the Research, Training, and Outreach Capacity of the Geographic Management of Cancer Health Disparities Program Through this FOA, the NCI intends to: support seven region-based "hubs" or networks to facilitate underrepresented investigator/trainee recruitment and career/professional development; provide enhanced capacity in the area of cancer health disparities research; and promote CHD research-related infrastructure development and evaluation. Application Deadline: December 17, 2018 Learn More >>

Recent Publications

Identification of cancer omics commonality and difference via community fusion.

Sun Y, Jiang Y, Li Y, Ma S.

Stat Med. 2018 Nov 12.

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Flexible fate determination ensures robust differentiation in the hair follicle.

Hope 110

Dynamics of 3D Genome Organization in Living Cells at Single-Molecule Resolution

Anders Sejr Hansen, PhD

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Pathology Research in Progress Talks

November 27; 9:30AM

TAC N-107

Adam Ducler and Gregory Breuer

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Genetics Department Special Seminar

November 27; 11:30AM

TAC N-107

Non-coding and epigenetic regulation of hematopoiesis

Jun Lu, PhD

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YCC Grand Rounds

November 27; 12PM

Park Street Auditorium

Updates in Endometrial Cancer Treatment

Alessandro Santin, MD

TBA

Francine Foss, MD

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YSM Cancer Student Interest Group Seminar

November 27; 5PM

Brady 131

Cancer Genetics: From Benchtop to Bedside

Ranjit S Bindra, MD, PhD, Lajos Pusztai, MD, DPhil, Erin Hofstatter, MD, and Marcus Bosenberg, MD, PhD

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YCCI Clinical Research Faculty Dinner Series

November 27; 5:30PM

Xin T, Gonzalez D, Rompolas P, Greco V.

Nat Cell Biol. 2018 Nov 12.

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Comparison of Local Control of Brain Metastases With Stereotactic Radiosurgery vs Surgical Resection: A Secondary Analysis of a Randomized Clinical Trial.

Churilla TM, Chowdhury IH, Handorf E, Collette L, Collette S, Dong Y, Alexander BM, Kocher M, Soffietti R, Claus EB, Weiss SE.

JAMA Oncol. 2018 Nov 8.

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Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo.

Marsh E, Gonzalez DG, Lathrop EA, Boucher J, Greco V.

Cell. 2018 Nov 1.

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Systematic review and meta-analysis of the effect of iron chelation therapy on overall survival and disease progression in patients with lower-risk myelodysplastic syndromes.

Zeidan AM, Giri S, DeVeaux M, Ballas SK, Duong VH.

Ann Hematol. 2018 Nov 9.

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Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell.

Si Y, Liu J, Shen H, Zhang C, Wu Y, Huang Y, Gong Z, Xue J, Liu T.

J Cell Mol Med. 2018 Nov 8.

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Long-Term Survival of Patients With Melanoma With Active Brain Metastases Treated With Pembrolizumab on a Phase II Trial.

Kluger HM, Chiang V, Mahajan A, Zito CR, Sznol M, Tran T, Weiss SA, Cohen JV, Yu J, Hegde U, Perrotti E, Anderson G, Ralabate A, Kluger Y, Wei W, Goldberg SB, Jilaveanu LB.

J Clin Oncol. 2018 Nov 8:JCO1800204.

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Cohen Auditorium

Enabling research through innovative uses of our Epic EHR, mobile technologies and digital health

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CME/Department of Obstetrics, Gynecology, & Reproductive Sciences Conference

November 28; 7AM

Yale's West Campus

34th Annual Ella T. Grasso Memorial Conference

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Grand Rounds for Non-Clinicians

November 28; 12PM

Park Street Auditorium

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Seminars in Surgical Research

November 28; 12PM

Brady Auditorium

Use of mHealth Apps to Monitor Post-Op Recovery in GI Cancer Patients'

Heather Yeo, MD, MHS

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SCH/YCC Meaning Centered Psychotherapy Group for Cancer Caregivers

November 28; 2:30PM

Smilow Cancer Hospital

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Smilow Screening & Prevention Informational Table

November 29; 11AM

Saint Raphael Campus

Lung Cancer Awareness Month

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Pathology Grand Rounds

November 29; 12:30PM

LMP 1094

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity.

Shi W, Ng CKY, Lim RS, Jiang T, Kumar S, Li X, Wali VB, Piscuoglio S, Gerstein MB, Chagpar AB, Weigelt B, Pusztai L, Reis-Filho JS, Hatzis C.

Cell Rep. 2018 Nov 6;25(6):1446-1457.

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Calnexin impairs the antitumor immunity of CD4+ and CD8+ T cells.

Chen Y, Ma D, Wang X, Fang J, Liu X, Song J, Li X, Ren X, Li Q, Li Q, Wen S, Luo L, Xia J, Cui J, Zeng G, Chen L, Cheng B, Wang Z.

Cancer Immunol Res. 2018 Nov 6.

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Inflammatory eruptions associated with immune checkpoint inhibitor therapy: A single-institutional, retrospective analysis with stratification of reactions by toxicity and implications for management.

Coleman E, Ko C, Dai F, Tomayko MM, Kluger H, Leventhal JS.

J Am Acad Dermatol. 2018 Nov 3.

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Concordance of cancer registry and self-reported race, ethnicity, and cancer type: a report from the American Cancer Society's studies of cancer survivors.

Layne TM, Ferrucci LM, Jones BA, Smith T, Gonsalves L, Cartmel B.

Cancer Causes Control. 2018 Nov 3.

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Stereotactic body radiotherapy with adjuvant systemic therapy for early-stage non-small cell lung carcinoma: A multi-institutional analysis.

Kann BH, Miccio JA, Stahl JM, Ross R, Verma V, Dosoretz AP, Park HS, Shafman TD, Gross CP, Yu JB, Decker RH.

Radiother Oncol. 2018 Oct 31.

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Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.

Liao L, Liu ZZ, Langbein L, Cai W, Cho EA, Na J, Niu X, Jiang W, Zhong Z, Cai WL, Jagannathan G, Dulaimi E, Testa

The Spectrum of Congenital Melanocytic Proliferations: A Complex Neurocristopathy

Miguel Reyes-Mujica, MD

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Smilow Cancer Genetics and Prevention Program Seminar

November 29; 2:30PM

Orchard Medical Center, Suite 107-109

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Smilow Screening & Prevention Informational Table

November 30; 11AM

YNHH

Lung Cancer Awareness Month

Learn More >>

Digestive Diseases GI Core Curriculum Lecture Series

November 30; 1PM

TAC 247

Familial Colonic Disease

Xavier Llor, MD, PhD

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Submissions

Please submit your recent publication

and grant announcements to:

Renee Gaudette Director, Public Affairs and Communications

JR, Uzzo RG, Wang Y, Stark GR, Sun J, Peiper S, Xu Y, Yan Q, Yang H.

Elife. 2018 Oct 25;7.

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MDM2-recruiting PROTAC Offers Superior, Synergistic Anti-proliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53.

Hines J, Lartigue S, Dong H, Qian Y, Crews CM.

Cancer Res. 2018 Nov 1.

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Reply: Complications in unilateral breast cancer patients who undergo contralateral prophylactic mastectomy versus unilateral mastectomy.

Huang J, Chagpar AB.

Surgery. 2018 Oct 29.

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Should chemotherapy plus immune checkpoint inhibition be the standard front-line therapy for patients with metastatic non-small cell lung cancer?

Goldberg SB, Herbst RS.

Cancer. 2018 Nov 1.

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Glycoprotein-130 expression is associated with aggressive bladder cancer and is a potential therapeutic target.

Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM.

Mol Cancer Ther. 2018 Oct 31.

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Treatment of primary non-metastatic melanoma at high-volume academic facilities is associated with improved long-term patient survival.

Cheraghlou S, Agogo GO, Girardi M.

J Am Acad Dermatol. 2018 Oct 23.

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Effect Sizes of Somatic Mutations in Cancer.

Cannataro VL, Gaffney SG, Townsend JP.

J Natl Cancer Inst. 2018 Oct 26.

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Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer.

Marshall S, Chen Y, Singh S, Berrios-Carcamo P, Heit C, Apostolopoulos N, Golla JP, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2018;1032:203-221.

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Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.

Chen Y, Han M, Matsumoto A, Wang Y, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2018;1032:37-53.

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Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut.

Huang H, Zhao N, Chen Y, Deziel N, Dai M, Li N, Udelsman R, Zhang Y.

Adv Exp Med Biol. 2018;1032:1-14.

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The Association of Robot-assisted Versus Pure Laparoscopic Radical Nephrectomy with Perioperative Outcomes and Hospital Costs.

Gershman B, Bukavina L, Chen Z, Konety B, Schumache F, Li L, Kutikov A, Smaldone M, Abouassaly R, Kim SP.

Eur Urol Focus. 2018 Oct 22.

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Blood mRNA Measurement (NETest) for Neuroendocrine Tumors diagnosis of Image-negative liver metastatic disease.

Malczewska A, Bodei L, Kidd M, Modlin IM.

J Clin Endocrinol Metab. 2018 Oct 24.

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