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Nutraceuticals and Cancer
Fazlul H. SarkarEditor
Nutraceuticals and Cancer
123
EditorFazlul H. Sarkar, Ph.D.Distinguished ProfessorDepartments of Pathology and OncologyKarmanos Cancer InstituteWayne State University740 HWCRC4100 JohnR StreetDetroit, Michigan [email protected]
ISBN 978-94-007-2629-1 e-ISBN 978-94-007-2630-7DOI 10.1007/978-94-007-2630-7Springer Dordrecht Heidelberg London New York
Library of Congress Control Number: 2011941667
© Springer Science+Business Media B.V. 2012No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or byany means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without writtenpermission from the Publisher, with the exception of any material supplied specifically for the purposeof being entered and executed on a computer system, for exclusive use by the purchaser of the work.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (www.springer.com)
Preface
I would like to thank the publisher to entrust me with organizing the special topicon the emerging role and molecular concepts of nutraceutical (natural agents) inhuman health especially the value of nutraceuticals for the prevention and/or treat-ment of human malignancies. This book illustrates the role of several dietary agents,collectively called nutraceuticals or natural agents in the prevention and/or treat-ment of human malignancies known to be mediated through alterations in multiplemolecular targets. This book contains sixteen chapters which begin with historicalperspective on the value of natural agents in the prevention of human malignanciesfollowed by a series of current topics on multiple nutraceuticals targeting multi-ple cancers. This collection would likely be useful for bringing newer generationswith broader perspectives in launching cutting-edge innovative molecular research,which would certainly help in designing targeted clinical trials in order to realize thedream of customize strategies for the prevention and/or treatment of human malig-nancies without causing any systemic toxicity. Moreover, the knowledge gainedwould allow novel utilization of nutraceuticals as adjunct to both conventionalchemotherapy and radiation therapy in order to improve the overall quality of lifeand survival of patients diagnosed with cancers. I would like to thank all the authorsfor their cooperation, hard work and talented contributions to bring this book tothe readers in a timely fashion. I would like to thank the publisher and the entirepublishing group for their dedication and professionalism. Finally, I would like todedicate this book to my lovely wife, Arfatun H. Sarkar and my wonderful chil-dren, Sarah, Sanila and Shaan for their understanding and sacrifice in allowing meto work harder and spend time away from them rather than with them which theyrightly deserved.
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Contents
1 Global Overview of the Role of Nutraceuticals in Cancer . . . . . . 1Vay Liang W. Go, Diane M. Harris, and Priya Srihari
2 Cancer Stem Cells: Novel Target Using DietaryComponents for Prevention and Treatment . . . . . . . . . . . . . 11Animesh Dhar, Laura Fogt, Dharmalingam Subramaniam,and Shrikant Anant
3 Polyphenols as Receptor Tyrosine Kinase Inhibitorsand Anti-cancer Agents . . . . . . . . . . . . . . . . . . . . . . . . 39David T. Coleman and James A. Cardelli
4 Role of Nutraceuticals on Nrf2 and Its Implicationin Cancer Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . 61Constance Lay-Lay Saw and Ah-Ng Tony Kong
5 Current Status and Future Prospects of Nutraceuticalsin Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . 77Sanjeev Shukla and Sanjay Gupta
6 Cellular, Molecular and Biological Insightinto Chemopreventive and Therapeutic Potentialof 3,3’-Diindolylmethane (DIM) . . . . . . . . . . . . . . . . . . . . 111Sanjeev Banerjee, Mansi A. Parasramka, and Fazlul H. Sarkar
7 Mechanism of Action of the Anti-cancer Agent, Triptolide . . . . . 135Veena Sangwan and Ashok K. Saluja
8 Nutraceuticals in Human Urinary Bladder CancerPrevention and Treatment . . . . . . . . . . . . . . . . . . . . . . . 151Xiaolin Zi and Christopher Blair
9 Exploiting Resveratrol for the Treatment of Cancer . . . . . . . . . 171Simone Fulda
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viii Contents
10 Role of Novel Nutraceuticals Garcinol, Plumbaginand Mangiferin in the Prevention and Therapy of HumanMalignancies: Mechanisms of Anticancer Activity . . . . . . . . . 179Aamir Ahmad, Subhash Padhye, and Fazlul H. Sarkar
11 Anthocyanins and Cancer Prevention . . . . . . . . . . . . . . . . . 201Li-Shu Wang, Steven Carmella, Robert Keyes, Chieh-Ti Kuo,Yi-Wen Huang, Stephen S. Hecht, and Gary D. Stoner
12 Slow but Steady Progress in Cancer Chemopreventionwith Phenethyl Isothiocyanate: Fulfilled Promisesand Translational Challenges . . . . . . . . . . . . . . . . . . . . . 231Anna A. Powolny, Ajay Bommareddy, and Shivendra V. Singh
13 Skin Cancer Chemoprevention: Current Statusand Future Potential . . . . . . . . . . . . . . . . . . . . . . . . . . 259Imtiaz A. Siddiqui, Vaqar M. Adhami, and Hasan Mukhtar
14 Dietary Phytochemicals and Chemoprevention of SolarUltraviolet Radiation-Induced Skin Cancer . . . . . . . . . . . . . 295Farrukh Afaq and Santosh K. Katiyar
15 The Role of Vitamin E Forms in Cancer Preventionand Therapy – Studies in Human Intervention Trialsand Animal Models . . . . . . . . . . . . . . . . . . . . . . . . . . . 323Silvia Y. Moya-Camarena and Qing Jiang
16 Augmenting the Efficacy of Chemo- and Radio-Therapy byNutraceuticals: Evidence from Pre-clinical and Clinical Trials . . . 355Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Contributors
Vaqar M. Adhami Department of Dermatology, University ofWisconsin-Madison, Madison, WI 53706, USA, [email protected]
Farrukh Afaq Department of Dermatology, Comprehensive Cancer Center,University of Alabama at Birmingham, Birmingham, AL 35294, USA,[email protected]
Aamir Ahmad Department of Pathology, Barbara Ann Karmanos CancerInstitute, Wayne State University School of Medicine, Detroit, MI, USA,[email protected]
Shrikant Anant Department of Molecular and Integrative Physiology, CancerCenter, University of Kansas Medical Center, Kansas City, KS 66160, USA,[email protected]
Sanjeev Banerjee Department of Pathology, Barbara Ann Karmanos CancerInstitute, Wayne State University School of Medicine, Detroit, MI 48201, USA,[email protected]
Bin Bao Department of Pathology, Barbara Ann Karmanos Cancer Institute,Wayne State University School of Medicine, Detroit, MI, USA,[email protected]
Christopher Blair Departments of Urology and Pharmaceutical Sciences,University of California, Irvine, Orange, CA 92868, USA, [email protected]
Ajay Bommareddy Department of Pharmaceutical Sciences, Nesbitt School ofPharmacy & Nursing, Wilkes University, Wilkes-Barre, PA, USA,[email protected]
James A. Cardelli Department of Microbiology and Immunology and theFeist-Weiller Cancer Center, Louisiana State University Health Sciences Center,Shreveport, LA 71130, USA, [email protected]
Steven Carmella Masonic Cancer Center, University of Minnesota, Minneapolis,MN 55455, USA, [email protected]
ix
x Contributors
David T. Coleman Department of Microbiology and Immunology and theFeist-Weiller Cancer Center, Louisiana State University Health Sciences Center,Shreveport, LA 71130, USA, [email protected]
Animesh Dhar Department of Cancer Biology, Cancer Center, University ofKansas Medical Center, Kansas City, KS 66160, USA, [email protected]
Laura Fogt Department of Molecular and Integrative Physiology, University ofKansas Medical Center, Kansas City, KS 66160, USA, [email protected]
Simone Fulda Institute for Experimental Cancer Research in Pediatrics,Goethe-University Frankfurt, 60528 Frankfurt, Germany, [email protected]
Vay Liang W. Go Department of Medicine, David Geffen School of Medicine,UCLA Center for Excellence in Pancreatic Diseases, University of California,Los Angeles, CA 90095-1786, USA, [email protected]
Sanjay Gupta Department of Urology, Case Comprehensive Cancer Center,University Hospitals Case Medical Center, Case Western Reserve University,Cleveland, OH 44106, USA, [email protected]
Diane M. Harris Department of Medicine, David Geffen School of Medicine,UCLA Center for Excellence in Pancreatic Diseases, University of California,Los Angeles, CA 90095-1786, USA, [email protected]
Stephen S. Hecht Masonic Cancer Center, University of Minnesota, Minneapolis,MN 55455, USA, [email protected]
Yi-Wen Huang Department of Obstetrics and Gynecology, Medical College ofWisconsin, Milwaukee, WI 53220, USA, [email protected]
Qing Jiang Department of Nutrition Science, Purdue University, West Lafayette,IN 47907, USA, [email protected]
Santosh K. Katiyar Department of Dermatology, Comprehensive Cancer Center,Nutrition Obesity Research Center, University of Alabama at Birmingham,Birmingham, AL 35294, USA; Birmingham VA Medical Center, Birmingham, AL,USA, [email protected]
Robert Keyes Division of Hematology and Oncology, Department of Medicine,Medical College of Wisconsin, Milwaukee, WI 53220, USA, [email protected]
Ah-Ng Tony Kong Department of Pharmaceutics, Ernest-Mario School ofPharmacy, Center for Cancer Prevention Research, Rutgers, The State Universityof New Jersey, Piscataway, NJ 08854, USA, [email protected]
Dejuan Kong Department of Pathology, Barbara Ann Karmanos Cancer Institute,Wayne State University School of Medicine, Detroit, MI, USA,[email protected]
Chieh-Ti Kuo Division of Hematology and Oncology, Department of Medicine,Medical College of Wisconsin, Milwaukee, WI 53220, USA, [email protected]
Contributors xi
Yiwei Li Department of Pathology, Barbara Ann Karmanos Cancer Institute,Wayne State University School of Medicine, Detroit, MI, USA,[email protected]
Silvia Y. Moya-Camarena Centro de Investigación en Alimentación yDesarrollo, A. C., Hermosillo, Sonora, 83000, Mexico, [email protected]
Hasan Mukhtar Department of Dermatology, University of Wisconsin-Madison,Madison, WI 53706, USA, [email protected]
Subhash Padhye Abeda Inamdar Senior College, Azam Campus, Pune 411 001,Maharashtra, India, [email protected]
Mansi A. Parasramka Department of Pathology, Barbara Ann Karmanos CancerInstitute, Wayne State University School of Medicine, Detroit, MI 48201, USA,[email protected]
Anna A. Powolny Department of Pharmacology and Chemical Biology,University of Pittsburgh School of Medicine, University of Pittsburgh CancerInstitute, Pittsburgh, PA, USA, [email protected]
Ashok K. Saluja Department of Surgery, University of Minnesota, Minneapolis,MN, USA, [email protected]
Veena Sangwan Department of Surgery, University of Minnesota, Minneapolis,MN, USA, [email protected]
Fazlul H. Sarkar Departments of Pathology and Oncology, Karmanos CancerInstitute, Wayne State University, 740 HWCRC, Detroit, Michigan 48201, USA,[email protected]
Constance Lay-Lay Saw Department of Pharmaceutics, Ernest-Mario School ofPharmacy, Center for Cancer Prevention Research, Rutgers, The State Universityof New Jersey, Piscataway, NJ 08854, USA, [email protected]
Sanjeev Shukla Department of Urology, University Hospitals Case MedicalCenter, Case Western Reserve University, Cleveland, OH 44106, USA,[email protected]
Imtiaz A. Siddiqui Department of Dermatology, University ofWisconsin-Madison, Madison, WI 53706, USA, [email protected]
Shivendra V. Singh Department of Pharmacology and Chemical Biology,University of Pittsburgh School of Medicine, University of Pittsburgh CancerInstitute, Pittsburgh, PA, USA, [email protected]
Priya Srihari Department of Medicine, David Geffen School of Medicine,UCLA Center for Excellence in Pancreatic Diseases, University of California,Los Angeles, CA 90095-1786, USA, [email protected]
Gary D. Stoner Division of Hematology and Oncology, Department of Medicine,Medical College of Wisconsin, Milwaukee, WI 53220, USA, [email protected]
xii Contributors
Dharmalingam Subramaniam Department of Molecular and IntegrativePhysiology, Cancer Center, University of Kansas Medical Center, Kansas City,KS 66160, USA, [email protected]
Li-Shu Wang Division of Hematology and Oncology, Department of Medicine,Medical College of Wisconsin, Milwaukee, WI 53220, USA, [email protected]
Xiaolin Zi Departments of Urology and Pharmaceutical Sciences, Chao FamilyComprehensive Cancer Center, University of California, Irvine, Orange, CA92868, USA, [email protected]
