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Nutritional therapy of intensive care renal
patients
Ione de Brito-Ashurst Trust Nutrition Lead
Overview
RF Definition
Malnutrition in RF
Nutrition recommendations
Low protein diets
Case study
Malnutrition is associated with high mortality in AKI
Fiaccadori et al. JASN 1999; 10:581-593
Malnutrition in CKD
Prevalence of malnutrition circa35% in patients beginning HD
Mostly in CKD stage 4 & 5
Characterised by loss of MM, loss of visceral protein and fat mass
Negative impact on QoL, morbidity and mortality
Malnutrition in CKD
Causes
Reduced oral intake – restrictive
diet
Anorexia of uraemia
Loss of nutrients
MIA syndrome (malnutrition
inflammatory atherosclerosis)
Metabolic abnormalities
Gastrointestinal symptoms
Social – poverty, dentition
Prevalence of malnutrition in HD
N= 7,123
BMI <20kg/m2 24%
LBM <90% centile 62%
Albumin <35g/l 20%
nPNA <1g/kg/d 35%
Normalised protein nitrogen appearance
-protein catabolic rate normalised for
weight
Aparicio M. et al. NDT 1999
ESPEN1 NKF2 EBPG3 ASPEN4
Protein g/kg/day
1.2-1.4 1.2 >1.1 1.2-2.0
Energy Kcal/kg/day
35 <60 yrs - 35 >60 yrs - 30
30-40 25-30
1. Toigo G. et al. CN, 2000
2. NKF. AJKD, 2000
3. Fouque D. et aol., EBPG. NDT 2007
4. McClave S.A. et al. JPEN, 2016
Dietary recommendations for RF
Occurs in 33-66% of all critically ill patients1
Hypercatabolic milieu
>50% mortality rate for severe AKI that needs RRT1
Loss in CRRT are up to 7.5gms/day for proteins + 6-15gm/day for amino acids2
Protein catabolic rate estimated at 1.4g/day2
Protein intake up of 1.5g/kg/day + N balance without increasing Urea generation1
Limited protein and calories provision exacerbates breakdown of protein for fuel
Protein intake ≥2.0g/kg/day leads to increased urea generation and intensified dialysis needs1
Acute Kidney Injury
1. Gervasio, J.M. et a. 2011, NCP
2. Kellum et al. 2013 Critic Care
Glucose
The kidneys contribute to:
15-25% of gluconeogenesis
10-20% of glucose uptake
30% of insulin catabolism
AKI – exacerbated insulin resistance due
to:
reduced gluconeogenesis
Reduced insulin and glucagon
clearance
Proteins
Increased catabolism
Metabolic acidosis
Change in amino acids
concentration
Lipids
Impaired lipolysis
Decrease hepatic triglyceride
lipase
Increase in triglycerides
No advantage
from increased
caloric intake
on Nitrogen
balance and
protein
catabolism
reduction
KDIGO – AKI Work Group
Parrish C.R, Practical Gastroenterology, 2011
Low Protein Diet in CKD
Bringing available evidence to bedside….
CASE STUDY
Case study
Male 65 yrs admitted with Type II RF 2nd to CAP for ECMO
Sedated (Morphine + midazolan) and paralysed (atracurium)
Weight 55kg, height 175cm, BMI= 18
Last weight 64kg (6/12)
Known renal impairment
Creatinine 235µmol (2.66mg/dl), Urea 35mmol, Bicarbonate 17mmol
UOP 10-20ml/hr – CRRT
BS present, BNO for 2/7
On polymeric non-fibre feed – Nutrison
ONS improves albumin levels
Clinical assessment
Establish eGFR
21.6ml/min by Cockroft-Gault Equation
CKD stage 4
Raised phosphate levels (<50% eGFR)
Raised potassium levels (<80% eGFR, ACEis)
Low serum creatinine for CKD stage 4
High Urea levels (catabolic)
High Serum urea:creatinine ratio
Malnutrition
Low muscle mass
U shaped urea curve for mortality (optimum 23-27mmol)
Assessment
Nutrition management
25cal/kg = 1600 cals
1.5g/kg = 96g proteins
1st week:
Nutrison Protein Plus –
1400ml @ 60ml/hr – Continuous
1750 cals
88g proteins
0 g fibre
2nd week:
Change to high protein feed
Nutrison Advanced Protison –
1300ml @ 55ml/hr
1664 cals
97.5g proteins
19.5g fibre
Bowel opening regularly type 5/6
Conclusion
Malnutrition is prevalent in CKD and AKI
Malnutrition is associated with high mortality
AKI REE is similar to other ICU groups
Adequate protein intake is essential
Very high caloric intake has no advantages
Dialysis increases nitrogen requirements to cover for losses
TANK YOU