表 Y04

國內專家學者出席國際學術會議報告 100 年 7 月 31 日

報告人姓名 簡敦誠

服務機構 及職稱

國立台灣師範大學化學系 助理教授

時間 會議

地點

2011 / 7 / 3 ~ 8

Newport, Rhode Island, USA

會議

名稱

(中文) Gordon Research Conferences - Nucleosides, Nucleotides & Oligonucleotides

(英文) Gordon Research Conferences - Nucleosides, Nucleotides & Oligonucleotides

發表 論文 題目

(中文) 利用醋酸鈀(二價)催化 Suzuki-Miyaura 偶合反應合成 6 位具芳香環取代的尿嘧啶核苷類衍生物

(英文) Practical Synthesis of 6-Aryluridines via Palladium(II) Acetate Catalyzed Suzuki-Miyaura Cross-coupling Reaction

附件三

表 Y04

報告內容應包括下列各項：

一、參加會議經過 Gordon Research Conferences (GRC) 是由 Neil E. Gordon 博士於 1920 年代所發起的學術會議, 目的在於提供相同領域的頂尖研究學者們一個直接面對面溝通與討論的機會. 基於這個理念, GRC 陸續在生物, 化學及物理等相關領域建立討論平台, 定期舉辦會議並廣邀該領域頂尖學者參與討論, 交換彼此的研究成果與心得. GRC 的特色是各個會議平台的主題明確, 在為期近一星期的會期中, 議程的安排讓所有參與者有充份的時間能夠面對面討論與溝通, 並提供/獲得寶貴的意見. 相關介紹詳見: http://www.grc.org/about.aspx GRC 的 Nucleosides, Nucleotides & Oligonucleotides 會議, 屬於 GRC 化學類別中的生物化學及有機化學, 源起於 1976 年第一次由 George B. Brown 博士所發起的 Chemistry and Biology of Purines & Related Derivatives 會議, 這項 GRC 的主題會議在 1981 年舉行第二次會議時更名為 Purines, Pyrimidines & Related Compounds, 隨後分別於 1984, 1986 及 1989 舉行第三至五次會議. 此後在 1991 年第六次會議時再度更明為 Purines, Pyrimidines & Related Substances, 並確立每兩年舉行一次會議的慣例, 與 International Round Table on Nucleosides, Nucleotides and Nucleic Acids (IRT) 會議交替舉行, 於是在 1993 至 2003 年間分別舉行第七至十二次會議. 2005 年第十三次會議起將會議更名為 Nucleosides, Nucleotides & Oligonucleotides 並延用至今 , 本屆 (2011) 是第十六次會議 . 本會議的歷史詳見 : http://www.grc.org/conferences.aspx?id=0000237 本屆會議由 Piet Herdewijn 博士 (Katholieke Universiteit Leuven, Leuven, Belgium) 擔任主席 , 於 2011 年 7 月 3 至 8 日 , 在 Newport, Rhode Island, USA 的 Salve Regina University 舉行. 參加人數約 100 人, 其中以美國參加的人數最多. 來自其他亞洲國家的與會者 , 僅有日本北海道大學的 Akira Matsuda 博士 , 長期擔任 International Society for Nucleosides, Nucleotides, and Nucleic Acids 的 committee, 以及日本神戶甲南大學的 Naoki Sugimoto 博士. 大部份出席者皆為學者, 僅有少數產業界專家及學生參與. 最著名的學者是來自美國哈佛大學醫學院, 2009 年諾貝爾醫學獎得主之一的 Jack W. Szostak 博士. 下屆會議 (2013 年) 將由現任副主席 William B. Parker 博士 (Southern Research Institute, Birmingham, AL, USA) 擔任主席, 在本屆會議中也由全體與會者推舉 Vern L. Schramm 博士 (Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA) 擔任下任副主席, 並依慣例於下屆會議結束後擔任主席. 前往美國, 需至美國在台協會 (AIT) 辦理簽證. 簽證時程冗長, 需要先上網登錄資料後預約面談時間, 通常在 2-4 週之後, 面談後依情況需要數日至數週等待審查, 才能核發簽證, 因此建議前往美國者要儘早取得簽證, 以免因為簽證問題影響出國行程. 這次出國行程於 6 月 29 日自台北出發, 搭乘達美 (Delta) 航空, 經由日本東京成田國際機場轉機後, 於當地 6 月 29 日星期三下午飛抵美國密西根州底特律機場, 隨後搭車前往過去求學的密西根大學所在地 Ann Arbor, Michigan. 6 月 30 日 (星期四) 當天調整時差並休息後, 於 7 月 1 日 (星期五) 與幾位當地化學公司的技術人員, 也是過去的實驗室的同事們敘舊並討論相關化學問題. 該公司是全球知名的核酸化學公司, 專門提供各類核苷及核酸化合物, 與他們討論 2-位去氧核苷化合物在製備上所面臨的問題與解決方案. 7 月 2 日 (星期六) 進行私人行程, 拜訪當地的朋友們. 於 7 月 3 日 (星期日) 上午七點半搭機赴波士頓機場並轉搭 GRC 提供的巴士前往會議地點, Salve Regina University, Newport, Rhode Island.

表 Y04

會議期間都在 Salve Regina University 校園中, Salve Regina University 是 GRC 會議的固定會址之一, 為一所私立大學, 學校規模不大, 以大學部為主. 該校臨海風景優美, 氣候相當宜人, 即使在夏天白天氣溫都維持在 25-30 度左右, 偶而會下陣雨. 7 月 8 日 (星期五) 會議結束後, 再搭乘 GRC 提供的巴士赴波士頓機場, 隨即搭機於晚間抵達美國首府華盛頓特區的雷根國際機場, 7 月 9-10 日 (星期六-日) 兩日於華盛頓 D. C. 地區進行私人行程, 並於 7 月 10 日晚間搭機返回底特律機場, 並回到 Ann Arbor. 7 月 11 日 (星期一) 則前往密西根大學化學系拜訪求學時期的老師 Masato Koreeda 博士, 並參觀了化學系的研究實驗室. 7 月 12 日 (星期二) 則另外與博士論文指導教授之一的 John C. Drach 博士會談一上午, 討論內容包括目前進行的研究成果, 以及未來可能合作的主題, 下午前往密西根大學藥學院拜訪 Ronald W. Woodard 與 George A. Garcia 博士. 7 月 13 日 (星期三) 中午前往底特律機場, 搭乘達美航空班機經由日本東京成田國際機場, 於 7 月 14 日 (星期四) 晚間抵達台北. 二、與會心得 本屆會議共區分為以下八項主題: 1. Synthetic Biology 2. Systems Chemistry 3. miRNA and siRNA Therapeutics 4. Structural Biology of Nucleic Acids 5. Epigenetics 6. Aptazymes 7. Antiviral / Antitumoral Nucleoside Analogues 8. Nucleotide Receptors 共計有 21 位學者專家發表演講, 另有 8 位博士班學生或者博士後研究員發表口頭論文報告. 最令人印象深刻的演講, 包括 2009 年諾貝爾醫學獎得主之一的 Jack W. Szostak 博士. 他演講的主題在於如何以化學方法 , 利用 Nucleoside-5'-Phosphorimidazolide Monomers, 以 DNA 作為 template 進行核酸合成, 過去核酸合成均仰賴 DNA Polymerase, 即 PCR 進行, 這項非酵素催化的核酸合成已經具有初步成果, 對於核酸領域的研究相當重要. Steven A. Benner 博士 (Foundation For Applied Molecular Evolution, Gainesville, FL, USA) 在尋找非天然配對鹼基的研究工作 (The Science and Technology of Six Letter DNA Alphabets), 相當具有啟發性. 這部份的工作仰賴於大量的核酸鹼基設計與合成, 與我們的研究工作有關. David R. Liu 博士 (Harvard University, Cambridge, MA, USA) 利用 DNA 作為 template 進行小分子的工作相當有趣, 然而實用性卻有限. Jyoti Chattopadhyaya 博士 (Uppsala University, Uppsala, Sweden) 在於具限制構形醣基的核酸 (LNA) 方面的研究相當令人欽佩, 他們已經成功合成多種具限制構形醣基的核酸並顯示其具有與天然 RNA 相當的生物活性 . 來自 Santaris Pharma (Hørsholm, Denmark) 的 Troels Koch 博士也發表了相關的研究. 此外, 利用結構生物

表 Y04

學方法來研究核酸的結構與功能是近年來相當重要的領域, 這次會議中, Dinshaw Patel 博士 (Memorial Sloan-Kettering Cancer Center, New York, NY, USA) 與 Wei Yang 博士 (National Institutes of Health, Bethesda, MD, USA) 報告了在這方面的研究. 與我們研究相關的部份, Maria Berdasco 博士 (Bellvitge Biomedical Research Institute, Barcelona, Spain) 在這次會議中報告的主題 "DNA methyltransferases, DNA methylation and DNA Demethylating Agents in Cancer" 相當令人振奮, 演講中提及 5-hydroxymethylcytidine 在 DNA 中可能扮演的角色, 是近五年來相當受到重視的主題. 雖然確實的功能未知, 但我們認為極有可能是 DNA 鹼基修補過程中, 所形成的中間產物, 這個假設我們也正以實驗確認中. Vern L. Schramm 博士 (Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA) 利用精確的同位素效應, 研究各種不同的 Purine Nucleoside Phosphorylase 的 Transition State 結構, 並依此設計針對不同的 Purine Nucleoside Phosphorylase 的 Transition State Analogs 作為有效的酵素抑制劑, 在 Cancer 及 Malaria 的藥物開發方面都具有相當的成果, 這是本屆會議最吸引我的演講. Katherine Seley-Radtke 博士 (University of Maryland at Baltimore County, Baltimore, MD, USA) 的 'Fleximer' 概念多年前就已經提出, 在化學合成上與我們過去及最近發表的研究成果密切相關, 這類屬於芳香環取代的鹼基核苷似乎都具備相當有趣的生物活性, 因此值得我們日後再深入探討. 這項會議的時程安排, 每位學者專家都有 40 分鐘的報告時間, 再加上 15 分鐘的開放討論時間, 由於討論時間相當充裕, 與會者均能夠充份和演講者討論並交換意見, 同時, 會期約一星期的時間裡, 大家都有機會面對面討論問題, 這一點與其他國際會議不同. 這次與 Akira Matsuda (日本北海道大學) 及 Thomas Kalman (SUNY Buffalo, Buffalo, NY, USA) 博士也針對我們自己的研究工作進行討論, 受益良多. 特別是我們近日發表的兩篇 paper, 關於 6-位取代 uridine analogs 的構形分析方面, 有非常重要的建議, 是此行最大收穫. 三、考察參觀活動(無是項活動者省略) 無 四、建議 國內也有學者專家從事核酸相關領域的研究, 但分散於各個化學及生命科學單位, 若能有類似的交流平台, 可以提供更多的機會討論及合作. 五、攜回資料名稱及內容 與會人員通訊名冊 (本會議不提供會議論文摘要, 壁報論文及口頭報告不允許攝影或拍照, 僅能筆記重點) 六、其他 會議演講時程請參見附件.

Nucleosides, Nucleotides & Oligonucleotides

July 3-8, 2011 Salve Regina University

Newport, RI

Chair: Piet Herdewijn Vice Chair: William B. Parker

Contributors

SUNDAY 2:00 pm - 9:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) 6:00 pm Dinner 7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff 7:40 pm - 7:50 pm Welcome and Introduction: Piet Herdewijn, Chair 7:50 pm - 8:50 pm Keynote Lecture Discussion Leader: Martin Egli (Vanderbilt University, USA) 7:50 pm - 8:30 pm Jack W. Szostack (Massachusetts General Hospital)

"Progress Towards Non-Enzymatic Replication of Genetic Polymers" 8:30 pm - 8:50 pm Discussion 9:00 pm - 10:00 pm Chair's Reception

MONDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Synthetic Biology Discussion Leader: Akira Matsuda (Hokaido University, Japan) 9:00 am - 9:40 am Steven Benner (FfAME, Foundation for Applied Molecular Evolution)

"The Science and Technology of Six Letter DNA Alphabets" 9:40 am - 9:55 am Discussion 9:55 am - 10:25 am Coffee Break / Group Photo 10:25 am - 11:05 am David R. Liu (Harvard University)

"Synthetic and Biological Small Molecule-Nucleic Acid Conjugates" 11:05 am - 11:20 am Discussion 11:20 am - 12:00 pm Andrew Ellington (University of Texas at Austin)

"Determinate and amorphous DNA circuits" 12:00 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Ishtiaq Saaem (Duke University)

"Affordable on-chip gene synthesis enables DNA nanostructure formation and control of protein expression"

12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session A 6:00 pm Dinner 7:30 pm - 9:30 pm Systems Chemistry Discussion Leader: Frank Seela (University of Münster, Germany) 7:30 pm - 8:10 pm Günther von Kiedrowski (Ruhr-University Bochum, Germany)

"Systems Chemistry of Replicators and Assemblers" 8:10 pm - 8:25 pm Discussion 8:25 pm - 9:05 pm Bernard Yurke (Boise State University)

"Catalytic DNA networks" 9:05 pm - 9:15 pm Discussion 9:15 pm - 9:25 pm Hanyang Yu (Arizona State University)

"Progress towards an artificial genetic system capable of Darwinian evolution" 9:25 pm - 9:30 pm Discussion TUESDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm miRNA and siRNA Therapeutics Discussion Leader: Barbara Ramsay Shaw (Duke University) 9:00 am - 9:40 am Jyoti Chattopadhyaya (University of Uppsala)

"Carba-LNA modified siRNAs against HIV" 9:40 am - 9:55 am Discussion

9:55 am - 10:25 am Coffee Break 10:25 am - 11:05 am Troels Koch (Santaris Pharma)

"Locked Nucleic Acid Enables efficient silencing of coding and non-coding RNA"

11:05 am - 11:20 am Discussion 11:20 am - 12:00 pm Muthiah Manoharan (Alnylam Pharmaceuticals)

"Medicinal Chemistry of siRNAs and their Delivery Approaches" 12:00 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Shenglong Zhang (Harvard Medical School)

"Studies of N3'-P5'-linked Phosphoramidate DNA for Genetic Self-replication" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session A 6:00 pm Dinner 7:30 pm - 9:30 pm Structural Biology of Nucleic Acids Discussion Leader: Jyoti Chattopadhyaya (University of Uppsala) 7:30 pm - 8:10 pm Dinshaw Patel (Memorial Sloan-Kettering Cancer Center)

"Structural Biology of RNA-mediated Gene Regulation" 8:10 pm - 8:25 pm Discussion 8:25 pm - 9:05 pm Wei Yang (National Institutes of Health)

"Cancer avoidance and chemotherapy: Ying and Yang of translesion DNA synthesis"

9:05 pm - 9:15 pm Discussion 9:15 pm - 9:25 pm Maciej MJ Jasinski (University of Warsaw)

"Thermodynamic of a PNA/RNA duplex: replica exchange molecular dynamics, calorimetric and spectroscopic studies"

9:25 pm - 9:30 pm Discussion WEDNESDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Epigenetics Discussion Leader: Victor Marquez (NIH, National Cancer Institute) 9:00 am - 9:40 am Stephen Baylin (John Hopkins Medicine)

"Clues to the molecular origins and biological significance of the Cancer Epigenome"

9:40 am - 9:55 am Discussion 9:55 am - 10:25 am Coffee Break 10:25 am - 11:05 am Maria Berdasco (Bellvitge Biomedical Research Institute)

"DNA methyltransferases, DNA methylation and DNA Demethylating Agents in Cancer"

11:05 am - 11:20 am Discussion

11:20 am - 12:00 pm Jason Dwyer (University of Rhode Island) "Nanopore Sequencing and the Demonstration of Single Nucleotide Resolution by Force Spectroscopy"

12:00 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Simon A. McManus (McMaster University)

"Self-phosphorylating DNAzymes and their potential as biosensors for nucleoside triphosphates"

12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session B 6:00 pm Dinner 7:00 pm - 7:30 pm Business Meeting (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms;

Discuss future Site & Scheduling preferences; Election of the next Vice Chair) 7:30 pm - 9:30 pm Aptazymes Discussion Leader: Barbara Nawrot (Polish Academy of Sciences, Centre of

Molecular and Macromolecular Studies, Poland) 7:30 pm - 8:10 pm Michael Yarus (University of Colorado at Boulder)

"RNA chemistry and an RNA world" 8:10 pm - 8:25 pm Discussion 8:25 pm - 9:05 pm Michael Famulok (University of Bonn, Germany)

"Oligonucleotide-based tools for pharmacology and nano-engineering" 9:05 pm - 9:15 pm Discussion 9:15 pm - 9:25 pm Thomas T. Zengeya (Binghamton University)

"Sequence Selective Recognition of Double Helical RNA Using Nucleobase Modified PNA"

9:25 pm - 9:30 pm Discussion THURSDAY 7:30 am - 8:30 am Breakfast 9:00 am - 12:30 pm Antiviral / Antitumoral Nucleoside Analogues Discussion Leader: Varsha Gandhi (University of Texas M.D. Anderson

Cancer Center) 9:00 am - 9:40 am Vern Schramm (Yeshiva University)

"Nucleoside Transition State Analogues in Cancer, Malaria and Quorum Sensing"

9:40 am - 9:55 am Discussion 9:55 am - 10:25 am Coffee Break 10:25 am - 11:05 am Choung Kim (Gilead Sciences, Inc.)

"1'-Substituted C-Nucleosides for Drug Discovery" 11:05 am - 11:20 am Discussion

11:20 am - 12:00 pm Katherine Seley-Radtke (University of Maryland at Baltimore County) "Flexibility. A New Paradigm for Nucleoside Drug Design"

12:00 pm - 12:15 pm Discussion 12:15 pm - 12:25 pm Joanna Szeremeta-Spisak (Polish Academy of Sciences)

"New analogs of triphosphates of 2'-deoxynucleosides" 12:25 pm - 12:30 pm Discussion 12:30 pm Lunch 1:30 pm - 4:00 pm Free Time 4:00 pm - 6:00 pm Poster Session B 6:00 pm Dinner 7:30 pm - 9:30 pm Nucleotide Receptors Discussion Leader: Zhen Huang (Georgia State University) 7:30 pm - 8:10 pm Kenneth Jacobson (National Institutes of Health)

"Novel ligands of purine and pyrimidine receptors: Structure-based discovery" 8:10 pm - 8:25 pm Discussion 8:25 pm - 9:05 pm Christa Müller (University of Bonn, Germany)

"Nucleotide Receptors in Cell Membranes - Targets for Novel Drugs" 9:05 pm - 9:15 pm Discussion 9:15 pm - 9:25 pm Sarah C. Zimmermann (University of Maryland, Baltimore County)

"Novel Carbocyclic C-5-Substituted Pyrimidines as Adenosine Deaminase Inhibitors"

9:25 pm - 9:30 pm Discussion FRIDAY 7:30 am - 8:30 am Breakfast 9:00 am Departure

Poster List Name Organization Poster Title AGROFOGLIO, LUIGI A

ICOA UMR CNRS 6005 Frontal analysis for characterization of binding sites in Molecularly Imprinted Polymer of Adenosine-5'-monophosphate

ASTAKHOVA, IRINA UNIVERSITY OF SOUTHERN DENMARK

Monitoring DNA Self-Assembly Using Novel Fluorescent alpha-L-LNA Analogue

BANDHAYA, ACHIRAPA

IMPERIAL COLLEGE LONDON

TBD

BAUM, DANA A SAINT LOUIS UNIVERSITY Development of small molecule sensors using DNA aptazymes BUCKOREELALL, KAJAL

SOUTHERN RESEARCH INSTITUTE - UAB

Expression and characterization of Rv0535, a probable methylthioadenosine phosphorylase in Mycobacterium tuberculosis

BUDOW, SIMONE CENTER FOR NANOTECHNOLOGY

DNA Gold Nanoparticle Conjugates With Thiooxonucleosides as Gold Surface Anchor

BURROWS, CYNTHIA J

UNIVERSITY OF UTAH A prebiotic role for oxidized purine nucleotides as mimics of flavins in cyclobutane pyrimidine dimer repair.

BUTORA, GABOR MERCK & CO. Nucleoside Optimization for RNAi: Development and Validation of a High Throughput Platform.

CHEEK, MARCUS A DUKE UNIVERSITY Inhibition of Hepatitis C Viral NS5B RNA dependent RNA polymerase by {alpha}-P-boranophosphate modified canonical and non-canonical chain terminating adenosine triphosphate analogues.

CHIEN, TUN-CHENG NATIONAL TAIWAN NORMAL UNIVERSITY

Practical Synthesis of 6-Aryluridines via Palladium(II) Acetate Catalyzed Suzuki-Miyaura Cross-coupling Reaction

CIUDAD, CARLOS J UNIVERSITY OF BARCELONA

Gene Silencing by using Round-PPRHs, RNA-PPRHs and Coding-PPRHs

DEITERS, ALEXANDER

NORTH CAROLINA STATE UNIVERSITY

Light-Regulation of DNA Assembly and DNA Function with Applications to Biological Systems

DUCHO, CHRISTIAN GEORG-AUGUST-UNIVERSITY GOETTINGEN

Synthetic Studies on Muraymycin Nucleoside Antibiotics

ESCUDIER, JEAN-MARC JME

CNRS D-CNA as structural elements of nucleic acids secondary structures

FAMULOK, MICHAEL

UNIVERSITAT BONN Oligonucleotide-based tools for pharmacology and nano-engineering

FORDHAM, DANIEL G

OXFORD NANOPORE TECHNOLOGIES LTD

TBD

GIBBS-DAVIS, JULIANNE M

UNIVERSITY OF ALBERTA Tuning DNA Stability to Achieve Turnover in Template

GRAHAM, STEVEN M

ST. JOHN'S UNIVERSITY Conformational analysis of nucleosides and nucleotides: PSEUROT 2011

HEEMSTRA, JENNIFER M

UNIVERSITY OF UTAH Small-Molecule-Dependent Split Aptamer Ligation

HEIL, KORBINIAN K LMU - MUNICH (AG CARELL)

Formation and Repair of DNA Dewar Lesions

HUANG, ZHEN GEORGIA STATE UNIVERSITY

Creating Nucleic Acid Base Pairs with Higher Fidelity Than the Nature

JASINSKI, MACIEJ MJ

ICM, UNIVERSITY OF WARSAW

Thermodynamics of a PNA/RNA duplex: replica exchange molecular dynamics, calorimetric and spectroscopic studies.

KANDIMALLA, EKAMBAR

IDERA PHARMACEUTICALS, INC

Gene-silencing oligonucleotides containing two exposed 3’-ends show efficient gene-knock down activity

KENSKI, DENISE M SIRNA/MERCK Nucleoside Optimization for RNAi: A High Throughput Platform for in vitro and in vivo analysis of modifications

KOCON-REBOWSKA, BEATA

POLISH ACADEMY OF SCIENCES

Chemically modified deoxyribozymes 10-23 with improved catalytic potential

LUTZ, STEFAN EMORY UNIVERSITY Directed evolution and enzyme design of orthogonal nucleoside analog kinases

MARQUEZ, VICTOR E NATIONAL CANCER INSTITUTE AT FREDERICK

4-(Hydroxymethyl)-2-oxabicyclo[3.1.0]hexane Pyrimidine Nucleosides: A New Template for Conformationally Locked Nucleosides

MARTIN, JENNIFER A US AIR FORCE/NATIONAL RESEARCH COUNCIL

Small-molecule Aptamer Selection for Detection of Cortisol

MCMANUS, SIMON A MCMASTER UNIVERSITY Self-Phosphorylating DNAzymes and their Potential as Biosensors for Nucleoside Triphosphates

PAYRASTRE, CORINNE

UNIVERSITY PAUL SABATIER OLIGONUCLEOTIDE DIRECT FLUORESCENT LABELING BY A NON FLUORESCENT HEMICARBOXONIUM

PENG, XIAOHUA UNIVERSITY OF WISCONSIN MILWAUKEE

Hypoxia-selective DNA interstrand cross-Link formation by a modified nucleoside

PRUZAN, RONALD GERON CORPORATION to be submitted at later date ROZNERS, ERIKS BINGHAMTON UNIVERSITY Synthesis and Properties of Non-Ionic RNA Analogues for

Applications in RNA Interference SAAEM, ISHTIAQ DUKE UNIVERSITY Affordable on-chip gene synthesis enables DNA nanostructure

formation and control of protein expression SETHI, DALIP THOMAS JEFFERSON

UNIVERSITY Neuronal mRNA PET Imaging

SHARAF, MARIAM L DUKE UNIVERSITY Unique and Versatile Boranophosphate-modified siRNA: Activity and Reduced Immunogenicity

SUGIMOTO, NAOKI KONAN UNIVERSITY Quantitative analysis of DNA duplex stability in the hydrated ionic liquid of choline dihydrogenphosphate

SZEREMETA-SPISAK, JOANNA

POLISH ACADEMY OF SCIENCES

NEW ANALOGS OF TRIPHOSPHATES OF 2’-DEOXYNUCLEOSIDES

TEMBURNIKAR, KARTIK W

UNIVERSITY OF MARYLAND BALTIMORE COUNTY

TBD

TRETYAKOVA, NATALIA

UNIVERSITY OF MINNESOTA Structurally modified DNA bases as biomarkers of exposure and probes of carcinogen-DNA interactions

WANG, CHI-KUANG LEO

NATIONAL LABORATORY ANIMAL CENTER

to be submitted at a later date (related to generating transgenic knockdown mice)

WANG, YONG UNIVERSITY OF CONNECTICUT

Nanogels for Delivery of Therapeutic Oligonucleotides

WAUCHOPE, ORRETTE R

UNIVERSITY OF MARYLAND BALTIMORE COUNTY

Exploring nucleoside structure and enzyme recognition

WILLIAMS, GAVIN J NORTH CAROLINA STATE UNIVERSITY

Cell-free screening and selection of synthetic riboswitches

YANG, XIANBIN AM BIOTECHNOLOGIES Enhanced Gene Silencing Activity using Phosphorodithioated siRNAs

YOUELL, JAMES H UNIVERSITY OF PORTSMOUTH

Purification and characterisation of eIF4a from P. falciparum for analysis using a novel high throughput screening device.

YU, HANYANG ARIZONA STATE UNIVERSITY Progress Towards an Artificial Genetic System Capable of Darwinian Evolution

ZENGEYA, THOMAS T

BINGHAMTON UNIVERSITY Sequence Selective Recognition of Double Helical RNA Using Nucleobase-Modified PNA

ZHANG, SHENGLONG

HARVARD MEDICAL SCHOOL Studies of N3´-P5´-linked Phosphoramidate DNA for Genetic Self-replication in Synthetic Cell

ZHU, HUIHE GIRINDUS AMERICA INC. Optimization of purification process for high purity oligonucleotides

ZIMMERMANN, SARAH C

UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

Novel Carbocyclic C5-Substituted Pyrimidines as Adenosine Deaminase Inhibitors

Conference Registration List

Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference Salve Regina University July 3-8, 2011

LUIGI A AGROFOGLIO ICOA UMR CNRS 6005 UFR SCIENCES/AR2T UNIVERSITY D'ORLEANS ORLEANS 45067 FRANCE

Phone: 33-2-3849-4582Fax: Email: luigi.agrofoglio@univ-orleans.fr Participation: Poster Presenter

ROWSHAN ALAM GIRINDUS AMERICA INC. OPERATIONS - OLIGONUCLEOTIDES 8560 READING ROAD CINCINNATI, OHIO 45215-5528

Phone: 513-679-3097Fax: 513-679-3053Email: ralam@girindus.com Participation: Attendee

IRINA ASTAKHOVA UNIVERSITY OF SOUTHERN DENMARK CAMPUSVEJ 55 ODENSE 5230 DENMARK

Phone: 45-617-89-547Fax: Email: ias@ifk.sdu.dk Participation: Poster Presenter

ACHIRAPA BANDHAYA IMPERIAL COLLEGE LONDON DEPARTMENT OF CHEMISTRY LEVEL 6, FLOWERS BUILDING SOUTH KENSINGTON CAMPUS LONDON SW7 2AZ UNITED KINGDOM

Phone: 44-789-4228384Fax: Email: a.bandhaya07@imperial.ac.uk Participation: Poster Presenter

DANA A BAUM SAINT LOUIS UNIVERSITY DEPARTMENT OF CHEMISTRY 3501 LACLEDE AVENUE MONSANTO HALL 125 ST. LOUIS, MO 63103

Phone: 314-977-2842Fax: 314-977-2521Email: dbaum1@slu.edu Participation: Poster Presenter

STEPHEN B BAYLIN JOHNS HOPKINS UNIVERSITY CRB1, SUITE 541 1650 ORLEANS STREET BALTIMORE, MD 21231

Phone: 410-955-8506Fax: 410 614-9884Email: sbaylin@jhmi.edu Participation: Speaker

LEONID BEIGELMAN ALIOS BIOPHARMA 260 EAST GRAND AVE SOUTH SAN FRANCISCO, CA 94080

Phone: 650-635-5508Fax: Email: lbeigelman@aliosbiopharma.com Participation: Attendee

STEVEN A BENNER FOUNDATION FOR APPLIED MOLECULAR EVOLUTION PO BOX 13174 GAINESVILLE, FL 32604

Phone: 352-271-7005Fax: 352-271-7076Email: sbenner@ffame.org Participation: Speaker

MARIA BERDASCO BELLVITGE BIOMEDICAL RESEARCH INSTITUTE CANCER EPIGENETICS AND BIOLOGY PROGRAM 3RD FLOOR, HOSPITAL DURAN I REYNALS, AV.GRAN VIA DE L'HOSPITALET BARCELONA 08908 SPAIN

Phone: 34-93-2607253Fax: 34-93-2607140Email: mberdasco@idibell.cat Participation: Speaker

KAJAL BUCKOREELALL SOUTHERN RESEARCH INSTITUTE - UAB 2000 9TH AVE SOUTH BIRMINGHAM, AL 35205

Phone: 205-581-2519Fax: Email: kbuck@uab.edu Participation: Poster Presenter

SIMONE BUDOW CENTER FOR NANOTECHNOLOGY CHEMBIOTECH HEISENBERGSTRASSE 11 MUENSTER, NRW D-48149 GERMANY

Phone: 49-25153406505Fax: 49-25153406857Email: sbudow@uni-osnabrueck.de Participation: Poster Presenter

CYNTHIA J BURROWS UNIVERSITY OF UTAH DEPARTMENT OF CHEMISTRY 315 S. 1400 EAST, RM 2020 SALT LAKE CITY, UT 84112-0850

Phone: 801-585-7290Fax: 801-585-0024Email: burrows@chem.utah.edu Participation: Poster Presenter

GABOR BUTORA MERCK & CO. 126 EAST LINCOLN AVE RAHWAY, NJ 08836

Phone: 732-594-8563Fax: Email: gabor_butora@merck.com Participation: Poster Presenter

MICHAEL L CASNER CASNER CONSULTING 110 LAUREL DRIVE PITMAN, NJ 08071-2029

Phone: 609-932-3361Fax: Email: casnerm@gmail.com Participation: Attendee

CLIFFORD M CHAN ABBOTT MOLECULAR INC 1300 E.TOUHY DES PLAINES, IL 60018

Phone: 224-361-7230Fax: Email: clifford.chan@abbott.com Participation: Attendee

JOHN C CHAPUT THE BIODESIGN INSTITUTE AT ASU 1001 S. MCALLISTER AVE TEMPE, AZ. 85048

Phone: 480-727-0392Fax: Email: john.chaput@asu.edu Participation: Attendee

JYOTI CHATTOPADHYAYA UPPSALA UNIVERSITY DEPT OF BIOORGANIC CHEMISTRY, BOX 581 BIOMEDICAL CENTER UPPSALA S-75123 SWEDEN

Phone: 46-184714577Fax: 46-18554495Email: jyoti@boc.uu.se Participation: Discussion Leader

MARCUS A CHEEK DUKE UNIVERSITY CHEMISTRY DEPARTMENT 124 SCIENCE DRIVE DURHAM, NC 27708

Phone: 919-699-9924Fax: Email: marcuscheek@yahoo.com Participation: Poster Presenter

TUN-CHENG CHIEN NATIONAL TAIWAN NORMAL UNIVERSITY NO.88, SEC.4, TING-ZHOU ROAD DEPARTMENT OF CHEMISTRY NATIONAL TAIWAN NORMAL UNIVERSITY TAIPEI 11677 TAIWAN

Phone: 886-277346126Fax: 886-229324249Email: tcchien@ntnu.edu.tw Participation: Poster Presenter

CARLOS J CIUDAD UNIVERSITY OF BARCELONA DEPARTMENT OF BIOCHEMISTRY & MOLECULAR BIOLOGY SCHOOL OF PHARMACY AV. DIAGONAL 643 BARCELONA E-08028 SPAIN

Phone: 34-934034455Fax: Email: cciudad@ub.edu Participation: Poster Presenter

CHRIS DEALWIS CWRU 1900 EUCLID AVE CLEVELAND, OH 44106

Phone: 216-368-1652Fax: Email: cxd114@case.edu Participation: Attendee

ALEXANDER DEITERS NORTH CAROLINA STATE UNIVERSITY DEPARTMENT OF CHEMISTRY CAMPUS BOX 8204 RALEIGH, NC 27695

Phone: 919-515-7607Fax: Email: alex_deiters@ncsu.edu Participation: Poster Presenter

CYRIL DOUSSON IDENIX LABORATORIES CAP GAMMA- 1682 RUE DE LA LA VALSIERE BP 50001 MONTPELLIER 34189 FRANCE

Phone: 33-499522252Fax: 33-499522250Email: hay.katia@idenix.com Participation: Attendee

JINFA DU PHARMASSET, INC 303-A COLLEGE ROAD, EAST PRINCETON, NJ 08540

Phone: 609-613-4106Fax: Email: jdu@pharmasset.com Participation: Attendee

CHRISTIAN DUCHO GEORG-AUGUST-UNIVERSITY GOETTINGEN DEPARTMENT OF CHEMISTRY INSTITUTE OF ORGANIC AND BIOMOLECULAR CHEMISTRY TAMMANNSTR. 2 GOETTINGEN 37077 GERMANY

Phone: 49-551-39-3285Fax: 49-551-39-9660Email: cducho@gwdg.de Participation: Poster Presenter

JASON DWYER UNIVERSITY OF RHODE ISLAND 51 LOWER COLLEGE ROAD DEPARTMENT OF CHEMISTRY KINGSTON, RI 02881

Phone: 401-874-4648Fax: 401-874-5072Email: jdwyer@chm.uri.edu Participation: Speaker

MARTIN EGLI VANDERBILT UNIVERSITY DEPT. OF BIOCHEMISTRY 607 LIGHT HALL BOX 35-1634 NASHVILLE, TN 37232

Phone: 615-343-8070Fax: 615-322-7122Email: martin.egli@vanderbilt.edu Participation: Discussion Leader

ANDREW D ELLINGTON UNIVERSITY OF TEXAS AT AUSTIN DEPARTMENT OF CHEMISTRY ICMB-MBB 3.424 26TH AND SPEEDWAY AUSTIN, TX 78712

Phone: 512-232-3424Fax: 512-471-7014Email: andy.ellington@mail.utexas.edu Participation: Speaker

JEAN-MARC JME ESCUDIER CNRS UNIVERSITY PAUL SABATIER TOULOUSE 31062 FRANCE

Phone: 33-561556291Fax: Email: escudier@chimie.ups-tlse.fr Participation: Poster Presenter

MICHAEL FAMULOK UNIVERSITAT BONN LIMES INSTITUTE C/O KEKULE INSTITUT FUR ORGANISCHE CHEMIE GERHARD-DOMAGK-STRASSE 1 BONN 53121 GERMANY

Phone: 49-228-731787Fax: 49-228-735388Email: m.famulok@uni-bonn.de Participation: Speaker

JOY FENG GILEAD SCIENCES 333 LAKESIDE DRIVE FOSTER CITY, CA 94404

Phone: 650-522-5549Fax: Email: joy.feng@gilead.com Participation: Attendee

DANIEL G FORDHAM OXFORD NANOPORE TECHNOLOGIES LTD EDMUND CARTWRIGHT HOUSE 4 ROBERT ROBINSON AVENUE OXFORD SCIENCE PARK OXFORD, OXFORDSHIRE OX44GA UNITED KINGDOM

Phone: 44-8450347900Fax: 44-8450347901Email: daniel.fordham@nanoporetech.com Participation: Poster Presenter

VARSHA GANDHI M.D. ANDERSON CANCER CENTER DEPT EXP THERAPEUTICS UNIT 71 1515 HOLCOMBE BLVD HOUSTON, TX 77030

Phone: 713-792-2989Fax: 713-794-4316Email: vgandhi@mdanderson.org Participation: Discussion Leader

JULIANNE M GIBBS-DAVIS UNIVERSITY OF ALBERTA DEPARTMENT OF CHEMISTRY 11227 SASKATCHEWAN DR. EDMONTON, AB T6G 2G2 CANADA

Phone: 780-492-7140Fax: Email: gibbsdavis@ualberta.ca Participation: Poster Presenter

STEVEN M GRAHAM ST. JOHN'S UNIVERSITY DEPARTMENT OF CHEMISTRY 8000 UTOPIA PARKWAY QUEENS, NY 11439

Phone: 718-990-5217Fax: 718-990-1876Email: grahams@stjohns.edu Participation: Poster Presenter

JENNIFER M HEEMSTRA UNIVERSITY OF UTAH DEPARTMENT OF CHEMISTRY 315 S 1400 E SALT LAKE CITY, UT 84108

Phone: 801-581-4191Fax: Email: heemstra@chem.utah.edu Participation: Poster Presenter

VISHNUMURTHY R. HEGDE ORGANIX INC. 240 SALEM STREET WOBURN, MA 01801

Phone: 781-932-4142Fax: 781-933-6695Email: hegde@organixinc.com Participation: Attendee

KORBINIAN K HEIL LMU - MUNICH (AG CARELL) FAKULTA FUR CHEMIE UND PHARMAZIE LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN BUTENANDTSTR. 5-13 (HAUS F) MUNICH D-81377 GERMANY

Phone: 49-89218077848Fax: 49-89218077756Email: khech@cup.uni-muenchen.de Participation: Poster Presenter

PIET HERDEWIJN KATHOLIEKE UNIVERSITEIT LEUVEN REGA INSTITUTE FOR MEDICAL RESEARCH MINDERBROEDERSSTRAAT 10 LABORATORY OF MEDICINAL CHEMISTRY LEUVEN B-3000 BELGIUM

Phone: 32-16337387Fax: 32-16337340Email: piet.herdewijn@rega.kuleuven.be Participation: Chair

ZHEN HUANG GEORGIA STATE UNIVERSITY DEPARTMENT OF CHEMISTRY P.O. BOX 4098 ATLANTA, GA 30302-4098

Phone: 404-413-5535Fax: Email: huang@gsu.edu Participation: Poster Presenter

KENNETH A JACOBSON NATIONAL INSTITUTE OF HEALTH LABORATORY OF BIORGANIC CHEMISTRY NIDDK BODG 8, ROOM B1A-19 BETHESDA, MD 20892-0810

Phone: 301-496-9024Fax: 301-480-8422Email: kajacobs@helix.nih.gov Participation: Speaker

MACIEJ MJ JASINSKI ICM, UNIVERSITY OF WARSAW INTERDISCIPLINARY CENTRE FOR MATHEMATICAL AND COMPUTATIONAL MODELLING ZWIRKI I WIGURY 93 WARSAW 02-089 POLAND

Phone: 48-22-5540-843Fax: 48-22-5540-801Email: maciejj@icm.edu.pl Participation: Poster Presenter

THOMAS I KALMAN UNIVERSITY AT BUFFALO DEPARTMENT OF CHEMISTRY NATURAL SCIENCES BLDG BUFFALO, NY 14260

Phone: 716-984-9011Fax: 716-645-6963Email: tkalman@buffalo.edu Participation: Attendee

RAO KAMBHAMPATI FDA DIVISION OF NEW DRUG QUALITY ASSESSMENT II/ONDQA WO BG 22, RM 1448 10993 NEW HAMPSHIRE AVENUE SILVER SPRING, MD 20993

Phone: 301-796-1382Fax: 301-796-9877Email: rao.kambhampati@fda.hhs.gov Participation: Attendee

EKAMBAR KANDIMALLA IDERA PHARMACEUTICALS, INC 167 SIDNEY STREET CAMBRIDGE, MA 02139

Phone: 617-679-5536Fax: Email: ekandimalla@iderapharma.com Participation: Poster Presenter

DENISE M KENSKI SIRNA/MERCK 1700 OWENS ST, 4TH FLOOR SAN FRANCISCO, CA 94158

Phone: 415-814-8407Fax: 415-558-1561Email: denise_kenski@merck.com Participation: Poster Presenter

CHOUNG U KIM GILEAD SCIENCES 353 LAKESIDE DRIVE FOSTER CITY, CA 94404

Phone: 415-572-6616Fax: 415-573-4899Email: ckim@gilead.com Participation: Speaker

TROELS KOCH SANTARIS PHARMA RESEARCH DEPT KOGLE ALLÉ 6 HØRSHOLM DK-2970 DENMARK

Phone: + 45 45 17 98 08Fax: + 45 45 17 98 10Email: tk@santaris.com Participation: Speaker

BEATA KOCON-REBOWSKA POLISH ACADEMY OF SCIENCES DEPARTMENT OF BIOORGANIC CHEMISTRY SIENKIEWICZA 112 LODZ 90-363 POLAND

Phone: 48-426847113Fax: Email: beatakr@cbmm.lodz.pl Participation: Poster Presenter

FENG-WU LIU ZHENGZHOU UNIVERSITY KE XUE DA DAO 100, SCHOOL OF PHARMACEUTICAL SCIENCES ZHENGZHOU, HENAN 450001 CHINA

Phone: 86-13-63-382-3596Fax: 86-37-16-778-1908Email: regafw@hotmail.com Participation: Attendee

DAVID R LIU HARVARD UNIVERSITY 12 OXFORD STREET CAMBRIDGE, MA 02138

Phone: 617-496-1067Fax: 617-496-5688Email: liu@chemistry.harvard.edu Participation: Speaker

STEFAN LUTZ EMORY UNIVERSITY DEPARTMENT OF CHEMISTRY 1515 DICKEY DRIVE ATLANTA, GA 30322

Phone: 404-712-2170Fax: 404-727-6586Email: sal2@emory.edu Participation: Poster Presenter

MUTHIAH MANOHARAN ALNYLAM PHARMACEUTICALS 300 THIRD STREET, 3RD FLOOR CAMBRIDGE, MA 02142

Phone: 617-551-8200Fax: Email: mmanoharan@alnylam.com Participation: Speaker

VICTOR E MARQUEZ NATIONAL CANCER INSTITUTE AT FREDERICK 888 BRICKELL KEY DRIVE APT. 1604 MIAMI, FL 33131

Phone: 305-374-9686Fax: 301-846-6063Email: marquezv@mail.nih.gov Participation: Discussion Leader

JENNIFER A MARTIN US AIR FORCE/NATIONAL RESEARCH COUNCIL 2947 FIFTH ST. AREA B BUILDING 840 WPAFB, OH 45433

Phone: 937-938-3768Fax: Email: jennifer.martin.ctr@wpafb.af.mil Participation: Poster Presenter

AKIRA MATSUDA HOKKAIDO UNIVERSITY KITA-12, NISHI-6 KITA-KU SAPPORO, HOKKAIDO 060-0812 JAPAN

Phone: 81-11-706-3228Fax: 81-11-706-4980Email: matuda@pharm.hokudai.ac.jp Participation: Discussion Leader

SIMON A MCMANUS MCMASTER UNIVERSITY DEPT OF BIOCHEMISTRY AND BIOMEDICAL SCIENCES HSC 4H31 1200 MAIN STREET WEST HAMILTON, ON L8N 3Z5 CANADA

Phone: 905-525-9140 X28813Fax: Email: mcmanusa@mcmaster.ca Participation: Poster Presenter

CRAIG MELLO UNIVERSITY OF MASSACHUSETTS CANCER CENTER 55 LAKE AVENUE NORTH WORCESTER, MA 01655

Phone: Fax: Email: craig.mello@umassmed.edu Participation: Speaker

CHRISTA MULLER UNIVERSITY OF BONN PHARMACENTER BONN, PHARMACEUTICAL INSTITUTE AN DER IMMENBURG 4 BONN D-53121 GERMANY

Phone: +49 228 73 2301Fax: +49 228 73 2567Email: christa.mueller@uni-bonn.de Participation: Speaker

BARBARA C. NAWROT POLISH ACADEMY OF SCIENCES SIENKIEWICZA 112 LODZ 90-363 POLAND

Phone: 48-42-6816970Fax: 48-42-6815483Email: bnawrot@bio.cbmm.lodz.pl Participation: Speaker

WILLIAM B PARKER SOUTHERN RESEARCH INSTITUTE 2000 NINTH AVENUE SOUTH BIRMINGHAM, AL 35205

Phone: 205-581-2797Fax: 205-581-2093Email: parker@sri.org Participation: Vice Chair

DINSHAW PATEL SLOAN-KETTERING INSTITUTE PROGRAM IN STRUCTURAL BIOLOGY 1275 YORK AVENUE NEW YORK, NEW YORK 10065

Phone: 212-639-8141Fax: 212-717-3066Email: pateld@mskcc.org Participation: Speaker

CORINNE PAYRASTRE UNIVERSITY PAUL SABATIER LSPCMIB UMR 5068 118, ROUTE DE NARBONNE TOULOUSE 31062 FRANCE

Phone: 33-561558392Fax: 33-561556011Email: payrastr@chimie.ups-tlse.fr Participation: Poster Presenter

XIAOHUA PENG UNIVERSITY OF WISCONSIN MILWAUKEE DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY 3210 N. CRAMER ST. MILWAUKEE, WI 53211

Phone: 414-229-5221Fax: 414-229-5530Email: pengx@uwm.edu Participation: Poster Presenter

RONALD PRUZAN GERON CORPORATION 230 CONSTITUTION DR MENLO PARK, CA 94025

Phone: 650-924-2013Fax: Email: rpruzan@geron.com Participation: Poster Presenter

MIKE RADTKE NATIONAL INSTITUTES OF HEALTH CENTER FOR SCIENTIFIC REVIEW 6701 ROKLEDGE DR., RM. 4144 BETHESDA, MD 20892-7806

Phone: 301-435-1728Fax: 301-480-2327Email: radtkem@csr.nih.gov Participation: Attendee

JOHN B. RANDOLPH GLEN RESEARCH CORPORATION 22825 DAVIS DRIVE #100 STERLING, VA 20164

Phone: 703-437-6191Fax: 703-435-9774Email: john@glenres.com Participation: Attendee

ERIKS ROZNERS BINGHAMTON UNIVERSITY 4400 VESTAL PARKWAY EAST BINGHAMTON, NY 13902

Phone: 607-777-2441Fax: 607-777-4478Email: erozners@binghamton.edu Participation: Poster Presenter

ISHTIAQ SAAEM DUKE UNIVERSITY DEPT OF BIOMEDICAL ENGINEERING ROOM 136, HUDSON HALL. RESEARCH DRIVE DURHAM, NC 27708

Phone: 609-865-4777Fax: Email: ies2@duke.edu Participation: Poster Presenter

VERN L. SCHRAMM YESHIVA UNIVERSITY ALBERT EINSTEIN COLLEGE OF MEDICINE 1300 MORRIS PARK AVENUE FORCH 308 BRONX, NY 10461

Phone: 718-430-2813Fax: 718-430-8565Email: vern.schramm@einstein.yu.edu Participation: Speaker

FRANK SEELA UNIVERSITY OF OSNABRUECK DEPARTMENT OF CHEMISTRY/BIOLOGY GUTENBERGSTR. 44 OSNABRUECK 49076 GERMANY

Phone: 49-173-7250-297Fax: 49-541-63236Email: frank.seela@uni-osnabrueck.de Participation: Discussion Leader

KATHERINE L SELEY-RADTKE UNIVERSITY OF MARYLAND, BALTIMORE CO DEPT OF CHEMISTRY AND BIOCHEMISTRY 1000 HILLTOP CIRCLE, MEYR 405C BALTIMORE, MD 20910

Phone: 410-455-8684Fax: 410-455-2608Email: kseley@umbc.edu Participation: Speaker

DMITRI SERGUEEV CEPHEID 1631 220TH STREET SE SUITE 102 BOTHELL, WA 98021

Phone: 425-686-1564Fax: Email: dsergueev@frontier.com Participation: Attendee

DALIP SETHI THOMAS JEFFERSON UNIVERSITY DEPT. OF BIOCHEMISTRY AND MOLECULAR BIOLOGY 233 S. 10TH ST., RM. 219 PHILADELPHIA, PA 19107

Phone: 215-955-1361Fax: Email: dalip.sethi@jefferson.edu Participation: Poster Presenter

MARIAM L SHARAF DUKE UNIVERSITY 124 SCIENCE DRIVE CHEMISTRY DEPARTMENT -FFSC 3203 DURHAM, NC 27708

Phone: 919-599-4533Fax: Email: mls32@duke.edu Participation: Poster Presenter

BARBARA RAMSAY SHAW DUKE UNIVERSITY DEPT OF CHEMISTRY FFSC BOX 90346 DURHAM, NC 27708-0346

Phone: 919-451-9197Fax: 919-660-1605Email: brshaw@chem.duke.edu Participation: Discussion Leader

NANDA SINHA CONSULTANT FOR GIRINDUS AMERICA INC. 8560 READING ROAD CINCINNATI, OH 45215

Phone: 513-679-3031Fax: 513-679-3053Email: nanda.sinha@comcast.net Participation: Attendee

NAOKI SUGIMOTO KONAN UNIVERSITY FRONTIER INSTITUTE FOR BIOMOLECULAR ENGINEERING RESEARCH 7-1-20 MINATOJIMA-MINAMIMACHI CHUO-KU KOBE, HYOGO 650-0047 JAPAN

Phone: 81-78-303-1457Fax: 81-78-303-1495Email: sugimoto@konan-u.ac.jp Participation: Poster Presenter

JOANNA SZEREMETA-SPISAK POLISH ACADEMY OF SCIENCES DEPARTMENT OF BIOORGANIC CHEMISTRY SIENKIEWICZA 112 LODZ 90-363 POLAND

Phone: 48-426847113Fax: Email: jszereme@cbmm.lodz.pl Participation: Poster Presenter

JACK W SZOSTAK MASS GENERAL HOSPITAL DEPARTMENT OF MOLECULAR BIOLOGY SIMCHES RESEARCH CENTER 185 CAMBRIDGE STREET BOSTON, MA 02114

Phone: 617-726-5981Fax: 617-726-6893Email: szostak@molbio.mgh.harvard.edu Participation: Speaker

KARTIK W TEMBURNIKAR UNIVERSITY OF MARYLAND BALTIMORE COUNTY CHEMISTRY AND BIOCHEMISTRY 1000 HILLTOP CIRCLE BALTIMORE, MD 21250

Phone: 4438513113Fax: Email: kartik1@umbc.edu Participation: Poster Presenter

XIA TIAN X-CHEM, INC. 100 BEAVER ST., SUITE 101 WALTHAM, MA 02453

Phone: 781-314-2933Fax: Email: xtian@x-chemrx.com Participation: Attendee

NATALIA TRETYAKOVA UNIVERSITY OF MINNESOTA UNIVERSITY OF MINNESOTA CANCER CENTER 420 DELAWARE ST SE - MMC 806 MINNEAPOLIS, MN 55455

Phone: 612-626-3432Fax: 612-626-5135Email: trety001@umn.edu Participation: Poster Presenter

SHIH-CHIEH TSAI NATIONAL LABORATORY ANIMAL CENTER NO.17, NANKE 2ND RD., XINSHI DIST. TAINAN 74147 TAIWAN

Phone: 886-6-510-8237Fax: Email: 1007200@nlac.narl.org.tw Participation: Attendee

GUNTER VON KIEDROWSKI UNIVERSITAET ORG CHEMIE I DEPARTMENT OF ORGANIC CHEMISTRY RUHR UNIVERSITAET BOCHUM BOCHUM 44780 GERMANY

Phone: 49-234-3228218Fax: 49-234-3214355Email: kiedro@ernie.orch.ruhr-uni-bochum.de Participation: Speaker

YONG WANG UNIVERSITY OF CONNECTICUT 191 AUDITORIUM ROAD STORRS, CT 06269

Phone: 860-486-4072Fax: 860-486-2959Email: yongwang@engr.uconn.edu Participation: Poster Presenter

CHI-KUANG LEO WANG NATIONAL LABORATORY ANIMAL CENTER 128, ACADEMIC ROAD SEC 2 NANKANG TAIPEI 11529 TAIWAN

Phone: 886-2-27895567Fax: 886-2-27895577Email: cklwang@nlac.narl.org.tw Participation: Poster Presenter

ORRETTE R WAUCHOPE UNIVERSITY OF MARYLAND BALTIMORE COUNTY DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY 1000 HILLTOP CIRCLE BALTIMORE, MD 21250

Phone: 410-455-5627Fax: 410-455-1174Email: orrette1@umbc.edu Participation: Poster Presenter

GAVIN J WILLIAMS NORTH CAROLINA STATE UNIVERSITY DEPT OF CHEMISTRY, DABNEY HALL RM 850 2620 YARBROUGH DRIVE RALEIGH, NC 27695-8204

Phone: 919-862-3127Fax: Email: gavin_williams@ncsu.edu Participation: Poster Presenter

XIANBIN YANG AM BIOTECHNOLOGIES RESEARCH & DEVELOPEMNT 12521 GULF FREEWAY HOUSTON, TX 77034

Phone: 832-379-2175Fax: Email: xianbin.yang@thioaptamer.com Participation: Poster Presenter

WEI YANG NIH, NIDDK LABORATORY OF MOELCULAR BIOLOGY BLDG. 5, RM. B1-03 9000 ROCKVILLE PIKE BETHESDA, MD 20892

Phone: 301-402-4645Fax: 301-496-0201Email: wei.yang@nih.gov Participation: Speaker

MICHAEL YARUS UNIVERSITY OF COLORADO MCD BIOLOGY PORTER BIOSCIENCE BOULDER, CO 80309-0347

Phone: 303-492-8376Fax: 303-492-7744Email: yarus@colorado.edu Participation: Speaker

JAMES H YOUELL UNIVERSITY OF PORTSMOUTH BIOLOGY DEPARTMENT KING HENRY BUILDING KING HENRY I STREET PORTSMOUTH, HAMPSHIRE PO1 2DY UNITED KINGDOM

Phone: 44-2392843077Fax: Email: jim.youell@port.ac.uk Participation: Poster Presenter

HANYANG YU ARIZONA STATE UNIVERSITY CEMI/CHAPUT BIODESIGN INSTITUTE 1001 S. MCALLISTER AVE. TEMPE, AZ 85287

Phone: 480-727-0463Fax: Email: hanyang.yu@asu.edu Participation: Poster Presenter

BERNARD YURKE BOISE STATE UNIVERSITY MATERIALS SCIENCE & ENGINEERING 1910 UNIVERSITY DRIVE BOISE, ID 83725

Phone: 208-426-4825Fax: Email: bernardyurke@boisestate.edu Participation: Speaker

THOMAS T ZENGEYA BINGHAMTON UNIVERSITY 4400 VESTAL PARKWAY VESTAL, NY 13850

Phone: 315-374-0146Fax: 607-777-4478Email: tzengey1@binghamton.edu Participation: Poster Presenter

SHENGLONG ZHANG HARVARD MEDICAL SCHOOL HHMI/DEPARTMENT OF MOLECULAR BIOLOGY/CCIB MASSACHUSETTS GENERAL HOSPITAL DEPARTMENT OF GENETICS BOSTON, MA 02114

Phone: 617-726-5980Fax: 617-643-3328Email: slzhang@molbio.mgh.harvard.edu Participation: Poster Presenter

HUIHE ZHU GIRINDUS AMERICA INC. 8560 READING ROAD CINCINNATI, OH 45215

Phone: 513-679-3021Fax: 513-679-3051Email: hzhu@girindus.com Participation: Poster Presenter

SARUNAS ZIGMANTAS THERMO FISHER SCIENTIFIC V. A. GRAICIUNO G. 8 VILNIUS LT-02241 LITHUANIA

Phone: 370-613-24981Fax: 370-2-602142Email: sarunas.zigmantas@thermofisher.com Participation: Attendee

SARAH C ZIMMERMANN UNIVERSITY OF MARYLAND, BALTIMORE COUNTY CHEMISTRY DEPARTMENT 1000 HILLTOP CIRCLE BALTIMORE, MD 21250

Phone: 410-455-8404Fax: Email: sarahz1@umbc.edu Participation: Poster Presenter

grcpacket_2011_nucleoside.pdfProgramPoster ListRegistration List