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Vol. 266, No. 35 The Journal of December 15,1991
Biological Chemistry Copyright 0 1991 by the American Society for Biochemistry and Molecular Biology, Inc.
428 East Preston St., Baltimore, MD 21202 U.S.A.
CONTENTS*
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MINIREVIEW CD45. A prototype for transmembrane protein ty- rosine phosphatases.
Ian S. Trowbridge
COMMUNICATIONS A phosphorylation site located in the NHz-terminal domain of c-Myc increases transactivation of gene expression.
Davis Alpna Seth, Elvira Alvarez, Shashi Gupta, and Roger J .
Regulation of gene expression by insulin and tumor necrosis factor a in 3T3-Ll cells. Modulation of the transcription of genes encoding acyl-CoA synthe- tase and stearoyl-CoA desaturase- 1.
mer, and Charles S. Rubin Francis R. Weiner, Pamela J. Smith, Stanley Werthei-
ARTICLES Psychotrine and its 0-methyl ether are selective inhibitors of human immunodeficiency virus-1 re- verse transcriptase.
and John M. Pezzuto Ghee T. Tan, A. Douglas Kinghorn, Stephen H. Hughes,
Glucose-induced increase in cytoplasmic pH in pan- creatic 8-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
Lisa Juntti-Berggren, Per Arkhammar, Thomas Nilsson, Patrik Rorsman, and Per-Olof Berggren
and its relationship to the sequences of other flavo- The sequence of squash NADH:nitrate reductase
pyridine nucleotide cytochrome reductases. protein oxidoreductases. A family of flavoprotein
Gregory E. Hyde, Nigel M. Crawford, and Wilbur H. Campbell
Oxalate decarboxylase from Collybia velutipes. Pu- rification, characterization, and cDNA cloning.
Anuradha Mehta and Asis Datta
Involvement of platelet glycoprotein IIb-IIIa (arm-@s integrin) in thrombin-induced synthesis of phospha- tidylinositol3’,4’-bisphosphate.
Claire Sultan, Monique Plantauid, Christilla Bachelot, Pascal Grondin, Monique Breton, Girard Mauco, Sylviane Guy-Toledano, Jacques P. Caen, and Hugues Chap
Substantial increase of the inhibitory activity of Mirabilis antiviral protein by an elimination of the disulfide bond with genetic engineering.
Noriyuki Habuka, Masashi Miyano, Jiro Kataoka, Hi- deaki Tsuge, Hideo Ago, and Masana Noma
Metabolism of 5,6-epoxyeicosatrienoic acid by the human platelet. Formation of novel thromboxane analogs.
Oleic acid promotes changes in the subcellular dis- tribution of protein kinase C in isolated hepatocytes.
Maria J . M. Diaz-Guerra, Maria Junco, and Lisardo Bosca
Purification and characterization of a third cyto- solic component of the superoxide-generating NADPH oxidase of macrophages.
Michael Balazy
Arie Abo and Edgar Pick
23586
23593
23602
23606
23611
23618
23624
23632
23637
23641
23648
23654
Mannose 6-phosphate-independent targeting of ca- thepsin D to lysosomes in HepG2 cells.
Simon Rijnboutt, Arnoud J. Kal, Hans J. Geuze, Hans Aerts, and Ger J. Strous
Skeletal myoblasts utilize a novel 81-series integrin and not a601 for binding to the E8 and T8 fragments of laminin.
Helga uon der Mark, Joachim Durr, Arnoud Sonnenberg, Klaus uon der Mark, Ruiner Deutzmann, and Simon L. Goodman
Drosophila 5 S RNA processing requires the 1-118 base pair and additional sequence proximal to the processing site.
Peter R. Preiser and Louis F. Levinger
Transport of proteins into chloroplasts. Delineation of envelope “transit” and thylakoid “transfer” sig- nals within the pre-sequences of three imported thy- lakoid lumen proteins.
Diane C. Bassham, Dieter Bartling, Ruth M. Mould, Bryan Dunbar, Peter Weisbeek, Reinhold G. Herrmann, and Colin Robinson
Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autolo- gous IgC binding, complement deposition, and phagocytosis.
Franco Turrini, Paolo Arese, Jie Yuan, and Philip S. Low
Regulation of agonist-induced prostaglandin E, ver- sus prostaglandin Ez production. A mass analysis.
Daniel Rubin and Michael Laposata
Binding and endocytosis of apo- and holo-lactofer- rin by isolated rat hepatocytes.
Douglas D. McAbee and Kari Esbensen
Proteolytic formation of either of the two prothrom- bin activation intermediates results in formation of a hirugen-binding site.
Le- Wen Liu, Jia Ye, Arthur E. Johnson, and Charles T. Esmon
Effect of polyanions on the refolding of human acidic fibroblast growth factor.
Middaugh Jonathan M. Dabora, Gautam Sanyal, and C. Russell
EPR characterization of the stereochemistry of the distal heme pocket of the engineered human myo- globin mutants.
Masao Zkeda-Saito, Rodney S. Lutz, Deborah A. Shelley, Erin J. McKeluey, Rafael Mattera, and Hiroshi Hori
Effect of amino acid substitution by site-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa 8-galactoside-binding lectin.
J u n Hirabayashi and Ken-ichi Kasai
Structural and functional consequences of amino acid substitutions in the second conserved loop of Escherichia coli adenylate kinase.
Thierry Rose, Philippe Glaser, Witold K. Surewicz, Henry H. Mantsch, Jochem Reinstein, Karine Le Blay, Anne- Marie Gilles, and Octavian Birzu
* The CONTENTS arranged by Subject Categories will be found immediately following these CONTENTS. Full Instructions to Authors will be found in (1991) J. Biol. Chem. 266, 12797-12807, and reprints may be obtained from the editorial office.
111 ...
iv
23660 Ligand recognition by influenza virus. The binding
Gary D. Glick, Peter L. Toogood, Don C. Wiley, John J. of bivalent sialosides.
Skehel, and Jeremy R. Knowles
23670 Complete structure of the glycan of lipopeptido- phosphoglycan from Trypanosoma cruzi epimasti- gotes.
Michael A. J . Ferguson, Steve W. Homans, and Jane Rosa M. de Lederkremer, Carlos Lima, Maria I. Ramirez,
Thomas-Oates
23676 Methylation patterns of the human apoA-I/C-III/A- IV gene cluster in adult and embryonic tissues sug- gest dynamic changes in methylation during devel- opment.
Aharon Razin Ruth Shemer, Shlomo Eisenberg, Jan L. Breslow, and
23682 Mobility of the terminal regions of flagellin in so-
Rieko Ishima, Kazuyuki A h a k a , Shin-Ichi Aizawa, and lution.
Ferenc Vonderviszt
23689 Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.
Ya Fang Liu and Paul R. Albert
23698 A residue substitution in phosphoribulokinase of Synechocystis PCC 6803 renders the mutant light- sensitive.
Xing Su and Lawrence Bogorad
23706 Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyl- transferase.
Shin-ichi Ohnuma, Tanetoshi Koyama, and Kyozo Ogura
23714 Two-dimensional NMR investigation of iron-sulfur cluster electronic and molecular structure of oxi-
pretability of contact shifts in terms of cysteine dized Clostridium pasteurianum ferredoxin. Inter-
orientation.
Howard Scott C. Busse, Gerd N. La Mar, and James Bryant
23724 The reductive half-reaction of xanthine oxidase. Identification of spectral intermediates in the hy- droxylation of 2-hydroxy-6-methylpurine.
Robert B. Mc Whirter and Russ Hille
23732 A novel 53-kDa polypeptide from chicken embryo. James A. Bassuk and Richard A. Berg
23739 The role of calcium in follicle-stimulating hormone signal transduction in Sertoli cells.
Eleonora Gorczynska and David J . Handelsman
23745 Translocation of HL-60 cell 5-lipoxygenase. Inhi- bition of A23187- or N-formyl-methionyl-leucyl- phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.
Stacia Kargman, Petpiboon Prasit, and Jilly F. Evans
23753 The phosphorylation and activation of B-raf in
Mari Oshima, Gunamani Sithanandam, Ulf R. Rapp, and PC12 cells stimulated by nerve growth factor.
Gordon Guroff
23761 Differential regulation of protein kinase C isozymes
Susan C. Kiley, Peter J . Parker, Doriano Fabbro, and by thyrotropin-releasing hormone in GH& cells.
Susan Jaken
23769 Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers.
Doron Rapaport and Yechiel Shai
23776 Function of glycoprotein Iba in platelet activation
Luigi De Marco, Mario Mazzucato, Adriana Masotti, induced by a-thrombin.
John W. Fenton, II, and Zaverio M. Ruggeri
23784 Determination of the tyrosine phosphokylation sites
Kathryn Wagner, Kathryn Edson, Lise Heginbotham, of the nicotinic acetylcholine receptor.
Marc Post, Richard L. Huganir, and Andrew J. Czernik
23790
23796
23802
23810
23815
23824
23829
23834
23840
23850
23856
23863
23872
23878
23886
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
Anna M. Leone, Richard M. J. Palmer, Richard G. Knowles, Peter L. Francis, David S. Ashton, and Salvador Moncada
The yeast GLC7 gene required for glycogen accu- mulation encodes a type 1 protein phosphatase.
Zhehui Feng, Susan E. Wilson, Zao-Yuan Peng, Keith K. Schlender, Erwin M. Reimann, and Robert J . Trumbly
Structure and function studies of the cGMP-stimu- lated phosphodiesterase.
Steven D. Stroop and Joseph A. Beavo
The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin.
Galen Cortina, Kathleen M. Krueger, and Joseph T. Barbieri
Identification of a functional domain of human granulocyte colony-stimulating factor using neu- tralizing monoclonal antibodies.
Judith E. Layton, George Morstyn, Louis J . Fabri, Gavin E. Reid, Antony W. Burgess, Richard J . Simpson, and Edouard C. Nice
The primary structure of the subunits of carbon monoxide dehydrogenase/acetyl-CoA synthase from Clostridium thermouceticum.
Ragsdale, T. Shanmugmundaram, Harland G. Wood, and Thomas A. Morton, Jennifer A. Runquist, Stephen W.
Lars G. Ljungdahl
system mediated by the pJMl plasmid in Vibrio Molecular characterization of the iron transport
anguillarum 775. Wolfgang L. Koster, Luis A. Actis, Lillian S. Waldbeser,
Marcelo E. Tolmasky, and Jorge H. Crosa
Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase.
Dong-Hoon Shin, Joseph D. Paulauskis, Naima Mous- tad, and Hei Sook Sul
Biosynthesis of 5-hydroxybenzimidazolylcobamid (factor 111) in Methanobacterium thermoautotro- phicum.
Wolfgang Eisenreich and Adelbert Bacher
Selective transcription of rat proenkephalin fusion genes from the spermatogenic cell-specific promoter in testis of transgenic mice.
Steven A. Zinn, Karl M. Ebert, Nitin D. Mehta, Jay Joshi, and Daniel L. Kilpatrick
The aminosteroid U-73 122 inhibits muscarinic receptor sequestration and phosphoinositide hy- drolysis in SK-N-SH neuroblastoma cells. A role for G, in receptor compartmentation.
Angela K. Thompson, Sam P. Mostafapour, Loren C. Denlinger, John E. Bleasdale, and Stephen K. Fisher
Mucin biosynthesis: purification and characteriza- tion of a mucin @6N-acetylglucosaminyltransferase.
Philip A. Ropp, Mark R. Little, and Pi- Wan Cheng
A single base pair deletion from the inactive octa- mer-like motif of the 75 K distal sequence element brings full functionality in uiuo.
Harmut Kleinert, Roland Assert, and Bernd-Joachim Benecke
Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thaliana. Identification of functional domains by in uitro mutagenesis.
Michael L. Sullivan and Richard D. Vierstra
Localization of an apolipoprotein A-I epitope criti- cal for activation of lecithin-cholesterol acyltrans- ferase.
Carole L. Banka, David J . Bonnet, Audrey S. Black, Richard S. Smith, and Linda K. Curtiss
V
23893
23900
23904
23909
23916
23921
23927
23932
23936
23945
23953
23959
23967
23977
23985
Crystal structure of the lysine-, arginine-, orni-
phimurium at 2.7-A resolution. thine-binding protein (LAO) from Salmonella ty -
Chul-Hee Kang, Whan-Chul Shin, Yuriko Yamagata, Sabiha Gokcen, Giovanna Ferro-Luzzi Ames, and Sung- Hou Kim
The K258R mutant of aspartate aminotransferase stabilizes the quinonoid intermediate.
Michael D. Toney and Jack F. Kirsch
Epimerization of 3-hydroxy-4-trans-decenoyl coenzyme A by a dehydration/hydration mechanism catalyzed by the multienzyme complex of fatty acid oxidation from Escherichia coli.
Tor E. Smeland, Dean Cuebas, and Horst Schulz
Purification and properties of a unique flavin-con- taining chloroperoxidase from the capitellid poly- chaete Notomastus lobatus.
Yung Pin Chen, David E. Lincoln, Sarah A. Woodin, and Charles R. Love11
The pH dependence of cytochrome a conformation in cytochrome c oxidase.
Naoko Ishibe, Stephen R. Lynch, and Robert A. Copeland
Mapping of trypsin cleavage and antibody-binding
@ subunit of Escherichia coli RNA polymerase. sites and delineation of a dispensable domain in the
lev, Andrey Lebedev, Irina Bass, Geoffrey C. Rowland, Ping- Sergei Borukhov, Konstantin Severinou, Mikhail Kash-
Ping Lim, Robert E. Glass, Vadim Nikiforov, and Alex Goldfarb
Mapping of the priming substrate contacts in the active center of Escherichia coli RNA polymerase.
Arkady Mustaev, Mikhail Kashlev, Jookyung Lee, An- drey Polyakov, Andrey Lebedev, Katya Zalenskaya, Mikhail Grachev, Alex Goldfarb, and Vadim Nikiforov
Mapping of a contact for the RNA 3' terminus in the largest subunit of RNA polymerase.
Sergei Borukhov, Jookyung Lee, and Alex Goldfarb
Molecular characterization of a mammalian smooth muscle myosin light chain kinase.
Patricia J . Gallagher, B. Paul Herring, Suzy A. Griffin, and James T. Stull
The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin.
Patricia J . Gallagher and B. Paul Herring
Purification, characterization, cloning, and amino acid sequence of the bifunctional enzyme 5 , l O - methylenetetrahydrofolate dehydrogenase/5,10- methenyltetrahydrofolate cyclohydrolase from Escherichia coli.
Linda D'Ari and Jesse C. Rabinowitz
Solubilization and affinity purification of the Yz receptor for neuropeptide Y and peptide YY from rabbit kidney.
Sdren P. Sheikh, Anette P. Hansen, and John A. Williams
Presence of terminal N-acetylgalactosamine resi- dues in subregions of the endoplasmic reticulum is influenced by cell differentiation in culture.
Juan Perez- Vilar, Josefina Hidalgo, and Angel Velasco
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expres- sion of acetylcholinesterase Cys-580 4 Ala mutant.
Moshe Leitner, Yehoshua Gozes, Arye Lazar, Yehuda Baruch Velan, Haim Grosfeld, Chanoch Kronman,
Flashner, Din0 Marcus, Sara Cohen, and Avigdor Shafferman
The type I and type I1 bovine scavenger receptors expressed in Chinese hamster ovary cells are tri- meric proteins with collagenous triple helical do- mains comprising noncovalently associated mono- mers and Cy~*~-disulfide-linked dimers.
Marsha Penman, Alison Lux, Neil J . Freedman, Lucia Rohrer, Yelena Ekkel, Hilarie McKinstry. David Resnick. and Monty Krieger
23994
24003
24011
24018
24025
24031
24038
24044
24048
24053
24059
24064
24070
24077
24084
24092
Site-specific DNA cleavage by antisense oligonucle- otides covalently linked to phenazine di-N-oxide.
Self-translocation of diphtheria toxin across model membranes.
Jean Xin Jiang, Laura A n n Chung, and Erwin London
Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes.
Kathleen I. J. Shennan, Andrew J. Seal, Steven P. Smeekens, Donald F. Steiner, and Kevin Docherty
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal re- gion of the a3(IV) chain of basement membrane collagen.
Karen C. Morrison, Mariko Mariyama, Kurt E. Ebner, Raghuram Kalluri, Sripad Gunwar, Stephen T. Reeders,
Milton E. Noelken, and Billy G. Hudson
Use of radiation suicide to isolate constitutive and temperature-sensitive conditional Chinese hamster ovary cell mutants with defects in the endocytosis of low density lipoprotein.
Expression of human aldose and aldehyde reduc- tases. Site-directed mutagenesis of a critical lysine 262.
Kurt M. Bohren, Joseph L. Page, Ragini Shanknr, Ste- phen P. Henry, and Kenneth H. Gabbay
@1,4(GalNAc to Ga1)N-acetylgalactosaminyltrans- Localization of UDP-GalNAc:NeuAca2,3Gal-R
ferase in human stomach. Enzymatic synthesis of a fundic gland-specific ganglioside and Gvz.
Taeko Dohi, Nobuo Hanai, Kenji Yamaguchi, and Mieko Oshima
Glucose increases the expression of the ATP/ADP translocator and the glyceraldehyde-3-phosphate dehydrogenase genes in Chlorella.
Christian Hilgarth, Norbert Sauer, and Widmar Tanner
Molecular basis of multiple UDP-glucuronosyl- transferase isoenzyme deficiencies in the hyper- bilirubinemic rat (Gunn rat).
An adipose tissue-specific &adrenergic receptor. Molecular cloning and down-regulation in obesity.
Patrick Muzzin, Jean-Pierre Revelli, Francoise Kuhne, Jeannine D. Gocayne, W. Richard McCombie, J. Craig Venter, Jean-Paul Giacobino, and Claire M. Fraser
Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth fac- tor-1 in human endothelial cells.
Timothy Hla and Thomas Maciag
Katsuyuki Nagai and Sidney M. Hecht
Kerstin Malmstrom and Monty Krieger
T a h h i Zyanagi
Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bul- lous pemphigoid antigen-2, a novel collagen of strat- ified squamous epithelium.
A. Diaz, Marie-Genevieve Mattei, Mon-Li Chu, and Jouni Kehua Li, Daisuke Sawamura, George J . Giudice, Luis
Uitto
Purified estrogen receptor DNA binding domain expressed in Escherichia coli activates transcrip-
cells. tion of an estrogen-responsive promoter in cultured
Ann M. Nardulli, Denise Lew, Leonard0 Erijman, and David J . Shapiro
A compact nucleoprotein structure is produced by binding of Escherichia coli integration host factor (IHF) to the replication origin of plasmid R6K.
Diacylglycerol signals the translocation of CTP: choline-phosphate cytidylyltransferase in HeLa cells treated with 12-O-tetradecanosl~horbol-13-
Marcin Filutowicz and Ross Inman
acetate. "
Amandip K. Utal, Haris Jamil, and Dennis E. Vance
Two additional common subunits, ABClOa and ABClOj3, are shared by yeast RNA polymerases.
Michel Riva, and Andri Sentenac Christophe Carles, Isabelle Treich, Franeoise Bouet.
vi
24097
24101
24109
24116
24121
24126
24134
24140
24149
Early induction of ribonucleotide reductase gene expression by transforming growth factor in ma- lignant H-raa transformed cell lines.
Robert A. R. Hurta, Shanti K. Samuel, Arnold H. Green- berg, and Jim A. Wright
Multipartite structure of a negative regulatory ele- ment associated with a steroid hormone-inducible promoter.
Jae Woon Lee, Patricia G. Moffitt, Kimberlin L. Morley, and David 0. Peterson
Cell transformation potential of a HER2 transmem- brane domain deletion mutant retained in the en- doplasmic reticulum.
Robert M. Hudziak and Axel Ullrich
A site-directed approach for constructing tempera- ture-sensitive ubiquitin-conjugating enzymes re- veals a cell cycle function and growth function for RAD6.
Kimberly S. Ellison, Todd Gwozd, John A. Prendergast, Malcolm C. Paterson, and Michael J . Ellison
Erythropoietin induces cytosolic protein phos- phorylation and dephosphorylation in erythroid cells.
Steven C. Bailey, Rudolph Spangler, and Arthur J. Sytkowski
Stimulation of tyrosine kinase activity in anti-phos- photyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.
Ian Zachary, James Sinnett-Smith, and Enrique Rozengurt
structures of CRE-BP1 are required for the E1A- Complete putative metal finger and leucine zipper
induced trans-activation.
suke Ishii You-Li Zu, Toshw Maekawa, Shinji Matsuda, and Shun-
Rho-dependent transcription termination. Charac- terization of the requirement for cytidine in the nascent transcript.
Craig M. Hart and Jeffrey W. Roberts
Similarities and differences in the function of reg- ulatory elements at the 5‘ end of the human apoli- poprotein B gene in cultured hepatoma (HepG2) and colon carcinoma (CaCo-2) cells.
Bernhard Paulweber, Martha A. Onasch, Brian P. Nagy, and Beatriz Levy- Wilson
24161
24169
24176
24184
24190
24198
24205
24212
24220
24226
24232
The mechanisms by which a human apoli o rotein B gene enhancer and reducer interact witg tEe pro- moter are different in cultured cells of hepatic and intestinal origin.
Protein kinase C (PKC) activation via human leu- cocyte antigen class I1 molecules. A novel regulation of PKC activity.
Temime, and Dominique Charron Chehrazade Brzck-Ghannam, Freesia L. Huang, Nathalie
Ex ression of human glyco horin A in wild type an$ gl cosylation-deficient ehinese hamster ovar cells. 6ole of N- and 0-linked glwosvlation in cefi
Bernhard Paulweber and Beatriz Levy- Wilson
surface expression.
Litzky, Scott R. Burger, Jonni 8. Moore, Minoru Fukuda, Alan T. Remaley, Maciej U orski, Nancy Wu, Leslie
” -
and Steven L. Spitalnik A Chinese hamster cDNA encoding a protein essen- tial for phosphatidylserine synthase I activity.
Osamu Kuge, Masahtro Ntshijima, and Yuzuru Akamatsu
bindin site for factor IX on coagulation factor XIa. Identification and chemical synthesis of a substrate-
Franf A. Baglia, Bradford A. Jameson, and Peter N. Walsh Studies on the interaction of ribonuclease inhibitor with pancreatic ribonuclease involving differential labeling of cysteinyl residues.
Jan Hofsteenge, Cathertne Servis, and Stuart R. Stone
pksts promote mRNA maturation and degradation. S ecific ribonuclease activities in spinach chloro-
Purification, characterization, and comparison of poliovirus RNA polymerase from native and recom-
Chen Hsu-Chzng and David B. Stern
binant sources. Kristi L. Neufeld, Oliver C. Richards, and Ellie Ehrenfeld
Characterization of the active part of the human transferrin gene enhancer and purification of two liver nuclear factors interacting with the TGTTTGC motif resent in this region.
M. Zakin Isabelle Petropoul!s, Corinne Auge-Gouillou, and Mario
Crystallins of the octopus lens. Recruitment from detoxification enzymes.
Piatigorsky Stanzslav I. Tomarev, Rina D. Zinovieva, and Joram
ADDITIONS AND CORRECTIONS Characterization of calcium-triggered secretion in
ermeabilized rat basophilic leukemia cells. Possi- le role of vectorially acting G proteins. Vol. 266
Marta Antonietta De Matteis, Giuseppe Di Tullio, Rob-
fJ (1991) 10452-10460.
erto Buccione, and Alberto Luini
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Vol. 266, No. 35 The Journal of Biological Chemistry December 15,1991
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CONTENTS Arrangec
MINIREVIEW CD45. A prototype for transmembrane protein ty- rosine phosphatases.
Ian S. Trowbridge
CARBOHYDRATES, LIPIDS, AND OTHER NATURAL PRODUCTS
Metabolism of 5,6-epoxyeicosatrienoic acid by the human platelet. Formation of novel thromboxane analogs.
Regulation of agonist-induced prostaglandin E1 ver- sus prostaglandin Ez production. A mass analysis.
phosphoglycan from Trypanosoma cruzi epimasti- Complete structure of the glycan of lipopeptido-
gotes.
Michael A. J. Ferguson, Steve W. Homans, and Jane Rosa M. de Lederkremer, Carlos Lima, Maria I. Ramirez,
Thomas-Oates
Biosynthesis of 5-hydroxybenzimidazolylcobamid
phicum. (factor 111) in Methanobacterium thermoautotro-
Mucin biosynthesis: purification and characteriza- tion of a mucin 86N-acetylglucosaminyltransferase.
Michael Balazy
Daniel Rubin and Michael Laposata
Wolfgang Eisenreich and Adelbert Bacher
Philip A. Ropp, Mark R. Little, and Pi- Wan Cheng
Localization of UDP-GalNAc:NeuAca2,3Gal-R @1,4(GalNAc to Ga1)N-acetylgalactosaminyltrans- ferase in human stomach. Enzymatic synthesis of a fundic gland-specific ganglioside and G m .
Oshima Taeko Dohi, Nobuo Hanai, Kenji Yamaguchi, and Mieko
Expression of human glycophorin A in wild type
cells. Role of N- and 0-linked glycosylation in cell and glycosylation-deficient Chinese hamster ovary
surface expression.
Litzky, Scott R. Burger, Jonni S. Moore, Minoru Fukuda, Alan T. Remaley, Maciej Ugorski, Nancy Wu, Leslie
and Steven L. Spitalnik
CELL BIOLOGY AND METABOLISM A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.
Davis Alpna Seth, Elvira Alvarez, Shashi Gupta, and Roger J .
Regulation of gene expression by insulin and tumor necrosis factor a in 3T3-Ll cells. Modulation of the transcription of genes encoding acyl-CoA synthe- tase and stearoyl-CoA desaturase- 1.
mer, and Charles S. Rubin Francis R. Weiner, Pamela J. Smith, Stanley Werthei-
Glucose-induced increase in cytoplasmic pH in pan- creatic &cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
Lisa Juntti-Berggren, Per Arkhammar, Thomas Nilsson, Patrik Rorsman, and Per-Olof Berggren
Involvement of platelet glycoprotein IIb-IIIa (am-& integrin) in thrombin-induced synthesis of phospha- tidylinositol3',4'-bisphosphate.
Pascal Grondin, Monique Breton, Gkrard Mauco, Sylviune Claire Sultan, Monique Plantauid, Christilla Bachelot,
Guy-Toledano, Jacques P. Caen, and Hugues Chap
Oleic acid promotes changes in the subcellular dis- tribution of protein kinase C in isolated hepatocytes.
Maria J. M. Diaz-Guerra, Maria Junco, and Lisardo Bosca
3 by Subject
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23753
23761
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23856
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24011
Categories
Purification and characterization of a third cyto- solic component of the superoxide-generating NADPH oxidase of macrophages.
Mannose 6-phosphate-independent targeting of ca- thepsin D to lysosomes in HepG2 cells.
Aerts, and Ger J . Strous Simon Rijnboutt, Arnoud J. Kal, Hans J . Geuze, Hans
Skeletal myoblasts utilize a novel 81-series integrin and not a681 for binding to the E8 and T8 fragments of laminin.
Helga von der Mark, Joachim Durr, Arnoud Sonnenberg, Klaus von der Mark, Rainer Deutzmann, and Simon L. Goodman
Clustering of integral membrane proteins of the human erythrocyte membrane stimulates autolo- gous IgG binding, complement deposition, and phagocytosis.
Low Franco Turrini. Pa010 Arese, Jie Yuan, and Philip S.
Binding and endocytosis of apo- and holo-lactofer- rin by isolated rat hepatocytes.
Douglas D. McAbee and Kari Esbensen
Cell-specific signaling of the 5-HT1A receptor. Modulation by protein kinases C and A.
The role of calcium in follicle-stimulating hormone signal transduction in Sertoli cells.
bition of A23187- or N-formyl-methionyl-leucyl- Translocation of HL-60 cell 5-lipoxygenase. Inhi-
phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors.
Stacia Kargman, Petpiboon Prasit, and Jilly F. Evans
The phosphorylation and activation of B-raf in PC12 cells stimulated by nerve growth factor.
Gordon Guroff Mari Oshima, Gunamani Sithanandam, Ulf R. Rapp, and
Differential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH& cells.
Susan Jaken Susan C. Kiley, Peter J . Parker, Doriano Fabbro, and
Function of glycoprotein Iba in platelet activation induced by a-thrombin.
John W. Fenton, II, and Zauerio M. Ruggeri Luigi De Marco, Mario Mazzucato, Adriana Masotti,
The aminosteroid U-73122 inhibits muscarinic
drolysis in SK-N-SH neuroblastoma cells. A role for receptor sequestration and phosphoinositide hy-
G, in receptor compartmentation.
Denlinger, John E. Bleasdale, and Stephen K. Fisher Angela K. Thompson, Sam P. Mostafapour, Loren C.
Presence of terminal N-acetylgalactosamine resi- dues in subregions of the endoplasmic reticulum is influenced by cell differentiation in culture.
Juan Perez-Vilar, Josefina Hidalgo, and Angel V e h c o
The type I and type I1 bovine scavenger receptors expressed in Chinese hamster ovary cells are tri- meric proteins with collagenous triple helical do- mains comprising noncovalently associated mono- mers and Cyses-disulfide-linked dimers.
Marsha Penman, Alison Lux, Neil J. Freedman, Luck Rohrer, Yelena Ekkel, Hilarie McKinstry, David Resnick, and Monty Krieger Site-directed mutagenesis and expression of PC2 in microinjected Xenopus oocytes.
Smeekens, Donald F. Steiner, and Kevin Docherty Kathleen I. J . Shennan, Andrew J. Seal, Steven P.
Arie Abo and Edgar Pick
Ya Fang Liu and Paul R. Albert
Eleonora Gorczynska and David J . Handelsman
Indicates a Communication
vii
Vlll ...
24025
24044
24053
24059
24084
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24126
24169
temperature-sensitive conditional Chinese hamster Use of radiation suicide to isolate constitutive and
ovary cell mutants with defects in the endocytosis of low density lipoprotein.
Kerstin Malmstrom and Monty Krieger
translocator and the glyceraldehyde-3-phosphate Glucose increases the expression of the ATP/ADP
dehydrogenase genes in Chlorella. Christian Hilgarth, Norbert Sauer, and Widmar Tanner
An adipose tissue-specific &adrenergic receptor. Molecular cloning and down-regulation in obesity.
Patrick Muzzin, Jean-Pierre Revelli, Francoise Kuhne, Jeannine D. Gocayne, W. Richard McCombie, J . Craig Venter, Jean-Paul Giacobino, and Claire M. Fraser
Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth fac- tor-1 in human endothelial cells.
Timothy Hla and T h o r n Maciag
choline-phosphate cytidylyltransferase in HeLa Diacylglycerol signals the translocation of CTP:
cells treated with 12-O-tetradecanoylphorbol-13- acetate.
Amandip K. Utal, Hark Jamil, and Dennis E. Vance
brane domain deletion mutant retained in the en- Cell transformation potential of a HER2 transmem-
doplasmic reticulum. Robert M. Hudziak and Axel Ullrich
Erythropoietin induces cytosolic protein phos- phorylation and dephosphorylation in erythroid cells.
Steven C. Bailey, Rudolph Spangler, and Arthur J. Sytkowski
Stimulation of tyrosine kinase activity in anti-phos- photyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.
Rozengurt Ian Zachary, James Sinnett-Smith, and Enrique
Protein kinase C (PKC) activation via human leu- cocyte antigen class I1 molecules. A novel regulation of PKC activity.
Chehrazade Brick-Ghannam, Freesia L. H u n g , Nathalie Temime, and Dominique Charron
24184 A Chinese hamster cDNA encoding a protein essen-
Osamu Kuge, Masahiro Nishijima, and Yuzuru tial for phosphatidylserine synthase I activity.
Akamatsu
24232 Characterization of calcium-triggered secretion in
ble role of vectorially acting G proteins. Vol. 266 permeabilized rat basophilic leukemia cells. Possi-
Maria Antonretta De Matteis, Giuseppe Di Tullio, Rob- (1991) 10452710460.
erto Buccione, and Albert0 Luini
ENZYMOLOGY 23529 Psychotrine and its 0-methyl ether are selective
verse transcriptase. inhibitors of human immunodeficiency virus-1 re-
Ghee T. Tan, A. Douglas Kinghorn, Stephen H. Hughes, and John M. Pezzuto
23654 Structural and functional consequences of amino acid substitutions in the second conserved loop of Escherichia coli adenylate kinase.
Thierry Rose, Philippe Glaser, Witold K. Surewicz, Henry H. Mantsch, Jochem Reinstein, Karine Le Blay, Anne- Marie Gilles, and Octavian B&zu
23698 A residue substitution in phosphoribulokinase of Synechocystis PCC 6803 renders the mutant light- sensitive.
Xing Su and Lawrence Bogorad
23706 Purification of solanesyl-diphosphate synthase
transferase. from Micrococcus luteus. A new class of prenyl-
Shin-ichi Ohnuma, Tanetoshi Koyama, and Kyozo Ogura
23724
23790
23802
23810
23878
23900
23904
23909
23953
24031
23606
23916
24003
N
23548
23602
23676
The reductive half-reaction of xanthine oxidase. Identification of spectral intermediates in the hy- droxylation of 2-hydroxy-6-methylpurine.
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
Anna M. Leone, Richard M. J. Palmer, Richard G. Knowles, Peter L. Francis, David S. Ashton, and Salvador Moncada
Structure and function studies of the cGMP-stimu- lated phosphodiesterase.
The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin.
Galen Cortina, Kathleen M. Krueger, and Joseph T. Barbieri
Cloning of a 16-kDa ubiquitin carrier protein from wheat and Arabidopsis thdiana. Identification of functional domains by in vitro mutagenesis.
Michael L. Sullivan and Richard D. Vierstra
The K258R mutant of aspartate aminotransferase stabilizes the quinonoid intermediate.
Michael D. Toney and Jack F. Kirsch
Epimerization of 3-hydroxy-4-trans-decenoyl
catalyzed by the multienzyme complex of fatty acid coenzyme A by a dehydrationhydration mechanism
oxidation from Escherichia coli.
Robert B. Mc Whirter and Russ Hille
Steven D. Stroop and Joseph A. Beavo
Tor E. Smelund, Dean Cuebas, and Horst Schulz
Purification and properties of a unique flavin-con- taining chloroperoxidase from the capitellid poly- chaete Notomaatus lobatus.
and Charles R. Love11 Yung Pin Chen, David E. Lincoln, Sarah A. Woodin,
Purification, characterization, cloning, and amino acid sequence of the bifunctional enzyme 6,lO- methylenetetrahydrofolate dehydrogenase/6,10-
Escherichia coli. methenyltetrahydrofolate cyclohydrolase from
Linda D’Ari and Jesse C. Rabinowitz
Expression of human aldose and aldehyde reduc- tases. Site-directed mutagenesis of a critical lysine 262.
Kurt M. Bohren, Joseph L. Page, Ragini Shankar, Ste- phen P. Henry, and Kenneth H. Gabbay
MEMBRANES AND BIOENERGETICS Transport of proteins into chloroplasts. Delineation of envelope “transit” and thylakoid “transfer” sig- nals within the pre-sequences of three imported thy- lakoid lumen proteins.
Bryan Dunbar, Peter Weisbeek, Reinhold G. Herrmann, Diane C. Bassham, Dieter Bartling, Ruth M. Mould,
and Colin Robinson
The pH dependence of cytochrome a conformation in cytochrome c oxidase.
Naoko Ishibe, Stephen R. Lynch, and Robert A. Copeland
Self-translocation of diphtheria toxin across model membranes.
Jean X in Jiang, Laura Ann Chung, and Erwin London
IUCLEIC ACIDS, PROTEIN SYNTHESIS, AND MOLECULAR GENETICS
Oxalate decarboxylase from Collybia velutipes. Pu- rification, characterization, and cDNA cloning.
Drosophila 5 S RNA processing requires the 1-118 base pair and additional sequence proximal to the processing site.
Anuradha Mehta and Asis Datta
Peter R. Preiser and Louis F. Levinger
Methylation patterns of the human apoA-I/C-III/A- IV gene cluster in adult and embryonic tissues sug- gest dynamic changes in methylation during devel- opment.
Aharon Razin Ruth Shemer, Shlomo Eisenberg, Jan L. Breslow, and
ix
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23834
23850
23872
23945
23994
24048
24064
24070
24077
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24134
The yeast CLC7 gene required for glycogen accu- mulation encodes a type 1 protein phosphatase.
K. Schlender, Erwin M. Reimann, and Robert J. Trumbly Zhehui Feng, Susan E. Wilson, Zao-Yuan Peng, Keith
Molecular characterization of the iron transport system mediated by the pJMl plasmid in Vibrio anguillarum 775.
Wolfgang L. Koster, Luis A. Actis, Lillian S. Waldbeser, Marcel0 E. Tolmasky, and Jorge H. Crosa
Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase.
tad, and Hei Sook Sul Dong-Hoon Shin, Joseph D. Paulauskis, Naima Mous-
Selective transcription of rat proenkephalin fusion genes from the spermatogenic cell-specific promoter in testis of transgenic mice.
Steuen A. Zinn, Karl M. Ebert, Nitin D. Mehta, Jay Joshi, and Daniel L. Kdpatrick
A single base pair deletion from the inactive octa- mer-like motif of the 75 K distal sequence element brings full functionality in vivo.
Benecke Harmut Kkinert, Roland Assert, and Bernd-Joachim
The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin.
Patricia J . Gallagher and B. Paul Herring
Site-specific DNA cleavage by antisense oligonucle- otides covalently linked to phenazine di-N-oxide.
Katsuyuki Nagai and Sidney M. Hecht
Molecular basis of multiple UDP-glucuronosyl- transferase isoenzyme deficiencies in the hyper- bilirubinemic rat (Gunn rat).
Takashi Zyanugi
Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bul-
ified squamous epithelium. lous pemphigoid antigen-2, a novel collagen of strat-
Kehua Li, Daisuke Sawamura, George J . Giudice, Luis A. Diaz, Marie-Genevieve Mattei, Mon-Li Chu, and Jouni Uitto
Purified estrogen receptor DNA binding domain expressed in Escherichia coli activates transcrip- tion of an estrogen-responsive promoter in cultured cells.
David J . Shapiro Ann M. Nardulli, Denise Lew, Leonard0 Erijman, and
A compact nucleoprotein structure is produced by binding of Escherichia coli integration host factor (IHF) to the replication origin of plasmid R6K.
Marcin Filutowicz and Ross Inman
Early induction of ribonucleotide reductase gene expression by transforming growth factor in ma- lignant H-ras transformed cell lines.
Robert A. R. Hurta, Shanti K. Samuel, Arnold H. Green- berg, and Jim A. Wright
Multipartite structure of a negative regulatory ele- ment associated with a steroid hormone-inducible promoter.
and David 0. Peterson Jae Woon Lee, Patricia G. Moffitt, Kimberlin L. Morley,
A site-directed approach for constructing tempera- ture-sensitive ubiquitin-conjugating enzymes re- veals a cell cycle function and growth function for RAD6.
Malcolm C. Paterson, and Michael J . Ellison Kimberly S. Ellison, Todd Gwozd, John A. Prendergast,
Complete putative metal finger and leucine zipper structures of CRE-BP1 are required for the ElA- induced trans-activation.
You-LiZu, Toshio Maekawa, Shinji Matsuda, and Shun- suke Ishii
24140
24149
24161
24205
24220
24226
23542
23558
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23648
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Rho-dependent transcription termination. Charac- terization of the requirement for cytidine in the nascent transcript.
Craig M. Hart and Jeffrey W. Roberts
Similarities and differences in the function of reg-
poprotein B gene in cultured hepatoma (HepG2) and ulatory elements at the 5' end of the human apoli-
colon carcinoma (CaCo-2) cells.
and Beatriz Levy- Wilson Bernhard Paulweber, Martha A. Onasch, Brian P. N%Y,
The mechanisms by which a human apolipoprotein B gene enhancer and reducer interact with the pro- moter are different in cultured cells of hepatic and intestinal origin.
Bernhard Paulweber and Beatriz Levy- Wilson
plasts promote mRNA maturation and degradation. Specific ribonuclease activities in spinach chloro-
Chen HswChing and David B. Stern
Characterization of the active part of the human transferrin gene enhancer and purification of two liver nuclear factors interacting with the TGTTTGC motif present in this region.
M. Zakin Isabelle Petropoulos, Corinne Augk-Goudlou, and Mario
Crystallins of the octopus lens. Recruitment from detoxification enzymes.
Piatigorsky Stanislav I. Tomnreu, Rina D. Zinouieua, and Joram
PROTEIN CHEMISTRY AND STRUCTURE The sequence of squash NADH:nitrate reductase and its relationship to the sequences of other flavo- protein oxidoreductases. A family of flavoprotein pyridine nucleotide cytochrome reductases.
Gregory E. Hyde, Nigel M. Crawford, and Wilbur H. Campbell
Mirabilis antiviral protein by an elimination of the Substantial increase of the inhibitory activity of
disulfide bond with genetic engineering.
deaki Tsuge, Hideo Ago, and Masana Noma Noriyuki Habuka, Masashi Miyano, Jiro Kataoka, Hi-
Proteolytic formation of either of the two prothrom- bin activation intermediates results in formation of a hirugen-binding site.
Le- Wen Liu, Jia Ye, Arthur E. Johnson, and Charles 2'. Esmon
Effect of polyanions on the refolding of human acidic fibroblast growth factor.
Jonathan M. Dabora, Gautam Sanyal, and C. Russell Middaugh
EPR characterization of the stereochemistry of the distal heme pocket of the engineered human myo- globin mutants.
Erin J. McKelvey, Rafael Mattera, and Hiroshi Hori Masao Zkeda-Saito, Rodney S. Lutz, Deborah A. Shelley,
Effect of amino acid substitution by site-directed
stability of human 14-kDa B-galactoside-binding mutagenesis on the carbohydrate recognition and
lectin. Jun Hirabayashi and Ken-ichi Kasai
Ligand recognition by influenza virus. The binding of bivalent sialosides.
Gary D. Glick, Peter L. Toogood, Don C. Wiley, John J. Skehel, and Jeremy R. Knowles
Mobility of the terminal regions of flagellin in so- lution.
Rieko Ishima, Kazuyuki Akasaka, Shin-Zchi Aizawa, and Ferenc Vonderuiszt
Two-dimensional NMR investigation of iron-sulfur cluster electronic and molecular structure of oxi- dized Clostridium pasteurianum ferredoxin. Inter- pretability of contact shifts in terms of cysteine orientation.
Howard Scott C. Busse, Gerd N. La Mar, and James Bryant
X
23732
23769
23784
23815
23824
23886
23893
23921
23927
A novel 53-kDa polypeptide from chicken embryo.
Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers.
Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.
Kathryn Wagner, Kathryn Edson, Lise Heginbotham, Marc Post, Richard L. Huganir, and Andrew J. Czernik Identification of a functional domain of human granulocyte colony-stimulating factor using neu- tralizing monoclonal antibodies.
E. Reid, Antony W. Burgess, Richard J . Simpson, and Judith E. Layton, George Morstyn, Louis J. Fabri, Gavin
Edouard C. Nice The primary structure of the subunits of carbon monoxide dehydrogenaselacetyl-CoA synthase from Clostridium thermoaceticum.
Ragsdale, T. Shanmugasundaram, Harland G. Wood, and Thomas A. Morton, Jennifer A. Runquist, Stephen W.
Lars G. Ljungdahl Localization of an apolipoprotein A-I epitope criti- cal for activation of lecithin-cholesterol acyltrans- ferase.
Richard S. Smith, and Linda K. Curtiss Carole L. Banka, David J . Bonnet, Audrey S. Black,
thine-binding prot in (LAO) from Salmonella ty- Crystal structure of the lysine-, arginine-, orni-
phimurium at 2.7-1 resolution. Chul-Hee Kan Whan-Chul Shin,, Yuriko Yamagata,
Hou Kim Sabiha Gokcen, 8iovanna Ferro-Luzzr Ames, and Sung-
Mapping of trypsin cleavage and antibody-binding sites and delineation of a dispensable domain in the j3 subunit of Escherichia coli RNA, polymerage.
Sergei Borukhov, Konstantin Severrnov, Mikharl Kash- lev, Andrey Lebedev, Irina Bass, Ge0ffrey.C: Rowland, Ping- Ping Lim, Robert E. Glass, Vadim Nrkrforov, and Alex Goldfarb Mapping of the priming substrate contacts in the active center of Escherichia coli RNA polymerase.
Arkady Mustaev, Mikhail Kashlev, Jookyung Lee,, An- drey Polyakou, Andrey Lebedev, Katya Zalenskaya, Mrkhail Gracheu, Alex Goldfarb, and Vadim Nikrforou
James A. Bassuk and Richard A. Berg
Doron Rapaport and Yechiel Shai
23932
23936
23959
23977
24018
24092
24190
24198
24212
Mapping of a contact for the RNA 3' terminus in the largest subunit of RNA polymerase.
Molecular characterization of a mammalian smooth muscle myosin light chain kinase.
Patricia J . Gallugher, B. Paul Herring, Suzy A. Griffin, and James T. Stull
receptor for neuropeptide Y and peptide YY from Solubilization and affinity purification of the YZ
rabbit kidney.
Williams Siren P. Sheikh, Anette P. Hansen, and John A.
The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expres- sion of acetylcholinesterase Cys-580 4 Ala mutant.
Moshe Leitner, Yehoshua Gozes, Arye Lazar, Yehuda Baruch Velan, Haim Grosfeld, Chanoch Kronman,
Flashner, Din0 Marcus, Sara Cohen, and Avigdor Shafferman
Goodpasture syndrome. Localization of the epitope
gion of the a3(IV) chain of basement membrane for the autoantibodies to the carboxyl-terminal re-
collagen.
Karen C. Morrison, Mariko Mariyama. Kurt E. Ebner. Raghuram Kalluri, Sripad Gunwar, Stephen T. Reeders,
Milton E. Noelken, and Billy G. Hudson
ABClOB, are shared by yeast RNA polymerases. Two additional common subunits, ABClOa and
Christophe Carles, Isabelle Treich, Frarqoise Bouet, Michel Riva, and Andrk Sentenac
Identification and chemical synthesis of a substrate- binding site for factor IX on coagulation factor XIa.
Frank A. Baglia, Bradford A. Jameson, and Peter N. Wakh
with pancreatic ribonuclease involving differential Studies on the interaction of ribonuclease inhibitor
labeling of cysteinyl residues. Jan Hofsteenge, Catherine Servis, and Stuart R. Stone
Purification, characterization, and comparison of poliovirus RNA polymerase from native and recom- binant sources.
Kristi L. Neufeld, Oliver C. Richards, and Ellie Ehrenfeld
Sergei Borukhov, Jookyung Lee, and Alex GoMfarb
