Oncology...Lung Cancer Cells. Cancer Res. 67, 643-650 (2007). Albert, B.J. et al. Meayamycin Inhibits Pre-MRNA Splicing and Exhibits Picomolar Activity against Multidrug Resistant

OncologyPublications List

2014 Edition

http://www.thermoscientific.com/highcontent

What is high Content sCreening (hCs)?High Content Screening (HCS), also known as High Content Analysis (HCA), image cytometry, quantitative cell analysis or automated cell analysis, is an automated method that is used to identify substances that alter the phenotype of a cell in a desired manner. This technology is primarily used in biological research and drug discovery and combines fluorescent microscopy, automated cell calculations, and phenotyping using image processing algorithms and informatics tools for the user to make decisions about a treatment.

moreKnoWledge

More knowledge evolved into products• More out-of-the-box reagents validated for high content• More flexibility in instrumentation to address new assay needs

More knowledge in how to execute HCA• More technical resources focused on high content• More experience in using, developing, and executing on high content assays

Scientific validity through literature• More peer-reviewed publications in the most relevant and respected journals• Automated solutions to increase throughput

More knowledge about cellular information• More measurements and data about cells and their response• More information than other cell-based assaysCellular

information

Validatedsolutions

ContextualreleVanCe

experienCedexeCution

sCientifiCValidity

More knowledge about cells in their context • More information in the context of a living cell • More tools to characterize complex biologies

thermo sCientifiC high Content produCts The portfolio of High Content Analysis products include assay development and screening tools like the Thermo Scientific™ ArrayScan™ XTI High Content Analysis (HCA) Reader and the Thermo Scientific™ CellInsight™ NXT High Content Screening (HCS) Platform. Multiple tools are available for assay development on the ArrayScan XTI HCA Reader like the Thermo Scientific™ X1 large field-of-view, high resolution camera; Live Cell Chamber; and the new Confocal Module, while our software products like Thermo Scientific™ HCS Studio™ enable users to develop and make decisions about our assays. With the Thermo Scientific™ HCS101 Class and the diverse portfolio of reagents and consumables, we enable scientists to increase their efficiency with their platform while generating more knowledge about the cell.

For more information on Thermo Scientific™ High Content Products, and a full list of applications by application area, go to thermoscientific.com/highcontent


appliCation BaCKground Cancer research is complex and multidimensional, therefore, a multiparametric approach is necessary to recognize new information when it presents itself. High Content Analysis (HCA) provides the technology necessary for cancer researchers to use cell-based assays, whether single-cell analysis or functional assays, to discover novel therapies which improve patient outcomes. Our platforms have been validated by your peers in many different cancer specific application areas. Their success has been demonstrated in publications featuring the application areas important to you.

angiogenesisThe process of Angiogenesis is critical in both growth and development. However, it is also a key step in the transformation from a normal state to a malignant state. High Content Analysis (HCA) can determine whether angiogenesis is being inhibited or enhanced with in vitro cell-based assays. In addition, tube morphology connectivity and the complexity of angiogenic tubes can be used to calculate angiogenic indices. The information gleaned from HCA enables researchers to learn about the process of angiogenesis and compounds that affect it.

Cell CyCle and Cell proliferationCritical in determining the proliferation rate or potential of cancer cells, cell counting and multiparametric cell cycle analysis is possible with high content technology. Individual cells are able to have their cell cycle phase classified, while multiple cell cycle related targets are simultaneously measured.

Cell signaling and transCription faCtorsCell-signaling is studied by activating or deactivating various areas of the signaling pathway. A wealth of information can be gained by studying a particular molecular target under a range of cellular conditions using correlation and classification of multiparametric cellular responses through automated detection of user-defined cellular events. HCA enables simultaneous study of the activation and/or translocation of multiple signaling molecules with complex signaling pathways such as NFkB and G-protein pathways.

CytotoxiCity and apoptosisEffects of chemotherapeutics and other anti-cancer therapies can be studied more closely with the use of in vitro multiparameter cytotoxicity assays. Changes in nuclear morphology, cell membrane integrity, and lysosomal physiology are quantifiable at the single-cell or plate level leading to indications of acute or chronic cellular death response. A range of cellular parameters are able to be measured and correlated in order to dissect cytotoxic mechanisms leading to apoptosis. HCA enables assays for decay in mitochondrial transmembrane potential, increased plasma membrane permeability, disruption of polarity of phosphatidylserine distribution in the plasma membrane, caspase activation, DNA fragmentation, degradation, and many other phenotypic changes exhibited during compromised cell health.

genotoxiCity and genetiCsChromosomal mutations and related events in oncogenes and tumor suppressor genes of somatic cells are involved in the induction and/or progression of some types of cancer in humans and experimental animals. Using HCA to identify micronuclei provides the ability to detect those agents that modify chromosome structure and segregation. By combining an automated comet assay with fluorescence in situ hybridization (FISH), specific DNA damage or gene sequence damage is easily identified.

immunologyTumor immune responses can be measured by using multiparametric analysis on tissue sections or co-cultures with rapid functional assays. Cell surface proteins and cell-cell interactions can be measured using suspension cells in both single-endpoint and live-cell kinetic endpoint assays.

inflammation and Cell stressThe inflammatory process releases a cascade of signaling events that can promote or inhibit tumorigenesis or tumor progression. Abnormal cellular phenotypes associated with chronic inflammation can be measured and the inflammatory pathway characterized which allows for correlations to be made between inflammaton and carcinogenesis.

metastasisStudying a cancer cell’s adhesiveness and motility provides information about a tumor cell’s metastatic potential. By measuring morphological features of cancer cells when they attach and spread, HCA can provide functional assays of various regulatory and structural molecules. By collecting net movement measurements of cells over several hours, information related to cell-substrate adhesion, cell spreading, alamellar protrusion, and directional control can be gathered.

angiogenesisGraff, J.R. et al. Therapeutic Suppression of Translation Initiation Factor EIF4E Expression Reduces Tumor Growth without Toxicity. J. Clin. Invest. 117, 2638-2648 (2007).

Holland, S.J. et al. Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation. Cancer Res. 65, 9294-9303 (2005).

Hu-Lowe, D.D. et al. Targeting Activin Receptor-Like Kinase 1 (ALK1) Inhibits Angiogenesis and Tumorigenesis through a Mechanism of Action Complementary to Anti-VEGF Therapies. Cancer Res. 71, 1362-1373 (2011).

Kendrew, J. et al. An Antibody Targeted to VEGFR-2 Ig Domains 4-7 Inhibits VEGFR-2 Activation and VEGFR-2-Dependent Angiogenesis without Affecting Ligand Binding. Mol. Cancer Ther. 10, 770-783 (2011).

Kim, K.H., Park, J.Y., Jung, H.J. & Kwon, H.J. Identification and Biological Activities of a New Antiangiogenic Small Molecule That Suppresses Mitochondrial Reactive Oxygen Species. Biochem. Biophys. Res. Commun. 404, 541-545 (2011).

Kim, Y.C., Kim, B.G. & Lee, J.H. Thymosin β10 Expression Driven by the Human Tert Promoter Induces Ovarian Cancer-Specific Apoptosis through Ros Production. PLoS One 7 (2012).

Kumar, P. et al. Tetrathiomolybdate Inhibits Head and Neck Cancer Metastasis by Decreasing Tumor Cell Motility, Invasiveness and by Promoting Tumor Cell Anoikis. Mol. Cancer 9, 206 (2010).

Lai, S.L., Cheah, S.C., Wong, P.F., Noor, S.M. & Mustafa, M.R. In Vitro and in Vivo Anti-Angiogenic Activities of Panduratin A. PLoS One 7 (2012).

Liu, J. et al. Angiogenesis Inhibition and Cell Cycle Arrest Induced by Treatment with Pseudolarix Acid B Alone or Combined with 5-Fluorouracil. Acta. Biochim. Biophys. Sin. 44, 490-502 (2012).

Liu, L. et al. Sorafenib Blocks the RAF/MEK/ERK Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5. Cancer Res. 66, 11851-11858 (2006).

Merchan, J.R. et al. Antiangiogenic Activity of 2-Deoxy-D-Glucose. PLoS One 5 (2010).

Okawa, Y. et al. SNX-2112, a Selective HSP90 Inhibitor, Potently Inhibits Tumor Cell Growth, Angiogenesis, and Osteoclastogenesis in Multiple Myeloma and Other Hematologic Tumors by Abrogating Signaling Via AKT and ERK. Blood 113, 846-855 (2009).

Okawa, Y. et al. Program and Abstracts: Ninth International Symposium on Ultrasonic Imaging and Tissue Characterization: June 3-6, 1984 Quality Inn on Capitol Hill Washington, Dc SNX-2112, a Selective HSP90 Inhibitor, Potently Inhibits Tumor Cell Growth, Angiogenesis, and Osteoclastogenesis in Multiple Myeloma and Other Hematologic Tumors by Abrogating Signaling Via AKT and ERK. Ultrason. Imaging 6, 201-241 (2009).

Pan, Q., Bao, L.W. & Merajver, S.D. Tetrathiomolybdate Inhibits Angiogenesis and Metastasis through Suppression of the NfκB Signaling Cascade. Mol. Cancer Res. 1, 701-706 (2003).

Qin, L. & Zhang, M. Maspin Regulates Endothelial Cell Adhesion and Migration through an Integrin Signaling Pathway. J. Biol. Chem. 285, 32360-32369 (2010).

Shin, E.K. & Kim, J.K. Indirubin Derivative E804 Inhibits Angiogenesis. BMC Cancer 12, 164 (2012).

Stilwell, J.L., Guan, Y., Neve, R.M. & Gray, J.W. Systems Biology in Cancer Research: Genomics to Cellomics. Methods Mol. Biol. 356, 353-365 (2007).

Tate, C.M. et al. Ly2228820 Dimesylate, a Selective Inhibitor of p38 Mitogen-Activated Protein Kinase, Reduces Angiogenic Endothelial Cord Formation in Vitro and in Vivo. J. Biol. Chem. 288, 6743-6753 (2013).

Tian, F. et al. The Endothelial Cell-Produced Antiangiogenic Cytokine Vascular Endothelial Growth Inhibitor Induces Dendritic Cell Maturation. J. Immunol. 179, 3742-3751 (2007).

Tian, F. et al. Philinopside E, a New Sulfated Saponin from Sea Cucumber, Blocks the Interaction Between Kinase Insert Domain-Containing Receptor (KDR) and αvβ 3 Integrin via Binding to the Extracellular Domain of KDR. Mol. Pharmacol. 72, 545-552 (2007).

Wedge, S.R. et al. AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer. Cancer Res. 65, 4389-4400 (2005).

Willard, M.D. et al. Somatic Mutations in CCK2R Alter Receptor Activity That Promote Oncogenic Phenotypes. Mol. Cancer Res. 10, 739-749 (2012).

Yang, C.L. et al. Curcumin Blocks Small Cell Lung Cancer Cells Migration, Invasion, Angiogenesis, Cell Cycle and Neoplasia through Janus Kinase-STAT3 Signalling Pathway. PLoS One 7 (2012).

Yang, N.-Y., Pasquale, E.B., Owen, L.B. & Ethell, I.M. The EPHB4 Receptor-Tyrosine Kinase Promotes the Migration of Melanoma Cells through Rho-Mediated Actin Cytoskeleton Reorganization. J. Biol. Chem. 281, 32574-32586 (2006).

Yu, D.C., Waby, J.S., Chirakkal, H., Staton, C.A. & Corfe, B.M. Butyrate Suppresses Expression of Neuropilin I in Colorectal Cell Lines through Inhibition of Sp1 Transactivation. Mol. Cancer 9, 276 (2010).

Zhao, G. et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows a Potent Broad Spectrum of Antitumor Activity in Several Tumor Xenograft Models. Mol. Cancer Ther. 10, 2200-2210 (2011).

Cell CyCle and Cell proliferationAchiwa, H. & Lazo, J.S. PRL-1 Tyrosine Phosphatase Regulates C-Src Levels, Adherence, and Invasion in Human Lung Cancer Cells. Cancer Res. 67, 643-650 (2007).

Albert, B.J. et al. Meayamycin Inhibits Pre-MRNA Splicing and Exhibits Picomolar Activity against Multidrug Resistant Cells. Mol. Cancer Ther. 8, 2308-2318 (2009).

Arsic, N. et al. A Novel Function for Cyclin A2: Control of Cell Invasion Via Rhoa Signaling. J. Cell Biol. 196, 147-162 (2012).

Astle, M.V. et al. AKT Induces Senescence in Human Cells Via mTORC1 and p53 in the Absence of DNA Damage: Implications for Targeting mTOR During Malignancy. Oncogene 31, 1949-1962 (2012).

Azzariti, A. et al. Aurora B Kinase Inhibitor AZD1152: Determinants of Action and Ability to Enhance Chemotherapeutics Effectiveness in Pancreatic and Colon Cancer. Br. J. Cancer 104, 769-780 (2011).

Baffert, F. et al. Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805. Mol. Cancer Ther. 9, 1945-1955 (2010).

Bao, Y. et al. A Cell-Based Assay to Screen Stimulators of the Hippo Pathway Reveals the Inhibitory Effect of Dobutamine on the Yap-Dependent Gene Transcription. J. Biochem. 150, 199-208 (2011).

Bhawe, K.M., Blake, R.A., Clary, D.O. & Flanagan, P.M. An Automated Image Capture and Quantitation Approach to Identify Proteins Affecting Tumor Cell Proliferation. J. Biomol. Screen. 9, 216-222 (2004).

Brave, S.R. et al. Assessing the Activity of Cediranib, a VEGFR-2/3 Tyrosine Kinase Inhibitor, against Vegfr-1 and Members of the Structurally Related Pdgfr Family. Mol. Cancer Ther. 10, 861-873 (2011).

Brisson, M. et al. Discovery and Characterization of Novel Small Molecule Inhibitors of Human CDC25B Dual Specificity Phosphatase. Mol. Pharmacol. 66, 824-833 (2004).

Cappell, K.M. et al. Multiple Cancer Testis Antigens Function to Support Tumor Cell Mitotic Fidelity. Mol. Cell. Biol. 32, 4131-4140 (2012).

Cathcart, M.C. et al. Examination of Thromboxane Synthase as a Prognostic Factor and Therapeutic Target in Non-Small Cell Lung Cancer. Mol. Cancer 10, 25 (2011).

Chen, Z. et al. 1-Benzyl-3-Cetyl-2-Methylimidazolium Iodide (NH125) Induces Phosphorylation of Eukaryotic Elongation Factor-2 (eEF2): A Cautionary Note on the Anticancer Mechanism of an eEF2 Kinase Inhibitor. J. Biol. Chem. 286, 43951-43958 (2011).

Cheung, P. & Dennis, J.W. MGAT5 and PTEN Interact to Regulate Cell Growth and Polarity. Glycobiology 17, 767-773 (2007).

Chresta, C.M. et al. AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with in Vitro and in Vivo Antitumor Activity. Cancer Res. 70, 288-298 (2010).

Colombo, R. et al. Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase. Cancer Res. 70, 10255-10264 (2010).

Coppé, J.P. et al. A Human-Like Senescence-Associated Secretory Phenotype Is Conserved in Mouse Cells Dependent on Physiological Oxygen. PLoS One 5 (2010).

CUCCHI, U. et al. Phosphorylation of TCTP as a Marker for Polo-Like Kinase-1 Activity in Vivo. Anticancer Res. 30, 4973-4985 (2010).

Davies, A.H. et al. YB-1 Evokes Susceptibility to Cancer through Cytokinesis Failure, Mitotic Dysfunction, and HER2 Amplification. Oncogene 30, 3649-3660 (2011).

Davies, B.R. et al. Preclinical Pharmacology of AZD5363, an Inhibitor of AKT: Pharmacodynamics, Antitumor Activity, and Correlation of Monotherapy Activity with Genetic Background. Mol. Cancer Ther. 11, 873-887 (2012).

Desmaison, A., Frongia, C., Grenier, K., Ducommun, B. & Lobjois, V. Mechanical Stress Impairs Mitosis Progression in Multi-Cellular Tumor Spheroids. PLoS One 8 (2013).

Du, H. et al. Effects of CS-1 on A431 Cell Proliferation, Cell Cycle, and Epidermal Growth Factor Receptor Signal Transduction. Acta. Biochim. Biophys. Sin. 44, 136-146 (2012).

Eapen, S.A. et al. Identification of a Novel Function for the Chromatin Remodeling Protein ING2 in Muscle Differentiation. PLoS One 7 (2012).

Emery, A. et al. A Novel Cell-Based, High-Content Assay for Phosphorylation of Lats2 by Aurora A. J. Biomol. Screen. 16, 925-931 (2011).

Geiger, M. et al. Cytotoxicity, Fractionation and Dereplication of Extracts of the Dinoflagellate Vulcanodinium Rugosum, a Producer of Pinnatoxin G. Mar. Drugs 11, 3350-3371 (2013).

Giuliano, K.A., Chen, Y.-T. & Taylor, D.L. High-Content Screening with Sirna Optimizes a Cell Biological Approach to Drug Discovery: Defining the Role of p53 Activation in the Cellular Response to Anticancer Drugs. J. Biomol. Screen. 9, 557-568 (2004).

Giuliano, K.A. et al. Systems Cell Biology Knowledge Created from High Content Screening. Assay Drug Dev. Technol. 3, 501-514 (2005).

Gonzalez-Suarez, E. et al. Rank Overexpression in Transgenic Mice with Mouse Mammary Tumor Virus Promoter-Controlled Rank Increases Proliferation and Impairs Alveolar Differentiation in the Mammary Epithelia and Disrupts Lumen Formation in Cultured Epithelial Acini. Mol. Cell. Biol. 27, 1442-1454 (2007).

Graff, J.R. et al. eLF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival. Cancer Res. 69, 3866-3873 (2009).

Guan, Y. et al. Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer. Clin. Cancer Res. 13, 5745-5755 (2007).

Gurtler, U. et al. Effect of Bi 811283, a Novel Inhibitor of Aurora B Kinase, on Tumor Senescence and Apoptosis. ASCO Meeting Abstracts 28, e13632- (2010).

Harikumar, K.B. et al. A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth in Vitro and in Vivo. Mol. Cancer Ther. 9, 1136-1146 (2010).

Hassan, S.B. et al. The Nanoparticulate Quillaja Saponin Bbe Is Selectively Active Towards Renal Cell Carcinoma. Anticancer Res. 33, 143-151 (2013).

He, X.W., Tao, F., Luo, S.S. & Yu, X.K. [Effect of Lentivirus-Mediated Nob1 Gene Silencing by Rna Interference on Proliferation and Apoptosis of Human Colon Cancer Cells]. Zhonghua Wei Chang Wai Ke Za Zhi 15, 1182-1186 (2012).

Hoesli, C.A., Johnson, J.D. & Piret, J.M. Purified Human Pancreatic Duct Cell Culture Conditions Defined by Serum-Free High-Content Growth Factor Screening. PLoS One 7 (2012).


Howes, A.L. et al. The Phosphatidylinositol 3-Kinase Inhibitor, Px-866, Is a Potent Inhibitor of Cancer Cell Motility and Growth in Three-Dimensional Cultures. Mol. Cancer Ther. 6, 2505-2514 (2007).

Hu, K. et al. Nanoparticulate Quillaja Saponin Induces Apoptosis in Human Leukemia Cell Lines with a High Therapeutic Index. Int. J. Nanomedicine 5, 51-62 (2010).

Hu, Z. et al. The Expression Level of Hjurp Has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer. Breast Cancer Res. 12, R18 (2010).

James, A.D., Chan, A., Erice, O., Siriwardena, A.K. & Bruce, J.I.E. Glycolytic ATP Fuels the Plasma Membrane Calcium Pump Critical for Pancreatic Cancer Cell Survival. J. Biol. Chem. 288, 36007-36019 (2013).

Jani, J.P. et al. PF-03814735, an Orally Bioavailable Small Molecule Aurora Kinase Inhibitor for Cancer Therapy. Mol. Cancer Ther. 9, 883-894 (2010).

Janssen, A., Kops, G.J.P.L. & Medema, R.H. Elevating the Frequency of Chromosome Mis-Segregation as a Strategy to Kill Tumor Cells. Proc. Natl. Acad. Sci. U. S. A. 106, 19108-19113 (2009).

Jia, W., Eneh, J.O., Ratnaparkhe, S., Altman, M.K. & Murph, M.M. Microrna-30c-2* Expressed in Ovarian Cancer Cells Suppresses Growth Factor-Induced Cellular Proliferation and Downregulates the Oncogene Bcl9. Mol. Cancer Res. 9, 1732-1745 (2011).

Jia, W., Eneh, J.O., Ratnaparkhe, S., Altman, M.K. & Murph, M.M. Abstracts of the 34th Annual Meeting of the United Kingdom Environmental Mutagen Society, 29th June - 1st July 2011. Held Jointly with the Association for Radiation Research at the University of Nottingham, UK. Microrna-30c-2* Expressed in Ovarian Cancer Cells Suppresses Growth Factor-Induced Cellular Proliferation and Downregulates the Oncogene Bcl9. Mutagenesis 27, 103-137 (2012).

Kawamura, E. et al. Identification of Novel Small Molecule Inhibitors of Centrosome Clustering in Cancer Cells. Oncotarget 4, 1763-1776 (2013).

Khan, G.N. et al. Pomegranate Fruit Extract Impairs Invasion and Motility in Human Breast Cancer. Integr. Cancer Ther. 8, 242-253 (2009).



Kuo, W.L. et al. A Systems Analysis of the Chemosensitivity of Breast Cancer Cells to the Polyamine Analogue Pg-11047. BMC Med. 7, 77 (2009).


LaPan, P., Zhang, J., Pan, J., Hill, A. & Haney, S.A. Single Cell Cytometry of Protein Function in Rnai Treated Cells and in Native Populations. BMC Cell Biol. 9, 43 (2008).

Lazo, J.S. et al. Identifying a Resistance Determinant for the Antimitotic Natural Products Disorazole C1 and A1. J. Pharmacol. Exp. Ther. 332, 906-911 (2010).

Lee, S.J. et al. Cross-Regulation between Oncogenic Brafv600e Kinase and the Mst1 Pathway in Papillary Thyroid Carcinoma. PLoS One 6 (2011).

Lee, Y.F. et al. JMJD6 Is a Driver of Cellular Proliferation and Motility and a Marker of Poor Prognosis in Breast Cancer. Breast Cancer Res. 14, R85 (2012).

Levina, V. et al. Elimination of Human Lung Cancer Stem Cells through Targeting of the Stem Cell Factor-C-Kit Autocrine Signaling Loop. Cancer Res. 70, 338-346 (2010).

Levina, V., Marrangoni, A.M., DeMarco, R., Gorelik, E. & Lokshin, A.E. Drug-Selected Human Lung Cancer Stem Cells: Cytokine Network, Tumorigenic and Metastatic Properties. PLoS One 3 (2008).

Levina, V., Marrangoni, A.M., DeMarco, R., Gorelik, E. & Lokshin, A.E. Multiple Effects of Trail in Human Carcinoma Cells: Induction of Apoptosis, Senescence, Proliferation, and Cytokine Production. Exp. Cell Res. 314, 1605-1616 (2008).

Levina, V. et al. Role of Eotaxin-1 Signaling in Ovarian Cancer. Clin. Cancer Res. 15, 2647-2656 (2009).

Levina, V., Su, Y. & Gorelik, E. Immunological and Nonimmunological Effects of Indoleamine 2,3-Dioxygenase on Breast Tumor Growth and Spontaneous Metastasis Formation. Clin. Dev. Immunol. 2012 (2012).

Levina, V. et al. Chemotherapeutic Drugs and Human Tumor Cells Cytokine Network. Int. J. Cancer 123, 2031-2040 (2008).

Levina, V.V. et al. Biological Significance of Prolactin in Gynecologic Cancers. Cancer Res. 69, 5226-5233 (2009).

Li, X. et al. Japonicone a Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB. Clin. Cancer Res. 19, 2917-2928 (2013).

Li, Y. et al. Transcriptional Changes Associated with Breast Cancer Occur as Normal Human Mammary Epithelial Cells Overcome Senescence Barriers and Become Immortalized. Mol. Cancer 6, 7 (2007).

Lindblom, P. et al. Tesaglitazar, a Dual PPAR-α/γ Agonist, Hamster Carcinogenicity, Investigative Animal and Clinical Studies. Toxicol. Pathol. 40, 18-32 (2012).


Liu, L. et al. Sorafenib Blocks the Raf/Mek/Erk Pathway, Inhibits Tumor Angiogenesis, and Induces Tumor Cell Apoptosis in Hepatocellular Carcinoma Model PLC/PRF/5. Cancer Res. 66, 11851-11858 (2006).

Low, J. et al. Knockdown of Ubiquitin Ligases in Glioblastoma Cancer Stem Cells Leads to Cell Death and Differentiation. J. Biomol. Screen. 17, 152-162 (2012).

Low, J. et al. High-Content Imaging Characterization of Cell Cycle Therapeutics through in Vitro and in Vivo Subpopulation Analysis. Mol. Cancer Ther. 7, 2455-2463 (2008).

Lyman, S.K. et al. High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor Xl888. PLoS One 6 (2011).

Ma, L. et al. Efficacy of LY2784544, a Small Molecule Inhibitor Selective for Mutant JAK2 Kinase, in JAK2 V617F-Induced Hematologic Malignancy Models. Blood (ASH Annual Meeting Abstracts) 116, 4087- (2010).

McLellan, J.L. et al. Synthetic Lethality of Cohesins with Parps and Replication Fork Mediators. PLoS Genet. 8 (2012).

Mendelsohn, R. et al. Complex N-Glycan and Metabolic Control in Tumor Cells. Cancer Res. 67, 9771-9780 (2007).


Mukhopadhyay, R. et al. Promotion of Variant Human Mammary Epithelial Cell Outgrowth by Ionizing Radiation: An Agent-Based Model Supported by in Vitro Studies. Breast Cancer Res. 12, R11 (2010).

Mumenthaler, S. et al. Evolutionary Modeling of Combination Treatment Strategies to Overcome Resistance to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. Mol. Pharm. 8, 2069-2079 (2011).

Mutka, S.C. et al. Identification of Nuclear Export Inhibitors with Potent Anticancer Activity in Vivo. Cancer Res. 69, 510-517 (2009).

Nakashima, M. & Lazo, J.S. Phosphatase of Regenerating Liver-1 Promotes Cell Migration and Invasion and Regulates Filamentous Actin Dynamics. J. Pharmacol. Exp. Ther. 334, 627-633 (2010).

Nandan, M.O., Chanchevalap, S., Dalton, W.B. & Yang, V.W. Krüppel-Like Factor 5 Promotes Mitosis by Activating the Cyclin B1/Cdc2 Complex During Oncogenic Ras-Mediated Transformation. FEBS Lett. 579, 4757-4762 (2005).

Nishitani, S., Horie, M., Ishizaki, S. & Yano, H. Branched Chain Amino Acid Suppresses Hepatocellular Cancer Stem Cells through the Activation of Mammalian Target of Rapamycin. PLoS One 8 (2013).

O’Brien, C. et al. Functional Genomics Identifies Abcc3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer. Cancer Res. 68, 5380-5389 (2008).

O’Brien, C. et al. Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3’ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models. Clin. Cancer Res. 16, 3670-3683 (2010).

Okawa, Y. et al. SNX-2112, a Selective Hsp90 Inhibitor, Potently Inhibits Tumor Cell Growth, Angiogenesis, and Osteoclastogenesis in Multiple Myeloma and Other Hematologic Tumors by Abrogating Signaling Via AKT and ERK. Blood 113, 846-855 (2009).

Okawa, Y. et al. Program and Abstracts: Ninth International Symposium on Ultrasonic Imaging and Tissue Characterization: June 3-6, 1984 Quality Inn on Capitol Hill Washington, Dc SNX-2112, a Selective HSP90

Inhibitor, Potently Inhibits Tumor Cell Growth, Angiogenesis, and Osteoclastogenesis in Multiple Myeloma and Other Hematologic Tumors by Abrogating Signaling Via AKT and ERK. Ultrason. Imaging 6, 201-241 (2009).

OKUI, T. et al. Antitumor Effect of Novel HSP90 Inhibitor NVP-AUY922 against Oral Squamous Cell Carcinoma. Anticancer Res. 31, 1197-1204 (2011).

Park, H.-J. et al. Chemical Enhancers of Cytokine Signaling That Suppress Microfilament Turnover and Tumor Cell Growth. Cancer Res. 66, 3558-3566 (2006).

Payton, M. et al. Preclinical Evaluation of Amg 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines. Cancer Res. 70, 9846-9854 (2010).

Pratt, S.E. et al. Human Carboxylesterase-2 Hydrolyzes the Prodrug of Gemcitabine (Ly2334737) and Confers Prodrug Sensitivity to Cancer Cells. Clin. Cancer Res. 19, 1159-1168 (2013).

Ravi, D. et al. 14-3-3 Σ Expression Effects G2/M Response to Oxygen and Correlates with Ovarian Cancer Metastasis. PLoS One 6 (2011).

Riffell, J.L., Janicke, R.U. & Roberge, M. Caspase-3-Dependent Mitotic Checkpoint Inactivation by the Small-Molecule Inducers of Mitotic Slippage Su6656 and Geraldol. Mol. Cancer Ther. 10, 839-849 (2011).

Sartore-Bianchi, A. et al. Bortezomib Inhibits Nuclear Factor- Kappa B Dependent Survival and Has Potent in Vivo Activity in Mesothelioma. Clin. Cancer Res. 13, 5942-5951 (2007).

Schimizzi, G.V., Currie, J.D. & Rogers, S.L. Expression Levels of a Kinesin-13 Microtubule Depolymerase Modulates the Effectiveness of Anti-Microtubule Agents. PLoS One 5 (2010).

Schmidt, M. et al. Molecular Alterations after Polo-Like Kinase 1 MRNA Suppression Versus Pharmacologic Inhibition in Cancer Cells. Mol. Cancer Ther. 5, 809-817 (2006).

Schoolmeesters, A., Brown, D.D. & Fedorov, Y. Kinome-Wide Functional Genomics Screen Reveals a Novel Mechanism of Tnfα-Induced Nuclear Accumulation of the Hif-1α Transcription Factor in Cancer Cells. PLoS One 7 (2012).


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Oncology...Lung Cancer Cells. Cancer Res. 67, 643-650 (2007). Albert, B.J. et al. Meayamycin Inhibits Pre-MRNA Splicing and Exhibits Picomolar Activity against Multidrug Resistant