ONE STEP FORWARDPut knee pain behind you by restoring your natural joint fluid.

Your knee joint is lubricated by synovial fluid, which contains hyaluronic acid and acts as the knee’s shock absorber.

With OA of the knee, less synovial fluid is produced naturally in your knee joint and you begin to feel pain and discomfort. Over time, as joint fluid continues to break down and cartilage wears away, bones may start to rub against each other, causing increased pain and swelling.

OA of the knee has several causes, such as:

• Excessive wear and tear on the knee joint

• Aging

• Heredity

• Traumatic injury

• Weight gain

• Repetitive stress injuries

• Gender

Women of age 50 and over are more likely to develop OA of the knee, however, it can affect both men and women much earlier in life. You may find yourself with limited movement and having to modify your activities to avoid or reduce your knee pain.

WHAT IS OSTEOARTHRITIS (OA) OF THE KNEE?

Your knee pain, the impact it is having on your life and what has or has not worked previously will dictate what may be the right treatment choice you and your doctor select.

Below are some common treatment options recommended to provide relief from OA of the knee. All treatment options have some risks/bene-fits. Please consult with your doctor as to which may be best for you.

Osteoarthritis is a degenerative, progressive disease. Ignoring its symptoms or modifying your lifestyle will not make it better.

OA STAGES FIND THE RIGHT TREATMENT FOR YOU

WHAT IS MONOVISC®?MONOVISC is an FDA-approved, non-drug therapy made from ultra-pure, high molecular weight hyaluronan. MONOVISC is a non-systemic injection that will not interact with any other medication you may be taking. It restores the natural joint fluid (hyaluronan) that cushions, protects and lubricates your knee joint. With better cushioning, your knee can move and function better.

Lifestyle & Exercise• Physiotherapy and knee exercises• Weight reduction• Massage and acupuncture

Over-the-Counter (OTC) Pain Relievers• Acetaminophen (TYLENOL1)• Glucosamine and other

nutraceuticals

Prescription Pain RelieversCelebrex2, Voltaren3, Ultram ER4, and others

Drugs that Treat InflammationNonsteroidal anti-inflammatory drugs (NSAIDS) including ibuprofen (MOTRIN5)

Joint Fluid TreatmentHyaluronic acid (natural joint fluid)injections into the knee joint, such as MONOVISC® High Molecular Weight Hyaluronan

Mild to Moderate OA As OA progresses, healthy joint fluid begins to break down

Severe OA Without healthy joint fluid, your knees become sore and swollen

Knee pain is not an indicator of how far your OA of the knee has progressed, as pain is different for each patient. Be sure to monitor your knee pain and talk with your doctor about the impact it is having on your life so you can find the relief you need based on your stage of knee OA.

• FDA approved

• A non-avian sourced viscosupplementationderived from bacterial cells

• Contains the highest amount of hyaluronanavailable for a single injection

• Can provide pain relief without the use ofadditional medications

• Administered in your doctor’s office

• May provide pain relief from OA of the kneefor up to six months7

• Can be an effective treatment beyond the firstinjection. Data supports safe retreatment, but thenumber of injections right for you is a decisionyou and your doctor can make together. Consultyour insurance provider to learn aboutcoverage for any additional treatments youmay receive.

• Clinical data shows that OA patients who aretreated earlier with hyaluronic acid injectionssuch as MONOVISC, can delay total jointreplacement surgery for over 2.6 years.6

• Covered by Medicare and most Commercialplans. For information regarding yourMONOVISC reimbursement, call our hotlineat 1-866-633-VISC (8472) or your insuranceprovider.

MONOVISC FACTS

AFTER A MONOVISC INJECTION…

• Avoid strenuous activities (high-impact sports like jogging or tennis) or prolonged weight bearing for approximately 48 hours following the injection. Consult your doctor regarding appropriate time to resume such activities.

• The most commonly reported adverse events observed in the original clinical studies were: joint pain, injection site pain, joint swelling and effusion. MONOVISC should not be injected in patients with infections or skin dis-eases in the area of the injection site or joint or with known systemic bleeding disorders. If you have circulatory problems in the legs, be sure to talk to your doctor about them before your treatment.

Joint fluid

Cartilage

Bone

Unhealthy joint fluid

Eroded cartilage

Damaged cartilage

Bone spurs

Scarce synovial fluid

Healthy KneeFluid cushions and lubricates your knees

© DePuy Synthes 2017. All rights reserved. DSUS/MTK/0117/0890a 03/17

DePuy Mitek, Inc.325 Paramount DriveRaynham, MA 02767 T. +1 (800) 382-4682

www.depuysynthes.com

1 TYLENOL® is a registered trademark of McNeil-PPC, Inc. 1998-2010.2 Celebrex® is a registered trademark of Pfizer Inc.3 Voltaren® is a registered trademark of Novartis Pharmaceuticals

Corporation.4 Ultram ER® is a registered trademark of Ortho-McNeil, Inc.5 MOTRIN® is a registered trademark of McNeil-PPC, Inc. 1997-20106 Abbott, T; Altman, R; Dimeff, R; Fredericson, M; Vad, V; Vitanzo, P; Yadalam, S;

Levine, R; Bisson, B; Bhattacharyya, S. Do Hyaluronic Acid Injections Delay Total Knee Replacement Surgery? Abstract: Poster presented October 29, 2013 at ACR/AHRP Annual Meeting, San Diego, CA

7. MONOVISC full prescribing information

For more information or to find a doctor near you, go to www.monovisc.com or call Mitek Sports Medicine at 1-800-382-4682

MONOVISC® is manufactured by and is a registered trademark of Anika Therapeutics, Inc.

Important Safety InformationMONOVISC High Molecular Weight Hyaluronan is indicated in the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics, e.g., acetaminophen. In clinical stud-ies, the most commonly reported adverse events were arthralgia, joint swelling and injection site pain.

MONOVISC is contraindicated in patients with known hypersensitivity to hyaluronate formulations or known hypersensitivity (allergy) to gram positive bacterial proteins. MONOVISC should not be injected in pa-tients with infections or skin diseases in the area of the injection site or joint. MONOVISC should not be administered to patients with known bleeding disorders. Intra-articular injection of sodium hyaluronate preparations has occasionally been associated with allergic/anaphylac-tic reactions and transient hypotension, which have generally resolved spontaneously or after conservative treatment.

Mitek Sports Medicine is a global leader in orthopaedic solutions and is dedicated to providing the tools needed to help you move and feel like yourself again.

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KEEP TRACK OF YOUR INJECTION APPOINTMENT HERE

MONOVISC injection scheduled:

Date: Time: