O U T C O M E S R E S E A R C H C o n s o r t i u m

Providing the evidence for evidence-based medicine©

2019 Annual Report

The OUTCOMES RESEARCH Group was formed in 1990 at the University of California in San Francisco and subsequently became an institute when the group's administrative center moved to the University of Louisville in March of 2000. In 2005, OUTCOMES RESEARCH became a department at the Cleveland Clinic. After 9 years, the Department of OUTCOMES RESEARCH now includes 65 members at the Clinic, among more than 190 academic investigators in twenty countries including the Austria, Canada, China, Ireland, Israel, Japan, China, and the United States. The Consortium is non-profit; its only goal is thus participation in high-quality research.

2015 year was the Consortium’s 25th Anniversary. This milestone was celebrated by an editorial in Anesthesiology by Henry Rosenberg (2015; 123:1233-4). It starts: “IMAGINE a research group made up of more than 100 members working both independently and collaboratively across many countries having no legal standing, no bank account, and loosely organized, but devoted to the goal of improving health care through the understanding of the results of health care practices. Furthermore, imagine that members of this organization have published more than 900 full journal articles since its inception and publish a new full paper every 5 days. [Since 2018, the Consortium has published a full paper every 3 days.] It may be hard to believe that such a unique organization exists, but it does. It is known as the OUTCOMES RESEARCH Consortium.”

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The Consortium is currently involved in about 200 clinical studies, including many large multi-center outcome trials. Much of the Consortium’s funding is from the National Institutes of Health, the Canadian Institutes of Health Research, and other peer-reviewed granting agencies. We also collaborate with companies that make innovative devices and drugs, often conducting major trials that lead to regulatory certification. The Consortium facilitates scientific exchange and collaboration necessary for technically complex outcomes studies involving hundreds or thousands of patients. Additional information is available at www.OR.org.

Aspirations

Outcomes research seeks to understand the end results of particular health care practices and interventions. End results include effects that people experience and care about, such as change in the ability to function. In particular, for individuals with chronic conditions—where cure is not always possible—end results include quality of life as well as mortality. By linking the care people get to the outcomes they experience, outcomes research has become the key to developing better ways to monitor and improve the quality of care.

The general goal of the OUTCOMES RESEARCH Consortium is to evaluate inexpensive, low-risk interventions that are easy to implement yet likely to markedly improve outcome. For example, we have shown that simply maintaining intraoperative normothermia markedly reduces the risk of complications — and does so at trivial cost. A consequence of our work is that active intraoperative warming has become routine, whereas it was rare a decade ago.

Mission Be the world’s leading anesthesia-related clinical research organization. Behaviors

1. Publish more high-impact, peer-reviewed clinical research papers (quantified as number times impact) than any other anesthesia organization.

2. Recruit more extra-mural clinical research funding than any other anesthesia organization, with “clinical research” being defined as research conducted with human subjects.

3. Train clinical investigators at all levels.

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Personnel

Administrative Structure

Director: Daniel I. Sessler, M.D. Cleveland USA

Associate Director: Alparslan Turan, M.D. Cleveland USA

2019 Site Directors: Donal Buggy, M.D. Dublin Ireland Peter Szmuk, M.D. Dallas USA Yuguang Huang, M.D. Beijing China Thomas Volk, M.D. Homburg Germany Colin Royse, M.D. Melbourne AustraliaBrian Ilfeld, M.D. San Diego USA

Members

1. Alaa A. Abd-Elsayed, M.D. Madison USA 2. Basem B. Abdelmalak, M.D. Cleveland USA 3. Janet Adegboye, B.S. Cleveland USA 4. Ruben Agudelo Jimenez, M.D. Clevleand USA 5. Sanchit Ahuja, M.D. Detroit USA 6. Wael Ali Sakr Esa, M.D. Cleveland USA 7. Ece Yamak Altinpulluk, M.D. Cleveland Turkey 8. Sibs Anwar, M.D., Ph.D. London United Kingdom 9. Harendra Arora, M.D. Chapel Hill USA 10. Amanda Artis, M.S. Cleveland USA 11. Valentina Assenzo, M.D. Suresnes, Paris France 12. Abdulkadir Atim, M.D. Ankara Turkey 13. Sabry Ayad, M.D. Cleveland USA 14. Rovnat Babazade, M.D. Galveston USA 15. Gausan Bajracharya, M.D. Cleveland USA 16. Ömer Bakal, M.D. Cleveland USA 17. Allen Bashour, M.D. Cleveland USA 18. Beatrice Beck-Schimmer, MD Zurich Switzerland 19. Sergio D. Bergese, M.D. Columbus USA 20. Bruce M. Biccard, M.B.Ch.B., F.C.A., Ph.D. Cape Town South Africa 21. Peter Biro, M.D. Zurich Switzerland 22. Joshua A. Bloomstone, M.D., M.Sc Glendale USA 23. James M. Blum, M.D. Decatur USA 24. Hagen Bomberg, M.D. Homburg Germany 25. Mauro Bravo, M.D. Cleveland USA 26. Donal J. Buggy, M.D., FRCPI, FRCACSI, FRCA Dublin Ireland 27. Juan Cata, M.D. Houston USA 28. Praveen Chahar, M.D., F.C.A.R.C.S.I. Cleveland USA 29. Christine Chang, B.S. Cleveland USA 30. David Chelnick, B.S. Cleveland USA 31. Surendrasingh S. Chhabada, M.D. Cleveland USA 32. Andrew Chiu, B.S. Cleveland USA 33. Praneeta Chodavarapu, M.D. Cincinnati USA 34. Barak Cohen, M.D. Cleveland USA 35. Allen Collins Cleveland USA 36. Jennifer Cook Cleveland USA 37. Jacek B. Cywinski, M.D. Cleveland USA 38. Jarrod E. Dalton, Ph.D. Cleveland USA

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39. Gildasio S. De Oliveira Jr., M.D., M.S.C.I. Providence USA 40. Stacie G. Deiner, M.D. New York USA 41. Jagan Devarajan, MD Cleveland USA 42. Philip J. Devereaux, M.D., Ph.D. Hamilton Canada 43. Anthony G. Doufas, M.D., Ph.D. Stanford USA 44. Lei Du, M.D. Chengdu China 45. Emmanuelle Duceppe, MD., Ph.D. Montreal Canada 46. Andra E. Duncan, M.D. Cleveland USA 47. Ruthy Edry, M.D. Haifa Israel 48. Proshad N. Efune, M.D. Dallas USA 49. Catherine Ekladios, M.D. Cleveland USA 50. Kavita Elliott, B.S. Cleveland USA 51. Hesham Elsharkawy, M.D. Cleveland USA 52. Hani Essbar, M.D. Cleveland USA 53. Tibi Ezri, M.D. Israel 54. Jonathan Fang, M.D. Cleveland USA 55. Ehab S.A. Farag, M.D., F.R.C.A. Cleveland USA 56. Tobias Fink, M.D. Homburg Germany 57. John J. Finneran IV, M.D. San Diego USA 58. Edith Fleischmann, M.D. Vienna Austria 59. Béla Fülesdi, M.D., Ph.D. Debrecen Hungary 60. Rodney A. Gabriel, M.D. La Jolla USA 61. Marcelo Gama de Abreu, M.D., Ph.D., D.E.S.A Dresden Germany 62. Ahmed Gharrash, M.D. Cleveland USA 63. Martin V. Grady, M.D. Mayfield Heights USA 64. Sarah Guirguis, M.D. Cleveland USA 65. Sven Halvorson, M.S. Cleveland USA 66. Hassan Hamadnalla, M.D. Cleveland USA 67. CeCelia Hanline, M.H.S. Cleveland USA 68. Manal Hassan, M.D. Mayfield Heights USA 69. Mohamed Hassan, M.D. Cleveland USA 70. Steve Hata, M.D., F.C.C.P., M.S.C. Cleveland USA 71. Yuguang Huang, M.D. Beijing China 72. Tobias Hüppe, M.D. Homburg (Saar) Germany 73. Brian M. Ilfeld, M.D., M.S. San Diego USA 74. Ilker Ince, M.D. Cleveland USA 75. Steven R. Insler, D.O. Cleveland USA 76. Daniela C. Ionescu, Ph.D., D.E.A.A. Cluj-Napoca Romania 77. Tadahiko Ishiyama, M.D., Ph.D. Chuo Japan 78. Pia Jaeger, M.D., Ph.D. Copenhagen Denmark 79. Jens-Ulrik S. Jensen, M.D., Ph.D. Copenhagen Denmark 80. Qiliang Jiang, M.D., Ph.D. Cleveland USA 81. Ruben A. Jiimenez, M.D. Cleveland USA 82. Roberta Johnson Cleveland USA 83. Barbara Kabon, M.D. Vienna Austria 84. Yusuke Kasuya, M.D. Tokyo Japan 85. Elliott Kavita cleveland USA 86. Roop Kaw, M.D. Cleveland USA 87. Zafeer Khan, M.D. Cleveland USA 88. Ashish K. Khanna, M.D., F.C.C.P., F.C.C.M. Cleveland USA 89. Sandeep Khanna, M.D. Cleveland USA 90. Dilara Khoshknabi, M.D. Cleveland USA 91. Daniel Kim, M.D. Cleveland USA 92. Oliver Kimberger, M.D. Vienna Austria 93. Ryu Komatsu, M.D. Baltimore USA 94. Sascha Kreuer, M.D. Homburg Germany 95. Priya A. Kumar, M.D. Chapel Hill USA

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96. Andrea M. Kurz, M.D. Cleveland USA 97. Giovanni Landoni, M.D. Milan Italy 98. Kate Leslie, M.D., F.A.N.Z.C.A. Parkville Australia 99. Kai Li, M.D., Ph.D. Cleveland USA 100. Qian Li, M.D. Chengdu China 101. Chen Liang, M.S. Cleveland USA 102. Jing Lin, M.D. Changdu China 103. Liu Liu, M.A. Cleveland USA 104. Ngai Liu, M.D., Ph.D. Suresnes France 105. Vladimir V. Lomivorotov, M.D., Ph.D. Novosibirsk Russia 106. Dominik Lorenz, M.D. Homburg / Saar Germany 107. Chao Ma, M.S. Cleveland USA 108. Anthony T. Machi, M.D. Dallas USA 109. Kamal Maheshwari, M.D. Cleveland USA 110. Natalya Makarova, M.S. Cleveland USA 111. Guangmei Mao, M.S. Cleveland USA 112. Edward J. Mascha, Ph.D. Cleveland USA 113. Takashi Matsukawa, M.D. Chuo Japan 114. Felix Maurer, B.S. Homburg Germany 115. Dianna Mehanny, M.D. Cleveland USA 116. Miluska Mejia, M.D. Cleveland USA 117. Mark Mettler Cleveland USA 118. Scott A. Miller, M.D. Winston Salem USA 119. Paul Minko Cleveland USA 120. Toshiki Mizobe, M.D., Ph.D. Kyoto Japan 121. Louretta Mosteller, B.A. Cleveland USA 122. Eassen Mu, M.D. Beijing China 123. Lukas M. Müller-Wirtz, M.D. Homburg Germany 124. Yasuko Nagasaka, M.D., Ph.D. Tokyo Japan 125. Yasufumi Nakajima, M.D., Ph.D. Hirakata Japan 126. Amanda Naylor, B.A. Chicago USA 127. Tyng Yan Ng, M.B.B.S. Kuala Lumpur Malaysia 128. Karen K. Ng-Wong, M.D. Cleveland USA 129. Azfar Niazi, M.D. Cleveland USA 130. Tara Nutchaaroen, M.S. Cleveland USA 131. Ben O’Brian, M.D., Ph.D., M.H.B.A., F.F.I.C.M. London United Kingdom 132. Detlef E.R. Obal, M.D., Ph.D., D.E.S.A. Palo Alto USA 133. Ibrahim Onal, M.D. Cleveland USA 134. Makoto Ozaki, M.D., Ph.D. Tokyo Japan 135. Matt A. Pappas, M.D., M.P.H. Cleveland USA 136. Marie-Odile Parat, Pharm.D., Ph.D. Woolloongabba Australia 137. Fabio R. Patarroyo, M.D. Cleveland USA 138. Lijian Pei, M.D. Beijing China 139. Silvia E. Perez-Protto, M.D., M.S. Cleveland USA 140. Reuven Pizov, M.D. Haifa Israel 141. Olga M. Plattner, M.D. Vienna Austria 142. Kanhaiya Poddar, M.D. Cleveland USA 143. Attila Podolyak, M.D. Cleveland USA 144. Xuan Pu, M.S. Cleveland USA 145. Yewei Qiu, M.D. Cleveland USA 146. Shobana Rajan, M.D. Cleveland USA 147. Eva Rivas Ferreira, M.D. Cleveland USA 148. Efrain Riveros-Perez, M.D. Augusta USA 149. Reitze N. Rodseth, M.B.Ch.B., F.C.A., M.Med. Durban South Africa 150. Colin Royse, M.D. Melbourne Australia 151. Kurt Ruetzler, M.D. Cleveland USA 152. Remie Saab, M.D. Cleveland USA

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153. Leif Saager, M.D. Germany 154. Wael Saasouh, M.D. Detroit USA 155. Partha Saha, M.D. Cleveland USA 156. Ogena Saied Cleveland USA 157. Ahmed Salih, M.D. Cleveland USA 158. Vafi Salmasi, M.D. Palo Alto USA 159. Bernd Saugel, M.D. E.D.I.C. Hamburg Germany 160. Yehoshua-Nadav Schacham, M.D. Ramat-Gan Israel 161. Martin Schläpfer, M.D., M.Sc. Zurich Switzerland 162. Daniel I. Sessler, M.D. Cleveland USA 163. Tetsuya Shimada, M.D. Tokorozawa Japan 164. Akhil K. Singh, M.B.B.S., M.D. New Delhi India 165. Alexis Skolaris Cleveland USA 166. Abraham Sonny, M.D. Boston USA 167. Jeff W. Steiner, D.O. Dallas USA 168. Matthew W. Swisher, M.D., M.S. La Jolla USA 169. Wojciech Szczeklik, M.D., Ph.D. Krakow Poland 170. Peter Szmuk, M.D. Dallas USA 171. Marianne Tanios, M.D. Cleveland USA 172. Abdullah S. Terkawi, M.D. Charlottesville USA 173. Uchida Tokujiro, M.D., Ph.D. Tokyo Japan 174. David Torres, M.D. Santiago Chile 175. Alparslan Turan, M.D. Cleveland USA 176. Tamás Végh, M.D., Ph.D. Debrecen Hungary 177. Andrew Volio, D.O. Cleveland USA 178. Thomas Volk, M.D. Homburg Germany 179. Anupama Wadhwa, M.D. San Diego USA 180. Michael Walters Cleveland USA 181. Catherine I. Wang, M.D. Beijing China 182. Dong-Xin Wang, M.D., Ph.D. Beijing China 183. Iris Wang, MD Cleveland USA 184. Jason Wu, M.D. Shanghai China 185. Lexie Xu, M.D. Beijing China 186. Esra K. Yalein, M.D. Cleveland USA 187. Dongsheng Yang, M.S. Cleveland USA 188. Jean-Pierre Yared, M.D. Cleveland USA 189. Oguz Yilmaz, M.D. Turkey 190. Hai Yu, M.D. Chengdu China 191. Kan Zhang, M.D. Cleveland USA 192. Xiaobao Zhang, M.D. Cleveland USA Research Fellows

Name Origin Dates Subsequent Position

1. Eva Rivas, M.D. Spain 2017-

2. Marianne Tanios, M.D. Egypt 2017-19

3. Dilara Khoshknabi, M.D. Azerbaijan 2017-

4. Remie Saab, M.D. Lebanon 2017-

5. Hani Essbar, M.D. Syria 2017-

6. Ilker Ince, M.D. Turkey 2018-19 Associate Prof, Ataturk University

7. Ahmed Salih, M.D. Iraq 2018-

8. Jonathan Fang, M.D. USA 2018-

9. Hassan Hamadnalla, M.D. Egypt 2018-

10. Mohamad Hassan, M.D. Egypt 2018-

11. Yuwei Qiu, M.D. China 2018-19 Faculty, Shanghai Chest Hospital

12. Tetsuya Shimada, M.D. Japan 2018-19 Faculty, National Defense Medical College

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13. Mauro Bravo, M.D. Venuzuela 2018-

14. Qiliang Jiang, M.D. China 2019 Faculty, Shanghai Chest Hospital

15. Omar Bakal, M.D. Turkey 2019-

16. Ece Yamak Altinpulluk, M.D. Turkey 2019-

17. Xiaobao Zhang, M.D. China 2019

18. Andrew Volio, D.O. United States 2019-

19. Ahmed Al Gharrash, M.D. Saudi Arabia 2019-

20. Ruben Agudelo Jimenez, M.D. Colombia 2019-

21. Kai Li, M.D. China 2019-

22. Esra Kutlu Yalcin, M.D. Turkey 2019-

23. Fabio Rodriguez Patarryo, M.D. Colombia 2019-

24. Ibrahim Onal, M.D. Turkey 2019-

25. Jiayi Wang, M.D. China 2019-

26. Daniel Kim, M.D. USA 2019-

Graduate and Medical Students (full year)

Name Origin Dates Subsequent Position

1. Paul Minko, B.S. USA 2017-19 LECOM, Masters in Medical Science

2. Janet Adegboye, B.S. USA 2018-19 Cleveland Clinic Lerner College of Medicine

3. Assad Ali, B.S. USA 2017-19 NSU College of Osteopathic Medicine

4. Kavita Elliott, B.S. USA 2017-19 Coordinator, Digestive Disease Institute

5. CeCelia Hanline, M.H.S. USA 2017-19 Ohio Univ School of Osteopathic Medicine

6. Yousuf Raza, B.S. Pakistan 2017-19 Digestive Diseases, Cleveland Clinc

7. David Chelnick, B.S. USA 2017-

8. Adam Hochman, M.S. USA 2018-19 Medial College of South Carolina

9. Lauretta Mosteller, B.A. USA 2018-

10. Andrew Chiu, B.S USA 2019-

11. Sofiya Lozovskiy, B.S. USA 2019-

12. Aratara Nutcharoen, B.S. USA 2019-

13. Alexis Skolaris, B.S. USA 2019-

Honors and Awards

Name Honor Organization

Barak Cohen 2nd Place, Resident Essay Contest American Society of Anesthesiologiusts Wael Saasouh Merit Award Detroit Medical Center Chetan Lokhande Best Resident Cleveland Clinic, Fairview Hassan Hamadnalla Best Case Report Ohio Society of Anesthesia Daniel Sessler Researcher of the Year Perioperative Care Congress Basem Abdelmalak Elected president Sociaty for Ambulatory Anesthesia

Consortium Research Awards

The Gladys Sessler Prize is an endowed award that is given yearly. All research fellows and junior faculty members of the OUTCOMES RESEARCH Consortium are eligible. This year’s award was to Kurt Ruetzler.

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The Best Fellow Award is given to the Department of OUTCOMES RESEARCH fellow who is voted by the faculty to have performed at the very highest level. This year’s award was given to Barak Cohen.

Publications

Contribution to the world’s literature

An article by Pagel and Hudetz (BMC Anesthesiology 12:5, 2012) evaluated anesthesia publication trends. In 2010, the last year they report, there were 665 clinical research articles published in the most influencial anesthesia journals: Anesthesiology, the British Journal of Anaesthesia, Anesthesia & Analgesia, Anaesthesia and the European Journal of Anaesthesia. Last year, the Consortium published 30 papers in the 14 journals they considered. The Outcomes Research Consortium thus publishes more than 4% of the clinical research in high-profile general anesthesia journals. Of note, the Consortium also publishes nearly as many papers in specialty journals ranging from pain to critical care to neuroscience, and in major multi-specialty journals. Overall, the Consortium publishes a full paper or editorial nearly every 3 days.

Since inception, the Consortium has published 1,400 full papers.

Featured on journal covers this year

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This year’s featured paper

Sessler DI, Pei L, Huang Y, Fleischmann E, Marhofer P, Kurz A, Mayers DB, Meyer-Treschan TA, Grady M, Tan EY, Ayad S, Mascha EJ, Buggy DJ, Tan G, Zhang Z, Keane H, Stokes M, Zotti O, Gnant M, Perez-Protto S, Wu J, Parra-Sanchez I, Yang D, Hassan M, Tey JBL: Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet 2019; 394: 1807-15 Background: Three perioperative factors impair host defense against recurrence during cancer surgery: the surgical stress response, volatile anaesthesia, and opioids. All are ameliorated by regional anaesthesia-analgesia. We tested the primary hypothesis that recurrence after potentially curative breast cancer surgery is lower with paravertebral/propofol than sevoflurane/opioid anaesthesia. Secondarily, we tested the hypothesis that paravertebral analgesia reduces persistent incision pain.

Methods: Women having potentially curative primary breast cancer resections were randomized to either paravertebral and propofol anaesthesia or sevoflurane-opioid volatile anaesthesia. The primary outcome was local or metastatic breast cancer recurrence. The secondary outcomes were incisional pain at six and twelve months. Primary analyses were intent-to-treat.

Findings: The study was stopped after crossing a pre-planned futility boundary with 213 cancer recurrence events (61% of the maximum required number of recurrences) observed in 2108 women of whom 59% were from China. There was good baseline balance between randomized groups; median [25-75%] follow-up was 36 [24-49] months. There were 102 (9.8%) recurrences among 1043 women assigned to paravertebral anaesthesia versus 111 (10.4%) among 1065 women who received sevoflurane anaesthesia. The hazard ratio for cancer recurrence in paravertebral versus general anaesthesia was an estimated 0.97 (0.74, 1.3), P=0.84. About half the patients in each group reported some pain at six months, and about a quarter reported pain at 12 months. The incidence of neuropathic breast pain was 10% at 6 months and 7% at 12 months in each group, and did not differ by anaesthetic technique.

Interpretation: Paravertebral-propofol anaesthesia did not reduce breast cancer recurrence after potentially curative surgery compared with sevoflurane-opioid anaesthesia in our patients. The incidence and severity of persistent incisional breast pain was unaffected by anaesthetic technique. ClinicalTrials.gov (NCT00418457).

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Published Full Papers and editorials

1. Abdelmalak B: The case against preoperative endoscopic airway examination (PEAE) in the “ENT airway” (editorial). Journal of Head & Neck Anesthesia 2019; 3

2. Abdelmalak BB, You J, Kurz A, Kot M, Bralliar T, Remzi FH, Sessler DI: The effects of dexamethasone, light anesthesia, and tight glucose control on postoperative fatigue and quality of life after major noncardiac surgery: A randomized trial. J Clin Anesth 2019; 55: 83-91

3. Ackland GL, Brudney CS, Cecconi M, Ince C, Irwin MG, Lacey J, Pinsky MR, Grocott MP, Mythen MG, Edwards MR, Miller TE, Physiology g, Preoperative blood pressure g, Intraoperative blood pressure g, Postoperative blood pressure g: Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine. Br J Anaesth 2019; 122: 542-51

4. Ayad S, Khanna AK, Iqbal SU, Singla N: Characterisation and monitoring of postoperative respiratory depression: current approaches and future considerations. Br J Anaesth 2019; 123: 178-391

5. Bautista AF, Lenhardt R, Yang D, Yu C, Heine MF, Mascha EJ, Heine C, Neyer TM, Remmel K, Akca O: Early prediction of prognosis in elderly acute stroke patients. Critical Care Explorations 2019; 1

6. Bergese SD, Melson TI, Candiotti KA, Ayad SS, Mack RJ, McCallum SW, Du W, Gomez A, Marcet JE: A phase 3, randomized, placebo-controlled evaluation of the safety of intravenous meloxicam following major surgery. Clin Pharmacol Drug Dev 2019; 8: 1062-72

7. Bhatia M, Kumar PA: Pro: Venoarterial extracorporeal membrane oxygenation should always include placement of a left ventricular vent. J Cardiothorac Vasc Anesth 2019; 33: 1159-62

8. Bhavani SS, Abdelmalak B: Nonoperating room anesthesia: Anesthesia in the gastrointestinal suite. Anesthesiol Clin 2019; 37: 301-16

9. Boggett S, Ou-Young J, Heiberg J, De Steiger R, Richardson M, Williams Z, Royse C: A randomized trial of desflurane or sevoflurane on postoperative quality of recovery after knee arthroscopy. PLoS One 2019; 14: e0220733

10. Bomberg H, Meiser F, Daume P, Bellgardt M, Volk T, Sessler DI, Groesdonk HV, Meiser A: Halving the volume of AnaConDa: Evaluation of a new small-volume anesthetic reflector in a test lung model. Anesth Analg 2019; 129: 371-9

11. Bregman G, Lahav Y, Kishinevsky Y, Grinevich G, Ezri T, Dukhan A: Early postoperative seizures after vocal fold surgery attributed to shigellosis. Anaesthesia Reports 2019; 7: 43-6

12. Buczkowski P, Puslecki M, Majewska N, Urbanowicz T, Misterski M, Juszkat R, Kulesza J, Zabicki B, Stefaniak S, Ligowski M, Szarpak L, Jemielity M, Rivas E, Ruetzler K, Perek B: Endovascular treatment of complex diseases of the thoracic aorta-10 years single centre experience. J Thorac Dis 2019; 11: 2240-50

13. Burrage PS, Low YH, Campbell NG, O’Brien B: New-onset atrial fibrillation in adult patients after cardiac surgery. Current Anesthesiology Reports 2019; 9: 174-93

14. Candiotti KA, Kranke P, Bergese SD, Melson TI, Motsch J, Siddiqui N, Chung F, Rodriguez Y, Minkowitz HS, Ayad SS, Diemunsch P, Fox G: Randomized, double-blind, placebo-controlled study of intravenous amisulpride as treatment of established postoperative nausea and vomiting in patients who have had no prior prophylaxis. Anesth Analg 2019; 128: 1098-105

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15. Canty DJ, Heiberg J, Yang Y, Royse AG, Margale S, Nanjappa N, Scott DA, Maier AB, Sessler DI, Chuan A, Palmer AJ, Bucknill A, French CJ, Royse CF: One-year results of the pilot multicentre randomised trial of preoperative focused cardiac ultrasound in hip fracture surgery. Anaesth Intensive Care 2019; 47: 207-8

16. Cheng J, Salmasi V, You J, Grille M, Yang D, Mascha EJ, Cheng OT, Zhao F, Rosenquist RW: Outcomes of sympathetic blocks in the management of complex regional pain syndrome: A retrospective cohort study. Anesthesiology 2019; 131: 883-93

17. Cohen B, Ahuja S, Schacham YN, Chelnick D, Mao G, Ali-Sakr Esa W, Maheshwari K, Sessler DI, Turan A: Intraoperative hyperoxia does not reduce postoperative pain: Subanalysis of an alternating cohort trial. Anesth Analg 2019; 128: 1160-6

18. Cohen B, Glosser L, Saab R, Walters M, Salih A, Zafeer-Khan M, Rivas E, Zhang K, Schacham NY, Chodavarapu P, Essber H, Chelnick D, Raza S, Hanline C, Khoshknabi D, Yang D, Seif J, Chhabada S, Turan A: Incidence of adverse events attributable to bupivacaine liposome injectable suspension or plain bupivacaine for postoperative pain in pediatric surgical patients: A retrospective matched cohort analysis. Paediatr Anaesth 2019; 29: 169-74

19. Cohen B, Ruetzler K, Kurz A, Leung S, Rivas E, Ezell J, Mao G, Sessler DI, Turan A: Intra-operative high inspired oxygen fraction does not increase the risk of postoperative respiratory complications: Alternating intervention clinical trial. Eur J Anaesthesiol 2019; 36: 320-6

20. Cohen B, Turan A: Enhanced recovery after cardiac surgery – Is evidence still necessary? (editorial). Journal of Clinical Anesthesia 2019; 54: 171-2

21. Doufas AG, Shafer SL, Rashid NHA, Kushida CA, Capasso R: Non-steady state modeling of the ventilatory depressant effect of remifentanil in awake patients experiencing moderate-to-severe obstructive sleep apnea. Anesthesiology 2019; 130: 213-26

22. Elsharkawy H, Ahuja S, DeGrande S, Maheshwari K, Chan V: Subcostal approach to anterior quadratus lumborum block for pain control following open urological procedures. J Anesth 2019; 33: 148-54

23. Elsharkawy H, Bajracharya GR, El-Boghdadly K, Drake RL, Mariano ER: Comparing two posterior quadratus lumborum block approaches with low thoracic erector spinae plane block: an anatomic study. Reg Anesth Pain Med 2019

24. Elsharkawy H, El-Boghdadly K, Barnes TJ, Drake R, Maheshwari K, Soliman LM, Horn JL, Chin KJ: The supra-iliac anterior quadratus lumborum block: a cadaveric study and case series. Can J Anaesth 2019; 66: 894-906

25. Elsharkawy H, El-Boghdadly K, Barrington M: Quadratus Lumborum Block: Anatomical Concepts, Mechanisms, and Techniques. Anesthesiology 2019; 130: 322-35

26. Elsharkawy H, Saasouh W, Babazade R, Soliman LM, Horn JL, Zaky S: Real-time ultrasound-guided lumbar epidural with transverse interlaminar view: Evaluation of an in-plane technique. Pain Med 2019

27. Farag E, Makarova N, Argalious M, Cywinski JB, Benzel E, Kalfas I, Sessler DI: Vasopressor infusion during prone spine surgery and acute renal injury: A retrospective cohort analysis. Anesth Analg 2019; 129: 896-904

28. Fischer P, Grigoras C, Bugariu A, Nicoara-Farcau O, Stefanescu H, Benea A, Hadade A, Margarit S, Sparchez Z, Tantau M, Ionescu D, Procopet B: Are presepsin and resistin better markers for bacterial infection in patients with decompensated liver cirrhosis? Dig Liver Dis 2019; 51: 1685-91

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29. Forget P, Aguirre JA, Bencic I, Borgeat A, Cama A, Condron C, Eintrei C, Eroles P, Gupta A, Hales TG, Ionescu D, Johnson M, Kabata P, Kirac I, Ma D, Mokini Z, Guerrero Orriach JL, Retsky M, Sandrucci S, Siekmann W, Stefancic L, Votta-Vellis G, Connolly C, Buggy D: How anesthetic, analgesic and other non-surgical techniques during cancer surgery might affect postoperative oncologic outcomes: A summary of current state of evidence. Cancers (Basel) 2019; 11

30. Freeman J, Crowley PD, Foley AG, Gallagher HC, Iwasaki M, Ma D, Buggy DJ: Effect of perioperative lidocaine, propofol and steroids on pulmonary metastasis in a murine model of breast cancer surgery. Cancers (Basel) 2019; 11

31. Fronczek J, Polok K, Devereaux PJ, Gorka J, Archbold RA, Biccard B, Duceppe E, Le Manach Y, Sessler DI, Duchinska M, Szczeklik W: External validation of the Revised Cardiac Risk Index and National Surgical Quality Improvement Program Myocardial Infarction and Cardiac Arrest calculator in noncardiac vascular surgery. Br J Anaesth 2019; 123: 421-9

32. Galway U, Zura A, Khanna S, Wang M, Turan A, Ruetzler K: Anesthetic considerations for bronchoscopic procedures: a narrative review based on the Cleveland Clinic experience. J Thorac Dis 2019; 11: 3156-70

33. Garg AX, Chan MTV, Cuerden MS, Devereaux PJ, Abbasi SH, Hildebrand A, Lamontagne F, Lamy A, Noiseux N, Parikh CR, Perkovic V, Quantz M, Rochon A, Royse A, Sessler DI, Shah PJ, Sontrop JM, Tagarakis GI, Teoh KH, Vincent J, Walsh M, Yared JP, Yusuf S, Whitlock RP, SIRS Investigators: Effect of methylprednisolone on acute kidney injury in patients undergoing cardiac surgery with a cardiopulmonary bypass pump: a randomized controlled trial. CMAJ 2019; 191: E247-E56

34. Habib AS, Kranke P, Bergese SD, Chung F, Ayad S, Siddiqui N, Motsch J, Leiman DG, Melson TI, Diemunsch P, Fox GM, Candiotti KA: Amisulpride for the rescue treatment of postoperative nausea or vomiting in patients failing prophylaxis: A randomized, placebo-controlled phase iii trial. Anesthesiology 2019; 130: 203-12

35. Ham KR, Boldt DW, McCurdy MT, Busse LW, Favory R, Gong MN, Khanna AK, Chock SN, Zeng F, Chawla LS, Tidmarsh GF, Ostermann M: Sensitivity to angiotensin II dose in patients with vasodilatory shock: a prespecified analysis of the ATHOS-3 trial. Ann Intensive Care 2019; 9: 63

36. Henley MD, Arora H, Farber MA, Caranasos TG, Teeter EG, Kumar PA: Anesthetic considerations for 3-branch endovascular total aortic arch aneurysm repair. J Cardiothorac Vasc Anesth 2019; 33: 1714-21

37. Henley MD, Kumar PA: Tracheal injury prior to sternotomy: A cautionary tale. Semin Cardiothorac Vasc Anesth 2019; 23: 319-23

38. Hernandez AV, Jeon A, Denegri-Galvan J, Ortega-Loayza F, Felix-Moscoso M, Pasupuleti V, Kaw R: Use of adaptive servo ventilation therapy as treatment of sleep-disordered breathing and heart failure: a systematic review and meta-analysis. Sleep Breath 2019

39. Hesler BD, Turan A, Egan CR, Yang D, Mascha EJ, Devine S, Kurz A, Sessler DI, Saager L: Incidence of insufficient intraoperative neuromuscular paralysis. A retrospective registry analysis. J Clin Anesth 2019; 56: 77-84

40. Huppe T, Klasen R, Maurer F, Meiser A, Groesdonk HV, Sessler DI, Fink T, Kreuer S: Volatile organic compounds in patients with acute kidney injury and changes during dialysis. Crit Care Med 2019; 47: 239-46

41. Iida J, Ishii S, Nakajima Y, Sessler DI, Teramae H, Kageyama K, Maeda S, Anada N, Shibasaki M, Sawa T, Nakayama Y: Hyperglycaemia augments lipopolysaccharide-induced reduction in rat and human macrophage phagocytosis via the endoplasmic stress-C/EBP homologous protein pathway. Br J Anaesth 2019; 123: 51-9

OUTCOMES RESEARCH Consortium 13

42. Ilfeld BM, Finneran JJt, Gabriel RA, Said ET, Nguyen PL, Abramson WB, Khatibi B, Sztain JF, Swisher MW, Jaeger P, Covey DC, Meunier MJ, Hentzen ER, Robertson CM: Ultrasound-guided percutaneous peripheral nerve stimulation: neuromodulation of the suprascapular nerve and brachial plexus for postoperative analgesia following ambulatory rotator cuff repair. A proof-of-concept study. Reg Anesth Pain Med 2019

43. Ilfeld BM, Said ET, Finneran JJt, Sztain JF, Abramson WB, Gabriel RA, Khatibi B, Swisher MW, Jaeger P, Covey DC, Robertson CM: Ultrasound-guided percutaneous peripheral nerve stimulation: Neuromodulation of the femoral nerve for postoperative analgesia following ambulatory anterior cruciate ligament reconstruction: A proof of concept study. Neuromodulation 2019; 22: 621-9

44. İnce İ, Ozcimen E, Turan A: Meta-analysis: A review article. JARSS 2019; 27: 1-8

45. Joosten A, Jame V, Alexander B, Chazot T, Liu N, Cannesson M, Rinehart J, Barvais L: Feasibility of fully automated hypnosis, analgesia, and fluid management using 2 independent closed-loop systems during major vascular surgery. Anesth Analg 2019; 128: e88-e92

46. Juhasz M, Molnar L, Fulesdi B, Vegh T, Pall D, Molnar C: Effect of sevoflurane on systemic and cerebral circulation, cerebral autoregulation and CO2 reactivity. BMC Anesthesiol 2019; 19: 109

47. Kabon B, Sessler DI, Kurz A, Crystalloid-Colloid Study Team: Effect of intraoperative goal-directed balanced crystalloid versus colloid administration on major postoperative morbidity: A randomized trial. Anesthesiology 2019; 130: 728-44

48. Karamchandani K, Khanna AK: Caring for critically ill patients with opioid use disorder: Phone a friend? (editorial). J Crit Care 2019; 54: 74-5

49. Kaw R, Nagarajan V, Jaikumar L, Halkar M, Mohananey D, Hernandez AV, Ramakrishna H, Wijeysundera D: Predictive value of stress testing, revised cardiac risk index, and functional status in patients undergoing noncardiac surgery. J Cardiothorac Vasc Anesth 2019; 33: 927-32

50. Keuffel EL, Rizzo J, Stevens M, Gunnarsson C, Maheshwari K: Hospital costs associated with intraoperative hypotension among non-cardiac surgical patients in the US: a simulation model. J Med Econ 2019; 22: 645-51

51. Keuffel EL, Stevens M, Gunnarsson C, Rizzo J, Sessler DI, Maheshwari K: A Monte Carlo simulation estimating US hospital cost reductions associated with hypotension control in septic ICU patients. J Med Econ 2019; 4: 383-9

52. Khanna AK: Surgical special care units: An unmet need or a unique paradox? (editorial). Anesth Analg 2019; 128: 396-8

53. Khanna AK, Hoppe P, Saugel B: Automated continuous noninvasive ward monitoring: future directions and challenges. Crit Care 2019; 23: 194

54. Khanna AK, Maheshwari K, Mao G, Liu L, Perez-Protto SE, Chodavarapu P, Schacham YN, Sessler DI: Association between mean arterial pressure and acute kidney injury and a composite of myocardial injury and mortality in postoperative critically ill patients: A retrospective cohort analysis. Crit Care Med 2019; 47: 910-7

55. Khanna S, Bustamante S: Wellens syndrome. Colombian Journal of Anesthesiology 2019; 47: 178-9

56. Khanna S, Bustamante S: Isolated left ventricular non compaction cardiomyopathy in pregnancy. Colombian Journal of Anesthesiology 2019; 47: 117-9

57. Khanna S, Bustamante S: Ebstein anomaly and left ventricular outflow tract obstruction. Colombian Journal of Anesthesiology 2019; 47: 243-4

58. Khanna S, Sreedharan R, Maheshwari K, Ruetzler K: Giant T-wave Inversions in Apical Hypertrophic Cardiomyopathy. Anesthesiology 2019; 131: 398-9

OUTCOMES RESEARCH Consortium 14

59. Kiss T, Wittenstein J, Becker C, Birr K, Cinnella G, Cohen E, El Tahan MR, Falcao LF, Gregoretti C, Granell M, Hachenberg T, Hollmann MW, Jankovic R, Karzai W, Krassler J, Loop T, Licker MJ, Marczin N, Mills GH, Murrell MT, Neskovic V, Nisnevitch-Savarese Z, Pelosi P, Rossaint R, Schultz MJ, Serpa Neto A, Severgnini P, Szegedi L, Vegh T, Voyagis G, Zhong J, Gama de Abreu M, Senturk M, investigators P, Research Workgroup PVNotESoA: Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial. Trials 2019; 20: 213

60. Klingensmith JD, Haggard AL, Ralston JT, Qiang B, Fedewa RJ, Elsharkawy H, Geoffrey Vince D: Tissue classification in intercostal and paravertebral ultrasound using spectral analysis of radiofrequency backscatter. J Med Imaging 2019; 6: 047001

61. Koch CG, Duncan AI, Figueroa P, Dai L, Sessler DI, Frank SM, Ness PM, Mihaljevic T, Blackstone EH: Real age: Red blood cell aging during storage. Ann Thorac Surg 2019; 107: 973-80

62. Lam SW, Barreto EF, Scott R, Kashani KB, Khanna AK, Bauer SR: Cost-effectiveness of second-line vasopressors for the treatment of septic shock. J Crit Care 2019; 55: 48-55

63. Maheshwari K, Cywinski J, Mathur P, Cummings KC, 3rd, Avitsian R, Crone T, Liska D, Campion FX, Ruetzler K, Kurz A: Identify and monitor clinical variation using machine intelligence: a pilot in colorectal surgery. J Clin Monit Comput 2019; 33: 725-31

64. Maheshwari K, Shimada T, Fang J, Ince I, Mascha EJ, Turan A, Kurz A, Sessler DI: Hypotension Prediction Index software for management of hypotension during moderate- to high-risk noncardiac surgery: protocol for a randomized trial. Trials 2019; 20: 255

65. Mascha EJ, Gan TJ, Vetter TR: Quality improvement interventions associated with improved postoperative nausea and vomiting: Separating the signal from the noise (editorial). Anesth Analg 2019; 128: 847-9

66. Mascha EJ, Sessler DI: Segmented regression and difference-in-difference methods: Assessing the impact of systemic changes in health care. Anesth Analg 2019; 129: 618-33

67. Maurer F, Geiger M, Volk T, Sessler DI, Kreuer S, Huppe T: Stability of propofol (2,6-diisopropylphenol) in thermal desorption tubes during air transport. Int J Anal Chem 2019; 2019: 3987417

68. McCann ME, de Graaff JC, Dorris L, Disma N, Withington D, Bell G, Grobler A, Stargatt R, Hunt RW, Sheppard SJ, Marmor J, Giribaldi G, Bellinger DC, Hartmann PL, Hardy P, Frawley G, Izzo F, von Ungern Sternberg BS, Lynn A, Wilton N, Mueller M, Polaner DM, Absalom AR, Szmuk P, Morton N, Berde C, Soriano S, Davidson AJ, Davidson AJ, Frawley G, Hardy P, Arnup S, Grobler A, Lee K, Hunt RW, Stargatt R, Sheppard SJ, Ormond GD, Hartmann PL, Takagi MJ, Taylor K, Malarbi S, Doyle M, Ragg P, Costi D, von Ungern-Sternberg B, Wilton NC, Knottenbelt G, Withington D, Furue K, Gagnon H, Disma N, Mameli L, Giribaldi G, Pini Prato A, Mattioli G, Wolfler A, Izzo F, Bova SM, Krachmalnicoff A, Guuva C, de Graaff JC, van der Werff DBM, van Gool JTDG, van Loon K, Kalkman CJ, van Baar AL, Absalom AR, Hoekstra FM, Volkers M, Oostra M, Bell G, Dorris L, Morton NS, Pownall J, Waldman J, Hind R, Symonds JD, Bagshaw O, McCann ME, Berde C, Soriano S, Sethna N, Kovatsis P, Cravero J, Bellinger D, Marmor J, Lynn A, Ivanova I, Hunyady A, Verma S, Polaner D, Thomas J, Mueller M, Haret D, Szmuk P, Steiner J, Kravitz B, Farrow-Gillespie A, Suresh S, et al.: Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial. Lancet 2019; 393: 664-77

OUTCOMES RESEARCH Consortium 15

69. McEvoy MD, Gupta R, Koepke EJ, Feldheiser A, Michard F, Levett D, Thacker JKM, Hamilton M, Grocott MPW, Mythen MG, Miller TE, Edwards MR, workgroup P-, chairs P, Miller TE, Mythen MG, Grocott MP, Edwards MR, Physiology g, Preoperative blood pressure g, Intraoperative blood pressure g, Postoperative blood pressure g: Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122: 575-86

70. Mehta S, Cro SC, Coomber B, Rolph R, Cornelius V, Farhadi J: A randomised controlled feasibility trial to evaluate local heat preconditioning on wound healing after reconstructive breast surgery: the preHEAT trial. Pilot Feasibility Stud 2019; 5: 5

71. Missair A, Cata JP, Votta-Velis G, Johnson M, Borgeat A, Tiouririne M, Gottumukkala V, Buggy D, Vallejo R, de Marrero EB, Sessler D, Huntoon MA, DeAndres J, Casasola OD: Impact of perioperative pain management on cancer recurrence: an ASRA/ESRA special article. RAPM 2019; 44: 13-28

72. Mrkobrada M, Chan MTV, Cowan D, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Sharma M, Brown C, Sigamani A, Szczeklik W, Sharma M, Guyatt G, Smith EE, Agid R, Dmytriw AA, Spence J, Adunuri NR, Borges FK, Short TG, Hill MD, Saad F, Copland I, Pettit S, Ibrahim Q, Bangdiwala SI, Yusuf S, Tsai S, Sahlas DJ, Mensinkai A, Sposato LA, Hussain S, Yang S, Siegal D, Khaw A, Mandzia J, Simpson S, Raval M, Karimuddin A, Phang PT, Mok VCT, Wu WKK, Yu SCH, Gin T, Loh PS, Liew MT, Ramli N, Siow YL, Fuentes M, Ortiz-Soriano V, Waymouth E, Kumar J, Sadana D, Thomas L, Kaczmarek B, Lindroth H, Sessler D, Apolcer S, Trombetta A, Handsor S, Dasgupta M, Murkin JM, Lee SF, Devereaux PJ: Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study. Lancet 2019; 394: 1022-9

73. Mukai N, Nakayama Y, Ishi S, Murakami T, Ogawa S, Kageyama K, Murakami S, Sasada Y, Yoshioka J, Nakajima Y: Cold storage conditions modify microRNA expressions for platelet transfusion. PLoS One 2019; 14: e0218797

74. Murphy GS, Wu CL, Mascha EJ: Methadone: New indications for an old drug? (editorial). Anesth Analg 2019; 129: 1456-8

75. Pappas MA, Sessler DI, Rothberg MB: Anticipated rates and costs of guideline-concordant preoperative stress testing. Anesth Analg 2019; 128: 241-6

76. Perez-Protto SE, Rowbottom JR, Taylor MA: "Wishes unknown: " A case report. A A Pract 2019; 13: 188-9

77. Perkins ZB, Captur G, Bird R, Gleeson L, Singer B, O'Brien B: Trauma induced acute kidney injury. PLoS One 2019; 14: e0211001

78. Poidinger B, Kotzinger O, Rutzler K, Kleinsasser A, Zierer A, Knotzer H: Intravenous levosimendan and vasopressin in new-onset acute pulmonary hypertension after weaning from cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2019; 33: 328-33

79. Riveros Perez E, Jimenez E, Albo C, Sanghvi Y, Yang N, Rocuts A: Are anesthesiology providers good guessers? Heart rate and oxygen saturation estimation in a simulation setting. Anesthesiol Res Pract 2019: 5914305

80. Riveros-Perez E, Davoud S, Sanchez MG, Montesinos H, Rocuts A: Ultrasound your NPO: Effect of body mass index on gastric volume in term pregnant women – retrospective case series. Annals of Medicine and Surgery 2019; 48: 95-8

81. Ruetzler K, Leung S, Chmiela M, Rivas E, Szarpak L, Khanna S, Mao G, Drake RL, Sessler DI, Turan A: Regurgitation and pulmonary aspiration during cardio-pulmonary resuscitation (CPR) with a laryngeal tube: A pilot crossover human cadaver study. PLoS One 2019; 14: e0212704

OUTCOMES RESEARCH Consortium 16

82. Ruetzler K, Yilmaz HO, Turan A, Zimmerman NM, Mao G, Hung MH, Kurz A, Sessler DI: Intra-operative tachycardia is not associated with a composite of myocardial injury and mortality after noncardiac surgery: A retrospective cohort analysis. Eur J Anaesthesiol 2019; 36: 105-13

83. Sanders RD, Hughes F, Shaw A, Thompson A, Bader A, Hoeft A, Williams DA, Grocott MPW, Mythen MG, Miller TE, Edwards MR, Physiology g, Preoperative blood pressure g, Intraoperative blood pressure g, Postoperative blood pressure g: Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122: 552-62

84. Sanford EL, Sanford NN, Alder A, Szmuk P: Trends in surgery for children younger than 3 years from 1998 to 2017 (research letter). JAMA 2019; 173: 1199-201

85. Saugel B, Khanna AK: Managing hemodynamic instability - If you want to know cardiac output, you need to measure it! (editorial). J Crit Care 2019; 49: 185-6

86. Saugel B, Kouz K, Hoppe P, Maheshwari K, Scheeren TWL: Predicting hypotension in perioperative and intensive care medicine. Best Pract Res Clin Anaesthesiol 2019; 33: 189-97

87. Saugel B, Kouz K, Scheeren TWL: The '5 Ts' of perioperative goal-directed haemodynamic therapy (editorial). Br J Anaesth 2019; 123: 103-7

88. Saugel B, Reese PC, Sessler DI, Burfeindt C, Nicklas JY, Pinnschmidt HO, Reuter DA, Sudfeld S: Automated ambulatory blood pressure measurements and intraoperative hypotension in patients having noncardiac surgery with general anesthesia: A prospective observational study. Anesthesiology 2019; 131: 74-83

89. Sessler DI, Bloomstone JA, Aronson S, Berry C, Gan TJ, Kellum JA, Plumb J, Mythen MG, Grocott MPW, Edwards MR, Miller TE, Perioperative Quality Initiative w, chairs P, Miller TE, Mythen MG, Grocott MP, Edwards MR, Physiology g, Preoperative blood pressure g, Intraoperative blood pressure g, Postoperative blood pressure g: Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery. Br J Anaesth 2019; 122: 563-74

90. Sessler DI, Pei L, Huang Y, Fleischmann E, Marhofer P, Kurz A, Mayers DB, Meyer-Treschan TA, Grady M, Tan EY, Ayad S, Mascha EJ, Buggy DJ, Tan G, Zhang Z, Keane H, Stokes M, Zotti O, Gnant M, Perez-Protto S, Wu J, Parra-Sanchez I, Yang D, Hassan M, Tey JBL: Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet 2019; 394: 1807-15

91. Sessler DI, Riedel B: Anesthesia and cancer recurrence: Context for divergent study outcomes (editorial). Anesthesiology 2019; 130: 3-5

92. Sessler DI, Saugel B: Beyond 'failure to rescue': the time has come for continuous ward monitoring. Br J Anaesth 2019; 122: 304-6

93. Sessler DI, Turan A, Stapelfeldt WH, Mascha EJ, Yang D, Farag E, Cywinski J, Vlah C, Kopyeva T, Keebler AL, Perilla M, Ramachandran M, Drahuschak S, Kaple K, Kurz A: Triple-low alerts do not reduce mortality: A real-time randomized trial. Anesthesiology 2019; 130: 72-82

94. Shopova T, Kiefer D, Wolf B, Maurer F, Sessler DI, Volk T, Fink T, Kreuer S: Simultaneous quantification of propofol, ketamine and rocuronium in just 10 muL plasma using liquid chromatography coupled with quadrupole mass spectrometry and its pilot application to a pharmacokinetic study in rats. Biomed Chromatogr 2019; 33: e4540

OUTCOMES RESEARCH Consortium 17

95. Short TG, Campbell D, Frampton C, Chan MTV, Myles PS, Corcoran TB, Sessler DI, Mills GH, Cata JP, Painter T, Byrne K, Han R, Chu MHM, McAllister DJ, Leslie K, Shulman M, Wallace S, Farrington C, Gallagher W, Ditoro A, Peyton P, Baulch S, Dalyell A, Sidiropoulos S, Reynolds J, Rowley J, Tan N, McCallum D, O'Loughlin E, Wong S, Owen K, Sim IK, Glazov L, Coutts P, Pushpanathan M, Findlay V, Paech M, Cavill D, Chuan A, Pope L, Lucas J, Robinson B, Millard A, Allen S, Allen M, McKeown S, Sivalingam P, Wilkes T, Jowett C, Kearney A, Bennett M, Favero JP, Sawhney S, Drummond K, Osborn S, Wing A, Taylor J, Edwards M, Reynolds H, Town C, Terblanche N, Challis M, Seale R, Button K, Cotter R, Stewart M, Zingerle N, Hannon S, Middleton D, Edgley C, March S, McCulloch T, Wong G, Jeong S, Connell K, Kramer K, Henderson G, Ward V, Buller Y, Hird N, Scott D, Evered L, Snyder G, Silbert B, Corcoran P, Fitzgerald E, Said S, Watson A, Baby D, Bolsin S, Marriott A, Ives K, Wakefeld BJ, Jeffreys A, Bates S, Halliwell R, Elliott D, Cope L, Paranthoiene R, Peng P, et al.: Anaesthetic depth and complications after major surgery: an international, randomised controlled trial. Lancet 2019; 394: 1907-14

96. Smereka J, Szarpak L, Czekajlo M, Abelson A, Zwolinski P, Plusa T, Dunder D, Dabrowski M, Wiesniewska Z, Robak O, Frass M, Sivrikaya GU, Ruetzler K: The TrueCPR device in the process of teaching cardiopulmonary resuscitation: A randomized simulation trial. Medicine (Baltimore) 2019; 98: e15995

97. Sowizdraniuk J, Smereka J, Ladny JR, Kaserer A, Palimonka K, Ruetzler K, Skierczynska A, Szarpak L: ECG pre-hospital teletransmission by emergency teams staffed with an emergency physician and paramedics and its impact on transportation and hospital admission. Medicine (Baltimore) 2019; 98: e16636

98. Stankowski T, Aboul-Hassan SS, Seifi-Zinab F, Fritzsche D, Misterski M, Sazdovski I, Marczak J, Szymanska A, Szarpak L, Ruetzler K, Ahuja S, Perek B: Descriptive review of patent ductus arteriosus ligation by video-assisted thoracoscopy in pediatric population: 7-year experience. J Thorac Dis 2019; 11: 2555-63

99. Suhre WM, Lang JD, Jr., Madtes DK, Abdelmalak BB: Partnership with interventional pulmonologist: An anesthesiologist's perspective. Otolaryngol Clin North Am 2019; 52: 1049-63

100. Szmuk P, Andropoulos D, McGowan F, Brambrink A, Lee C, Lee KJ, McCann ME, Liu Y, Saynhalath R, Bong CL, Anderson BJ, Berde C, de Graaff JC, Disma N, Kurth D, Loepke A, Orser B, Sessler DI, Skowno JJ, von Ungern-Sternberg BS, Vutskits L, Davidson A: An open label pilot study of a dexmedetomidine-remifentanil-caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study. Paediatr Anaesth 2019; 29: 59-67

101. Sztain JF, Finneran JJt, Monahan AM, Khatibi B, Nguyen PL, Madison SJ, Bellars RH, Gabriel RA, Ahmed SS, Schwartz AK, Kent WT, Donohue MC, Padwal JA, Ilfeld BM: Continuous popliteal-sciatic blocks for postoperative analgesia: Traditional proximal catheter insertion superficial to the paraneural sheath versus a new distal insertion site deep to the paraneural sheath. Anesth Analg 2019; 128: e104-e8

102. Tat RM, Golea A, Rahaian R, Vesa SC, Ionescu D: Resistin and cardiac arrest-a prospective study. J Clin Med 2019; 9

103. Tat RM, Golea A, Vesa SC, Ionescu D: Resistin-Can it be a new early marker for prognosis in patients who survive after a cardiac arrest? A pilot study. PLoS One 2019; 14: e0210666

104. Tat RM, Golea A, Vesa SC, Ionescu D: Determination of cut-off serum values for resistin and s100b protein in patients who survived a cardiac arrest. J Crit Care Med (Targu Mures) 2019; 5: 97-102

105. Tat T, Jurj A, C S, Pasca S, Ionescu D: Antiproliferative effects of propofol and lidocaine on the colon adenocarcinoma microenvironment. JBUON 2019; 24: 106-15

OUTCOMES RESEARCH Consortium 18

106. The Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators: Association between complications and death within 30 days after noncardiac surgery. Can Med Assoc J 2019; 191: E830-E7

107. Trostchansky I, Nimrod A, Tiberiu E, Vigorita V, Valinas R, Karp G: Is Norton Score a useful tool for identifying high-risk patients prior to emergency surgery? ANZ J Surg 2019; 89: 362-6

108. Turan A, Bajracharya GR, Leung S, Yazici Kara M, Mao G, Botsford T, Ruetzler K, Maheshwari K, Ali Sakr Esa W, Elsharkawy H, Sessler DI: Association of neuraxial anesthesia with postoperative venous thromboembolism after noncardiac surgery: A propensity-matched analysis of acs-NSQIP database. Anesth Analg 2019; 128: 494-501

109. Turan A, Chang C, Cohen B, Saasouh W, Essber H, Yang D, Ma C, Hovsepyan K, Khanna AK, Vitale J, Shah A, Ruetzler K, Maheshwari K, Sessler DI: Incidence, severity, and detection of blood pressure perturbations after abdominal surgery: A prospective blinded observational study. Anesthesiology 2019; 130: 550-9

110. Turan A, Cohen B, Whitlock RP, Essber H, Niazi A, Makarova N, Saasouh W, Alfirevic A, Marciniak D, Sessler DI: Methylprednisolone does not reduce acute postoperative pain after cardiac surgery: Subanalysis of a randomized clinical trial. Anesth Analg 2019; 129: 1468-73

111. Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study Investigators: Association between complications and death within 30 days after noncardiac surgery. CMAJ 2019; 191: E830-E7

112. Wada K, Masamune T, Ino H, Ueda K, Ishiyama T, Sessler DI, Matsukawa T: Severe hypoglycemia reduces the shivering threshold in rabbits. BMC Anesthesiology 2019; 19: 126

113. Wakefield BJ, Busse LW, Khanna AK: Angiotensin II in vasodilatory shock. Critical Care Clinics 2019; 35: 229-45

114. Wall T, Sherwin A, Ma D, Buggy DJ: Influence of perioperative anaesthetic and analgesic interventions on oncological outcomes: a narrative review. Br J Anaesth 2019; 123: 135-50

Book Chapters 1. Reem Almuqati, Sandeep Khanna, Roshni Sreedharan. Transplantation. Critical Care Medicine

and Review: 1000 Questions and Answers. Editors: Abraham Sonny, Edward A Bittner, Ryan J Horvath, Sheri M Berg. ISBN-13: 978-1975102906

2. Végh, T.: Anesthesia for esophageal surgery. In Anesthesia in Thoracic Surgery: Changes of Paradigms. Ed.: Granell Gil, Manuel, Sentürk, Mert, Springer International Publishing, 2019. ISBN: 9783030285272