An American HeartAssociation/American Stroke Association Journal

April 2017Volume 48Number 4

Stroke : Highlights of Selected Articles 827

ORIGINAL CONTRIBUTIONSClinical SciencesStroke and Circulating Extracellular RNAs 828Eric Mick, ScD; Ravi Shah, MD; Kahraman Tanriverdi, PhD; Venkatesh Murthy, MD, PhD; Mark Gerstein, PhD; Joel Rozowsky, PhD; Robert Kitchen, PhD; Martin G. Larson, SD; Daniel Levy, MD; Jane E. Freedman, MD

Association Between Acute Kidney Disease and Intravenous Dye Administration in Patients With Acute Stroke: A Population-Based Study

835

Stacie L. Demel, DO, PhD; Aaron W. Grossman, MD, PhD; Jane C. Khoury, PhD; Charles J. Moomaw, PhD; Kathleen Alwell, RN, BSN; Brett M. Kissela, MD, MS; Daniel Woo, MD, MS; Matthew L. Flaherty, MD; Simona Ferioli, MD; Jason Mackey, MD, MS; Felipe De Los Rios la Rosa, MD; Sharyl Martini, MD, PhD; Opeolu Adeoye, MD; Dawn O. Kleindorfer, MD

Increased Vascular Disease Mortality Risk in Prediabetic Korean Adults Is Mainly Attributable to Ischemic Stroke

840

Nam Hoon Kim, MD, PhD; Tae Yeon Kwon, PhD; Sungwook Yu, MD, PhD; Nan Hee Kim, MD, PhD; Kyung Mook Choi, MD, PhD; Sei Hyun Baik, MD, PhD; Yousung Park, PhD; Sin Gon Kim, MD, PhD

Temporal Trends in Sex Differences With Regard to Stroke Incidence: The Dijon Stroke Registry (1987–2012)

846

Marie Giroud, MD; Benoit Delpont, MD; Benoit Daubail, MD; Christelle Blanc, MD; Jérôme Durier, MSc; Maurice Giroud, MD; Yannick Béjot, MD, PhD

Distributions of Subclinical Cardiovascular Disease in a Socioeconomically and Racially Diverse Sample

850

Carrington R. Wendell, PhD; Shari R. Waldstein, PhD; Michele K. Evans, MD; Alan B. Zonderman, PhD

Is There an Obesity Paradox for Outcomes in Atrial Fibrillation?: A Systematic Review and Meta-Analysis of Non–Vitamin K Antagonist Oral Anticoagulant Trials

857

Marco Proietti, MD; Elisa Guiducci, MD; Paola Cheli, MD; Gregory Y.H. Lip, MD

Embolic Stroke of Undetermined Source: A Systematic Review and Clinical Update 867Robert G. Hart, MD; Luciana Catanese, MD; Kanjana S. Perera, MBBS; George Ntaios, MD, PhD; Stuart J. Connolly, MD

Natural History of Perihematomal Edema and Impact on Outcome After Intracerebral Hemorrhage

873

Teddy Y. Wu, FRACP; Gagan Sharma, MCA; Daniel Strbian, MD, PhD; Jukka Putaala, MD, PhD; Patricia M. Desmond, MD, FRANZCR; Turgut Tatlisumak, MD, PhD; Stephen M. Davis, MD, FRACP; Atte Meretoja, MD, PhD, FRACP

Cerebral Aneurysm Morphology Before and After Rupture: Nationwide Case Series of 29 Aneurysms

880

Torbjørn Øygard Skodvin, medical student; Liv-Hege Johnsen, MD; Øivind Gjertsen, MD; Jørgen Gjernes Isaksen, MD, PhD; Angelika Sorteberg, MD, PhD

Stroke

On the Cover: The image is taken from an article in this issue, “Cerebral Aneurysm Morphology Before and After Rupture: Nationwide Case Series of 29 Aneurysms” by Skodvin et al (Stroke. 2017;48:880–886. doi: 10.1161/STROKEAHA.116.015288). The image is Figure 2.

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Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke: The ACROSS-China Study (Abnormal Glucose Regulation in Patients With Acute Stroke Across China)

887

Jing Jing, MD, PhD; Yuesong Pan, MD; Xingquan Zhao, MD, PhD; Huaguang Zheng, MD, PhD; Qian Jia, MD, PhD; Donghua Mi, MD, PhD; Weiqi Chen, MD; Hao Li, PhD; Liping Liu, MD, PhD; Chunxue Wang, MD, PhD; Yan He, PhD; David Wang, DO; Yilong Wang, MD, PhD; Yongjun Wang, MD; on behalf of the investigators for ACROSS-China

Baseline Hemodynamic Impairment and Future Stroke Risk in Adult Idiopathic Moyamoya Phenomenon: Results of a Prospective Natural History Study

894

Colin P. Derdeyn, MD; Gregory J. Zipfel, MD; Allyson R. Zazulia, MD; Patricia H. Davis, MD; Shyam Prabhakaran, MD; Cristina S. Ivan, MD; Venkatesh Aiyagari, MBBS, DM; James R. Sagar, MD; Nancy Hantler, CCRC; Lina Shinawi, BA; John J. Lee, MD, PhD; Hussain Jafri, BA; Robert L. Grubb, Jr, MD; J. Philip Miller, BA; Ralph G. Dacey, Jr, MD

Predictors and Outcomes of Dysphagia Screening After Acute Ischemic Stroke 900Raed A. Joundi, MD, DPhil; Rosemary Martino, PhD; Gustavo Saposnik, MD, MSc; Vasily Giannakeas, MPH; Jiming Fang, PhD; Moira K. Kapral, MD, MSc

Absent Filling of Ipsilateral Superficial Middle Cerebral Vein Is Associated With Poor Outcome After Reperfusion Therapy

907

Sheng Zhang, PhD; Yangxiao Lai, MM; Xinfa Ding, BA; Mark Parsons, MD, PhD; John H. Zhang, MD, PhD; Min Lou, MD, PhD

Decreased Adiponectin-Mediated Signaling Through the AdipoR2 Pathway Is Associated With Carotid Plaque Instability

915

Karina Gasbarrino, BSc; Huaien Zheng, MD, PhD; Anouar Hafiane, MSc; John P. Veinot, MD; Chi Lai, MD; Stella S. Daskalopoulou, MD, MSc, PhD

Relationship Between Changes in the Temporal Dynamics of the Blood-Oxygen-Level-Dependent Signal and Hypoperfusion in Acute Ischemic Stroke

925

Ahmed A. Khalil, MBBS, PGDip, MSc; Ann-Christin Ostwaldt, PhD; Till Nierhaus, Dr.rer.medic, Dipl.-Ing.(FH); Ramanan Ganeshan, MD; Heinrich J. Audebert, MD; Kersten Villringer, MD; Arno Villringer, MD; Jochen B. Fiebach, MD

Predictive Value of RAPID Assessed Perfusion Thresholds on Final Infarct Volume in SWIFT PRIME (Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment)

932

Maxim Mokin, MD, PhD; Elad I. Levy, MD, MBA; Jeffrey L. Saver, MD; Adnan H. Siddiqui, MD, PhD; Mayank Goyal, MD; Alain Bonafé, MD; Christophe Cognard, MD; Reza Jahan, MD; Gregory W. Albers, MD; for the SWIFT PRIME Investigators

Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke

939

Christopher D. d’Esterre, PhD;  Anurag Trivedi, MD;  Pooneh Pordeli, PhD; Mari Boesen, BSc; Shivanand Patil, MD; Seong Hwan Ahn, MD; Mohamed Najm, BSc; Enrico Fainardi, MD; Jai Jai Shiva Shankar, MD; Marta Rubiera, MD; Mohammed A. Almekhlafi, MD, MSc; Jennifer Mandzia, MD; Alexander V. Khaw, MD; Philip Barber, MD; Shelagh Coutts, MD; Michael D. Hill, MD; Andrew M. Demchuk, MD; Tolulope Sajobi, PhD; Nils D. Forkert, PhD; Mayank Goyal, MD;  Ting-Yim Lee, PhD; Bijoy K. Menon, MD, MSc

Delays in Door-to-Needle Times and Their Impact on Treatment Time and Outcomes in Get With The Guidelines-Stroke

946

Noreen Kamal, PhD; Shubin Sheng, PhD; Ying Xian, MD, PhD; Roland Matsouaka, PhD; Michael D. Hill, MD, MSc; Deepak L. Bhatt, MD, MPH; Jeffrey L. Saver, MD; Mathew J. Reeves, PhD; Gregg C. Fonarow, MD; Lee H. Schwamm, MD; Eric E. Smith, MD, MPH

Intraoperative Completion Studies, Local Anesthesia, and Antiplatelet Medication Are Associated With Lower Risk in Carotid Endarterectomy

955

Christoph Knappich, MD; Andreas Kuehnl, MD, MPH; Pavlos Tsantilas, MD; Sofie Schmid, MD; Thorben Breitkreuz; Michael Kallmayer, MD; Alexander Zimmermann, MD, MHBA; Hans-Henning Eckstein, MD, PhD

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Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Score ≤6

963

Jean-Philippe Desilles, MD; Arturo Consoli, MD; Hocine Redjem, MD; Oguzhan Coskun, MD; Gabriele Ciccio, MD; Stanislas Smajda, MD; Julien Labreuche, MST; Cristian Preda, PhD; Clara Ruiz Guerrero, MD; Jean-Pierre Decroix, MD; Georges Rodesch, MD, PhD; Mikael Mazighi, MD, PhD; Raphaël Blanc, MD; Michel Piotin, MD, PhD; Bertrand Lapergue, MD, PhD; on behalf of the ETIS (Endovascular Treatment in Ischemic Stroke) Research Investigators

Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation: Systematic Review and Meta-Analysis

970

Ying Bai, PhD; Hai Deng, PhD; Alena Shantsila, PhD; Gregory Y.H. Lip, MD

PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): Results of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

977

Inger R. de Ridder, MD; Heleen M. den Hertog, MD, PhD; H. Maarten A. van Gemert, MD, PhD; A.H.C.M.L. (Tobien) Schreuder, MD; Annemieke Ruitenberg, MD, PhD; E. (Lisette) Maasland, MD, PhD; Ritu Saxena, MD, PhD; Jordie H. van Tuijl, MD; Ben P.W. Jansen, MD; Renske M. Van den Berg-Vos, MD, PhD; Frederique Vermeij, MD; Peter J. Koudstaal, MD, PhD; L. Jaap Kappelle, MD, PhD; Ale Algra, MD, PhD; H. Bart van der Worp, MD, PhD; Diederik W.J. Dippel, MD, PhD

Vessel Patency at 24 Hours and Its Relationship With Clinical Outcomes and Infarct Volume in REVASCAT Trial (Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset)

983

Mònica Millán, MD, PhD; Sebastià Remollo, MD; Helena Quesada, MD; Arturo Renú, MD; Alejandro Tomasello, MD; Priyanka Minhas, MD; Natalia Pérez de la Ossa, MD, PhD; Marta Rubiera, MD, PhD; Laura Llull, MD, PhD; Pedro Cardona, MD; Fahad Al-Ajlan, MD; María Hernández, MD; Zarina Assis, MD; Andrew M. Demchuk, MD; Tudor Jovin, MD; Antoni Dávalos, MD, PhD; on behalf of the REVASCAT Trial Investigators

Individual and System Contributions to Race and Sex Disparities in Thrombolysis Use for Stroke Patients in the United States

990

Roland Faigle, MD, PhD; Victor C. Urrutia, MD; Lisa A. Cooper, MD, MPH; Rebecca F. Gottesman, MD, PhD

Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With CYP2C19 Genetic Variants

998

Yi Lin, MD, PhD; Anxin Wang, PhD; Jiejie Li, MD, PhD; Jinxi Lin, MD, PhD; David Wang, DO; Xia Meng, MD, PhD; Lixian Ou, MD; Weiqi Chen, MD; Xingquan Zhao, MD, PhD; Liping Liu, MD, PhD; Yilong Wang, MD, PhD; Yongjun Wang, MD; on behalf of the CHANCE Investigators

Symptomatic Patients Remain at Substantial Risk of Arterial Disease Complications Before and After Endarterectomy or Stenting

1005

Cristina Hobeanu, MD; Philippa C. Lavallée, MD; Peter M. Rothwell, MD; Leila Sissani, BST; Gregory W. Albers, MD; Natan M. Bornstein, MD; Louis R. Caplan, MD; Geoffrey A. Donnan, MD; José M. Ferro, MD; Michael G. Hennerici, MD; Julien Labreuche, BST; Carlos Molina, MD; Philippe Gabriel Steg, MD; Pierre-Jean Touboul, MD; Shinichiro Uchiyama, MD; Éric Vicaut, MD, PhD; Lawrence K.S. Wong, MD; Pierre Amarenco, MD; on behalf of the TIAregistry.org Investigators

Predicting Recovery Potential for Individual Stroke Patients Increases Rehabilitation Efficiency

1011

Cathy M. Stinear, PhD; Winston D. Byblow, PhD; Suzanne J. Ackerley, PhD; P. Alan Barber, PhD; Marie-Claire Smith, BHSc

Development and Validation of a Bilingual Stroke Preparedness Assessment Instrument 1020Lesli E. Skolarus, MD, MS; Kathleen M. Mazor, EdD; Brisa N. Sánchez, PhD; Mackenzie Dome, MA; José Biller, MD; Lewis B. Morgenstern, MD

Quality of Acute Care and Long-Term Quality of Life and Survival: The Australian Stroke Clinical Registry

1026

Dominique A. Cadilhac, PhD; Nadine E. Andrew, PhD; Natasha A. Lannin, PhD; Sandy Middleton, PhD; Christopher R. Levi, MBBS; Helen M. Dewey, PhD; Brenda Grabsch, BSW; Steve Faux, MBBS; Kelvin Hill, BAppSci; Rohan Grimley, MBBS; Andrew Wong, PhD; Arman Sabet, MD; Ernest Butler, PhD; Christopher F. Bladin, MD; Timothy R. Bates, MBBS (hons); Patrick Groot, MHSc; Helen Castley, MBBS; Geoffrey A. Donnan, MD; Craig S. Anderson, PhD; on behalf of the Australian Stroke Clinical Registry Consortium

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Basic SciencesNeuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

1033

Marietta Zille, PhD; Saravanan S. Karuppagounder, PhD; Yingxin Chen, MD; Peter J. Gough, DPhil; John Bertin, PhD; Joshua Finger, MS; Teresa A. Milner, PhD; Elizabeth A. Jonas, MD; Rajiv R. Ratan, MD, PhD

Acupuncture Attenuated Vascular Dementia–Induced Hippocampal Long-Term Potentiation Impairments via Activation of D1/D5 Receptors

1044

Yang Ye, PhD; Hui Li, MB; Jing-Wen Yang, PhD; Xue-Rui Wang, MB; Guang-Xia Shi, PhD; Chao-Qun Yan, PhD; Si-Ming Ma, MB; Wen Zhu, MB; Qian-Qian Li, MB; Tian-Ran Li, MB; Ling-Yong Xiao, PhD; Cun-Zhi Liu, MD, PhD

Monocyte Chemotactic Protein-1–Interleukin-6–Osteopontin Pathway of Intra-Aneurysmal Tissue Healing

1052

Koji Hosaka, PhD; Kelley Rojas, BS; Hanain Z. Fazal, BS; Matheus B. Schneider, BS; Jorma Shores, BS; Vincent Federico, BS; Matthew McCord, BS; Li Lin, BS; Brian Hoh, MD

Targeting Different Monocyte/Macrophage Subsets Has No Impact on Outcome in Experimental Stroke

1061

Antje Schmidt, MD; Jan-Kolja Strecker, PhD; Stephanie Hucke, PhD; Nils-Martin Bruckmann; Martin Herold, PhD; Matthias Mack, MD; Kai Diederich, PhD; Wolf-Rüdiger Schäbitz, MD; Heinz Wiendl, MD; Luisa Klotz, MD; Jens Minnerup, MD

BRIEF REPORTSDynamic Arterial Compression in Pediatric Vertebral Arterial Dissection 1070Nancy Rollins, MD; Bruno Braga, MD; Amy Hogge, MD; Stefanie Beavers, MSN, RN; Michael Dowling, MD, PhD

Association Between Absolute Eosinophil Count and Complex Aortic Arch Plaque in Patients With Acute Ischemic Stroke

1074

Takaya Kitano, MD; Tomohisa Nezu, MD, PhD; Takashi Shiromoto, MD; Satoshi Kubo, MD; Jyunichi Uemura, MD, PhD; Yuko Wada, MD, PhD; Yoshiki Yagita, MD, PhD

Clinical Significance of Wall Changes After Recanalization Therapy in Acute Stroke: High-Resolution Vessel Wall Imaging

1077

Woo-Keun Seo, MD, PhD; Kyungmi Oh, MD, PhD; Sang-il Suh, MD, PhD; Hae Young Seol, MD, PhD

Natural History of Ruptured but Untreated Intracranial Aneurysms 1081Miikka Korja, MD, PhD; Riku Kivisaari, MD, PhD; Behnam Rezai Jahromi, BM; Hanna Lehto, MD, PhD

Critical Illness–Associated Cerebral Microbleeds 1085Evgenia M. Fanou, MD; Jonathan M. Coutinho, MD, PhD; Patrick Shannon, MD; Tim-Rasmus Kiehl, MD; Marcel M. Levi, MD, PhD; M. Elizabeth Wilcox, MD, MPH; Richard I. Aviv, MD; Daniel M. Mandell, MD, PhD

Cerebral Arteriovenous Malformation Flow Is Associated With Venous Intimal Hyperplasia 1088Sophia F. Shakur, MD; Ahmed E. Hussein, MD; Sepideh Amin-Hanjani, MD; Tibor Valyi-Nagy, MD; Fady T. Charbel, MD; Ali Alaraj, MD

Shifting Perceptions of Risk and Reward: Use of Anticoagulation in Patients With Acute Brain Ischemia and Atrial Fibrillation: Nine-Year Data From a National Acute Stroke Registry (National Acute Stroke Israeli Survey [NASIS])

1092

Yvonne Schwammenthal, MD; Rakefet Tsabari, MD; David Orion, MD; Oleg Merzlyak, MD; Salo Haratz, MD, PhD; Shlomi Peretz, MD; Natan M. Bornstein, MD; Gal Ifergane, MD; Michal Einhorn, BSc; Ehud Schwammenthal, MD, PhD; Diklah Geva, PhD; David Tanne, MD; on behalf of the NASIS Investigators

Prehospital Emergency Care in Childhood Arterial Ischemic Stroke 1095Belinda Stojanovski, BSN; Paul T. Monagle, MD; Ian Mosley, PhD; Leonid Churilov, PhD; Fiona Newall, PhD; Grant Hocking, GradDipEd; Mark T. Mackay, PhD

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Ischemic Stroke After Treatment of Intraprocedural Thrombosis During Stent-Assisted Coiling and Flow Diversion

1098

Nimer Adeeb, MD; Christoph J. Griessenauer, MD; Justin M. Moore, MD, PhD; Paul M. Foreman, MD; Hussain Shallwani, MD; Rouzbeh Motiei-Langroudi, MD; Raghav Gupta, BS; Carlos E. Baccin, MD, PhD; Abdulrahman Alturki, MBBS; Mark R. Harrigan, MD; Adnan H. Siddiqui, MD, PhD; Elad I. Levy, MD, MBA; Christopher S. Ogilvy, MD; Ajith J. Thomas, MD

Effectiveness of an Intervention to Improve Risk Factor Knowledge in Patients With Stroke: A Randomized Controlled Trial

1101

Muideen T. Olaiya, MSc; Dominique A. Cadilhac, PhD; Joosup Kim, PhD; David Ung, BMedSc; Mark R. Nelson, PhD; Velandai K. Srikanth, PhD; Christopher F. Bladin, PhD; Richard P. Gerraty, PhD; Sharyn M. Fitzgerald, PhD; Thanh Phan, PhD; Judith Frayne, MBBS; Amanda G. Thrift, PhD

Renal Denervation in the Acute Phase of Ischemic Stroke Provides Brain Protection in Hypertensive Rats

1104

Yu Hasegawa, MD, PhD; Takashi Nakagawa, MD, PhD; Kunihiko Matsui, MD, PhD; Shokei Kim-Mitsuyama, MD, PhD

Role of Periostin in Early Brain Injury After Subarachnoid Hemorrhage in Mice 1108Lei Liu, MD; Fumihiro Kawakita, MD; Masashi Fujimoto, MD, PhD; Fumi Nakano, MD; Kyoko Imanaka-Yoshida, MD, PhD; Toshimichi Yoshida, MD, PhD; Hidenori Suzuki, MD, PhD

TOPICAL REVIEWSFostering Poststroke Recovery: Towards Combination Treatments 1112Clemens J. Sommer, MD; Wolf-Rüdiger Schäbitz, MD

Noncontrast Computed Tomography Markers of Intracerebral Hemorrhage Expansion 1120Gregoire Boulouis, MD, MSc; Andrea Morotti, MD; Andreas Charidimou, MD, PhD; Dar Dowlatshahi, MD, PhD; Joshua N. Goldstein, MD, PhD

CONTROVERSIES IN STROKEEmergent Carotid Stenting After Thrombectomy in Patients With Tandem Lesions 1126Daniel Behme, MD; Carlos A. Molina, MD; Magdy H. Selim, MD; Marc Ribo, MD

STATE-OF-THE-SCIENCE NURSING REVIEWReview of Evidenced-Based Nursing Protocols for Dysphagia Assessment e99Wende N. Fedder, DNP, RN, MBA

COCHRANE CORNERRepetitive Task Training for Improving Functional Ability After Stroke: A Major Update of a Cochrane Review

e102

Lois H. Thomas, PhD; Beverley French, PhD; Jacqueline Coupe, MPH; Naoimh McMahon, MA; Louise Connell, PhD; Joanna Harrison, MA; Christopher J. Sutton, PhD; Svetlana Tishkovskaya, PhD; Caroline L. Watkins, PhD

ILLUSTRATIVE TEACHING CASEMore to Atherosclerosis Than Stenosis: Symptomatic Carotid Artery With Intraplaque Hemorrhage

e104

Samhitha Rai, MD; David E. Thaler, MD, PhD; Payam Salehi, MD, PhD; Neel Madan, MD; Lester Y. Leung, MD

ORGANIZATIONAL UPDATEAmerican Stroke Association Stroke Council Update e108Colin P. Derdeyn, MD; Joseph P. Broderick, MD; Karen Furie, MD

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LETTERS TO THE EDITORLetter by Moris et al Regarding Article, “Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)”

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Demetrios Moris, MD, PhD; Chris Bakoyiannis, MD, PhD; Efthymios Avgerinos, MD, PhD

Response by Wang and Johnston to Letter Regarding Article, “Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients: From the SOCRATES Trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes)”

e111

Yongjun Wang, MD; S. Claiborne Johnston, MD, PhD

Letter by Nabavizadeh et al Regarding Article, “Prediction of Blood–Brain Barrier Disruption and Intracerebral Hemorrhagic Infarction Using Arterial Spin-Labeling Magnetic Resonance Imaging”

e112

S. Ali Nabavizadeh, MD; Ashkan Mowla, MD; Arastoo Vossough, MD, PhD

Letter by Rustemi Regarding Article, “Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])”

e113

Oriela Rustemi, MD

Response by Hänggi and Macdonald to Letter Regarding Article, “Randomized, Open-Label, Phase 1/2a Study to Determine the Maximum Tolerated Dose of Intraventricular Sustained Release Nimodipine for Subarachnoid Hemorrhage (NEWTON [Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage])”

e114

Daniel Hänggi, MD; R. Loch Macdonald, MD, PhD

Letter by Nielsen and Johnsen Regarding Article, “Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation”

e115

Peter Brønnum Nielsen, PhD; Søren Paaske Johnsen, PhD

Response by Pennlert et al to Letter Regarding Article, “Optimal Timing of Anticoagulant Treatment After Intracerebral Hemorrhage in Patients With Atrial Fibrillation”

e116

Johanna Pennlert, MD, PhD; Kjell Asplund, MD, PhD; Marie Eriksson, PhD

Letter by Dexter and Hindman Regarding Article, “Anesthesia Technique and Outcomes of Mechanical Thrombectomy in Patients With Acute Ischemic Stroke”

e117

Franklin Dexter, MD, PhD; Bradley J. Hindman, MD

Response by Bekelis et al to Letter Regarding Article, “Anesthesia Technique and Outcomes of Mechanical Thrombectomy in Patients With Acute Ischemic Stroke”

e118

Kimon Bekelis, MD; Pascal Jabbour, MD; Symeon Missios, MD

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CORRECTIONSCorrection to: Early Trajectory of Stroke Severity Predicts Long-Term Functional Outcomes in Ischemic Stroke Subjects: Results From the ESCAPE Trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times)

e119

Correction to: Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Score ≤6

e120

Correction to: Cerebral Aneurysm Morphology Before and After Rupture: Nationwide Case Series of 29 Aneurysms

e121

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