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MEL GIBSON

NICHOLAS

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P2RY5 IS

DR AZLINA AHMAD ANNUAR

MTEB 3303 CURRENT TOPICS IN BIOMEDICAL SCIENCE

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 THE NEWSPAPER

•News Straits Times•03 March 2008

•RESEARCHERS havefound the geneticbasis of two distinctforms of inherited

hair loss, opening abroad path totreatments forthinning locks,according to a

recent pair of 

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Human hair• Hair structures

 –Follicle in the skin

Several layer –Shaft

keratin

 Three layeroMedulla

oCortex

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Hair• Normal cycle hair

growth lasts for 2 to 6years

•Approximately 1 cm permonth

• Causes hair loss: – Major surgery

 – After 3 months delivery

 – Medicines

 – Hormonal problems Thyroid gland

 

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What is the• Symbol to:

 – Purinergic receptor P2Y, G-protein coupled,5

•

Gene type: – Protein coding

• Summary: – The protein encoded by this gene belongs

to the family of G-protein coupledreceptors, that are preferentially activatedby adenosine and uridine nucleotides

 – This gene aligns with an internal intron of the retinoblastoma susceptibility gene inthe reverse orientation.

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Research on P2RY5

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Methodology

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Study findings•  The P2RY5 is the first receptor in human

 – Roles in hair growth

• Study shown it was cause from:

 – Rare inherited form calledhypotrichosis simplex 

• Hypotrichosis simplex 

 – An autosomal dominant form of isolated alopecia

 – Complete loss of scalp hair

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• The disease affects both men

and women

 –

Begin to baldduring childhood

• Genetic defect

 –Prevent certainreceptor on the surface of hair

follicle cells

Study findings

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•  The P2RY5 plays aspecific role in hairgrowth

•

For hair follicle functionnormal

 – Messenger bind tothese receptor

 – Triggering a chainreaction in the cellinterior

•  This study revealed the

Study

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Others

AngelaChristiano

( ColumbiaUniversity)

STUDY 

- On P2RY5

- Among families inPakistan

- Mutation on inner root

sheath of hair follicles

RESULT- Woolly hair

- Sparse

- Dry

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• Bias on thesubject matter –

Arabians –Pakistans

• Recommended –Broadersubject

Comments

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Bold is beautiful ?

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• Ahmad, W. et al. Alopecia universalis associated with a mutation in the humanhairless gene. Science 279, 720–724 (1998).

• Al Aboud, D., Al Aboud, K., Al Hawsawi, K. & Al Aboud, A. Hereditaryhypotrichosis simplex of the scalp: a report of 2 additional families. Sudan J.Dermatol. 3, 128–131(2005).

• Al Aboud, K., Al Hawsawi, K., Al Aboud, D. & Al Githami, A. Hereditaryhypotrichosis simplex: report of a family. Clin. Exp. Dermatol. 27, 654–656(2002).

• Herzog, H., Darby, K., Hort, Y.J. & Shine, J. Intron 17 of the human retinoblastoma

susceptibility gene encodes an actively transcribed G protein-coupled receptor gene.Genome Res. 6, 858–861 (1996).

• Sandra M Pasternack, Ivar von Ku¨gelgen, Khalid Al Aboud, Young-Ae Lee, FranzRu¨schendorf,Katrin Voss, Axel M Hillmer, Gerhard J Molderings, Thomas Franz,

¨ ¨

References

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