Organized by

Federation of European Biochemical Societies (FEBS)

Italian Society of Biochemistry and Molecular Biology (SIB)

University of Torino

in collaboration with

Italian Federation of Life Sciences (FISV)

Italian Society of Biophysics and Molecular Biology (SIBBM)

Italian Society of Immunology, Clinical Immunology and Allergology (SIICA)

Italian Society of Pharmacology (SIF)

Italian Proteome Association (ItPA)

Co-sponsored by the Department of Life Sciences,

Italian Research Council Rome

Scientific Committee and International Advisory Board

Chairman Sergio Papa

Organizing Committee

Chairman Gianfranco Gilardi

36th FEBS CONGRESS

Torino, Italy June 25 – 30, 2011

“Biochemistry for Tomorrow’s Medicine”Scientific Committee:Chairman

Sergio Papa SIB

Honorary Chairman

Paolo Arese SIB

MembersLilia Alberghina SIB Giulio Magni SIB

Andrea Bellelli SIB Fabio Malavasi SIB

Irene Bozzoni SIB Alberto Mantovani SIICA

Maurizio Brunori SIB Jacopo Meldolesi FISV

Federico Bussolino SIB Salvatore Oliviero FISV

Felice Cervone FISV Valerio Orlando FISV,SIBBM

Filiberto Cimino SIB Pier Giuseppe Pelicci FISV

Daniela Corda SIB Carola Ponzetto SIB

Riccardo Cortese SIB Piero Pucci SIB, ItPA

Paolo Comoglio FISV Menico Rizzi SIB

Vincenzo Cuomo SIF Maria Grazia Roncarolo FISV

Antonio De Flora SIB Giuseppe Rotilio SIB

Aldo Fasolo SINS Francesco Salvatore SIB

Giorgio Lenaz SIB Gianpietro Semenzato SIICA

Giovanna Lucchini FISV Roberto Sitia FISV

Lucio Luzzatto FISV Tommaso Russo SIB

International Advisory board:Philip Cohen UK Pier Paolo Pandolfi USA

Pascale Cossart F Israel Pecht IL

Stephanie Dimmeler D Leena Peltonen FIN

Paul Freemont UK Francesco Ramirez USA

Joseph Houstek CZ Francisco Sanchez-Madrid E

Sirpa Jalkanen FIN Claudina Rodrigues Pousada P

Karl Kuchler A Anthony Schapira UK

Nils-Goran Larsson S Kai Simons D

Iain Mattaj D Vladimir Skulachev RUS

Gerry Melino UK

Adam Szewczyk FEBS Congress Counsellor

36th FEBS CONGRESS Torino, Italy

June 25 – 30, 2011 “Biochemistry for Tomorrow’s Medicine”

Organizing Committee

Chair

Gianfranco Gilardi SIB

Deputy

Fiorella Altruda FISV Marco Arese SIB Mauro Patrone SIB Luciana Avigliano SIB Enrica Pessione SIB Maria Cavaletto SIB Marco Piccinini SIB Tiziana Crepaldi SIB Menico Rizzi SIB Silvia Deraglio SIB Sheila Sadeghi SIB Ada Funaro SIII Guido Serini SIB Dario Ghigo SIB Francesca Silvagno SIB Giuliana Giribaldi SIB Fabiola Sinigaglia SIB Carlo Giunta SIB Guido Tarone FISV Andrea Graziani SIB Franco Turrini SIB Emilio Hirsch FISV Francesca Valetti SIB Evelin Keiling Schwarzer SIB Bruno Venerando SIB

The scientific programme will consist of Plenary Lectures, 45 parallel

Symposia/Workshops and Poster Sessions covering the following areas.

• The Genome in the 3rd millennium

• Complexity in RNA biology

• Following the life of a protein

• Cell-Cell communication

• Membrane dynamics

• Molecular basis of development

• Systems Biology

• Molecular engineering for medicine

• Prokaryote biochemistry: Friends and foes in the microbial world

• Metabolic control and disorders

• Recent advances in cancer biology

• Cellular Senescence and Aging

• Rare diseases reveal new biochemical mechanisms

• Biochemistry of the Brain and Neurodegenerative disorders

• Molecular basis of Cardiovascular diseases

• Biochemistry of immunity and inflammation

• Biochemistry and molecular biology of malaria and tuberculosis

• Plant Biochemistry for Health and Tomorrow’s Medicine

• Molecular and cellular therapeutics

Poster sessions will cover the areas of Symposia/Workshops

and additional areas:

• Bioenergetics

• Lipid metabolism

• Enzymology

Special sessions/tutorials on Science and Society, Women in Science,

Education in Biochemistry, Satellite Industry sponsored Symposia,

and a Commercial Exhibition are scheduled.

The Congress will be preceded on June 22-25, 2011 by the Young Scientists Forum.

36th FEBS CONGRESS Torino, Italy

June 25 – 30, 2011 “Biochemistry for Tomorrow’s Medicine”

Fee Structure (VAT 20% included)

Early Till 31/03

€

Regular Till 30/06

€

On Site €

ACADEMIC

400

470

550

GRADUATE STUDENTS

150

170

200

NON-ACADEMIC

500

600

700

ACCOMPANYING PERSONS

80

100

120

Category N. of rooms

at Conference site

N. of rooms

available

At 10-20 mins

Prices

5-star hotels 295 80 160-210

4-star hotels 630 1,600 130-170

3-star hotels 500 1,300 65-125

Low-cost

Accommodation

(Olympic Village)

1,100 400 25-35

TOTAL 2,525 3,380

36th FEBS CONGRESS

Torino, Italy

June 25 – 30, 2011

“Biochemistry for Tomorrow’s Medicine”

Rates for accommodation in Torino

Elena Conti (Germany) confirmed Sir Hans Krebs Plenary Lecture

(scheduled for Sunday June 26th at 11:30 –12:30)

- Sirpa Jalkanen (Finland) confirmed Prakash Datta Plenary Lecture

Homing-associated molecules as targets to prevent harmful inflammations (scheduled for Monday June 27th at 17.30 – 18.30 )

and cancer spread

- Luis Serrano (Spain) confirmed EMBO Plenary Lecture

(scheduled for Wednesday June 29th at 11:30 –12:30)

- John Mattick (Australia) confirmed IUBMB Plenary LectureRNA as the computational engine of the epigenomic control (scheduled for Tuesday June 28th at 11:30 – 12:30)

of development and brain function

- Pier Giuseppe Pelicci (Italy) confirmed Theodor Bücher Plenary Lecture

Regulation of Self Renewal in Cancer Stem ( scheduled for Sunday June 26th – 17.30 – 18.30)

- Roger D. Kornberg (USA) Opening Plenary Lecture acceptance pending

- Bruce Spiegelman (USA) Closing Plenary Lecture acceptance pending

PABMB Plenary Lecture pending

Wise Lecture * pending

Plenary Lectures

* The Lecturer will be the one that the WISE Committe will select.

Symposia Area S1 The Genome in the 3rd millenium

S1.1 Coding and noncoding information in genome function (Sunday, June 26th)

Thomas Jenuwein German Epigenetic control by histone methylation

Job Dekker USA Three-dimensional architecture of the human genome

Thomas R. Gingeras USA Making sense of the pervasive transcription in eukaryotic cell

Geoff Faulkner United Kingdom Junk" DNA remodelling the human genome and transcriptome

S1.2 Mechanisms controlling genome integrity (Sunday, June 26th)

John F.X. Diffley United Kingdom Mechanism and regulation of DNA replication

Yosef Shiloh Israel The ATM-Mediated DNA Damage Response: The System and the Pathways

Julie Cooper United Kingdom Telomeres and the challenges to chromosome integrity

Andrea Musacchio Italy

S1.3 Epigenetic control of cell fate ( Monday, June 27th )

Geneviève Almouzni France

Dirk Schübeler Switzerland

Renato Paro Switzerland Epigenetic reprogramming during tissue regeneration

Amanda Fisher United Kingdom

Symposia and Confirmed Speakers

Symposia Area S2 Complexity in RNA biology

S 2.1 Non coding RNA: evolution, function ( Tuesday, June 28th )

Witold Filipowicz Switzerland Regulation of miRNA function and metabolism in mammalian cells including neurons

Caroline Dean United Kingdom

Rene Ketting The Netherlands

Pier Paolo Pandolfi USA

S 2.2 Small RNA in disease ( Wednesday, June 29th )

Reuven Agami The Netherlands

John Rossi USA Small RNA Therapies for the Treatment of HIV Infection

Adrian Krainer USA

Maria Carmo-Fonseca Portugal

Symposia and Confirmed Speakers

Symposia Area S3 Following the life of a protein

S 3.1 Protein synthesis, traffic and turnover (Sunday, June 26th)

Aaron Ciechanover Israel

Ada Yonath Israel

Hidde Ploegh USA

Peter-Michael Kloetzel Germany

S 3.2 Protein folding and binding (Sunday, June 26th)

William. A. Eaton USA Watching single protein molecules fold by FRET spectroscopy

Alan R. Fersht United Kingdom

Joel L. Sussman Israel

Peter Tompa Hungary Unusual binding modes of intrinsically disordered proteins

S 3.3 NAD-dependent Post-translational modifications ( Monday, June 27th )

Andreas Ladurner Germany

Daniela Corda Italy Novel developments in protein mono-ADP-ribosylation

Mathias Ziegler Norway NAD+ - a key molecule in cellular signalling

Michael Hottiger Switzerland

Symposia and Confirmed Speakers

Symposia Area S4 Cell-Cell communication

S 4.1. Intercellular trafficking of signal molecules (Sunday, June 26th)

Elena Zocchi Italy Abscisic acid, a new mammalian pro-inflammatory hormone

Friedrich Koch-Nolte Germany Regulation of P2X7 activation by extracellular NAD

Alberto Darszon Mexico

Shin-ichiro Imai USA

S 4.2 Regulation of cell functions by intercellular contact systems (Sunday, June 26th)

Charles Streuli United Kingdom How integrins control breast development and function

Paola Defilippi Italy Integrin regulation of tumour cell growth and invasive properties

Walter Birchmeier Germany Wnt/beta-catenin in stem and cancer stem cells

Geert Berx Belgium acceptance pending

Symposia Area S 5 Membrane dynamics

S 5.1 Membrane dynamics

(Sunday, June 26th)

Alberto Luini Italy Organization and homeostasis of the intracellular membrane transport pathways

Vivek Malhotra Spain Mechanism of protein secretion: conventional and unconventional

Marino Zerial Germany Systems analysis of endocytosis and signalling

Enrique Rodriguez-Boulan USA

Symposia and Confirmed Speakers

S 5.2 Organelle dynamics (Sunday, June 26th)

Luca Scorrano Switzerland

Graca Raposo France

Sharon Tooze United Kingdom Trafficking and signalling in mammalian autophagy

Graham Warren Austria

S 5.3 Membrane dynamics and disease

( Monday, June 27th )

William Balch USA

Ari Helenius Switzerland Role of endosomes in virus entry

Sergio Grinstein Canada Membrane dynamics during phagocytosis

Ira Milosevic USA

Symposia Area S 6 Molecular basis of development

S 6.1 Stress adaptation and development ( Monday, June 27th )

David Ron United Kingdom

Andrea Ballabio Italy

Naihe Jing China The molecular mechanisms of spinal cord development

Richard I Morimoto USA

Symposia and Confirmed Speakers

S 6.2 Cell shape determination ( Tuesday, June 28th )

Frank Costantini USA Cellular events in branching morphogenesis during kidney development

S 6.3 Development of cognition and language ( Tuesday, June 28th )

Wieland Huttner Germany

Lamberto Maffei Italy

Symposia Area S 7 Systems Biology

S 7.1 Omics and Bioinformatics (Sunday, June 26th)

Sampsa Hautaniemi Finland Efficient bioinformatics approaches for large-scale data analysis

Alfonso Valencia Spain

Peer Bork Germany

Søren Brunak Denmark

S 7.2 Networks and circuits (Sunday, June 26th)

Barbara Bakker The Netherlands Kinetic modelling of fatty acid metabolism in mouse

Carstern Carlberg Luxembourg

Thomas Höfer Germany Transcriptional regulatory networks that specify T cell fate

Symposia and Confirmed Speakers

Symposia Area S 8 Molecular Engineering for medicine

S 8.1 Synthetic biology for medicine ( Monday, June 27th )

Rita Bernhardt Germany Bacterial hydroxylases and their potential to synthesize pharmaceutical products

Debashis Ghosh USA

S 8.2 Biomedical application of nanotechnology ( Monday, June 27th ) Francesco Stellacci USA

Ruth Duncan United Kingdom

Symposia Area S 9 Prokaryote biochemistry: Friends and foes in the microbial world

S 9.1 Probiotics as health-promoting agents ( Monday, June 27th )

Kathryn Riedel Switzerland Moonlighting proteins as biomarkers for probiotic safety

Brian Henderson United Kingdom Bacterial Communication with the Human Host in Health and Disease

Through the Medium of Molecular Chaperones

Effie Tsakalidou Greece Milk protein fragments induce bacteriocin biosynthesis in Streptococcus

macedonicus: perspectives in food preservation and infection control

S 9.2 Antimicrobial drug discovery: a new challenge for the future

Jean Marie Pagès France Antibiotic Transport and Efflux pumps: New Strategies to combat bacterial resistance

Lloyd Czaplewski United Kingdom

Vanessa Sperandio USA

Symposia and Confirmed Speakers

Symposia Area S 10 Metabolic control and disorders

S 10.1 Nuclear receptors and lipid metabolism ( Monday, June 27th )

Nagy Laszlo Hunghery Crosstalk between nuclear receptors and cytokine signaling coordinates lipid

metabolism and inflammatory signaling and underpins cell type specific gene expression

Peter Tontonoz USA Transcriptional and post-transcriptional control of cholesterol metabolism

Bart Staels France Role of PPAR signalling in diabetic dyslipidemia

Susanne Mandrup Denmark

S 10.2 Molecular perspectives for diabetes ( Tuesday, June 28th )

Johan Auwerx Switzerland NAD sensor and metabolic control

Massimo Federici Italy TIMP3/TACE: acting at the interface of metabolic and vascular disorders

Agnieszka Dobrzyn Poland

Jiarui Wu China Systems Biology for diabetic biomarker discovery

S 10.3 Redox balance and obesity ( Tuesday, June 28th )

Louise Casteilla France

Paul Holvoet Belgium

Vladimir Skulachev Russia Mitochondria-targeted penetrating ions as inhibitors of organismal senescence program

and obesity

Symposia and Confirmed Speakers

Symposia Area S 11 Recent advances in cancer biology

S 11.1 Genes and Pathways in Cancer ( Wednesday, June 29th )

René Bernards The Netherlands Dissecting mechanisms of cancer drug resistance

through functional genetics

Chris J. Marshall United Kingdom

S 11.2 Cancer Stem Cells and Metastasis ( Wednesday, June 29th )

Tomas Brablets Germany

Klaus Pantel Germany

S 11.3 Cancer Genomics and Epigenetics ( Thursday, June 30th)

Michael Stratton United Kingdom

Symposia and Confirmed Speakers

Symposia Area S 12 Cellular Senescence and Aging

S 12.1 Plasticity of Aging ( Tuesday, June 28th )

Rafael de Cabo USA

Linda Partridge United Kingdom

Michael Hall Switzerland

Fontana Luigi USA Metabolic and molecular effects of long-term calorie restriction in humans

S 12.2 Cellular Senescence ( Tuesday, June 28th )

Judith Campisi USA Cellular senescence links inflammation and aging

Daniel Peeper The Netherlands Senescence and tumor suppression

Lenhard K. Rudolph Germany

Fabrizio d’Adda di Fagagna Italy

Symposia Area S 13 Rare diseases reveal new biochemical mechanisms

S 13.1 Rare metabolic diseases ( Wednesday, June 29th )

Stylianos E. Antonarakis Switzerland The Connectivity of Genomic Elements

Miguel C. Seabra United Kingdom Pathogenesis of diseases involving defects in Rab GTPase function and

membrane traffic

Francesco Salvatore Italy The internal fight of nutritional genetic diseases: the cases of hereditary fructose

intolerance and hyperphenylalaninemias or Nature and nurture in genetic diseases: the

cases of hereditary fructose intolerance and hyperphenylalaninemias

Santiago Rodríguez de Córdoba Spain Pathogenic mechanism in Lafora’s disease.

Symposia and Confirmed Speakers

S 13.2 Mitochondrial diseases ( Wednesday, June 29th )

Massimo Zeviani Italy

Arnold Munnich France

Douglas Wallace USA

Michael Ryan Australia Characterisation of factors required for assembly of mitochondrial complex I and their

defects in disease

Symposia Area S 14 Biochemistry of the Brain and Neurodegenerative disorders

S 14.1 Recent advances in neurodegenerative disorders ( Monday, June 27th )

Luca Steardo Italy

Maria Grazia Spillantini United Kingdom

Dominic Walsh Ireland

Inna Slutsky Israel Amyloid-beta: from release to synaptic function

S 14.2 Dopaminergic neurons and Parkinson disease. ( Tuesday, June 28th )

Antonio Simeone Italy Otx2 in adult meso-diencephalic dopaminergic neurons

Anders Björklund Sweden

Alain Prochiantz France Therapeutic transcription factors in Parkinson's disease

Symposia and Confirmed Speakers

Symposia Area S 15 Molecular Basis of Cardiovascular diseases

S 15.1 Development of vascular system ( Wednesday, June 29th )

Lena Claesson Welsh Sweden

Ralf Adams Germany

Srivastava Deepak USA Regulatory Networks Controlling Cardiac Cell Fate

Guido Serini Italy

S 15.2 Molecular basis of cardiovascular diseases ( Thursday, June 30th )

Stefan Engelhardt Germany MicroRNAs as therapeutic targets in cardiac disease.

Emilio Hirsch Italy Genetic Modeling of PI3K inhibition in health and disease

Alain Tedgui France Role of T and B lymphocytes in atherosclerosis

Eli Keshet Israel Re-vascularization mediated rescue of dysfunctional cardiomyocytes and reversal

of heart remodeling

Symposia Area S 16 Biochemistry of immunity and inflammation

S16.1 Ectoenzyme network and diseases ( Wednesday, June 29th )

Simon Robson USA

Laura Airas Finland

Silvia Deaglio Italy

Richard Ebstein Israel CD38 Mediates Social Behavior in Clinical and non-Clinical Subjects

Symposia and Confirmed Speakers

S 16.2 Structure and function of innate immunity receptors ( Wednesday, June 29th )

Luke O'Neill Ireland

Veit Hornung Germany

Jürg Tschopp Switzerland

Lorenzo Moretta Italy Human NK receptors: functional characteristcs and clinical applications

S 16.3 Receptors and signal transduction ( Thursday, June 30th )

Oreste Acuto United Kingdom T cell antigen receptor signalling

Ada Funaro Italy

Symposia Area S 17 Biochemistry and molecular biology of malaria and tuberculosis

S 17.1 Biochemistry and molecular biology of Tuberculosis (Wednesday, June 29th )

Barry Clifton E. USA The role of the deazaflavin cofactor F420 in Mycobacterium tuberculosis

Stewart Cole Switzerland

Roland Brosch France ESX/Type VII secretion in tubercle bacilli - a key factor in virulence and protection

Katarina Mikusova Slovakia Playing biochemistry with mycobacterial cell wall - an old good drug target

Symposia and Confirmed Speakers

S 17.2 Biochemistry and molecular biology of Malaria (Thursday, June 30th )

Maria Mota Portugal Approching malaria from the host side

Dominique Soldati-Favre Switzerland Molecular events governing the lytic cycle in Apicomplexa

Michael Lanzer Germany Transporters as mediators of drug resistance in the human malaria parasite

Plasmodium falciparum

Artur Scherf France

Symposia Area S 18 Plant Biochemistry for Health and Tomorrow’s Medicine

S 18.1 Green Factory ( Tuesday, June 28th )

Cathie Martin United Kingdom Engineering phenylpropanoid metabolism in crops for healthier foods

Eva Stöger Austria Plant-produced pharmaceutical antibodies

Roberto Bassi Italy Domeaticating unicellular photosynthetic eucariotes for the production of biofuels

and recombinant proteins

Harro Bouwmeester The Netherlands acceptance pending

S 18.2 Plant Innate Immunity ( Tuesday, June 28th )

Brian Staskawicz USA

Ulla Bonas Germany Plant targets of bacterial effector proteins

Jonathan Jones United Kingdom

Giulia De Lorenzo Italy Healthy food for a healthy life: engineering resistance by constructing chimeric

receptors for pathogen recognition

Symposia and Confirmed Speakers

Symposia Area S 19 Molecular and cellular therapeutics

S 19.1 Vectors for therapeutic and experimental applications (Wednesday, June 29th )

Thierry Vanden Driessche Belgium

Tony Cathomen Germany

Luigi Naldini Italy

S 19.2 Gene and cell therapy for genetic diseases (Thursday, June 30th )

Natalie Cartier France

Alessandro Aiuti Italy

Juan Bueren Spain Perspectives for the Gene Therapy of Inherited Diseases Affecting the Hematopoietic Stem Cells:

The Fanconi Anemia Model

Shin-ichi Muramatsu Japan Gene therapy for Parkinson's disease: Strategies to restore local dopamine production

Symposia and Confirmed Speakers