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PROVIDING PRODUCTS OF UNCOMPROMISING QUALITY WITH UNQUESTIONABLE INTEGRITY SINCE 1997 It’s estimated that 90% of the population may have parasites lurking in their body. They deprive us of vitamins, nutrients, and amino acids, decrease our energy levels, alter our natural pH levels, and create an acidic environment. Parasites live on or in other organisms from which they obtain nutrients to live and cause harm in the process. Their name comes from the Greek word para that means beside, and sitos, which means food. In North America, diarrhea caused by intestinal parasites is the third leading cause of illness. Symptoms of infestation can be quite common and include gas, diarrhea, chronic constipation, bloating, fatigue, skin rashes, nail biting, mood swings, insomnia, dry skin, brittle hair, hair loss, weight gain, bad breath and muscle cramping. Parasites can occur any- where in the body and can contribute to major diseases in- cluding Crohn’s disease, ulcerative colitis, arthritis and rheu- matoid symptoms, diabetes, some heart disease, asthma and others. There can be over 100 different types of parasites or worms living in human bodies. Some are microscopic in size while others can be seen quite easily. These organisms can be found everywhere in our environment, in the air we breath, in the water we drink and in the food we eat. Parasites also lay eggs, often thousands every day. Many parasites hide in the folds of the large intestine or under the membrane lining of the intestines. When the eggs hatch, there is often some acute pain or discomfort and usually the need to go to the bathroom immediately. Whether in the environment or in the body, parasites are difficult to eliminate. An infected person may have to go to great lengths to minimize the organisms’ presence in their environment and food. Certain herbs and herbal formula- tions can effectively relieve parasitic infections and their symptoms. To effectively combat parasitic infection, a formulation must target a broad range of these organisms. Although many individual herbs effectively target different sets of parasites, their effect can be enhanced when combined with other syn- ergistic herbs. Thus, a formulation must be carefully blended to yield the maximum effect and in addition, must also pro- vide a gentle laxative effect to expedite elimination of af- fected organisms. ParaCide was formulated with exactly this in mind. It com- bats parasites and worms aggressively yet it is gentle on the patient. Its protocol is easy to follow and therefore patient compliance remains high. The following is a description of the herbs used in this formula. Each has been chosen for their individual qualities and their synergistic relationship with the other ingredients. Green Hulled Black Walnut The genus name “Juglans” or “jovis glans” means “Jupiter’s nut.” Mythology tells us that the ‘gods’ residing on earth lived off Walnuts. The name “Walnut” is from the Teutonic “welsche nuss”, meaning “foreign nut”. Ancient Greeks, Asian Peoples, Romans and some American Indian tribes used Black Walnut Hull to promote intestinal health, beneficial microbial activ- ity and cleansing of the intestinal tract. The high tannin con- tent and a naphthoquinone, known as juglone, are primarily responsible for its beneficial properties along with juglandin and juglandic acid. Black Walnut oxygenates the blood creating an environment hostile to invasive organisms including parasites and fungi. The brown stain found in the green husk contains organic io- dine which has antiseptic and healing properties. Black Wal- nut has been used to promote healthy sugar levels, reduce fatty materials and detoxify the colon. In addition, it is an excellent source of soluble fibre and acts as a mild laxative, causing no nausea, irritation or pain as it helps flush waste. Cloves Cloves (Eugenia caryophyllata) is an ancient herbal medicine used for killing internal parasites and their eggs. It exhibits broad anti-microbial properties against fungi and bacteria, thus supporting its traditional use as a treatment for diar- rhea, intestinal worms, and other digestive ailments. Cloves help relax the smooth muscle lining of the digestive tract thus promoting digestion and reducing spasms. Cloves in- crease the circulation of the blood, promote digestion, and eliminate gas and intestinal spasms Rhizoma Rhei Rhizoma Rhei is also known as Chinese Rhubarb, Da Huang, Garden Rhubarb and Rhei radix. The active constituents of Rhizoma Rhei are the anthraquinone glycosides, sennosides A-F and rheinosides A-D. The rheinosides are similar to al- oin A and B, the main cathartic principles of aloe. Both the sennosides and rheinosides are hydrolyzed by intestinal bac- teria and then reduced to the active anthrone metabolite, which acts as a stimulant and irritant to the gastrointestinal tract and increases its motor activity. This stimulates colonic motility and accelerates colonic emptying. Rhizoma Rhei also increases paracellular permeability across the colonic mucosa increasing the water content in the large intestine. This laxative effect speeds the elimination of waste including weakened or destroyed parasites. For the treatment of schistosomiasis, studies effective recov- ery and patients are mobile within one week after serious infection. Nausea subsides, the epigastric region feels more 960 Augusta Court Kelowna, BC 1-888-566-8297 www.integranutrition.com ParaCide Benefits Powerful killer of multiple parasites Mild laxative to flush waste debris Gentle on system Protocol addresses eggs Easy to follow protocol Research Years of clinically demonstrated effectiveness NHPD site licensed manufacturer Pharmaceutical Manufacturing License Good Manufacturing Practices (GMP) 2009/2010 Supplier Award Winner

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PROVIDING PRODUCTS OF UNCOMPROMISING QUALITY WITH UNQUESTIONABLE INTEGRITY SINCE 1997

It’s estimated that 90% of the population may have parasites lurking in their body. They deprive us of vitamins, nutrients, and amino acids, decrease our energy levels, alter our natural pH levels, and create an acidic environment. Parasites live on or in other organisms from which they obtain nutrients to live and cause harm in the process. Their name comes from the Greek word para that means beside, and sitos, which means food.

In North America, diarrhea caused by intestinal parasites is the third leading cause of illness. Symptoms of infestation can be quite common and include gas, diarrhea, chronic constipation, bloating, fatigue, skin rashes, nail biting, mood swings, insomnia, dry skin, brittle hair, hair loss, weight gain, bad breath and muscle cramping. Parasites can occur any-where in the body and can contribute to major diseases in-cluding Crohn’s disease, ulcerative colitis, arthritis and rheu-matoid symptoms, diabetes, some heart disease, asthma and others.

There can be over 100 different types of parasites or worms living in human bodies. Some are microscopic in size while others can be seen quite easily. These organisms can be found everywhere in our environment, in the air we breath, in the water we drink and in the food we eat.

Parasites also lay eggs, often thousands every day. Many parasites hide in the folds of the large intestine or under the membrane lining of the intestines. When the eggs hatch, there is often some acute pain or discomfort and usually the need to go to the bathroom immediately.

Whether in the environment or in the body, parasites are difficult to eliminate. An infected person may have to go to great lengths to minimize the organisms’ presence in their environment and food. Certain herbs and herbal formula-tions can effectively relieve parasitic infections and their symptoms.

To effectively combat parasitic infection, a formulation must target a broad range of these organisms. Although many individual herbs effectively target different sets of parasites, their effect can be enhanced when combined with other syn-ergistic herbs. Thus, a formulation must be carefully blended to yield the maximum effect and in addition, must also pro-vide a gentle laxative effect to expedite elimination of af-fected organisms.

ParaCide was formulated with exactly this in mind. It com-bats parasites and worms aggressively yet it is gentle on the patient. Its protocol is easy to follow and therefore patient compliance remains high. The following is a description of the herbs used in this formula. Each has been chosen for their individual qualities and their synergistic relationship with the other ingredients.

Green Hulled Black WalnutThe genus name “Juglans” or “jovis glans” means “Jupiter’s nut.” Mythology tells us that the ‘gods’ residing on earth lived off Walnuts. The name “Walnut” is from the Teutonic “welsche nuss”, meaning “foreign nut”. Ancient Greeks, Asian Peoples, Romans and some American Indian tribes used Black Walnut Hull to promote intestinal health, beneficial microbial activ-ity and cleansing of the intestinal tract. The high tannin con-tent and a naphthoquinone, known as juglone, are primarily responsible for its beneficial properties along with juglandin and juglandic acid.

Black Walnut oxygenates the blood creating an environment hostile to invasive organisms including parasites and fungi. The brown stain found in the green husk contains organic io-dine which has antiseptic and healing properties. Black Wal-nut has been used to promote healthy sugar levels, reduce fatty materials and detoxify the colon.

In addition, it is an excellent source of soluble fibre and acts as a mild laxative, causing no nausea, irritation or pain as it helps flush waste.

ClovesCloves (Eugenia caryophyllata) is an ancient herbal medicine used for killing internal parasites and their eggs. It exhibits broad anti-microbial properties against fungi and bacteria, thus supporting its traditional use as a treatment for diar-rhea, intestinal worms, and other digestive ailments. Cloves help relax the smooth muscle lining of the digestive tract thus promoting digestion and reducing spasms. Cloves in-crease the circulation of the blood, promote digestion, and eliminate gas and intestinal spasms

Rhizoma RheiRhizoma Rhei is also known as Chinese Rhubarb, Da Huang, Garden Rhubarb and Rhei radix. The active constituents of Rhizoma Rhei are the anthraquinone glycosides, sennosides A-F and rheinosides A-D. The rheinosides are similar to al-oin A and B, the main cathartic principles of aloe. Both the sennosides and rheinosides are hydrolyzed by intestinal bac-teria and then reduced to the active anthrone metabolite, which acts as a stimulant and irritant to the gastrointestinal tract and increases its motor activity. This stimulates colonic motility and accelerates colonic emptying.

Rhizoma Rhei also increases paracellular permeability across the colonic mucosa increasing the water content in the large intestine. This laxative effect speeds the elimination of waste including weakened or destroyed parasites.

For the treatment of schistosomiasis, studies effective recov-ery and patients are mobile within one week after serious infection. Nausea subsides, the epigastric region feels more

960 Augusta CourtKelowna, BC

1-888-566-8297www.integranutrition.com

Para

Cide

Benefits Powerful killer of multiple parasites Mild laxative to flush waste debris Gentle on system Protocol addresses eggs Easy to follow protocol Research Years of clinically demonstrated effectiveness NHPD site licensed manufacturer Pharmaceutical Manufacturing License Good Manufacturing Practices (GMP)

2009/2010 Supplier Award Winner

Page 2: ParaCide - Integra Nutritionintegranutrition.com/index/pdfs/ParaCide.pdf · The cellulase in ParaCide helps to digest the cell wall ... medicinal plants. ... Atlas of microscopy of

comfortable and bowel movement becomes regular.

Wormwood (Artemesia annua)The herb wormwood has been used for centuries as an herbal remedy for parasites. It contains the bitter principles, absinthin and anabsinthin, and a volatile oil composed of up to 70% thujone. Thujone demon-strates antioxidant, antimicrobial and antifungal activity.

Wormwood also contains sesquiterpene lactones, which work similar to peroxide by weakening the parasite membranes. It is especially effec-tive against pinworms, roundworms and giardia.

Garlic The active principal isolated from garlic is allicin which comprises ap-proximately 1.5% of the plant. It is a yellowish liquid with a strong odor. It exists in the fresh plant as a pro-drug called alliin, which is colorless and odorless. Under catalysis by the enzyme alliinase, it is hydrolyzed to form one molecule of allicin and two molecules of diallyl disulfide. The latter has an antilipemic effect.

Garlic is well known for its blood cleansing and antibacterial proper-ties which are helpful during and after parasitic infection. Studies have shown that garlic has a strong inhibitory effect against amoebae and hookworms and pinworms. Traditionally, garlic has been used in com-bination with Arecu Catechu (Betel Nut) and polyporous mylittae for hookworm and pinworm. Garlic can also be considered a stomachic, which stimulates gastric secretion and gastric motility. It is also an anti-inflammatory.

Pumpkin SeedsPumpkin seeds contain large amounts of fat, protein and urease but the active anti-parasitic agent is cucurbitine, which acts primarily on the egg and segments of tapeworms. In vitro and in vivo studies have also shown it’s effect against tapeworms and other intestinal parasites. They have preventative effects against the development of schistosomiasis and kills young and adult schistosomes and also expel the intestinal worms and parasites they destroy.

Polyporous MylittaeThe active ingredient in this herb is an unknown protease. Clinical stud-ies have consistently noted the presence of eggs and tapeworms in the stool after 4-6 days with generally no worms or eggs observed upon completion of treatment. The parasites most affected by this herb are tapeworm, hookworm and roundworm. Traditionally, polyporous mylit-tae has been used with garlic and betel nut.

Betel NutBetel nut eliminates parasites in two ways. First, it contains the alka-loid arecoline which paralyzes tapeworm liberating the head and seg-ments of the parasite from the intestinal wall. Second, it promotes the movement of qi, reduces accumulation, and leads stagnation out by mildly draining downward and unblocking the bowels. This ability to drain downward helps expel the bodies of the paralyzed parasites.

Betel nut can also paralyze pinworm, hookworm, roundworm, fascio-lopsis and blood flukes, but is slightly less potent against these organ-isms.

MintMint contains the volatile oils menthol and menthone. Studies show that mint helps relieve the symptoms of giardia and amoeba infec-tions in children and adults and helps prevent and relieve intestinal gas. In addition, it helps to flush these parasites form the intestine.

CellulaseThe cellulase in ParaCide helps to digest the cell wall of the herbs to fully release the active ingredients and increase their concentration in the vicinity of intestinal parasites.

RecommendationsFor a more overall effect, ParaCide can be used with our Ultimate Fi-bre Plus and Digezyme as a complete and easy to follow anti-parasite protocol.

Our CompanyIntegra Nutrition Inc. is the exclusive distributor of Alpha Science products. We have been servicing the health care professional since 1997. Our mission is to provide products of uncompromising quality with unquestionable integrity.

Alpha Science is a pharmaceutical licensed manufacturer and as such has to meet the highest standards set out by governmental health agencies. This includes meeting the requirements of Good Manufac-turing Practices (GMP) and new NHP regulations.

Further, Alpha Science also meets the highest standards set out by our natural health care clientele. All our products are 100% natural and contain no additives. Our products are regularly assayed for heavy metal contamination and a complete certificate of analysis verifies the purity and content of each ingredient.

REFERENCES1. Bastidas CJ. Effect of ingested garlic on Necator americanus and Ancylostoma caninum. Am J Trop Med Hyg 1969;13:920–3.2. Bisset NG. Max Wichtl’s herbal drugs & phytopharmaceuticals. Boca Raton. Fl., CRC Press, 1994. 3. Bradley PR, ed. British herbal compendium, Vol. 1. Bournemouth. British Herbal Medicine Association, 1992. 4. Bruneton J. Phamacognosy, phytochemistry, medicinal plants. Paris, Lavoisier. 1995. 5. Chou HC, Ming H. Pumpkin seed (Cucurbita moschata) in the treatment of acute schistosomiasis. Chin Med J 1960;80:115–20.6. European pharmacopoeia, 3rd ed. Strasbourg, Council of Europe. 1997. 7. German Commission E monograph, Rhei radix. Bundesanzeiger, 1993. 13:21 July. 8. Godding EW. Therapeutics of laxative agents with special reference to the anthraquinones. Pharmacology, 1976, 14(Suppl. 1): 78-101. 9. Goodman and Gilman’s the pharmacological basis of therapeutics, 8th ed. New York. McGraw Hill, 1990. 10. Heizer WD et al. Protein-losing gastroenteropathy and malabsorption associated with factitous diarrhoea. Annals of internal medicine, 1968, 68:839-852.11. The Indian pharmaceutical codex. Vol. I. Indigenous drugs. New Delhi, Council of Scientific & Industrial Research, 1953. 11. Jackson BP, Snowden DW. Atlas of microscopy of medicinal plants culinary herbs and spices. Boco Raton, FL, CRC Press. 1990. 12. Kliks MM. Studies on the traditional herbal anthelmintic Chenopodium ambrosioides L.: Ethnopharmacological evaluation and clinical field trials. Soc Sci Med 1985;21:879–86.13. Koch HP, Lawson LD, eds. Garlic: The Science and Therapeutic Application of Allium sativum L. and Related Species. Baltimore: Williams & Wilkins, 1996, 173–4.14. Leng-Peschlow E. Dual effect of orally administered sennosides on large intestine transit and fluid absorption in the rat, Journal of pharmacy and pharmacology, 1986. 36:230-236. 15. Mirelman D, Monheit D, Varon S. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). J Infect Dis 1987;156:243–4.16. Muller Lissner SA. Adverse effects of laxatives: facts and fiction. Pharmacology. 1993. 47(Suppl. 1): 138-145. 17. Nishioka I. Biological activities and the active components of rhubarb. International journal of Oriental medicine. 1991, 16:193-212. 18. Patel PM et al. Anthraquinone laxatives and human cancer. Postgraduate medical journal, 1989, 65:216-217. 19. Physicians’ desk reference, 49th ed., Montvale, NJ. Medical Economics Company. 1995. 20. Sagara K, Oshima T, Yoshida T. Rapid and simple determination of sennosides A and B in Rhei Rhizoma by ion-pair high-performance liquid chromatography. Journal of chromatography, 1987, 403:253-261. 21. de Santana CF, de Almeida ER, Dos Santos ER, Souza IA. Action of Mentha crispa hydroethanolic extract in patients bearing intestinal protozoan. Fitoterapia 1992;63:409–10.22. Tyler VE. Brady LR. Robbers JE. Eds. Pharmacognesy. 9th ed. Philadelphia. Lea & Febiger, 1988. 23. Weiss RF. Herbal Medicine. Beaconsfield, UK: Beaconsfield Publishers Ltd., 1985, 119–20.24. de Witte P. Metabolism and pharmacokinetics of anthranoids. Pharmacology. 1993. 47(Suppl. 1):86-97. 25. Yamauchi K et al. Suppression of the purgative action of rhein anthrone. The active metabolite of sennosides A and B, by calcium channel blockers. calmodulin antagonists and indo-methacin. Pharmacology, 1993, 47(Suppl. 1):22-31. 26. Young ken HW. Textbook of pharmacognosy 6th ed. Philadelphia. Blakiston, 1950. 960 Augusta Court, Kelowna, BC

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