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PATHOLOGY OF THE LIVER VII. practical training 3 rd year General Medicine

PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

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Page 1: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

PATHOLOGY OF THE LIVER

VII. practical training

3rd year General Medicine

Page 2: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Haemochromatosis

Page 3: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Congestion of the liver

Page 4: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Congestion of the liver

Page 5: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Congestion of the liver (hepar moschatum)

1 Portobilial spaces

2 Ways of congestion (congestion with

necrosis of hepatocytes)

Pseudolobulus from residues of 3 lobuli, in

centre is portobilium

1

1

1

2

2

Page 6: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Congestion of the liver (hepar moschatum), detail

1

3

2

3

1 Portobilium- dilatated branch of v. portae

2 Pseudolobulus from residues of 3 lobuli, in centre is

portobilium

3 Ways of congestion (congestion with necrosis of

hepatocytes)

4 Biliary duct

5 Branch of a. hepatica

4

5

Page 7: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Acute stage of

viral hepatitis

Page 8: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Viral hepatitis

subacute fatal

Page 9: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Chronic viral

hepatis

Page 10: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Liver – chronic viral hepatis

1

2

3 1 Portobiliar space with chronic inflammatory infiltrate

2 „piece-meal necroses“

3 Central part of lobulus with mixed steatosis

Page 11: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Liver – chronic viral hepatis

1

2

1 Chronic inflammatory

infiltrate in portobiliar space

2 Biliary duct

Page 12: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Chronic viral hepatis, active

1

2

2

1 Necrosis of hepatocytes with

accumulation of lymphocytes

2 Steatosis

3 Swelling of hepatocytes

3

Page 13: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Massive necrosis (hepatodystrophy, yellow atrophy)

1

2

3

4

1 Biliary duct

2 Artery

3 Vena

4 Parenchyma

Page 14: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Massive necrosis (hepatodystrophy, yellow atrophy)

1

2

3

1 Hepatocyt with eosinophilic

cytoplasm and partly defunct nucleus

2 Hepatocyt with degradated nucleus

and eosinophilic cytoplasm

3 Lipofuscin

4 Completely defunct hepatocytes

4

Page 15: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Acute hepatodystrophy

Page 16: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cirrhosis hepatis

Page 17: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cirrhosis hepatis

Page 18: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cirrhosis hepatis

Page 19: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cavernous haemangioma – liver

kopie

Page 20: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cavernous haemangioma

Page 21: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cavernous haemangioma

1 Vascular spaces

2 Flat endothelial cells

3 Fibrous septum

1

1

3 2

2

Page 22: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cavernous haemangioma Angiosarcoma

Mitosis

copy

Page 23: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Primary liver

carcinoma

Page 24: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Hepatocellular carcinoma

Page 25: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Hepatocellular carcinoma

Page 26: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Hepatocellular carcinoma

Page 27: PATHOLOGY OF THE LIVERustavpatologie.upol.cz/_data/section-1/174.pdf · Congestion of the liver (hepar moschatum), detail 1 3 2 3 1 Portobilium- dilatated branch of v. portae 2 Pseudolobulus

Cholangiocarcinoma of the liver