Patricia Silveyra, Ph.D. Curriculum Vitae Page 1...2015/07/29 · Patricia Silveyra, Ph.D. Curriculum Vitae Page 2 ONGOING RESEARCH SUPPORT Center for Research on Women and Newborn

Patricia Silveyra, Ph.D. Curriculum Vitae Page 1

Patricia Silveyra, M.Sc., Ph.D. Assistant Professor of Pediatrics, and Biochemistry and Molecular Biology

The Pennsylvania State University College of Medicine CONTACT INFORMATION

Office Address: 500 University Drive, MC H085. Hershey, PA, 17033 Office Phone: (717) 531-0003 ext. 285487 Email: [email protected] Web: https://profiles.psu.edu/profiles/display/112384

https://www.linkedin.com/in/patriciasilveyra

PERSONAL INFORMATION

Date of Birth: January 20, 1981 Place of Birth: Buenos Aires, Argentina Citizenship: Argentina (U.S. Permanent Resident since 10/22/2012)

EDUCATION

1999-2002, B.S., M.Sc. Licenciada en Ciencias Biológicas. University of Buenos Aires, Argentina

Magna cum laude U.S. Equivalence: Bachelor of Science degree with a major in Biological Sciences plus a Master of Science degree in Biological Sciences

2003-2009, Ph.D. Doctora en Ciencias Químicas. University of Buenos Aires, Argentina. Summa cum laude U.S. Equivalence: Doctor of Philosophy degree in Biological Chemistry

(diploma issued on July 24, 2009) Thesis Advisor: Dr. Carlos Libertun Thesis dissertation: “Orexins and Orexin Receptors in the Neuroendocrine Integration of Appetite and Reproduction” (defense date: Dec 28, 2007)

2008-2011, postdoc Postdoctoral Research Fellow (Pulmonary Molecular Biology)

Center for Host Defense, Inflammation and Lung Disease (CHILD) Research, Department of Pediatrics, Penn State College of Medicine Postdoctoral Advisor: Dr. Joanna Floros Project: Regulation of expression of variants of the human SP-A genes

2015 - ongoing Graduate Certificate in Applied Bioinformatics Pennsylvania State University World Campus Expected graduation date: July 2016

CURRENT POSITION

Assistant Professor of Pediatrics and Biochemistry and Molecular Biology. In this role, I conduct research on the molecular mechanisms of development and resolution of inflammatory lung disease. My laboratory uses a combination of molecular biology, immunology, and endocrinology approaches to study hormonal regulation of gene expression networks in response to environmental insults. I also lead an interdisciplinary research project focused on the identification of microRNA biomarkers for pediatric inflammatory lung disease.


ONGOING RESEARCH SUPPORT Center for Research on Women and Newborn Health (R Siddaiah, PI) 01/01/2015-12/31/2015 “Role of inflammatory biomarkers in the development of pulmonary hypertension in extremely low birth weight premature infants” The goal of this study is to identify proteomic biomarkers for early detection of pulmonary hypertension. Role: Co-investigator Oklahoma Clinical and Translational Science Institute (F Bhatti, PI) 07/01/2014-12/31/2015 “The Clinical Impact of Allelic Variants of Surfactant Protein-A in Neonates with Proliferative Retinopathy” The goal of this project is to study the role of genetic variation in surfactant proteins A and D in neonatal proliferative retinopathy. Role: Collaborator COMPLETED RESEARCH SUPPORT Penn State BIRCWH K12 (C. Weisman, PI) 01/01/2013-06/30/2015 Career Development Program in Women’s Health Research at Penn State “Gender differences in lung disease susceptibility in response to oxidative stress: role of miRNAs” The goal of this project was to determine whether sex-differences in lung miRNA expression play a role in the susceptibility to lung disease in response to oxidative stress. Role: Research Scholar Junior Faculty Development Program Project Support 06/01/2014-05/31/2015 “Identification of miRNA biomarkers for pediatric inflammatory lung disease” The goal of this study was to characterize the microRNome of tracheal aspirates from pediatric patients with chronic inflammatory lung disease. Role: PI Center for Research on Women and Newborn Health 12/01/2013-11/30/2014 “Identification of novel non-invasive biomarkers for bronchopulmonary dysplasia in prematurely born infants” The goal of this study was to identify new non-invasive biomarkers for early detection of bronchopulmonary dysplasia in tracheal aspirates of neonatal patients. Role: PI Children’s Miracle Network 07/01/2012-06/30/2013 “MiRNAs in the differential regulation of translation of human Surfactant Protein A gene variants” The goal of this study was to determine the effects of specific miRNAs in the expression of reporter genes controlled by SP-A 3’UTRs. Role: PI SDE/GWIS Adele Lewis Grant Fellowship (highest scoring nationwide) 07/01/2012-06/30/2013 “Role of miRNAs in the differential translation of Surfactant Protein A gene variants” The goal of this project was to determine the effects on SP-A levels in cellular models expressing different SP-A variants, after over-expression of specific miRNAs. Role: PI Children’s Miracle Network 07/01/2013-06/30/2014 “Characterization of the miRNA profile in tracheal aspirates and BAL from Pediatric Patients with Inflammatory Lung Disease” The goal of this study was evaluate miRNA profiles in lung secretions from pediatric patients with inflammatory lung disease. Role: PI


PENDING SUPPORT

NIH Research Project Grant (Parent R01) (Z. Chroneos, PI) (PA-13-302) “Regulation of the lung antiviral inflammatory response” This project is focused on the study of the role of SP-R210L in influenza virus entry and resolution of inflammation through coordination of ATF3 activation and clearance of apoptotic cells. Role: Co-PI (20% effort, 10% credit)

NIH Exploratory/Developmental Research Grant (Parent R21) (PA-13-303) “Mechanisms of gender disparity in ozone induced pulmonary inflammation" The goal of this study is to investigate the role of ATF3 and female sex hormones in the inflammatory response to a major air pollutant. Role: PI (25% effort, 50% credit)

Department of Defense PRMRP Investigator-Initiated Research Award “Hormonal control of acute lung injury triggered by environmental exposures” The goal of this project is to elucidate the mechanisms by which male and female sex hormones modulate lung inflammation and injury in response to air pollution. Role: PI

AWARDS AND HONORS

• 2015 Gordon Research Conference “Lung Development, Injury and Repair” Travel Award • NHLBI Programs to Increase Diversity in Health-Related Research (PRIDE). Selected as a

scholar for the “Functional and Applied Genomics of Blood Disorders” 2015-2017 cohort. • 2015 NIDDK Network of Minority Health Research Investigators (NMRI) Conference Travel

Award • 2014 Society for the Advancement of Chicanos/Hispanics and Native Americans in Science

(SACNAS) Conference Travel Award • 2014 FASEB/MARC Travel Award to attend the American Physiological Society (APS)

Professional Skills Training Course • 2014 Penn State Commission for Women “Achieving Women Award” in the Faculty category • 2014 Paul Harris Fellow Award, The Rotary Foundation, Rotary International • 2013-2014 Junior Faculty Development Program Research Award • 2013 Carl Storm Underrepresented Minority Fellowship to attend the Gordon Research

Conference on “Lung Development, Injury and Repair” • 2012 SDE/GWIS Adele Lewis Grant Fellowship Award (highest scoring nationwide) • 2012 American Thoracic Society Minority Trainee Travel Award • 2011 Bond and Bradley Outstanding Postdoctoral Award • 2009 American Society for Cell Biology Postdoctoral Travel Award • 2008-2009 The Rotary Foundation Academic-Year Ambassadorial Scholarship • 2007 Summa cum laude Doctoral Thesis dissertation • 2007 Argentinean Physiological Society Student Travel Award • 2004-2006 Argentinean Society for Clinical Investigation Travel Award (awarded 3

consecutive years) • 2004 Argentinean National Research Council Ph.D. scholarship • 2003 Argentinean Agency for the Promotion of Science and Technology Ph.D. scholarship


PROFESSIONAL EXPERIENCE 2013- Assistant Professor of Pediatrics and Biochemistry and Molecular Biology.

Penn State College of Medicine. In this capacity, I am responsible for writing grants and research manuscripts, and to guide and mentor postdocs, clinical fellows and students in the lab. I am fully responsible for two research technicians, and four undergraduate students.

2011-2012 Research Associate. Department of Pediatrics. Penn State College of Medicine. In this role, I served as a teacher, preceptor, and mentor for postdocs, fellows, and students, and I was fully responsible for one research technician, and for the administration of two research budgets.

2008-2011 Postdoctoral Research Fellow (Pulmonary Molecular Biology). Department of Pediatrics, Penn State College of Medicine. Advisor: Joanna Floros, PhD. My postdoctoral project was focused on the role of mRNA untranslated regions in the regulation of expression of Surfactant Protein A gene variants. I was responsible for mentoring and training students and postdocs and I collaborated in the experimental design, data analysis, and manuscript writing with all members of the lab.

2008 Visiting Research Faculty (3 months). Department of Medicine. Penn State Hershey Medical Center, Hershey, PA. Advisor: Claudia Gragnoli, MD, PhD. In this role, I performed research on the role of human orexin genes in the molecular genetics of obesity and type 2 diabetes.

2003-2007 Graduate Student (PhD candidate). Neuroendocrinology Laboratory, Institute of Biology and Experimental Medicine, Argentina. Advisor: Carlos Libertun, MD, PhD. My project entitled “Neuroendocrine control of energy balance and its relationship with the reproductive axis: orexins and other neuropeptides”, involved a combination of endocrinology and molecular biology techniques to study the role of orexins and their receptors in the control of appetite and reproduction.

2002-2003 Student intern. Leloir Research Institute, Argentina. Advisor: Dr. Roberto Staneloni. Project: Regulation of gene expression by light exposure in plants. My role in this project was to identify regulatory regions in the promoters of 4neumonia4s genes that were transcriptionally regulated by phytocrome A.

2001-2002 Student intern. Carbohydrate Research Center. Exact and Natural Sciences College, University of Buenos Aires, Argentina. Advisor: Dr. R. M. de Lederkremer. Project: Influence of exo-β-D-galactofuranosidase inhibitors in cultures of P. fellutanum. I contributed to this project by applying biotechnology techniques to purify fungal enzymes to be used for functional assays of synthetic inhibitors.

2001 Summer intern. Federal Police Department Chemistry Laboratory, Argentina. Under the guidance of Dr. Ricardo Padula, PhD, I performed routine Forensic Research lab techniques including PCR, capillary electrophoresis, and STR analysis.

TEACHING EXPERIENCE 2015 Teaching Assistant. “Foundations in Biomedical Research” (BMS 597A) summer

graduate course. Penn State College of Medicine. Hershey, PA. 2015 Instructor. “Review Skills and Biotechniques Bootcamp”. Penn State College of

Medicine. Hershey, PA. I was in charge of the development and teaching of this two-day session for incoming summer undergraduate students.

2015 Lecturer. “Preventing Impostor syndrome and Stereotype Threat”. Offered to Summer Undergraduate Students. Penn State College of Medicine. Hershey, PA.

2015 Invited faculty. Penn State Hershey Junior Faculty Development Program session on “Impact of Unconscious Bias and Micro-aggressions on the workplace”, March 6th


2014 Lecturer. “Integrative Physiology” (BMS 520) graduate course. I delivered five lectures on the Respiratory block: Lung Volume & Ventilation, Gas Transport, Acid/Base, Mechanics, Control of Breathing, and a clinical case.

2014 Teaching Assistant. “Foundations in Biomedical Research” (BMS 597A) summer graduate course. Penn State College of Medicine. Hershey, PA. I facilitated problem-based-learning sessions on scientific papers, and I mentored students in the preparation of journal club presentations.

2014 Instructor. “Summer Bootcamp: Introduction to Laboratory Techniques”. Penn State College of Medicine. Hershey, PA. I was in charge of the development and teaching of this one-week course for incoming summer undergraduates. This program was sponsored by the NIH/NHLBI INTREPID program (Introduction to a Novel Tiered Research Experience Promoting Inclusion and Diversity).

2013 Teaching Assistant. “Introduction to common Laboratory Practices”. Penn State College of Medicine. Hershey, PA. I assisted in this training session of basic laboratory techniques and calculations offered to incoming undergraduate students of the INTREPID and STEP-UP programs (sponsored by NIH).

2013-2015 Facilitator. Problem Based Learning, Penn State College of Medicine. I facilitated sessions in the following courses: Cellular and Molecular Basis of Medical Practice, Biological Basis of Disease, Endocrinology, Scientific Principles of Medicine, Pulmonary Medicine, Pediatric Hypertension.

2007 Lecturer. “Physiology or Reproduction” graduate course. Institute of Biology and Experimental Medicine (IBYME-CONICET), Buenos Aires, Argentina.

2007-2008 Tutor. Biology, Anatomy and Physiology, and Biochemistry online courses. Smarthinking.com. I provided online tutoring to American students.

2005-2006 Lecturer. “Forensic Research” graduate course. Argentinean Police Academy University, Buenos Aires, Argentina.

2005-2006 Lecturer. “General Chemistry” undergraduate course. Argentinean Police Academy University, Buenos Aires, Argentina.

2004-2005 Lecturer. “DNA in Forensic Sciences” graduate course. Argentinean Police Academy University, Buenos Aires, Argentina.

2006-2007 Teaching Assistant. “Molecular Physiology” undergraduate course. Department of Biological Chemistry. University of Buenos Aires, Argentina. In this position, I was charge of seminars and small group discussion sessions.

2003-2006 Teaching Assistant. “Biochemistry” undergraduate course. Department of Biological Chemistry. University of Buenos Aires, Argentina. In this position, I was in charge of laboratories, seminars and lectures.

1998-2003 Tutor. Biology, Chemistry, Math (high school students). Bulnes Institute. Buenos Aires, Argentina.

MENTORING EXPERIENCE

Undergraduate Students: Robyn Harding (Summer 2015). Sponsored by the NIH/NHLBI INTREPID program (Introduction to a Novel Tiered Research Experience Promoting Inclusion and Diversity). Project: “The Effects of Ovarian Hormones in the Acute Inflammatory Response to Ozone” Ndifrieke Ekpa (Summer 2015). Sponsored by a grant from the Center for Research on Women and Newborn Health (CROWN foundation) Project: “Protein Expression in the Pathogenesis of Bronchopulmonary Dysplasia and Pulmonary Hypertension in Preterm Infants”


Tejas Gowda (Summer 2015). Sponsored by a grant from the Center for Research on Women and Newborn Health (CROWN foundation) Project: “Evaluation of proteomic profiles in tracheal aspirates of pulmonary hypertension preterm neonates using IPA analysis” Naseem Zomorodi (Spring 2015). Sponsored by the Penn State Schreyers Honors College. Project: “Expression of estrogen and progesterone receptors in the mouse lung”. Noe Cabello (Summer 2013 and 2014). Sponsored by the NIH/NHLBI INTREPID program (Introduction to a Novel Tiered Research Experience Promoting Inclusion and Diversity). Project year 1: “Sex differences in the lung inflammatory response to acute ozone exposure”. Project year 2: “Effects of ambient pollution on the female reproductive axis: impact of acute ozone exposure on steroidogenesis and folliculogenesis in cycling female mice.” While working in my lab, he received a travel award to attend the 2014 SACNAS Conference and present his research. Tram Anh (Melody) Pham (Summer 2014). Sponsored by a grant from the Center for Research on Women and Newborn Health (CROWN foundation). Project: “Identification of miRNA biomarkers for pediatric inflammatory lung disease” While working in my lab, she received the Franklin and Marshall “Hershfield-Rosenthal Award”. Utkarshna Sinha (Summer 2014 and 2015). Project year 1: “ATF3 regulation of interleukin-6 in response to acute ozone exposure”. Sponsored by the University of Waterloo “Summer Undergraduate Experience Award”, and Department of Pediatrics, Penn State College of Medicine. Project year 2: “The Role of the Inflammasome and ATF3 in the Lung Inflammatory Response to Acute Ozone Exposure”. This project was carried out under the Penn State Summer Undergraduate Research Internship Program (SURIP) Her work was selected for oral presentation at the Canadian Undergraduate Conference on Healthcare (CUCOH) Research Competition, and at the Women in Science and Engineering (WISE) at the University of Toronto. She also received the APS “David S. Bruce Outstanding Abstract Award” at the 2015 Experimental Biology meeting. Pryianka Nadar (Summer 2011)

Lautaro Zubeldia-Brenner (assisted in training for 6 months, 2006)

Graduate Students/Visiting Research Fellows:

Gabriela Silveyra (2011-2012) Masters of Science program, Universidad CAECE, Argentina. Project: “Translational regulation of surfactant protein A variants: role of UTRs and mRNA circularization”. Thesis defense: “The role of circularization in the control of translation of SP-A variants” December 26, 2012. Universidad CAECE, Argentina. Summa cum laude Nikolaos Tsotakos (assisted in training, 2012-2013)

Manmeet Raval (assisted in training, 2009-2011)

Barbara Olmeda-Lozano (assisted in training for 4 months, 2008)

Natalia Cataldi (assisted in training for 10 months, 2007)


Postdocs:

Vikas Mishra (December 2013-August 2014) Project: “The role of IL-6 in acute ozone induced inflammation”.

Residents:

Carla Caruso (July 2014-current) Project: “Effects of ambient pollution in female reproductive function”. Her project was highlighted in a press release at the 2015 Experimental Biology meeting.

Fellows:

Christiana Oji-Mmuo (2013-2014). Neonatal/Perinatal Fellow Project: “Characterization of the miRNA profile in tracheal aspirates and BAL from Pediatric Patients with Inflammatory Lung Disease” Melissa Grageda (assisted in training, 2010-2012)

Faizah Bhatti (assisted in training, 2008-2010)

Faryal Durrani (assisted in training, 2008-2010)

High School Students:

Ange Kandolo (summer 2015). Milton Hershey School Spartan Academic Medical Experience.

Shaneeka Emile (summer 2015). Milton Hershey School Spartan Academic Medical Experience.

Vincent Dong (summer 2014). Milton Hershey School Spartan Academic Medical Experience.

Dylan Yates (summer 2014). Milton Hershey School Spartan Academic Medical Experience.

Michael Guo (summer 2011). Hershey High School.

Tammy Lin (summer 2010). Hershey High School.

PUBLICATIONS

Peer-reviewed articles 1- Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos V.

Effect of Androgens on Sexual Differentiation of Pituitary Gamma-Aminobutyric Acid Receptor Subunit GABA (B) Expression. Neuroendocrinology. 2004;80(3):129-42.

2- Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos V. GABAB1 Knock-Out Mice Reveal Alterations In Prolactin Levels, Gonadotropic Axis and Reproductive Function. Neuroendocrinology. 2005;82(5-6):294-305.

3- Silveyra P, Catalano PN, Lux-Lantos V, Libertun C. Impact of the Proestrous Milieu on Expression of Orexin Receptors and Prepro-Orexin in Rat Hypothalamus and Hypophysis. Actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E820-8.


4- Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle. Effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E977-85.

5- Wang G, Guo X, Silveyra P, Kimball S, Floros J. Cap-independent translation of human SP-A 5’-UTR variants; A double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L635-47.

6- Garcia-Tornadu IA, Diaz-Torga GS, Risso G, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, α-MSH and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug;43(4):267-74.

7- Silveyra P, Cataldi N, Lux-Lantos V, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27;158(1-3):121-6.

8- Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3′UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L523-34.

9- Silveyra P, Raval M, Simmons B, DiAngelo S, Wang G, Floros J. The Untranslated Exon B of Human Surfactant Protein A2 (SFTPA2) mRNAs is an Enhancer for Transcription and Translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L795-803.

10- Floros J, Londono D, Gordon D, Silveyra P, DiAngelo S, Viscardi, R Worthen G, Shenberger J, Wang G, Lin Z, Thomas N. IL18R1 and IL18RAP SNPs may associate with Bronchopulmonary Dysplasia in African American infants. Pediatr Res. 2012 Jan;71(1):107-14.

11- Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice and phagocytosis after Klebsiella 8neumonia infection. Exp Lung Res. 2012 May;38(4):165-72.

12- Yang W*, Ni L*, Silveyra P, Singh A, Noutsios G, Wang G, DiAngelo S, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. J Mol Biochem. 2013 Feb 20;2(1):40-55. (*contributed equally)

13- Noutsios GT, Silveyra P, Bhatti, F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L722-35.

14- Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. Journal of Proteomics and Genomics Research 2013, Vol. 1, issue 2, pp2-26.

15- Olmeda B, Umstead TM, Silveyra P, Pascual A, López-Barneo J, Phelps DS, Floros J, Pérez-Gil J. Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response. J Proteomics. 2014 Apr 14;101:179-91.


16- Silveyra P, DiAngelo S, Floros J. An 11-nt sequence polymorphism at the 3’UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol 2014 Jul 1;307(1):L106-19.

17- Silveyra P, Chroneos Z, Thomas N, DiAngelo S, Howrylak, J, Noutsios G, Tsotakos N, Umstead T, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of Surfactant Protein A in culture: a pilot study. Exp Lung Res. 2014 Sep;40(7):354-66.

18- Grageda M*, Silveyra P*, Thomas N, DiAngelo S, Floros J. DNA Methylation Profile and Expression of Surfactant Protein A2 gene in Lung Cancer (*equal contribution). Exp Lung Res. 2014 Dec 16.

19- Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A (SP-A1) splice variants. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L58-75.

20- Yang L, Carrillo M, Wu Y, DiAngelo S, Silveyra P, Umstead TM, Halstead SE, Davis M, Hu S, Floros J, McCormack FX, Chroneos ZC. SP-R210 (Myo18A) variants as intrinsic modulators of macrophage priming and activation. PLoS One. 2015 May 12;10(5):e0126576.

21- Cabello N, Mishra V, Sinha U, DiAngelo S, Silveyra P. Sex differences in the expression of lung inflammatory mediators in response to ozone. Am J Physiol Lung Cell Mol Physiol 2015. In press.

22- Mishra V, DiAngelo S, Silveyra P. IL-6 induced AKT-dependent JAK2/STAT3 activation in ozone-associated lung inflammation during the female estrous cycle. Under revision.

23- Mishra V, Howrylak JA, Cabello N, DiAngelo S, Silveyra P. Sex differences in miRNA-mRNA expression networks in response to acute lung inflammation. Submitted.

Invited Reviews

24- Silveyra P, Cataldi N, Lux-Lantos V, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar;198(3):355-60.

25- Silveyra P, Floros J. Genetic variant associations of human SFTPA1, SFTPA2, and SFTPD with acute and chronic lung injury. Front Biosci (Landmark Ed). 2012 Jan 1;17:407-29.

26- Silveyra P, Floros J. Air Pollution and Epigenetics: Effects on SP-A and Innate Host Defense in the Lung. Swiss Med Wkly. 2012 May 2;142:w13579.

27- Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2013 Dec 1;531(2):126-32.

Books, book chapters, websites, and collaborations

1- Chapter 12: Developmental Lung Disease. In “Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide”. In press.


2- Chapter 10: “Biochemical Forensic Systems for Human Identification”. In “La Escena del Crimen” (The Crime Scene), by Silveyra J. Buenos Aires; La Rocca, 2003. ISBN: 9789875170605.

3- Silveyra J, Silveyra P. Sistemas de Identificación Humana (Human Identification Systems). Buenos Aires; La Rocca (2006). ISBN: 9789875170933.

4- Machado Schiaffino, CA. Diccionario Multilingüe de Criminalística (Multilingual Criminalistics Dictionary). Buenos Aires; La Rocca (2008). ISBN 978-987-517-119-0 (collaboration in writing, with English, Spanish, Portuguese and French term translations).

5- Surfactant protein A1 Wikipedia page : http://en.wikipedia.org/wiki/Sftpa1

6- Surfactant protein A2 Wikipedia page: http://en.wikipedia.org/wiki/SFTPA2

7- Visit the world through the eyes of international women in science: “Science in Argentina”. GWIS Iota Nu News Bulletin. Vol. 1 August 2013, p.10.

Press Releases

http://www.sciencedaily.com/releases/2015/03/150329141015.htm http://www.healthcanal.com/sexual-health/62413-ozone-air-pollution-could-impact-fertility.html http://www.youthhealthmag.com/articles/13024/20150331/ozone-air-pollution-fertility.htm http://www.healthaim.com/fertility-women-affected-ozone-study/19321 http://medicalxpress.com/news/2015-03-ozone-air-pollution-women-fertility.html http://www.universityherald.com/articles/17387/20150329/air-pollution-could-harm-womens-fertility.htm http://news.softpedia.com/news/There-s-Ozone-in-the-Air-We-Breathe-and-It-s-Messing-Us-Up-Study-Warns-477038.shtml http://www.2015technology.com/science/ozone-air-pollution-could-harm-womens-fertility.html http://news.psu.edu/story/353224/2015/04/15/research/ozone-air-pollution-could-impact-fertility?utm_source=newswire&utm_medium=email&utm_term=353325_TEXT&utm_content=04-16-2015-08-36&utm_campaign=hershey%20newswire http://www.biospace.com/News/ozone-air-pollution-could-harm-womens-fertility/370623/source=Featured http://www.onenewspage.com.au/n/Science/754y8rmnf/Ozone-air-pollution-could-harm-women-fertility.htm http://www.sciencenutshell.com/ozone-in-air-could-damage-female-fertility/ http://www.zliving.com/news/science-says-ozone-air-pollution-harm-female-fertility-51969/ http://www.bioportfolio.com/news/article/2278160/Ozone-air-pollution-could-harm-womens-fertility.html http://mountholyokenews.org/2015/04/09/study-suggests-fertility-in-women-affected-by-ozone-air-pollution/ http://www.demanjo.com/news/science/1001874/ozone-air-pollution-could-harm-women-s-fertility.html http://www.greenstyle.it/inquinamento-da-ozono-mette-a-rischio-la-fertilita-femminile-144408.html http://www.novemeses.pt/pt/atualidade/poluicao-do-ar-pode-prejudicar-fertilidade-da-mulher http://www.datoanuncios.org/?a=50581 http://azfreepress.com/News--Science-and-Technology&article_id=7250 http://www.fertilitypost.com/2015/04/16/breathing-ozone-air-pollution-could-impact-fertility/

PRESENTATIONS

Scientific Abstracts 1- Sinha U, Harding R, DiAngelo S, Chroneos Z, Silveyra P. The Role of the Inflammasome and

ATF3 in the Lung Inflammatory Response to Acute Ozone Exposure. Penn State Summer Undergraduate Research Symposium, Hershey, PA. July 30, 2015.

2- Gowda T, Siddaiah R, Silveyra P. Evaluation of proteomic profiles in tracheal aspirates of pulmonary hypertension preterm neonates using IPA analysis. Penn State Summer Undergraduate Research Symposium, Hershey, PA. July 30, 2015.


3- Ekpa N, DiAngelo S, Siddaiah R, Silveyra P. Protein Expression in the Pathogenesis of Bronchopulmonary Dysplasia and Pulmonary Hypertension in Preterm Infants. Penn State Summer Undergraduate Research Symposium, Hershey, PA. July 30, 2015.

4- Harding R, DiAngelo S, Sinha U, Silveyra P. The Effects of Ovarian Hormones in the Acute Inflammatory Response to Ozone. Penn State Summer Undergraduate Research Symposium, Hershey, PA. July 30, 2015.

5- Pham M, Oji-Mmuo C, DiAngelo S, Spear D, Group K, Thomas N, Silveyra P. Identification of miRNA Biomarkers for Pediatric Bronchopulmonary Dysplasia. The 94th Annual National GWIS Conference. State College, PA. June 20th, 2015. Poster #103

6- Sinha U, Mishra V, DiAngelo S, Chroneos Z, Silveyra P. Mechanisms of interleukin-6 regulation in response to acute ozone exposure. The 94th Annual National GWIS Conference. State College, PA. June 20th, 2015. Poster #101

7- Siddaiah R, Graff G, Stanley B, Silveyra P. Role of inflammatory biomarkers in the development of pulmonary hypertension in extremely low birth weight premature infants. American Thoracic Society Annual Meeting. Denver, CO. May 15-20, 2015. Am J Respir Crit Care Med 191;2015:A4748

8- Howrylak J, Pham M, Oji-Mmuo C, DiAngelo S, Spear D, Group K, Siddaiah R, Thomas N, Silveyra P. Expression profiling of miRNAs in pediatric bronchopulmonary dysplasia. American Thoracic Society Annual Meeting. Denver, CO. May 15-20, 2015. Am J Respir Crit Care Med 191;2015:A3480

9- Oji-Mmuo C, Howrylak JA, Siddaiah R, Spear D, DiAngelo S, Group K, Thomas N, Silveyra P. MicroRNA expression signatures as non-invasive biomarkers for pediatric Bronchopulmonary Dysplasia. Pediatrics Academic Society Meeting. San Diego, CA. April 25-28, 2015. E-PAS2015:1599.738

10- Caruso C, Cabello N, DiAngelo S, Silveyra P. Exposure to ambient ozone affects circulating progesterone levels and ovulation in mice. Eight Annual Departments of Medicine and Pathology Research Day. Hershey, PA, May 8, 2015. Abstract # 5. Top presentation award.

11- Silveyra P, Sinha U, Mishra V, DiAngelo S, Chroneos Z. Mechanisms of interleukin-6 regulation in response to acute ozone exposure. Keystone Symposium on “Mechanisms of Pro-Inflammatory Diseases (Z4)”. Olympic Valley, CA, April 19-24, 2015. Abstract # Z4 3014.

12- Silveyra P, Cabello N, Mishra V, DiAngelo S. Sex differences in the expression of lung inflammatory mediators in response to acute ozone exposure. 13th workshop of the NIH Network of Minority Health Research Investigators. Bethesda, MD, April 15-17, 2015.

13- Caruso C, Cabello N, DiAngelo S, Silveyra P. Exposure to ambient ozone affects progesterone levels and ovulation in mice. Experimental Biology Meeting. Boston, MA. March 28 – April 1, 2015. Abstract #2825. FASEB J. 29: 612.4

14- Sinha U, Mishra V, Cabello N, DiAngelo S, Chroneos Z, Silveyra P. ATF3 Regulation of IL-6 in Response to Acute Ozone Exposure. Experimental Biology Meeting. Boston, MA. March 28 – April 1, 2015. Abstract #1272. FASEB J. 29: 863.2. David S. Bruce Outstanding Undergraduate Abstract Award.

15- Silveyra P, Cabello N, Floros J. Sex Differences in the Lung Inflammatory Response to Acute Ozone Exposure. Experimental Biology Meeting. Boston, MA. March 28 – April 1, 2015. Abstract #1262. FASEB J. 29: 863.1

16- Sinha U, Mishra V, Cabello N, DiAngelo S, Chroneos Z, Silveyra P. ATF3 Regulation of IL-6 in Response to Acute Ozone Exposure. Canadian Women in Science and Engineering Conference. University of Toronto, Toronto, ON, Canada. March 21, 2015.

17- Sinha U, Mishra V, Cabello N, DiAngelo S, Chroneos Z, Silveyra P. ATF3 Regulation of IL-6 in Response to Acute Ozone Exposure. Canadian Undergraduate Conference on Healthcare (CUCOH) Research Competition, November 14-16, 2014. Queen’s University, Kingston, ON, Canada. Selected for oral presentation.


18- Silveyra P, Mishra V, DiAngelo S, Floros J. Sex differences in the mouse lung inflammatory miRNA profile in response to ozone inhalation. 11th Annual Interdisciplinary Women's Health Research Symposium of the NIH Office of Research on Women's Health. Bethesda, MD. November 6, 2014. Journal Of Womens Health 23 (10), 869-870

19- Pham M, Oji-Mmuo C, DiAngelo S, Spear D, Group K, Thomas N, Silveyra P. MicroRNA expression signatures as non-invasive biomarkers for pediatric Bronchopulmonary Dysplasia. MiRNA World Conference. Boston, MA. October 29-30, 2014.

20- Cabello N, Silveyra P. Investigating the Effects of Acute Ozone Exposure in Female Reproductive Function. SACNAS conference. Los Angeles, CA. October 16-18, 2014. Poster# SAT-342

21- Cabello N, DiAngelo S, Mishra V, Caruso C, Silveyra P. Effects of Acute Ozone Exposure in Female Reproductive Function. Penn State College of Medicine Department of Biochemistry and Molecular Biology, 3rd Annual Departmental Retreat. Hershey, PA. September 19 2014. Abstract book, Poster #22.

22- Pham M, Oji-Mmuo C, DiAngelo S, Spear D, Group K, Thomas N, Silveyra P. Identification of miRNA Biomarkers for Pediatric Bronchopulmonary Dysplasia. Penn State Summer Undergraduate Research Symposium. University Conference Center, Hershey, PA. July 31, 2014.

23- Cabello N, DiAngelo S, Mishra V, Caruso C, Silveyra P. Investigating the Effects of Acute Ozone Exposure in Female Reproductive Function. Penn State Summer Undergraduate Research Symposium. University Conference Center, Hershey, PA. July 31, 2014.

24- Sinha U, Mishra V, Cabello N, DiAngelo S, Chroneos Z, Silveyra P. ATF3 Regulation of IL-6 in Response to Acute Ozone Exposure. Penn State Summer Undergraduate Research Symposium. University Conference Center, Hershey, PA. July 31, 2014.

25- Mishra V, DiAngelo S, Floros J, Silveyra P. Sex differences in the lung inflammatory microRNA profile in a mouse model of ozone-induced oxidative stress. Pediatrics Research Day. Hershey Lodge. Hershey, PA, May 22, 2014. Abstract book, p60.

26- Silveyra P, Oji-Mmuo C, DiAngelo S, Howrylak J, Ishmael F, Thomas N. Identification of microRNA Biomarkers for Pediatric Bronchopulmonary Dysplasia. Pediatrics Research Day. Hershey Lodge. Hershey, PA, May 22, 2014. Abstract book, p.96.

27- Silveyra P, DiAngelo S, Floros J. Sequence polymorphisms at the 3’UTR of human Surfactant Protein A gene variants differentially affect gene expression levels and miRNA regulation in vitro. Pediatrics Research Day. Hershey Lodge. Hershey, PA, May 22, 2014. Abstract book, p.97. Selected for oral presentation.

28- Tsotakos N, Silveyra P, Lin Z, Thomas N, Vaid M, Floros J. Regulation of translation by upstream translation initiation codons of surfactant protein A1 (SP-A1) splice variants. Pediatrics Research Day. Hershey Lodge. Hershey, PA, May 22, 2014. Abstract book p.104.

29- Silveyra P, DiAngelo S, Floros J. Sex differences in the lung inflammatory response to acute ozone exposure. Inaugural Women’s Health Research Day. Hershey, PA. April 8, 2014. Selected for oral presentation.

30- Oji-Mmuo C, DiAngelo S, Howrylak J, Ishmael F, Thomas N, Silveyra P. MiRNAs as biomarkers for pediatric bronchopulmonary dysplasia. 10th Annual MicroRNA: Targets & Tools for Therapeutic Development conference. Cambridge, MA. March 17-18, 2014. Abstract book, p.10, #21.

31- Mishra V, DiAngelo S, Floros J, Silveyra P. Sex differences in the lung inflammatory microRNA profile in a mouse model of ozone-induced oxidative stress. 12th annual Data and Dine. Penn State College of Medicine, Hershey, PA. February 25, 2014.

32- Silveyra P, Cabello N, DiAngelo S, Floros J. Differential STAT3 signaling mediates sex differences in ozone-induced lung inflammatory response. Annual Meeting of the American Society for Cell Biology. New Orleans, LA. December 14-18, 2013. Mol. Biol. Cell. 2013 24:24 3775. Abstract 1542.


33- Silveyra P, DiAngelo, Cabello N, Howrylak J, Floros J. Sex differences in lung gene expression in response to ozone exposure: role of microRNAs. BIRCWH (Building Interdisciplinary Research Careers in Women’s Health) conference. Tenth Anniversary Interdisciplinary Women’s Health Research Symposium. National Institutes of Health. Bethesda, MD. October 23-25, 2013. Journal of Women’s Health Vol 22, Number 10, p.898, abstract p-64.

34- Silveyra P, Cabello N, Howrylak J, DiAngelo S, Floros J. Sex differences in the lung inflammatory response to ozone-induced oxidative stress: implications for miRNA regulation. Gordon Research Seminar and Conference on Lung Development, Injury and Repair. Proctor Academy, Andover, NH. August 17-23, 2013.

35- Cabello N, DiAngelo, Floros J, Silveyra P. Sex Differences in the Lung Inflammatory Response to Acute Ozone Exposure. Penn State Summer Undergraduate Research Symposium. University Conference Center, Hershey, PA. August 1, 2013.

36- Silveyra P, Chroneos Z, Thomas N, Howrylak J, DiAngelo S, Floros J. Regulation of human alveolar epithelial type II cell differentiation in vitro: role of miRNAs. 32nd Summer Symposium in Molecular Biology “Sensing and Signaling across the Mucosa: From Homeostasis to Pathogenesis”. Penn State University. University Park, PA. June 4-6, 2013. Abstract book, p.85, abstract #20.

37- Silveyra P, Chroneos Z, Thomas N, DiAngelo S, Noutsios G, Tsotakos N, Umstead T, Floros J. Knock-down of Drosha in human alveolar type 2 cells: a physiologically relevant model to study miRNA regulation of SP-A expression. 2013 ATS international meeting, May 17-23 2013 Philadelphia, PA. Am J Respir Crit Care Med 187;2013:A3433

38- Tsotakos N, Silveyra P, Floros J. Upstream start codons (uAUGs) of Surfactant Protein A1 (SP-A1) splice variants are associated with reduced translational activity. 2013 ATS international meeting, May 17-23 2013 Philadelphia, PA. Am J Respir Crit Care Med 187;2013:A4808

39- DiAngelo S, Floros J, Silveyra P. Sequence variability at miRNA targets of the 3'UTR of pulmonary surfactant protein A (SP-A) gene variants affects reporter gene expression in vitro. 9th Annual MicroRNA: Targets & Tools for Therapeutic Development conference. March 4-5, 2013, Cambridge, MA. Abstract book, p.13, abstract #25.

40- Silveyra P, Floros J. Air Pollution and Epigenetics: Effects on SP-A and Innate Host Defense in the Lung. All-Russian Conference with International Participation. Saratov State Medical University, Saratov, Russia, Nov.23, 2012.

41- Noutsios G, Silveyra P, Floros J. Exon B of human surfactant protein A2 mRNA alone or within the context of the surrounding sequences binds 14-3-3 protein family, a trans-acting factor, which may affect translation and account for individual susceptibilities to environmental cues. All-Russian Conference with International Participation. Saratov State Medical University, Saratov, Russia, Nov.23, 2012.

42- Silveyra P, DiAngelo S, Floros J. MicroRNAs mir-183 and mir-449b regulate the expression of human Surfactant Protein A gene variants in vitro. FASEB Summer Research Conference “The Lung Epithelium in Health and Disease” Saxton Rivers, Vermont. July 22-27, 2012

43- Tsotakos N, Silveyra P, Floros J. Upstream start codons (uAUGs) of the SP-A1 gene are associated with reduced activity of a reporter gene. FASEB Summer Research Conference “The Lung Epithelium in Health and Disease” Saxton Rivers, Vermont. July 22-27, 2012

44- Noutsios G, Silveyra P, Floros J. Exon B of human surfactant protein A2 mRNA alone or within the context of the surrounding sequences binds 14-3-3 protein family, a trans-acting factor, which may affect translation. FASEB Summer Research Conference “The Lung Epithelium in Health and Disease” Saxton Rivers, Vermont. July 22-27, 2012

45- Silveyra P, DiAngelo S, Floros J. Knockdown of specific miRNA processing enzymes affects Surfactant Protein A mRNA and protein levels in vitro. ATS international meeting, May 18-23 2012, San Francisco, CA, USA. Am J Respir Crit Care Med 185;2012:A1983

46- Noutsios G, Silveyra P, Floros J. Exon B of human Surfactant Protein A2 mRNA alone or within the context of the surrounding sequences binds trans-acting factors that may affect translation.


ATS international meeting, San Francisco, CA, USA, May 18-23, 2012. Am J Respir Crit Care Med 185;2012:A1996

47- Grageda M, Silveyra P, Thomas N, Mu D, Floros J. Surfactant Protein A2 (SP-A2) Gene As A Potential DNA Methylation Marker In Lung Cancer. ATS international meeting, San Francisco, CA, USA, May 18-23, 2012. Am J Respir Crit Care Med 185;2012:A3478

48- Silveyra P, DiAngelo S, Floros J. Knockdown of specific miRNA processing enzymes affects Surfactant Protein A mRNA and protein levels in vitro. Penn State College of Medicine Pediatrics Research Day, April 5th 2012. Hershey, PA.

49- Noutsios G, Silveyra P, Floros J. Exon B of human Surfactant Protein A2 mRNA alone or within the context of the surrounding sequences binds trans-acting factors that may affect translation. Penn State College of Medicine Pediatrics Research Day, April 5th 2012. Hershey, PA.

50- Crowder R, Silveyra P, Leone M, Hu J, Ouyang A. Using Postdoc Feedback to Develop a Postdoc Professional Development Workshop Series. The 10th Annual Meeting of the National Postdoctoral Association. March 16-18 2012. San Francisco,CA.

51- Grageda M, Silveyra P, Thomas N, Mu D, Floros J. Surfactant Protein A2 (SP-A2) gene as a potential DNA methylation marker in lung cancer. 4th Annual Resident/Fellow Research Day. Penn State College of Medicine. March 9th 2012. Abstract book, p.8. Top presentation award.

52- DiAngelo S, Floros J, Silveyra P. Downregulation of miRNA biogenesis enzymes affects the in vitro expression of human Surfactant Protein A gene variants. 8th Annual microRNA in Human Disease and Development. March 12-13, 2012, Cambridge, MA. Abstract book, p.7, #17.

53- Silveyra P, DiAngelo S, Floros J. Knockdown of specific miRNA processing enzymes affects Surfactant Protein A mRNA and protein levels in vitro. 10th annual Data and Dine. Penn State College of Medicine, Hershey, PA; Feb 21, 2012

54- Noutsios G, Silveyra P, Floros J. Exon B of human Surfactant Protein A2 mRNA alone or within the context of the surrounding sequences binds trans-acting factors that may affect translation. 10th annual Data and Dine. Penn State College of Medicine, Hershey, PA; Feb 21, 2012

55- Noutsios G, Silveyra P, Floros J. Exon B of human Surfactant Protein A2 mRNA alone or within the context of the surrounding sequences binds trans-acting factors that may affect translation. Hellenic Bioscientific Assoc. Conference, Columbia University, New York, NY; Oct 15-16, 2011

56- Bhatti F, Silveyra P, Floros J. Protein binding at 5’UTR mRNA in surfactant protein A splice variants. 23rd annual meeting of the Eastern Society for Pediatric Research (Philadelphia, PA, March 25-27, 2011), Abstract book, p.15, abstract 204.

57- Silveyra P, Wang G, Floros J. Analysis of the 3’ untranslated regions (UTR) of hSP-A1 variants: impact of sequence elements on differential expression, secondary structure and microRNA binding. European Respiratory Society (ERS) meeting (Barcelona, Spain; Sep 19-22, 2010), Abstract book, p.780s (P4300).

58- Silveyra P, Wang G, Floros J. Analysis of the 3’ untranslated regions (UTR) of hSP-A1 variants: impact of sequence elements on differential expression, secondary structure and microRNA binding. Penn State Pediatrics Research Day, Hershey, PA; Sep 8, 2010, Abstract book, p.72.

59- Silveyra P, Wang G, Floros J. Analysis of the 3’ untranslated regions (UTR) of hSP-A1 variants: impact of sequence elements on differential expression, secondary structure and microRNA binding. 9th annual Data and Dine. Penn State College of Medicine, Hershey, PA; Nov 9, 2010

60- Silveyra P, Raval M, Simmons B, Wang G, Floros J. Study of gene expression control elements of the human surfactant protein A (hSP-A) genes: role of exon B of the 5’ untranslated region (5’UTR). Penn State Pediatrics Research Day (Hershey, PA; Sep 8, 2010), Abstract book, p.73

61- Raval M, Silveyra P, Simmons B, DiAngelo S, Wang G, Floros J. Identification and analysis of regulatory regions within the human SP-A 5’UTR exon B. Penn State Pediatrics Research Day (Hershey, PA; Sep 8, 2010), Abstract book, p.62

62- Silveyra P, Wang G, Floros J. Human SP-A1 (SPTPA1) variant-specific 3’UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. The second International


Conference in Lung Innate Immunity and Pulmonology (i-CLIIP). The Louisiana State University, New Orleans. USA. May 15, 2010. Abstract book, p.8 (S2, #3)

63- Silveyra P, Simmons B, Raval M, Wang G, Floros J. Study of gene expression control elements of the human SP-A genes: role of the 5’UTR exon B. ERS annual meeting (Barcelona, Spain; Sep 19-22, 2010), Abstract book, p.780s (P4301).

64- Silveyra P, Simmons B, Raval M, Wang G, Floros J. Study of gene expression control elements of the human SP-A genes: role of the 5’UTR exon B. i-CLIIP 2010. Abstract book, p.12 (S3, #5)

65- Silveyra P, Raval M, Simmons B, Wang G, Floros J. Analysis of the human SP-A 5’UTR exon B: identification of regulatory regions. ERS annual meeting (Barcelona, Spain; Sep 19-22, 2010), Abstract book, p.780s (P4302).

66- Silveyra P, Wang G, Floros J. Impact of untranslated regions (UTRs) on differential translation among SftpA1 and SftpA2 gene variants. Experimental Biology annual meeting, Anaheim,CA; Apr 24-28, 2010. FASEB J. 24: 612.27

67- Silveyra P, Wang G, Floros J. Role of the 5’UTR and 3’UTR variants of SftpA1 and SftpA2 genes in the regulation of translation. 49th Annual meeting of the American Society for Cell Biology. San Diego, CA; Dec 5-9, 2009. Abstract book, p.133 (#2068)

68- Silveyra P, Wang G, Floros J. Translational control of Surfactant Protein A: participation of polyA tail and 5’ and 3’ Untranslated Regions (UTRs). 8th annual Data and Dine. Penn State College of Medicine, Hershey, PA; Oct. 20, 2009

69- Wang G, Guo X, Silveyra P, Kimball S, Floros J. Cap-independent translation of human SP-A 5'-UTR variants; a double-loop structure and cis element contribution. European Respiratory Society Annual Congress. Vienna, Austria. Abstract book, p.845s (E4763), 2009

70- Floros J, Londono D, Gordon D, DiAngelo S, Wang G, Silveyra P, Lin Z, Singh A, Shenberger J, Thomas N. Genetic variations in IL18R1 and IL18RAP associate with the development of bronchopulmonary dysplasia in African American Infants. Annual Meeting of the Pediatric Academic Societies (PAS). Baltimore, MD. May 2-5, 2009

71- Olmeda B, Umstead T, Silveyra P, Pascual A, López-Barneo J, Phelps D, Floros J, Pérez-Gil J. Changes in gene expression and lung tissue and bronchoalveolar lavage proteomic profiles in a rat model of chronic hypoxia. 18th IFCC European Congress of Clinical Chemistry & Laboratory Medicine, Congress of the Austrian Society of Laboratory Medicine and Clinical Chemistry, 2009

72- Libertun C, Silveyra P, Cataldi NI, Lux-Lantos V. Role of orexins in the hypothalamic-pituitary-ovarian relationship. International Symposium “10 years of Hypocretins/Orexins. Physiology and Patophysiology” Kastelli Research Centre. University of Oulu, Finland, 2008. Acta Physiol. International Symposium, p.22.

73- Silveyra P, Cataldi NI, Lux-Lantos V, Libertun C. Estradiol Modulates Female Hypothalamic and Pituitary Orexin Receptor 1 Expression in a Daytime Dependent Manner. 90th Meeting of The Endocrine Society. San Francisco, CA, USA. Abstract Book, p1-732 (pp 368-369), 2008

74- Silveyra P, Zubeldia-Brenner L, Lux-Lantos V, Libertun C. Effect of the GnRH analog Buserelin on the orexin receptor OX1 expression in adenohypophyseal and ovarian cultures. Argentine Physiological Society Annual Meeting. Mar del Plata, Argentina. Medicina 67, (III) p.221, 2007

75- Silveyra P; Lux-Lantos V, Libertun C. Both orexin receptors are present in rat ovaries and fluctuate with the estrous cycle; effects of an OX1 receptor antagonist. 89th Annual Meeting of The Endocrine Society. Toronto, Canada. Abstract Book p1-318 (pp 237-238), 2007

76- Silveyra P, Lux-Lantos V, Libertun C. Expression of the hypothalamic, pituitary and ovarian orexin receptors OX1 and OX2 during the estrous cycle. Role of GnRH and gonadotropins. Selected for oral presentation at the LI Meeting of the Argentine Society of Clinical Investigation (SAIC). Mar del Plata, Argentina. Medicina 66 (II), p.51, 2006

77- Libertun C, Silveyra P, Catalano P, Lux-Lantos V. Expression of orexin receptors 1 (OX1) and 2 (OX2) in hypothalamus and adenohypophysis in cycling female and male rats. 6th International Congress of Neuroendocrinology. Pittsburgh, PA, USA. Front. Neuroendoc. 27/1 (2006) 1-168


78- Catalano P, Bonaventura M, Silveyra P, Bettler B, Libertun C, Lux-Lantos, V. Evaluation of hypothalamic-pituitary-gonadal axis in GABAB1 (-/-) female mice: cyclicity and reproductive function. VII Annual Meeting of the Argentinean Society of Biology, 2005

79- Silveyra P, Catalano P, Lux-Lantos V, Libertun C. Differential expression of the orexin receptor 1 (OX1) during the estrous cycle. L SAIC Meeting. Mar del Plata, Argentina. Medicina 65, Supl. II, p 46, N°26, 2005

80- Catalano P, Bonaventura M, Silveyra P, Bettler B, Libertun C, Lux-Lantos V. Endocrine Evaluation of GABAB1 Knock-Out Mice. 87th Annual Meeting of The Endocrine Society. San Diego, CA, USA. Abstract Book P2-175, 2005

81- Silveyra P, Catalano P, Lux-Lantos V, Libertun C. Circadian Variation of Orexin Receptors During Proestrous in the Rat. XLIX Meeting of the SAIC. Mar del Plata, 2004. Medicina 64, Supl. II, p.243.

82- Catalano P, Bonaventura M, Silveyra P, Bettler B, Libertun C, Lux-Lantos V. Endocrine Evaluation of GABAB1 Knock-Out Mice. XLIX SAIC Meeting. Mar del Plata, Argentina. Medicina 64, Supl.II, p.167, 2004

83- Catalano P, Silveyra P, Bianchi M, Lux-Lantos V, Libertun C. Effects of sexual differentiation on hypothalamic aminoacidic neurotransmitters. XLVIII SAIC Meeting, Mar del Plata, Argentina. Medicina 63, (5/2) p.522 (43), 2003

Podium Presentations and Seminars 1- “Gene Expression Regulatory Networks in Acute Lung Inflammation. Research Seminar,

Department of Pediatrics, Penn State College of Medicine, Hershey, PA. March 2015. 2- “Posttranscriptional Regulation of Surfactant Protein A variants”. Research Interest

Seminar, QPS, LLC. Newark, DE. November 2014.

3- “MicroRNAs in Pediatric Inflammatory Lung Disease”. MicroRNA World 2014 Conference, Boston, MA. October 2014.

4- “MiRNAs as non-invasive biomarkers for inflammatory lung disease”. Research Seminar, Department of Pediatrics, Penn State College of Medicine, Hershey, PA. June 2014.

5- “Identification of novel non-invasive biomarkers for bronchopulmonary dysplasia in prematurely born infants”. Heart of Lancaster Hospital, Lititz, PA. June 2014.

6- “Sequence polymorphisms at the 3’UTR of human Surfactant Protein A gene variants differentially affect gene expression levels and miRNA regulation in vitro”. Pediatrics Research Day, Hershey, PA, May 2014.

7- “Identification of miRNA biomarkers for pediatric inflammatory lung disease”. Penn State College of Medicine Junior Faculty Development Program. Hershey, PA, May 2014.

8- “Sex differences in the lung inflammatory response to acute ozone exposure”. Inaugural Women’s Health Research Day. Hershey, PA. April 2014.

9- “MicroRNA and mRNA regulation networks in acute lung inflammation”. Department of Biology, Dickinson College. Carlisle, PA, February 2014.

10- “MicroRNA regulation of Surfactant Protein A variants”. Penn State College of Medicine Department of Biochemistry and Molecular Biology Research Interest Seminar. Hershey, PA, June 2013.

11- “MiRNAs in the translational control of Surfactant Protein A variants”. Pulmonary Medicine Grand Rounds. Department of Medicine. Stanford University, Palo Alto, CA, December 2012.


12- “MicroRNAs mir-183 and mir-449b regulate the expression of human Surfactant Protein A gene variants in vitro”. FASEB Summer Research Conference “The Lung Epithelium in Health and Disease” Saxton Rivers, VT, July 2012.

13- “Surfactant Protein A gene variants: variant-specific elements, regulation of gene expression, and disease susceptibility”. 10th Annual Data and Dine award presentation. Penn State College of Medicine, Hershey, PA, February 2012.

14- “Translational control of gene variants of the Surfactant Protein A: impact of variant-specific elements”. Universidad Complutense de Madrid, Spain, October 2010.

15- “Analysis of the 5’ and 3’ untranslated regions (UTRs) of human SPA genes: impact of variant-specific sequence elements on translation, secondary structure, and miRNAs”. Penn State College of Medicine, Pediatrics Research Day, Hershey, PA, May 2010

16- “Impact of untranslated regions (UTRs) on differential translation among SftpA1 and SftpA2 gene variants”. Respiratory Highlights. Experimental Biology annual meeting, Anaheim, CA, April 2010.

17- “Translational control of gene variants of the innate immunity molecule Surfactant Protein A”. CHILD Research Monthly Conference. Department of Pediatrics, Penn State College of Medicine, Hershey, PA, September 2009.

18- “Orexins and orexin receptors: relationships with the encephalic-pituitary-gonadal axis”. Institute of Biology and Experimental Medicine. Buenos Aires, Argentina, October 2006.

Non-Scientific Presentations 1- “Argentina: Landscapes, culture and traditions”. World Culture Club of Central PA.

Hershey, PA, 2015.

2- “Introducing the Rotary Alumni Association of District 7390”. District 7390 Annual Conference, Harrisburg, PA.

3- “Social Media and Web Resources”. Free workshop offered for the Harrisburg Latino community as part of the EUP professional development seminar series. Temple University Harrisburg. Harrisburg, PA, 2013.

4- “Current Challenges of a Junior Investigator”. Lessons learned walking the path to a successful academic research career”. Penn State College of Medicine Graduate Students Career Day. Hershey, PA, 2013.

5- “My experience as a Rotary International Ambassadorial Scholar”. District 7390 Annual Conference, Rotary Clubs of central PA and training for ambassadorial scholars (Boxborough, MA), 2012.

6- “The Penn State Hershey Postdoctoral Society”. Welcome & Orientation for Postdoctoral Scholars and Fellows. Penn State College of Medicine, 2010-2011.

7- “Argentina Today”. World Culture Club of Central PA. Hershey, PA, 2008.

8- “Tools for teaching Molecular Biology in the High School”. National Conference of Science and Technology. San Rafael, Mendoza. Argentina, 2008.


MEMBERSHIP AND SERVICE IN PROFESSIONAL SOCIETIES Membership

• American Thoracic Society (ATS) • American Physiological Society (APS) • Organization for the Study of Sex Differences (OSSD) • American Society for Cell Biology (ASCB) • Graduate Women in Science (GWIS) • Society for Advancement of Chicanos and Native Americans in Science (SACNAS) • Argentinean Society of Physiology (SAFIS) • Association for Women in Science (AWIS) • Organization for the Advancement of Women (OAW) • Estamos Unidos de Pennsylvania (EUP) • Latino Hispanic Professional Association (LHPA) • League of United Latin American Citizens (LULAC) • Hershey Rotary Club • Rotary Alumni Association of D7390

Current Leadership positions

• Co-chair. Penn State Hershey Campus Council on Diversity • Chair-Elect. Organization for the Advancement of Women Executive Committee • Chair. Organization for the Advancement of Women, Nominations and Awards Committee. • Chair. National SDE Graduate Women in Science Nominating Committee. • President. Graduate Women in Science Hershey chapter • Webmaster. GWIS Hershey chapter (http://gwiskapparho.wordpress.com/) • Faculty Advisor. Penn State Hershey Latino Medical Student Association. • Outreach Activities Coordinator. Association for Women in Science (AWIS) Hershey. • Board Member. Estamos Unidos de Pennsylvania. • Chair. Rotary Alumni Association of District 7390. • Youth Exchange Hershey Inbound Activities Coordinator. Hershey Rotary Club.

Past Leadership positions

• Committee Member. ATS Respiratory Cell & Molecular Biology Junior Professionals Working Group (2012-2015).

• President. League of United Latin American Citizens (LULAC) of PA (2013-2014). • Secretary. Estamos Unidos de Pennsylvania (2012-2014). • Member of the Nominations and Awards Committee. Organization for the Advancement of

Women, Penn State Hershey (2013-2014). • Member of the Nominating Committee. National Graduate Women in Science (2013-2014). • Member of the Penn State Hershey Dean’s Council on Diversity (2012-2013) • Vice-president. AWIS Hershey (2012-2013) • Officer of the Youth and Vocational Service Committee, Hershey Rotary Club (2012-2013) • Faculty advisor of the Penn State College of Medicine Rotaract Club (2012-2013) • Faculty Advisor for the Graduate Women in Science Hershey chapter (2012-2013) • Secretary. Penn State Hershey Postdoctoral Society (PSHPS) (2011-2012) • Secretary. Graduate Women in Science Hershey chapter (2011-2012) • Officer of the PSHPS social events committee, and executive council (2008-2012)


Abstract reviewer and poster judge

• SACNAS 2014 National Conference Undergraduate and Graduate Poster Session Judge • SACNAS National Conference abstract reviewer, 2013-2015 • Penn State Hershey Graduate Student Research Forum, 2012-2014 • Penn State Data and Dine, 2013-2014 • Penn State Hershey Summer Undergraduate Research Symposium, 2012-2013 • American Society for Cell Biology Minority Affairs Committee undergraduate poster session • Graduate Women in Science Bridges STEM symposium, University Park, PA, 2010 • Capital Area Science and Engineering Fair (CASEF), 2010-2015 • American Physiological Society Special Award sponsor at CASEF, 2012-2015 • Graduate Women in Science Special Award sponsor at CASEF, 2014-2015

Symposium Organizer

• Penn State Hershey Medical Interpreter Workshop, 2015 • Penn State Hershey Campus Council on Diversity Retreat, 2015 • Penn State Hershey Campus Council on Diversity Retreat, 2013 • AWIS 2013 Career Event. Penn State College of Medicine, 2013 • AWIS Career Forum: Advancing Women towards Success, Penn State COM 2012

Discussion Leader

• Penn State Student National Medical Association (SNMA) Primary Care Day, Diversity Panel, 2014

• Gordon-Kenan Research Seminar: Lung Development, Injury & Repair. Andover, NH, 2013 • Graduate Student Acclimation Discussion (GRAD) Panel Discussion on Time Management.

Penn State College of Medicine, 2012 Ad hoc reviewer & Editorial Board Membership

• Biomarker Research • Neonatology • European Journal of Pediatrics • Journal of Molecular Biochemistry • Yonsei Medical Journal • PLOS One • BMC Pulmonary Medicine • Gene • Experimental Lung Research • International Journal of Contemporary Medical Research (Editorial Board) • Journal of Environmental Studies (Editorial Board) • Pediatrics and Neonatal Nursing Open Journal (Editorial Board) • Pulmonary Research and Respiratory Open Journal (Editorial Board) • HSOA Journal of Cell Biology & Cell Metabolism (Editorial Board)

Advisory Committees and Review Panels

• Reviewer. Cellular and Molecular Medicine (CAMM) scientific review panel. Department of Veterans Affairs.


• International Programs Reviewer. Bec.ar international Masters in Science and Technology Program. Buenos Aires, Argentina.

• Committee member (candidacy exam). Penn State College of Medicine Biomedical Sciences Graduate Program.

• Committee Member (project evaluation). Penn State Hershey Medical Student Research Program.

Other

• Columnist. Biocareers blog, http://biocareers.com/authors/patricia-silveyra • Volunteer, Junior Achievement “Our Community” program (Hershey elementary school). • Counselor for the Rotary International Youth Exchange Program, 2013 • Interviewer of prospective medical students at Penn State College of Medicine, 2012-2013

ACTIVITIES FOR PROFESSIONAL DEVELOPMENT AND TRAINING (selected)

Teaching Skills Training:

• Medical Education Scholarship in 2015: The Expanding Horizon. Penn State College of Medicine, 2015

• Program Evaluation: Learning how to determine whether your course, clerkship, or residency training innovation is "successful. Penn State College of Medicine, 2015

• Education Retreat: Curriculum Integration Across the Years. Penn State College of Medicine, 2014

• Publishing Your Teaching Innovations. Penn State College of Medicine Office for Scholarship in Learning and Education Research, 2014.

• Getting Started with Education Scholarship: Asking the Questions and Planning the First Steps. Penn State College of Medicine Office for Scholarship in Learning and Education Research, 2014.

• American Physiological Society Professional Skills Training “Becoming an Effective Teacher”. Bar Harbor, ME. June 2014

Diversity Training:

• Campus Council on Diversity Strategic Planning Retreat, March 2015 • 2nd Annual Diversity Practicum “Louder than Words-Action”. Penn State College of

Medicine, Hershey, PA. February 2015 • Medical Interpreter Training. Pennsylvania Department of Health 2014 • 1st Annual Diversity Practicum “Difficult Conversations-Practical Solutions”. Penn State

College of Medicine, Hershey, PA. February, 2014 Professional Development:

• Writing, Procrastination, and Resistance: How to Identify your Writing Blocks and Move Through. STEM-UP PA. Dixon University, Harrisburg, PA. March 2015

• Grants Academy. Penn State College of Medicine 2014-2015. • Coaching Strong Women in the Art of Strategic Performance. Los Angeles, CA, 2014. • Writing a Successful K application workshop series. Penn State College of Medicine, 2014.


• Junior Faculty Development Program. Penn State College of Medicine September 2013- May 2014

• ASCB Minority Affairs Committee Grant Writing Workshop. American Society for Cell Biology Annual Meeting. New Orleans, LA. December 2013

• ASBMB Grant Writing Workshop for New and Early Career Faculty. American Society for Biochemistry and Molecular Biology. Arlington, VA. August 2013

• Research Ethics for Clinical Investigators. PHS 500 Graduate Course (1 credit). The Graduate School at Penn State University. Fall Semester 2013.

• OASIS 2013: Objective Analysis of Self and Institution Seminar. STEM-UP PA. Dixon University, Harrisburg, PA. April 2013

• Data Management in Biomedical Research. Information Challenges and Practical Strategies. Penn State College of Medicine. March 2013.

• The Academic Development and Career Advancement of Underrepresented Faculty. Penn State University, State College, PA, August 2012

• ASCB Minority Affairs Committee 7th Annual Junior Faculty and Postdoctoral Fellows Career Development Workshop. San Antonio, TX. June 2012

Language proficiency

• Spanish. Native. Certified Medical Interpreter.

• French. Advanced professional proficiency.

• Portuguese. Advanced professional proficiency. Certified Medical Interpreter.

• English. Fluent professional proficiency.

Documents

Patricia Silveyra, Ph.D. Curriculum Vitae Page 1...2015/07/29 · Patricia Silveyra, Ph.D. Curriculum Vitae Page 2 ONGOING RESEARCH SUPPORT Center for Research on Women and Newborn