1
ings. This supports the argument that there may be no patho- gnomonic eye signs in shaken baby syndrome. Pediatric ocular myasthenia gravis. Steven Ortiz, Mark Borchert Introduction: Pediatric ocular myasthenia gravis (MG) is an uncommon condition that mimics common problems encoun- tered by the ophthalmologist. The course and outcomes of this disorder have not been well reported. The purpose of this study was to review the presentation, course, and treatment of pediatric ocular MG. Methods: The medical records of children less than 12 years old presenting with ocular MG and having at least 2 years of follow-up at the Children’s Hospital of Los Angeles eye clinic were reviewed retrospectively. Data collected included age of onset of symptoms, presenting signs, medical and surgical treatments, and outcomes, including systemic generalization and partial or complete resolution. Results: ‘X’ patients with a mean age of onset of symptoms at 22 months were included. The initial presenting sign was ptosis in 77%, strabismus in 55%, with exotropia most frequently. Systemic generalization occurred in 10% and resolution of symptoms occurred in 14%. Strabismus surgery was required in 25% and ptosis repair in 8%. Conclu- sions: This series of children with ocular MG contains the largest reported cohort of patients with this uncommon disorder. These findings will help elucidate the outcomes of the condition to help in the diagnosis, therapy, and counseling of children with ocular MG. Monocanalicular versus bicanalicular silicone tube intubation for congenital nasolacrimal duct obstruction. Gregory Ostrow, Srinivas E. Iyengar, Scott E. Olitsky, Merrill Stass-Isern, Denise Hug, Laura P. Smith Introduction: Both monocanalicular and bicanalicular silicone tube intubation are useful in the treatment of congenital naso- lacrimal duct obstruction. Monocanalicular intubation is less traumatic, less time consuming, and does not potentially require general anesthesia for removal of the tube. If the outcomes of monocanalicular intubation are similar to bicanalicular intuba- tion, it may be a preferable procedure. Methods: The records of all patients that underwent silicone tube intubation for congen- ital nasolacrimal duct obstruction at Children’s Mercy Hospital between January 2000 and July 2006 were reviewed. Successful treatment was defined as a lack of tearing or mattering following at least one postoperative visit and at the most recent visit. Patients were excluded if they had prior intubation of the naso- lacrimal system. Results: One hundred fifty-five total eyes met the inclusion criteria (41 bicanalicular intubations and 85 mono- canalicular intubations). Twenty-nine of 41 (70.7%) bicanalicu- lar intubations and 69/85 (81.2%) of monocanalicular intuba- tions were successful. These results were not statistically differ- ent with an absolute risk reduction (ARR) of 0.048 to 0.258 (CI, 95%). When intubation was the primary treatment proce- dure, 7/12 (58.3%) bicanalicular and 14/15 (93.3%) were suc- cessful. This was significant with an ARR of 0.0631-0.636 (CI, 95%). Conclusions: Monocanalicular intubation for congenital nasolacrimal duct obstruction is as successful as bicanalicular intubation and may be superior as a primary procedure. Mono- canalicular intubation is less time consuming, less invasive, and does not potentially require sedation for removal. Monocanal- icular intubation may be a preferable procedure in the treatment of uncomplicated congenital nasolacrimal duct obstruction. ROP outcomes in the post-ETROP era. Manoj V. Parulekar, Steve Conti, Wai Ching Lam, Nasrin Najm Tehrani Introduction: This retrospective study compared outcomes of laser treatment for ROP in a large tertiary referral center before and after adopting recommendations from the Early Treatment for Retinopathy of Prematurity (ETROP) trial. Methods: Ninety- two consecutive infants treated with laser for ROP at our unit from 2001 to 2006 were included. The anatomical and functional results in both groups in the 3 years prior to adopting the ETROP criteria were compared with our results in the 2 years following implementation of the ETROP recommendations. Results: Analysis by 2 was performed on outcome measures for both groups. There was an increase in the number of babies treated, with a significant improvement in anatomical outcomes with earlier treatment. There was a trend toward referral earlier in the course of disease from referring NICUs to our unit for treatment, and a significant increase in the number of laser spots, reflecting more confluent laser treatment in the post-ETROP period. Discussion: While the number of laser episodes has increased as a result of treating earlier in the course of disease, there has been a significant reduction in the need for subsequent surgical interventions for retinal detachment. Conclusions: Ear- lier referral and treatment for ROP, restructuring of the ROP service in our department, and utilization of digital imaging following implementation of ETROP guidelines has resulted in fewer surgical interventions and better outcomes. Quality of life in intermittent exotropia. Christine J. Powell, Deborah Buck, Michael P. Clarke, Sarah R. Hatt Introduction: This study assesses the impact of intermittent exotropia on health related quality of life (HRQoL) from parent and child perspectives using the PedsQL questionnaire. Method: The PedsQL rates HRQoL on four scales: physical (PF), emo- tional (EF), social (SF), and school (SchF) functioning. Parents and children 5 years completed a questionnaire as part of a prospective data collection exercise: the UK Improving Out- comes in Intermittent Exotropia study. Results: One hundred forty questionnaires were analyzed ( parent, n 70; child, n 70). Children with intermittent exotropia scored their QoL lower than “healthy” children in a published sample on PF, SF, and SchF scales (one-sample t-test, t 4.45 to 5.02, p 0.001). Study parents rated their child’s QoL worse than the parents of the “healthy” population only in EF (one-sample t-test, t 5.21, p 0.001). Study data show poor correlation between parent and child scores on all four individual scales and total HRQoL score(Pearson’s product moment, r 0.01-0.13). Discussion: Children with intermittent exotropia report a range of problems with HRQoL. These are different from the prob- lems perceived by the parents. This may relate to the severity of the condition. Conclusion: HRQoL data are a useful adjunct in assessing the impact of intermittent exotropia and in planning surgery for this condition. The ocular motor questionnaire study. Leah G. Reznick, Richard W. Hertle Introduction: To test the reliability of this ocular motor ques- tionnaire as a tool to quantify visual function in patients with strabismus and nystagmus, and to determine how this measure of visual function is effected by treatment of patients with ocular motor disorders. Methods: This study was a prospective case series that includes 100 children and adults with strabismus Volume 11 Number 1 February 2007 100 Abstracts Journal of AAPOS

Pediatric ocular myasthenia gravis

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Page 1: Pediatric ocular myasthenia gravis

ings. This supports the argument that there may be no patho-gnomonic eye signs in shaken baby syndrome.

Pediatric ocular myasthenia gravis. Steven Ortiz, MarkBorchertIntroduction: Pediatric ocular myasthenia gravis (MG) is anuncommon condition that mimics common problems encoun-tered by the ophthalmologist. The course and outcomes of thisdisorder have not been well reported. The purpose of this studywas to review the presentation, course, and treatment of pediatricocular MG. Methods: The medical records of children less than12 years old presenting with ocular MG and having at least 2years of follow-up at the Children’s Hospital of Los Angeles eyeclinic were reviewed retrospectively. Data collected included ageof onset of symptoms, presenting signs, medical and surgicaltreatments, and outcomes, including systemic generalization andpartial or complete resolution. Results: ‘X’ patients with a meanage of onset of symptoms at 22 months were included. The initialpresenting sign was ptosis in 77%, strabismus in 55%, withexotropia most frequently. Systemic generalization occurred in10% and resolution of symptoms occurred in 14%. Strabismussurgery was required in 25% and ptosis repair in 8%. Conclu-sions: This series of children with ocular MG contains thelargest reported cohort of patients with this uncommon disorder.These findings will help elucidate the outcomes of the conditionto help in the diagnosis, therapy, and counseling of children withocular MG.

Monocanalicular versus bicanalicular silicone tubeintubation for congenital nasolacrimal duct obstruction.Gregory Ostrow, Srinivas E. Iyengar, Scott E. Olitsky, MerrillStass-Isern, Denise Hug, Laura P. SmithIntroduction: Both monocanalicular and bicanalicular siliconetube intubation are useful in the treatment of congenital naso-lacrimal duct obstruction. Monocanalicular intubation is lesstraumatic, less time consuming, and does not potentially requiregeneral anesthesia for removal of the tube. If the outcomes ofmonocanalicular intubation are similar to bicanalicular intuba-tion, it may be a preferable procedure. Methods: The records ofall patients that underwent silicone tube intubation for congen-ital nasolacrimal duct obstruction at Children’s Mercy Hospitalbetween January 2000 and July 2006 were reviewed. Successfultreatment was defined as a lack of tearing or mattering followingat least one postoperative visit and at the most recent visit.Patients were excluded if they had prior intubation of the naso-lacrimal system. Results: One hundred fifty-five total eyes metthe inclusion criteria (41 bicanalicular intubations and 85 mono-canalicular intubations). Twenty-nine of 41 (70.7%) bicanalicu-lar intubations and 69/85 (81.2%) of monocanalicular intuba-tions were successful. These results were not statistically differ-ent with an absolute risk reduction (ARR) of �0.048 to 0.258(CI, 95%). When intubation was the primary treatment proce-dure, 7/12 (58.3%) bicanalicular and 14/15 (93.3%) were suc-cessful. This was significant with an ARR of 0.0631-0.636 (CI,95%). Conclusions: Monocanalicular intubation for congenitalnasolacrimal duct obstruction is as successful as bicanalicularintubation and may be superior as a primary procedure. Mono-canalicular intubation is less time consuming, less invasive, anddoes not potentially require sedation for removal. Monocanal-icular intubation may be a preferable procedure in the treatmentof uncomplicated congenital nasolacrimal duct obstruction.

ROP outcomes in the post-ETROP era. Manoj V.Parulekar, Steve Conti, Wai Ching Lam, Nasrin NajmTehraniIntroduction: This retrospective study compared outcomes oflaser treatment for ROP in a large tertiary referral center beforeand after adopting recommendations from the Early Treatmentfor Retinopathy of Prematurity (ETROP) trial. Methods: Ninety-two consecutive infants treated with laser for ROP at our unitfrom 2001 to 2006 were included. The anatomical and functionalresults in both groups in the 3 years prior to adopting theETROP criteria were compared with our results in the 2 yearsfollowing implementation of the ETROP recommendations.Results: Analysis by �2 was performed on outcome measures forboth groups. There was an increase in the number of babiestreated, with a significant improvement in anatomical outcomeswith earlier treatment. There was a trend toward referral earlierin the course of disease from referring NICUs to our unit fortreatment, and a significant increase in the number of laser spots,reflecting more confluent laser treatment in the post-ETROPperiod. Discussion: While the number of laser episodes hasincreased as a result of treating earlier in the course of disease,there has been a significant reduction in the need for subsequentsurgical interventions for retinal detachment. Conclusions: Ear-lier referral and treatment for ROP, restructuring of the ROPservice in our department, and utilization of digital imagingfollowing implementation of ETROP guidelines has resulted infewer surgical interventions and better outcomes.

Quality of life in intermittent exotropia. Christine J. Powell,Deborah Buck, Michael P. Clarke, Sarah R. HattIntroduction: This study assesses the impact of intermittentexotropia on health related quality of life (HRQoL) from parentand child perspectives using the PedsQL questionnaire. Method:The PedsQL rates HRQoL on four scales: physical (PF), emo-tional (EF), social (SF), and school (SchF) functioning. Parentsand children �5 years completed a questionnaire as part of aprospective data collection exercise: the UK Improving Out-comes in Intermittent Exotropia study. Results: One hundredforty questionnaires were analyzed ( parent, n � 70; child, n �70). Children with intermittent exotropia scored their QoLlower than “healthy” children in a published sample on PF, SF,and SchF scales (one-sample t-test, t � �4.45 to �5.02, p �0.001). Study parents rated their child’s QoL worse than theparents of the “healthy” population only in EF (one-samplet-test, t � �5.21, p � 0.001). Study data show poor correlationbetween parent and child scores on all four individual scales andtotal HRQoL score(Pearson’s product moment, r � 0.01-0.13).Discussion: Children with intermittent exotropia report a rangeof problems with HRQoL. These are different from the prob-lems perceived by the parents. This may relate to the severity ofthe condition. Conclusion: HRQoL data are a useful adjunct inassessing the impact of intermittent exotropia and in planningsurgery for this condition.

The ocular motor questionnaire study. Leah G. Reznick,Richard W. HertleIntroduction: To test the reliability of this ocular motor ques-tionnaire as a tool to quantify visual function in patients withstrabismus and nystagmus, and to determine how this measure ofvisual function is effected by treatment of patients with ocularmotor disorders. Methods: This study was a prospective caseseries that includes 100 children and adults with strabismus

Volume 11 Number 1 February 2007100 Abstracts

Journal of AAPOS