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Percivall Pott
1714 – 1788 Chimney sweeps
cancer of the scrotum
Pott’s disease – vertebral tuberculosis
John Hunter
1728 – 1793 Papers at the Royal
Society on experimental pathology, including the use of a microscope
Described inflammation
Hunterian Museum, Royal College of Surgeons, London
First Systematic Textbook of Pathology
Matthew Baillie – 1761 – 1823
Nephew of John Hunter
The Morbid Anatomy of Some of the Most Important Parts of the Human Body
Microscopic pathology atlas
Physician of King George III
Thomas Hodgkin
1798 – 1866 On Some Morbid
Appearances of the Absorbent Glands and the Spleen
“Lister’s compound microscope might lead to useful discoveries in the future.”
Joseph Recamier – 1774 – 1852 – metastasis
Richard Bright – 1789 – 1858 – Kidney disease
Thomas Addison – 1793 – 1860 – Pernicious anemia
Cell Theory
Robert Hooke – 1635 – 1703 – cell
Matthias Jacob Schleiden – 1804 – 1881 – botanist
Theodor Schwann – 1810 – 1882 – zoologist
Cell TheoryJohannes Peter Müller
1801 – 1858 Berlin Father of medical
microscopy Microscopic criteria for
benign and malignant tumors
Über den Feinern Bau und die Formen der Krankhaften Geschwülste – On the Finer Structure and Form of Morbid Tumors
Cell TheoryRudolph Virchow
1821 – 1902 The greatest
figure in the history of Pathology
Die Cellularpathologie
“Omnis cellula e cellula” – all cells from cells
Herman Lebert – 1831 – 1878
Microscopic atlas
1850s
Pathology developed as a separate specialty
Medical schools, Professors of Pathology Microscope, diagnostic histopathology,
neoplasia France – laboratories Germany – universities
Microscope
Fresh tissue, cut by hand, unstained
Formaldehyde fixation – Isaac Blum – 1833 – 1903
Paraffin embedding – Edwin Klebs – 1834 – 1913
Microtome – Minot – 1852 – 1914
Biological stains Hematoxalin – Franz
Böhmer Paul Ehrlich – 1854 – 1915
Anaplasia
David Von Hansemann 1858 – 1920
Grading, Carcinoma in Situ
Albert Compton Broders 1885 – 1964 Mayo Clinic
Staging
Cuthbert Esquire Dukes 1890 – 1977 St. Mark’s
Hospital, London
Pap Smear
George Papanicolaou – 1883 – 1962 January, 1928 – New
Cancer Diagnosis – Betterment Conference Battle Creek Michigan
1941 – The Diagnostic Value of Vaginal Smears in Carcinoma of the Uterus
1943 – Diagnosis of Uterine Cancer by the Vaginal Smear
1954 – Atlas of exfoliative Cytology