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PerkinElmer Signals™ Turning Data Science into Reality with Spotfire
Jens Hoefkens, Ph.D.
September 15, 2016
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Safe Harbor Statement
• This document shows current intentions regarding product features,
behavior, schedules and support; these intentions may change without
notice as we respond to customer requirements.
• Any unreleased products, services or features referenced herein are
not currently available and may not be delivered on time or at all.
Customers who purchase PerkinElmer informatics applications should
make their purchase decisions based upon products, features, and
services that are currently available.
New Informatics for New Science
The pace of life science data generation and the complexity of the
generated data is outperforming existing informatics solutions
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Big Data Challenges in Life Science
Transactional Systems, Data Silos, Discovery & Access Restrictions
Isolation
Distributed Research Models Limited Sharing and Collaboration
Collaboration
On-premise Data Centers, Expensive and Complex
Infrastructure Patients, Assays, Tissues,
Organisms, Proteins, Genes,
Variety
100,000s of samples, 100s of GB per day per Experiment
Volume
Structured vs. Unstructured Data, How to make Sense of the Data
Complexity
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Cloud-based data store and analytics platform designed
for today’s and tomorrow’s life science needs. Enabling
user experience around TIBCO Spotfire supports wide
range of data processing workflows and applications.
PerkinElmer Signals™
Domain-specific entity model and ontologies
Machine learning for data normalization and mapping
Signals App Store with scientific applications
Intelligent
Big data technology foundation - Spark & HDFS
Cloud-scale, elastic SaaS deployment
Automated workflows with Automation Services
Scalable
User friendly scientific applications in TIBCO Spotfire
User-driven, self-service access to all relevant data
Collaboration within and across the firewall
Enabling
Introducing PerkinElmer Signals™
PerkinElmer Signals™ for Translational Break Down The Firewall Between Data And Discovery
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PerkinElmer’s Vision of Translational Medicine
Multiplex ELISA
NGS
GEA
Quantitative
Pathology
IHC
Fusion CNV
Getting the right drug to the right patient at the right time
Stratified Patient Population Patient Population
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From Translational Medicine to Personalized Medicine
Multiplex ELISA
NGS
GEA
Quantitative
Pathology
IHC
Fusion CNV
Getting the right drug to the right patient at the right time
Precise diagnosis
Targeted Therapy
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Translational Medicine Workflows
Raw Data
Select Processed
Data
QA/QC
Results
Review Secondary
Analysis Select Clinical
Subject & Samples
Secondary
Analysis
Data
Processing
Select Secondary
Results
Perform Integrated
Analysis
Bioinformatician / Data Scientist
Focuses on single experiment
and starts with an instrument run
Translational Scientist
Starts with a scientific hypothesis
and scientific Entities
PerkinElmer Signals Annotated Raw Data
Annotated Processed Data
Derived Data
Translational Video
PerkinElmer Signals for Screening How Big Data Becomes Breakthrough Data
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Extensible and configurable analytics applications to
TIBCO Spotfire. The Signals Apps Store for Screening
supports users to create configurable screening data
analytics workflows for a wide range of applications.
Signals App Store for Screening
Configurable and extensible; apps can be combined to
protocols; protocols can be saved and shared between
users; extension and configuration with custom apps
Flexible
Protocols can be run interactive or fully automated
using Automation Services; reporting apps for fully
integrated workflows
Automated
Intrinsic domain model awareness enables apps to
configure themselves and guide user through input
parameters selection
Intelligent
PerkinElmer Signals™ for Screening
Data Import and
Aggregation
Spotfire Templates
High Content Profiler
Curve Fitting
SAR
Real-time Analytics
Alerts, Reports,
Publish, Collaborate
Automated Workflow
Screening Video
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Signals for Screening: System Components & Data Flow
HPC image analysis
Image storage/archive
Thumbnail generation
Automation Services
Signals App Store for Screening
Image Rendering Open APIs
HCS 3rd Party Image/Data Analysis Software
Matlab, ImageJ, Cellomics, CellProfiler,
Definiens, IDBS, Genedata, etc.
Data Warehouse
Repository, ELN
HTS
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Takeaways – PerkinElmer Signals™
• Life science data generation outpaces perception capabilities
• Need to bring Big Data technologies to life science
• Distributed research models require collaborative informatics
• PerkinElmer Signals™ for agile, cloud-scale data management
• Signals App Store for flexibility and automation in TIBCO Spotfire
• Addressing business problems with intelligent scientific applications
