Personal Genomics Company(DiagnomicsTM Technology)

Min Seob Lee Ph.D.President/CEO

(San Diego, CA)

Diagnomics, Inc.

• Next Generation Healthcare from Per-

sonal Genomics

Established 2011

San Diego,California

Mission

Diagnomics Business Strategy(Next Generation Health Care)

PersonalGenomics

Diagnostic

PersonalizedMedicine

Informatics

• Diagnomics, Inc. focuses on development of technology for personalized medicine (PM) based on personal genome to revolutionize the next generation healthcare.

• Diagnomics applies modern genomics tech-nologies to the development of products and services that translate a patient's personal genome into clinically actionable information.  

Diagnomics, Inc.

Diagnomics, Inc.Management Team

Min Seob Lee, Ph.D. (Founder, President & CEO)World learder in Genomic Based Personalized Medicines and Diagnostics

COH, Harvard Med, DoubleTwist, Genaissance Pharm, Clinical Data, Sequenonm, TBI. PGI

Stefan Gruenwald, MD, Ph.D. (Co-Founder, CTO)Experienced implementer of innovative technologies in the life science space and beyond

Goethe U, Scripps, UCSD, PharMingen, DB, Orbigen, CGP, Quadraspec, Genautica

Dan Scholefield (Co-Founder & CFO)Successful venture investment & management in pharma & medical device

Managing Director, Genautica; Principal, Three Layer Capital; Trustee, private family offices

Michael O’Reilly (VP of BD)Strategic business development, marketing, & sales in early stage technology companies

Concordia U, IBM, APC, Flashcom, ICC, StreetDeck, GIT

World Leaders in Genomics and Informatics for Personalized Medicines

Next $100 Billion Technology?

A technology that will change mankind (Dr. James Watson)

Google and PayPal’s founders are heavily invested in it.

Every major publication is talking about it.

Major companies are scrambling to be a part of it

Forbes magazine calls it “The next $100 billion technology market”

Personal Genomics

Personalized Medicine Market Trend & Dynamics

• US Healthcare Expenditure exceed $2.5 Trillion, over 17% of GDP• Urgent Need of Revolutionary Next Generation Healthcare System• Personalized Medicine (PM) market is estimated to be $520 Billion

by 2015.• The core technology is primarily new diagnostics and targeted thera-

peutics and expected to grow $42 Billion in 2015.• Drug development by personal genomics.• Personal genomics market is growing CAGR of 97.4% for the next

five years. • P4 Medicine : Personalized, Predictive, Preventive & Participatory• New technology and applications will lead the market Source : PriceWaterhouse Coopers

Next Generation Healthcare from Personal Genomics

Personal Genome Analysis Past, Present & Future

• 2003: HGP: 13 years, $2.7 billion• 2007: Craig Venter: 4 years, $100 million• 2008: James Watson: 2 years, $2 million • 2009: 6 months, $200,000• 2010: 1 month, $20,000• 2011: 2 weeks, $5,000• 2012 : 2 weeks, $3,000• 2015(?): <2 days, <$1,000

<NGS

<TGS

BIG DATA ; Personal Genome Sequence Data Explosion

– 3 giga base of diploid Genome– Massive parallel short read of se-

quence by NGS– Average 30X of human genome se-

quencing (3GBX30=90GB)– 2-3 TB of Raw Data for Solexa, 10TB of

Data for Solid Technology– Over 100 GB of processed data per in-

dividual genome– 6 billion bases per Person X 6 billion

people in the world

Particle PhysicsLarge Hadron Col-

lider(15PB)

Human Genomics(7000PB)1GB / person

200PB+ captured>200% CAGR

http://www.intttp://www.intetp://www.intelp://www.intel.://www.intel.c//www.intel.co

World Wide Web(~1PB)

wiki wikiiki wiki wki wiki wii wiki wik

Wikipedia(10GB)

100% CAGR

Internet Archive(1PB+)

Typical Oil Com-pany

(350TB+)

Estimated On-line RAM in Google

(8PB)

Personal Digital Photos

(1000PB+)100% CAGR

Total digital data to be created this year 270,000PB (IDC)Data-Intensive Computing Symposium : Phillip B Gibbons

200 of London’s Traffic Cams

(8TB/day)2004 WalmartTransaction DB(500TB)

Annual Email Traf -fic, no spam

(300PB+)

Merck BioResearch DB

(1.5TB/qtr)

One Day of Instant Messaging in 2002

(750GB)Terashake Earth-

quake Model of LA Basin

(1PB)

MIT BabytalkSpeech Experi-

ment(1.4PB)

UPMC HospitalsImaging Data

(500TB/yr)

Personal Genome Race for Personalized Medicine

Diagnomics Business Roadmap

BioinformaticsData Center (AIS)Genome Annotation System (GAS) PAS & CAS

Personalized DiagnosticsNon-Invasive Can-cer Diagnosis(Patent Pending)

Next Generation Drug DevelopmentPharmacogenomicMajor Pharma Collabora-tion Cancer Focus

Personalized Medicine From Per-sonal Genomics

Personalized Medicine

Personal Genomics

DiagnomicsTM Technology

DiagnomicsTM Technology for Personalized Medicine

DiagnomicsTM Technology

Next Gener-ation Se-quencing

(NGS)

AIS Datacen-ter

DGF Tech-nology

GAS/CAS In-formatics

Diagnomics Intellectual

Property

CLAS Data-base

Diagnomics in News

Benefits of DiagnomicsTM Technology

Diagnostic Companies

Consumers Pharmaceuticals & Biotech Companies

Managed Care

Healthcare Providers

Pharmacy Benefit Managers

Thanks!