PERSONAL INFORMATION Anna Giovanetti

Curriculum Vitae Anna Giovanetti

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PERSONAL INFORMATION Anna Giovanetti

Via Borricella 3A, Anguillara Sabazia 00061 (RM), IT

+39 0630483621 +39 3381335599

[email protected]

Sex F | Date of birth 22/05/1955| Nationality Italian

WORK EXPERIENCE

EDUCATION AND TRAINING

From 06/01/1985- to now

From 05/1980- to12/1981

ENEA (Italian National Agency for New Technologies, Energy and the Environment) (www.enea.it)

Planning and coordinating research programs in the following fields:

▪ 1985-1999: Inhalation toxicology: toxic effects induced in respiratory tract by airborne pollutants: sodium fire’s products, organic solvents, urban air pollutants; ultrafine particles

▪ from 2000: effects induced by exposures to ionizing radiation, in particular on the non-targeted effects induced by low doses (in vitro, in vivo and human studies) .Main projects:

▪ The Ret Protooncogene. (N QLG1200101646-5FWP); Realization of a DNA microchip to quantify genetic damage induced by ionizing radiation (Italian Spatial Agency-ASI 20022004-N771),

▪ Non targeted effects induced by low doses of ionizing radiation and anti-oxidant treatment (PROGETTO MAE-MIUR “Development of New Antioxidant drugs”),

▪ Radiation Ecotoxicology : Comparison of the toxicities of natural uranium and depleted uranium using the soil reference organisms Eisenia fetida (In collaboration with IAEA).

▪ Exposure to ionizing radiation: risk assessment, early biomarkers, recognition of countermeasures in treated patients and in animal models. Hungarian-Italian intergovernmental S&T cooperation project 2011-2013- 2011-2013 (partner Prof Katalin Lumniczky -Div. Head - Division of Cellular and Immune Radiobiology"Frederic Joliot-Curie" National Research Institute for Radiobiology and Radiohygiene Budapest, Hungary): (HU11MO6). Italian coordinator.

▪ Analysis of (the early and) persistent DNA damage in DTC patients treated with 131I in hypothyroidism or after rh TSH stimulation, in collaboration with S..Andrea Hospital (Rome) and RomaTre University (Rome).

▪ ‘On-site Technical Assistance to the Chemical, Biological, Radiological and Nuclear Centres of Excellence Secretariats in Georgia, Kenya and Morocco’ coordinated by AESA (Bruxelles, BE)

▪ A Panel of Biomarkers as Novel Tool for Early Detection of Radiation Exposure NATO funded SPS multi-year Project G4815 "", in collaboration with Alexandria Univ, (Egypt) (2015-2018). Coordinator.

▪ Implementation of a novel set of early biomarkers for measuring radiation dose in case of emergency Director of the Italian Foreign Minister PGR bilateral project Italy-Egypt, in collaboration with Alexandria Univ, (Egypt) (2016-2018). Coordinator.

▪ ToR13:The preparation of a Biosecurity toolbox to strengthen European Biosecurity (tender HOME/2014/ISFP/PR/CBRN/0025) (2019) coordinated by RIVM (Utrecht, NE).

▪ Working Group on Biosecurity of the CNBBSV (Italian Committee for Biosafety, Biotechnology and Sciences of Life) established at the Presidency of the Council of Ministers (from 2020..).

▪ Disinfection by UV-C rays of masks contaminated with the Phi6 phage (surrogate for SARS-CoV-2) (ENEA project SmartBin 2020-2021).

▪ INCIENSA (Public Research Centre), Costa Rica, as laboratory supervisor and coordinator of

research programs on genetic toxicology of pesticides and genetic diseases.



PERSONAL SKILLS

18/12/1978 Laurea cum laude, in Biological Sciences, with the experimental thesis: “Distribution of monomeric plutonium 238 and 239 in mouse’s organs” (110/110 cum Laude) “La Sapienza” University (Rome)

Mother tongue(s) Italian

Other language(s)

Listening Reading Spoken interaction Spoken production

English C1/C2 C1/C2 C1/C2 C1/C2 Enter level

Spanish C1/C2 C1/C2 C1/C2 C1/C2 Enter level Replace with name of language certificate. Enter level if known. Levels: A1/A2: Basic user - B1/B2: Independent user - C1/C2 Proficient user

Common European Framework of Reference for Languages



Communication skills

Organisational / managerial skills

Additional skills

Memberships

During years of scientific collaborative work in Italy and abroad, she has consolidated her good personal predisposition with regard to dissemination in science and teaching, communication to the non-expert public, teamwork, coordination, and active participation in discussions. Organization of courses, responsible for the scientific, administrative and financial managing of projects. Evaluator of research programs submitted to the European Commission CT-EX2002B007158 for the following FPs: - FP5 Quality of Life and Management of Living Resources: - FP6 Life sciences for Health - From July 2007: Member of the Ethical Review FP7 Community - Currently Member of the H2020 ERC Ethics Expert Team - From 2014 to now participation as expert to Remote/Central reviews (three/four times/yearly) for ERC-ETHICS and H2020-MSCA - Participation to the Discussion panels:

Ethics in research and international cooperation Jul 2009 Human intervention Oct-Nov 2009 Misuse of research Dec 2009-Feb 2010

▪ PHEA Evaluation of research proposals ▪ Participation to the DoReMi Consultation Meeting on lens Opacities (Bombon France September

2011). ▪ From 2018: Participation to Research Team of Reviewers for the “la Caixa” Foundation Call for

Health Research. ▪ Reviewer for: Int J Environ Res Public Health, Int J Rad Biology, Inflammation Research, Journal of

Environmental Pathology, Toxicology and Oncology, Mutation Research, Frontiers in Genetics, PlosOne.

▪ Participation in cooperation programs in Nicaragua, Costa Rica, Argentina, Egypt and Greece. ▪ 1995-97 member of the ENEA equal opportunities committee; ▪ Participation to the Conference Women and Sciences held in Bruxelles on 28-29 April 1998;

Organization of the Meeting: Le opportunità della scienza. Donne della ricerca nel V programma Quadro dell’Unione Europea, Rome, 22-02-1999;

▪ Member of the Associazione Italiana di Radio-Protezione-AIRP working group Communication in Radiation Protection;

▪ Member of the Directive Committee of the Italian Radiation Protection School “Carlo Polvani”; Member of the Directive Committee and of the Scientific Committee of the FIRR (Federazione Italiana Ricerca nelle radiazioni);

▪ Referent for the Radiation Protection’s issues of the AIMN (Associazione Italiana di Medicina Nucleare ed Imaging Molecolare) working group Radiobiology and Radiation Protection.

▪ Member of the Indo-Italian bilateral program on Antioxidant Chemistry (2009-2010). ▪ Member of the International Advisory Committee of Society for Radiation Research India ▪ Member of the H2020 ERC Ethics Expert Team. ▪ Member of the working group on Biosecurity of the CNBBSV (Italian Committee for Biosafety,

Biotechnology and Sciences of Life) established at the Italian Presidency of the Council of Ministers.



Edited Handbooks

Teaching

Organization of courses

Publications

▪ Giovanetti A, Sgura A, Aversa G. Handbook. Practical course on biological dosimetry as part of

the International congress:“From dosimetry to biological effect: radiobiology as guide to clinical practice in nuclear medicine” 5-8/11, 2011 -Sorrento, 2011 ENEA ed ISBN: 978-88-8286-264-0 2012.

▪ Cantone MC, Ciani V, Giovanetti A, Osimani C. How to communicate the radiation risk (Comunicare i rischi delle radiazioni) ed ENEA-ISBN 978-88-88648-36-1 eISBN978-88-88648-37-8. 2012.

▪ Cartocci V, Gerlini M, Giovanetti A CBRN risks in marittime and land containers transport. ENEA ed. ISBN 978-88-8286-347-0. 2017.

▪ 1980: Preparation of teaching programs, Biological Sciences Faculty University of Leon, Nicaragua; ▪ From 1985 up to now tutor of students, fellowships, technical training; ▪ 1990: Teacher in the Environmental Toxicology Course for the formation of Environmental

Managers (COMITEC) ENEA; ▪ 1992: Realization of the Environmental Toxicology postgraduate course, Universidad Nacional,

Tucuman, Argentina; ▪ 2002: Participation to the ENEA training activities for teachers and courses for students; ▪ 2008: ENEA-IRP training course for workers exposed to ionizing radiations; ▪ 2009-2015: Teacher at the IAEA-JRC INTERNATIONAL SUMMER SCHOOL ON NUCLEAR

WASTES; ▪ 2009-2012: Medicine Faculty, Contract Professor course Tecnico Della Prevenzione nell' Ambiente

e nei Luoghi Di Lavoro, University “Tor Vergata”, Rome.; ▪ From 2016 Contract Professor Master course Tecniche di Preparazione Uso e Dosimetria dei

radio-farmaci, UOC di Medicina Nucleare dell'Ospedale S. Andrea “La Sapienza” University, Rome. ▪ Radiological and nuclear emergencies’ Management: Biological aspects. Casaccia, ENEA Center

(Rome) 5-7/11/2012. ▪ From dosimetry to biological effect: radiobiology as guide to clinical practice in nuclear medicine. 5-8

November 2011 Sorrento (NA) Italy Low doses and non targeted effects (genomic instability, bystander effect, adaptive response).

▪ Cruz M, Giovanetti A, de Cespedes C Fernandez R "Relaciones entre syndrome de Down, edad

materna y presencia de translocaciones cromosomicas" Acta Med Cost 26:2 1983 ▪ Villaschi S Giovanetti A, Lombardi C, Nicolai G, Garbati M, Andreozzi U "Damage and repair on

mouse bronchial epithelium following acute inhalation of TCE" Exp Lung Res 15. 601, 1991 ▪ Giovanetti A Indicatori precoci del danno da inalazione applicazione di un set multidisciplinare di

endpoint biologici In Gli aerosoli in terapia inalatoria ed in patologia ambientale PICCIN ed Padova 1995

▪ Mancuso M Giovanetti A Brittebo E "Effects of dichlobenil on the ultrastructural morphology" Toxicol Pathol 25:186 1997

▪ Giovanetti A Mancuso M Lombardi C Massa E "Analysis of lung damage induced by TCE inhalation in mice fed diets with low, normal and high copper content" Toxicol Pathol 26:628 1998

▪ Bergstrom U, Giovanetti A, Piras E, Brittebo E "Methimazole-induced damage in the olfactory mucosa effects on ultrastructure and glutathione levels" Toxicol Pathol 31:19 2003

▪ Amendola R, Basso E, Pacifici P, Piras E, Giovanetti A, G Romeo G "Mouse RET, cAbl, and TP53 gene fragmentations detected in COMET-FISH assay act as in vivo bio-markers of radiation exposure" Rad Res 165,5:553-561 2006

▪ Limatola C, Massa V, Lauro C, Giovanetti A, Nuccitelli S, Spinedi A. "Evidence for a role of glycosphingolipids in CXCR4-dependent cell migration". FEBS Lett. 581(14):2641-2646, 2007.

▪ Giovanetti, E. Basso, T. Deshpande “Persistence of Genetic Damage in Mice Exposed to low dose of X Rays” Int J Rad Biol.Volume 84 Issue 3, 227-235, 2008

▪ Giovanetti, S. Fesenko, M.L. Cozzella, L. D. Asencio, U. Sansone “Bioaccumulation and biological effects in the earthworm Eisenia fetida exposed to natural and depleted uranium”, J Environm Radioact, 101, 6: 509-516, 2010

▪ Fabrini R, Bocedi A, Pallottini V, Canuti L, De Canio M, Urbani A, Marzano V, Cornetta T, Stano P, Giovanetti A, Stella L, Canini A, Federici G, Ricci G. “Nuclear shield: a multi-enzyme task-force for nucleus protection.” PLoS One. 2010 Dec 10;5(12):e14125.

▪ Jahan Z, Castelli S, Aversa G, Rufini S, Desideri A, Giovanetti A Role of Human Topoisomerase IB on Ionizing Radiation Induced Damage.Biochem Biophys Res Commun. 2013 Feb 16. doi:pii: S0006-291X(13)00279-9. 10.1016/j.bbrc.2013.02.032.

▪ Teodori L, Giovanetti A , Albertini MC, Rocchi M, Perniconi B, Valente MG, and Coletti D Static magnetic field modulates X-ray-induced DNA damage in human glioblastoma primary cells J Radiat Res. 2014 Mar 1;55(2):218-27. doi: 10.1093/jrr/rrt107. Epub 2013 Dec 17.Dec 17.



▪ Jahan Z, Cerreto M Aversa G, Rufini S, Desideri A, Giovanetti. 2015 Role of Topoisomerase IB on

Damage Induced by Ionizing Radiation In: K P Mishra Editor Biological Responses, Monitoring and Protection from Radiation Exposure, Hauppauge NY: Nova publishers ISBN: 978-1-63463-852-4

▪ Caputo F, De Nicola M, Sienkiewicz A, Giovanetti A, Bejarano I, Licoccia S, Traversa E, Ghibelli L. Cerium oxide nanoparticles, combining antioxidant and UV shielding properties, prevent UV-induced cell damage and mutagenesis. Nanoscale. 2015 Oct 14;7(38):15643-56. doi: 10.1039/c5nr03767k. Epub 2015 Sep 9.

▪ De Chiara G, Racaniello M, Mollinari C, Marcocci ME, Aversa G, Cardinale A, Giovanetti A, Garaci E, Palamara AT, Merlo D. Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons. Front Aging Neurosci. 2016 Oct 18;8:242.

▪ Cerreto, M., Sennato, S., Tortolici, F., Chieppa, G., Giovanetti, A. and Rufini, S. (2017) Different physical and biological features of Neuroblastoma-derived microvesicles before and after irradiation. Colloids and Surfaces A: Physicochemical and Engineering Aspects https://doi.org/10.1016/j.colsurfa.2017.05.029

▪ Caputo F, Giovanetti A, Corsi F, Maresca V, Briganti S, Licoccia S, Traversa E, Ghibelli L. Cerium Oxide Nanoparticles Re-establish Cell Integrity Checkpoints and Apoptosis Competence in Irradiated HaCat Cells via Novel Redox-Independent Activity. Front Pharmacol. 2018 Oct 16;9:1183. doi: 10.3389/fphar.2018.01183. eCollection 2018.

▪ Marconi R, Serafini A, Giovanetti A, Bartoleschi C, Pardini MC, Bossi G, Strigari L. Cytokine Modulation in Breast Cancer Patients Undergoing Radiotherapy: A Revision of the Most Recent Studies. Int J Mol Sci. 2019 Jan 17;20(2). pii: E382. doi: 10.3390/ijms20020382. Review.

▪ Giovanetti A, Tortolici F, Rufini S. Why Do the Cosmic Rays Induce Aging? Front Physiol. 2020 Aug 12;11:955. doi: 10.3389/fphys.2020.00955. PMID: 32903447; PMCID: PMC7434975.

▪ Giovanetti A*, Marconi R, Bartoleschi C, Pardini MC, Turchi R, Awad N, Sanguineti G, Pinnarò P, Tortolici F, Rufini S, Canfora M, Strigari L. ”Learning from NATO biomarker research for humans” chapter of the NATO SPS book “Biomarkers of Radiation in the Environment - Robust Tools for Risk Assessment”, Eds Wood D, Mothersill D, Tsakanova G, Cresswell T, Gayle T, Woloschak E..Originally published with the title: NATO Security through Science Series A: Chemistry and Biology ISSN: 1874-6489, 2021.

▪ Tortolici F, Vumbaca S, Incocciati B, Dayal R, Aquilano K, Giovanetti A, Rufini S. Ionizing Radiation-Induced Extracellular Vesicle Release Promotes AKT-Associated Survival Response in SH-SY5Y Neuroblastoma Cells. Cells. 2021 Jan 8;10(1):107. doi: 10.3390/cells10010107. PMID: 33430027; PMCID: PMC7827279.

▪ Giovanetti A, Marconi R, Awad N, Abuzied H, Agamy N, Barakat M, Bartoleschi C, Bossi G, Canfora M, Elsaid AA, Ioannilli L, Ismail HM, Issa YA, Novelli F, Pardini MC, Pioli C, Pinnarò P, Sanguineti G, Tahoun MM, Turchi R, Strigari L. Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation. Sci Rep. 2021 Apr 14;11(1):8118. doi: 10.1038/s41598-021-87173-3. PMID: 33854097; PMCID: PMC8047015.

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PERSONAL INFORMATION Anna Giovanetti