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Pharma 3.0 and Technology

Nagesh

Sr. Princ

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Where did I go from XIM ?

Mafatlal Textiles, Navsari, Mumbai 1995

Siemens, Mumbai, 1996

CBSI, Farmington Hills, MI, 2000

Rebranded as Covansys

Acquired by CSC, Falls Church, VA, 2008-09

Lived in CA, MI, MO, NJ

Currently Sr. Principal

Housekeeping9:45 pm ?

US examplesQuestions and perspective

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Disruptive Nature of Technology

The Convergence of Key Technolog

Pharma 3.0

By the end of this session

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Focus on sustained shareholder value

Aggressively Deliver the Phase II and Phase III Portfolio

Prioritize Our Portfolio to Deliver the Most Value

Become a Top Tier Biotherapeutics Company

Be Respected by Society

Strategic Imperatives

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Life Sciences Is a Fast-Changing Business Environment

Heighteningfor managing

Invent and bring to market pipeline and generate com

Worldwide, payers are pushto counter their own budg

health care more affor

Payers and drug regulatoproducts demonstrate subefore granting reimburs

approv

Growing reand risk co

New pharmacovigilance le

increase data provision requon regulatory operat

Weak or incomplete suexacerbating the spread

Increasing scrutiny of manensure prod

Market Treatment Changes

#1

Convergence of product innovation, lifestyleevolution, and government mandates/regulations

taking place.

Companies are leveraging new techniques todevelop improved treatments for high unmet

medical needs for increasingly informedconsumers.

Business Portfolio

Evolution

Patent cliff, over $100 billion $ in drug sales lostbetween 0912.

Evolution of chronic, easier-to-treat conditionsto diseases with higher medical need.

Developing orphan drugs, which have extrapatent protections and a streamlined regulatory

review in some countries.

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General Timeline to bring a new drug to market ... ~

The full cost to bring a new drug (a new chemical entity) from

discovery to approval and launch is estimated to be $1.2 1.3 billion.

5-10,000compounds

with 5-10,000 compounds and that th

average cost to bring a new product market is $1.2-1.3 billion.

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http://projects.propublica.org/http://online.wsj.com/news/articles/SB100014240

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Patent Cliff - $63B

http://www.rsc.org/chemistryworld/Issues/2009/January/PharmaRefocusesOnThePatentCliff

Th Aff d bl C A

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The Affordable Care ActWHY THE LAW WAS NEEDED

Insurance companies had discretion to deny coverage for pre-existing conditions

Premiums had more than doubled over the last decade, while insurance company profits w

Tens of millions were underinsured. Insurance companies had discretion to withdraw cove

50 million Americans had no insurance at all

Cost of healthcare was spiralingWHAT THE LAW DID

Insurance companies cannot deny coverage for pre-existing conditions or put lifetime max

Preventive services became free - Cancer screenings such as mammograms & colonoscopisuch as flu, mumps & measles, Blood pressure screening, Cholesterol screening, Tobacco c

and interventions, Birth control, Depression screening

Mandated that Insurance companies overhead decrease from 40% to 20%

Mandated that all Americans have coverage

Children can stay on parent policies till they are 26

Established competitive Insurance exchanges at State and Federal level

Strengthened accountability and penalties

Introduced pay for health outcomes

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What is Pharma 3.0

PHARMA 1.0

BLOCKBUSTER ERA

PHARMA 2.0

INNOVATION &PORTFOLIO

DIVERSIFICATION

PERSONALIZEDMEDICINE

PHARMA 3.0

HEALTH OUTCOME

PATIENT PARTICIPAT

RISE OF MED DEVIC

PHARMA 4.0FOUNDATIONGENETICS AND

INDIVIDUAL THERA

DRIVERS FOR CHANGEPatent Expiration

R&D ROIGlobalization

Personalized MedicineRise of the Payors

DRIVERS FOR CHANGEHealthcare ReformPatient participation

Emerging TechnologiesPharma, Payor, Provider and other

PhysicianP

Pa

P ti t E S t

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Patient care Eco-System

https://www.google.com/url?url=https://www.apple.com/&rct=j&frm=1&q=&esrc=s&sa=U&ei=VUXSU-bsHZGRuAS5-4GIAg&ved=0CBwQ9QEwAw&usg=AFQjCNFwF8GHsri7hWC_984tDxdFt_3TrA

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Industry in Active consolidation phase

ValeantAllergan $54B

AbbvieShire $53B

MedtronicCovidien $42B

PfizerWyeth $62B

PfizerAstraZeneca $116B ?

The INVERSION Debate

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End User / Consumer Behavior

As patients,

We take what the doctor prescribes

We rarely look at who made the drug

We rarely research the literature around the drug

We almost never try to find out what experiences other users have had

We pay for the service not for the outcome

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The Trust Issue

A Deloitte survey of general population in 2012: Respondents Trust:

Doctors and academic centers most

Companies like WebMD Next

Google search results next

At the bottom of the list is pharma and payor companies.

A more recent study, by Makovsky Health:

Found that only around 35 percent of consumers would trust a disease web

sponsored by a pharmaceutical company,

and 16 percent said they would never visit a disease website sponsored by

pharma company.

http://mobihealthnews.com/32728/in-depth-pharmas-digital-health-opportunities/

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Focus on sustained shareholder value

Aggressively Deliver the Phase II and Phase III Portfolio

Prioritize Our Portfolio to Deliver the Most Value

Become a Top Tier Biotherapeutics Company

Be Respected by Society

Strategic Imperatives

The Disruptive Power of Technology

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The Disruptive Power of Technology

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http://scoop.intel.com/files/2012/03/infographic_1080_logo.jpg

My plane was 50 mins away from landing in Minneapolis for AGT auditions today, when it turned round and is now heading BACK

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Can someone explain to me, perhaps from Delta, what the **** is going on as none of your crew seem to have the foggiest?

I will now be landing back in New York an hour before Im supposed to start judging AGT auditions in Minneapolis. Thanks Delta.

Someone told me DELTA stands for DontEver Leave The Airport. Not correct. They leave, then come back again. #utterfarce

Pilot: Good news is well be on the ground in about 25 mins. Yes, but its the wrong ground, isnt it my friend? The WRONG BLOO

Still on tarmac. Not moving. Ominous.

Flight attendant just smiled, then whispered to me: Not looking good. #mixedmessageWe are de-planing everyone off. What aashamed Delta. This is shocking even by your standards.

And you can all relax at Delta now because the gates of Hades will freezeth over before I darken your pitifully incomptent doors a

So sorry to AGT audience for not being there today. Never missed a show in six years. Will be there tomorrow if I have to yomp th

Admit it, even if you hate my guts, youre pulling for me now in Operation Get Morgan To Minneapolis right?

This is at about 9 p.m. last night:

Engines on. De-icing finished. I see a flicker of light at the end of this long dark tunnel.

Taking off! Minneapolis, here I come. #notgoodnewsfordodgycontestants

At midnight today Touchdown. Im in Minneapolis. Thank you Tim Mapesthe man who single-handedly, and against all odds, re

To deploy, and slightly amendm, the vernacular of @charliesheenits been a day of quite spectacular whining, duh Apologies.

Morgan will be in Atlanta April 12 to 14 for Americas Got Talent auditions at Fox Theatre. Will he use Delta then?

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50 BILLION DEVICES INTERNET CONNECTED BY

Vehicle, Asset, Person & PetMonitoring & Controlling

AgricultureAutomation

Security & Surveillance M

+ -

EmbeddedMobile

EverydayThings

Smart Homes& Cities

The Internet of Things

8/10/2019 pharama

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APPLICATIONS

MOBILITYCLOUD

BIG DATACYBER SECURITY

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APPLICATIONS

MOBILITYCLOUD

BIG DATACYBER SECURITY

50% of Americans who had a credi t card w ere impa

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p

December 19, 2013 announces data breach. 4

records initially repor

January 26, 2014 - Mannounces possible da

alerting customers and o

monitoring servic

January 22, 2014 - Neimreleases a statement abou

stolen payment d

February 19, 2014 - UnMaryland announces da

300,000 million recordreported lost

Malware attacks on Yahoo! (Ja

Syrian Electronic Army Hacks S

(January, 2014)Snapchat Hacked in Dec 2013-

million accountssafe hackAdobe Hacking - 38 Million Ac

(Oct 2013)Fake Tweet on 'Obama, Explos

Market PanicBurger King Hacking (US) (Feb

Saudi Arabia Hackers Breach 4Credit Cards (Jan 2012)Sony Pictures and Playstation

2011)1 Million accounts

Top 10 healthc are breaches fo r 2

Utah Department of Health - 780,0

Emory Healthcare - 315,000 recor

S.C. Dept. of Health and Human S

records

Alere Home Monitoring, Inc. - 116,

Memorial Healthcare System, Fla.

Howard University Hospital - 66,60 Apria Healthcare - 65,700 records

University of Miami - 64,846 recor

Safe Ride Services - 42,000 recor

Medical Integration Services, Puer

records

N t l N t k h d k t f $398B i S t 2000

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Nortel Networks had a market cap of $398B in Sept 2000.

The stock represented 36% of the entire Toronto Stock Excha

In Aug 2002, the Market Cap was less than $5B

Stock price went from $124 to $0.47

There were many business reasons for the collapse.

Hacking was one of them: The passwords of seven top execstolen and used to copy internal R&D reports, design, code echeap knockoffs that flooded the market.

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Code Spaces : Is Down!Dear Customers,On Tuesday the 17th of June 2014 we received a well orchestrated DDOS against our servers, this hap

normally overcome them in a way that is transparent to the Code Spaces community. On this occasion hjust the start.An unauthorisedperson who at this point who is still unknown (All we can say is that we have no reasois or was employed with Code Spaces) had gained access to our Amazon EC2 control panel and had lefor us to contact them using a hotmail addressReaching out to the address started a chain of events that revolved around the person trying to extort a resolve the DDOS.Upon realisation that somebody had access to our control panel we started to investigate how access haccess that person had to the data in our systems, it became clear that so far nomachine access had b

intruder not having our Private Keys.At this point we took action to take control back of our panel by changing passwords, however the intrudand had already created a number of backup logins to the panel and upon seeing us make the attempteaccount he proceeded to randomly delete artifacts from the panel. We finally managed to get our panel before he had removed all EBS snapshots, S3 buckets, all AMI's, some EBS instances and several macIn summary, most of our data, backups, machine configurations and offsite backups were either deleted.This took place over a 12 hour period which I have condensed into this very brief explanation, which I w

once we have managed our customers needs.

The gains from a networked world is matched by the pains

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A 2012 study revealed that the median # days before a cis detected is 416 days

94% of data breaches were discovered by an external en

2013 Data Breach cost by industry, per lost record: Healt($233), Financial ($215), Pharmaceuticals ($207)

The gains from a networked world is matched by the pains

Barnab Jack Co ld Hack Yo r Pacemaker and stop the

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Barnaby Jack Could Hack Your Pacemaker and stop the

http://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerimplantable cardioverter defibrillator

APPLICATIONS

http://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemakerhttp://www.vice.com/read/i-worked-out-how-to-remotely-weaponise-a-pacemaker

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APPLICATIONS

MOBILITYCLOUD

BIG DATACYBER SECURIT

Moving Business Analytics to the Next Level

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In Memory BIG DATA Repository & Replication Services

Moving Business Analytics to the Next LevelIntegrating M2M, Data Services and Open Source Data Drilling

EDWE

Transactio

EnterpSyste

Machine-to-machineData

Volunteered SocialData

Data Services & OpenSource Data

When You Connect the Right Dots the Ocean of Data Become

http://www.thingworx.com/

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When You Connect the Right Dots, the Ocean of Data Become

Chronic Diseases

Treatment Options

QuickerApprovals

Orphan Drugs

Regulatory Review

Age, Gender

Geography

Medication

Lab Results

ICD Codes

ResultReports

Risk Profile

Diagnoses

Health PlansQuality Reports

PatientMedicalHistory

DischargeLetters

Clinical Trials

Claims Data

Patient Satisfaction

Payers

Patients

Treatment Plans

Regulatory

Improved TreatmentsImproved Clinical

Trials

PersonalizedMedicine

Superior PatientOutcomes

Scientific data

Exposure data

How Target Figured Out A Teen Girl Was Pregnant Before Her

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g g g

http://www.forbes.com/sites/kashmirhill/2012/02/16/how-target-figured-out-a-teen-girl-was-pregnant-before-her-fathe

Through Data Mining of birth registry data, Target identifieproducts that, when analyzed together, allowed them to ashopper a pregnancy prediction score.

Apart from the score, they could also estimate a shopper

to within a small window, so Target could send coupons tispecific stages of the pregnancy.

Would it spook customers if stores knew about their pre

Target grew from $44 billion in 2002 $67 billion in 2010 prihuge success in tapping into the baby product ma

PRIVACY & ETHICS

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Right to be Forgotten online

639800 G Data moved each second

The use of Sensors will increase data mu

Consumer behavior variedGovernment regulations not uniform

PRIVACY & ETHICS

WHOSE DATA IS IT ANYWAY ?

APPLICATIONS

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THE CONVERGEN

APPLICATIONSMOBILITY

CLOUDBIG DATA

CYBER SECURITY

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BUSINESS PROCESS MANAGEMENT SYSTEMS

ENTERPRISE APPLICATION INTEGRATION MESH

CLOUDIFICATIONTHROUGH MODERNIZATION

MID RANGE

APPLICATIONS

EXISTINGAPPLICATIONS

MAINFRAMEAPPLICATIONS

TRADITIONALAPPLICATIONS

DATA SERVICES

SECURITY

SaaSDEPLOYMENT

SaaS-BASEDVERTICAL

APPLICATIONS

SaHO

APP

PVT Cloud

INNOVATION QUOTIENT

APPLICATIONS

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APPLICATIONS

MOBILITYCLOUD

BIG DATACYBER SECURIT

Mobile use exceeds PC in 2014

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http://internetmedicine.com/2012/12/14/top-ten-medical-uses-of-the-iphone/

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Google Novartis: Contact lens that can measure Sugar le

http://internetmedicine.com/wp-content/uploads/2012/08/breathalyzer1.jpghttp://internetmedicine.com/wp-content/uploads/2012/08/withings4.jpghttp://internetmedicine.com/wp-content/uploads/2012/09/slitlamp31.jpghttp://internetmedicine.com/wp-content/uploads/2012/08/ePetri.jpghttp://internetmedicine.com/wp-content/uploads/2012/10/smartultra1.jpghttp://internetmedicine.com/wp-content/uploads/2012/08/micro1.jpghttp://internetmedicine.com/wp-content/uploads/2012/08/alivecor2.pnghttp://internetmedicine.com/wp-content/uploads/2012/08/alivecor.jpghttp://internetmedicine.com/wp-content/uploads/2012/09/remotoscope1.jpg

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Google Novartis: Contact lens that can measure Sugar le

Medical Apps in the Pharma 3.0 Era

http://mobihealthnews.com/wp-content/uploads/2013/07/proteus-digital-health.top_.jpg

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http://mobihealthnews.com/32728/in-depth-pharmas-digital-health-opportunities/

- Non-medical apps critical for health care providers

- Drug Reference

- Medical Literature Curation apps

- Medical Calculators

- Medical Language translators

- General Reference

- Patient Education

- Specialty Education

- Continuing Medical Education (CME)

- Social Networks

Cost of Human Gene Mapped for the first time in 2003:

http://mobihealthnews.com/wp-content/uploads/2013/07/proteus-digital-health.top_.jpg

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Cost of Human Gene Mapped for the first time in 2003:

Cost of Human Gene Mapping in 2013: $10,0

Cost of Human Gene Mapping in 2014: $1,00

Cost of Human Gene Mapping in 2015-16: $1

You will have your Gene Map on your smart

GOOGLE XPROJECT BASELINEhttp://www.theverge.com/2014/7/25/5935413/google-project-baseline-collect-medical-data-for-huma

3D printers for medical purposes

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3D printers for medical purposes

In 2013, scientists in China used a 3D printer to successfullfunctioning kidney.

In February 2014, a surgeon in England created and implanfrom a 3D printer to help a cancer patient walk again.

But where does3D printingof body parts stop? And should

APPLICATIONS

http://www.csc.com/innovation/insights/102869-4_ways_3d_printing_will_impact_your_lifehttp://www.csc.com/innovation/insights/102869-4_ways_3d_printing_will_impact_your_lifehttp://www.csc.com/innovation/insights/102869-4_ways_3d_printing_will_impact_your_life

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APPLICATIONS

MOBILITYCLOUD

BIG DATACYBER SECURIT

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TrendsCIOs View Cont

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Q4. Approximately what percentage of the enterprise applications at your organization are legacy applications?

Base: 102 qualified respondents

Levels of legacy apps at enterprise organizations are mixed.One-quarter (25%) of the respondents indicate that 50% or more of their enterprise applications are legacy applquarter (27%) estimate that between 25%-49% of their enterprise apps are legacy apps, while another 25% replegacy apps. Just under one-quarter (23%) reveal that less than ten percent are legacy apps , with 6% of those

their enterprise apps are legacy apps.

None

Less than 10%

10%-24%

25%-49%

50%-74%

75% or more

6%

17%

18%

7%

TrendsCIOs View Cont.

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Q6. What are the top challenges to application modernization in your organization? (Please check all that apply.)

Base: 102 qualified respondents

Over half of respondents report that implementation costs (55%) and a lack of resources (53%) are the greatapplication modernization in their organization.

0% 10% 20% 30% 40%

Implementation costs

Lack of resources

Downtime

Risk/liability

Hard to build an ROI case

Compliance/regulatory requirement

Lack of skill sets

Lack of integrated planning between IT and business

Security concerns

TCO

No internal strategy developed

Absence of proven technology

Possible loss of customers

Other

36%

35%

28%

27%

27%

25%

24%

21%

20%

15%

8%

8%

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BUSINESS PROCESS MANAGEMENT SYSTEMS

ENTERPRISE APPLICATION INTEGRATION MESH

CLOUDIFICATIONTHROUGH MODERNIZATION

MID RANGEAPPLICATIONS

EXISTINGAPPLICATIONS

MAINFRAMEAPPLICATIONS

TRADITIONALAPPLICATIONS

DATA SERVICES

SECURITY

SaaSDEPLOYMENT

SaaS-BASEDVERTICAL

APPLICATIONS

SaHO

APP

PVT Cloud

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83,000

CS

EMPLOYEE

IN 70 C

#162 RANKINFORTUNE

$15.5B GLOSERVICES P

50+ YEARS OF

100+ GLOBALWITH BE

PAR

CSC

A GLOBAL IT

POWERHOUSE

Computer Sciences Corporation

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Industries

Solutions

PublicSector

Energyand NaturalResources

FinancialServices

Traveland

Transportation

INDUSTRY EXPERTISE

Healthcare &Life-sciences

Communicationsand

High-Tech

Manufacturing

Cloud CybersecurityBig Data &Analytics

ConsultingSoftware

and IPApplications

Services

Business ProcessServices andOutsourcing

InfrastructureServices

Leading Next-Gen Technology and BusinessSolutions

CSC:S i E t i d G t W ld id *

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Financial Services

Healthcare and Life Sciences

Manufacturing

Energy/Natural Resources

Tech/Consumer

Transportation

Public Sector

Serving Enterprises and Governments Worldwide*

Ministry

Moving Business Analytics to the Next LevelIntegrating M2M Data Services and Open Source Data Drilling

http://en.wikipedia.org/wiki/File:State-farm-logo.svghttp://en.wikipedia.org/wiki/File:Cpic.pnghttp://www.baesystems.com/index.htm

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In Memory BIG DATA Repository & Replication Services

Integrating M2M, Data Services and Open Source Data Drilling

EDWE

Transactio

EnterpSyste

Machine-to-machineData

Volunteered SocialData

Data Services & OpenSource Data

http://www.informationweek.com/big-data/big-data-analytics/16-top-big-data-analytics-platforms/d/d-id/1113609?piddl_msgorder=asc&image_number=3

http://www.bigdata-startups.com/open-source-tools/#!prettyPhoto

http://www.thingworx.com/

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eGain

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eGain