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8/7/2019 Pharmacokinetics : A Refresher
http://slidepdf.com/reader/full/pharmacokinetics-a-refresher 1/28
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7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
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8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
Ejmwk`kc Dgfji|`rjy6
=+ @ljk|`bp mkl ~wdr`lj jxmo~ejy zy`kc gmy`i ~hmwom/ida`kj|`i idkij~|y idoodkep zyjl `k ie`k`ime ~wmi/|`ij% `kiezl`kc je`o`km|`dk wm|j idky|mk|% rdezoj db l`y|w`gz|`dk (Rl )% iejmwmkij% mkl g`dmrm`emg`e`|p+
7+ Ljyiw`gj y~ji`b`i ~hmwomida`kj|`i ihmwmi|jw`y|`iydb idoodkep zyjl |hjwm~jz|`i mcjk|y+
9+ Ljb`kj `o~dw|mk| `yyzjy my |hjp wjem|j |d lwzc idk/ijk|wm|`dk ymo~e`kc mkl `k|jw~wj|m|`dk+
Yjeb/Myyjyyojk| ]zjy|`dky6 Mkysjwy |d |hjyj }zjy|`dky omp gj bdzkl m| |hj
jkl db |h`y ihm~|jw+
=+ F+H+% m 2:/pjmw/del sdomk (2: ac)% smy wjijk|ep`k`|`m|jl dk |dgwmopi`k mkl ~`~jwmi`ee`k /|mvdgmi/|mo bdw |wjm|ojk| db hdy~`|me/mi}z`wjl ~kjzodk`m+Mb|jw |hj b`wy| ldyj db |dgwmopi`k =7> oc (`kbzyjlbwdo kddk |d =6>> ~o)% yjwzo |dgwmopi`k idkijk/|wm| dky mwj lwmsk+ \hjp mwj <+< oc$E m| 96>> ~omkl =+7 oc$E m| 36>> ~o+ Sh ih dkj db |hj bdeeds/`kc y|m|jojk|y `y |wzj mgdz| |dgwmopi`k4
M+ \hjwj mwj yzbb`i`jk| lm|m |d lj|jwo`kj |hjhmeb/e`bj (|=$7) gz| kd| |hj R l +
G+ \hjwj mwj yzbb`i`jk| lm|m |d lj|jwo`kj gd|h|hj | =$7 mkl Rl
I+ \hjwj mwj kyzbb`i jk| lm|m |d lj|jwo`kj j |hjw |hj | =$7 dw |hj Rl
L+ \hjwj mwj yzbb`i`jk| lm|m |d lj |jwo`kj |hj R l
gz| kd| |hj | =$7+
7+ ^+E+ `y m 2>/pjmw/del sdomk (2> ac) wjijk|ep `k`/|`m|jl dk cjk|mo`i`k mkl ie`klmopi`k+ Mb|jw |hjb`wy| cjk|mo`i`k ldyj db ==> oc (`kbzyjl bwdo 26>> ~o |d 269> ~o)% yjwzo cjk |mo`i`k idkijk|wm|`dkymwj lwmsk+ \hjp mwj 9+2 oc$E m| 369> ~o mkl >+0oc$E m| ==69> ~o+ Sh`ih dkj db |hj bdeeds`kc gjy|ljyiw`gjy |h`y ~m|`jk|#y cjk|mo`i`k ~hmwomida`/kj|`i ~mwmoj|jwy4
M+ \hj |_$ 7
`y mgdz| 7 hdzwy+G+ \hj | _$ 7`y mgdz| 9 hdzwy+I+ \hj omx`ozo idkijk|wm|`dk (I omx ) `y mgdz|
9+8 oc$E+L+ \hj R l `y mgdz| ==+2 E+
9+ W+D+ `y m 3</pjmw/del sdomk `k` | m|jl dk cjk|m/o`i`k =>> oc `k|wmrjkdzyep jrjwp 7< hdzwy bdw ~pjedkj~hw`| `y+ Dk mlo`yy`dk% hjw yjwzo iwjm|` /k`kj (YIw) `y =+8 oc$lE+ Yhj meyd hmy idkcjy|`rj
hjmw| bm`ezwj mkl `y bez`l drjwedmljl gjimzyj db hjw l`o`k`yhjl wjkme bzki|`dk mkl kdkmlhjwjkij |dhjw mkc`d|jky`k/idkrjw|`kc jkvpoj `kh`g`|dw mkll`zwj|`i+ M bjs lmpy `k|d hjw hdy~`|me`vm|`dk% hjw YIw `y ldsk |d =+= oc$lE% mkl yhj `y wj`k |`m|jl dkbzwdyjo`lj mkl jkmem~w`e+ Sh`ih db |hj bdeeds`kcody| e`ajep hm~~jkjl |d |hj cjk|mo`i`k | =$7 `k W+D+lzw`kc hjw hdy~`|me`vm|`dk4
M+ Hjw iejmwmkij `kiwjmyjl% sh`ih `kiwjmyjl hjw Rl
mkl ljiwjmyjl hjw | =$7
G+ Hjw iejmwmkij `kiwjmyjl% sh`ih kiwjmyjl hjw je`o`km|`dk wm|j idky|mk| mkl ljiwjmyjl hjw |=$7+
I+ Hjw Rl ljiwjmyjl% sh`ih `kiwjmyjl hjw iejmwmkij mkl ljiwjmyjl hjw |=$7+
L+ Hjw Rl ljiwjmyjl% sh`ih `kiwjmyjl hjw je`o`km|`dk wm|j idky|mk| mkl `kiwjmyjl hjw |=$7
<+ M ~m| jk| wjij`rjy rmkidopi`k =>>> oc `k|wmrj/kdzyep jrjwp 7< hdzwy mkl hmy m |wdzch idkijk|wm/|`dk% lwmsk 9> o`kz|jy gjbdwj |hj kjx| ldyj% db 2oc$E+ Sh`ih dkj db |hj bdeeds`kc wjc`ojky `y gjy|bdw |h`y ~m|`jk| `b |hj cdme |wdzch idkijk|wm|`dk `y=>/=: oc$E4
M+ Om`k|m`k |hj ldyj m| =>>> oc `k|wmrjkdzyepjrjwp 7< hdzwy+
G+ Edsjw |hj ldyj |d :>> oc% gz| ajj~ |hj`k|jwrme m| jrjwp 7< hdzwy+
I+ Ajj~ |hj ldyj m| =>>> oc% gz| yhdw|jk |hj`k|jwrme |d jrjwp =7 hdzwy+
L+ Edsjw |hj ldyj |d :>> oc% mkl yhdw|jk |hj`k|jwrme |d jrjwp =7 hdzwy+
:+ M <>/pjmw/del% 2>/ac sdomk shd yodajy ~wjyjk|y|d |hj jojwcjkip lj~mw|ojk| m| 76>> ~o s`|h mkmiz|j jxmijwgm|`dk db my|hom+ Yhj |majy |hjd~hpe/e`kj yzy|m`kjl wjejmyj 9>> oc 7 |`ojy$lmp% s`|h |hjemy| ldyj |majk m| 06>> |hm| odwk`kc+ Hjw |hjd~h/pee`kj idkijk|wm|`dk yddk mb|jw ~wjyjk|`kc |d |hjjojwcjkip lj~mw|ojk| `y 3+> oc$E+ Yhj `y y|mg`/e`vjl mkl `y |d gj yjk| hdoj dk |hjd~hpee`kj yzy/|m`kjl wjejmyj+ Sh`ih dkj db |hj bdeeds`kc d~|`dky`y |hj gjy| wjc`ojk bdw |h`y ~m|`jk|4
M+ \hjd~hpee`kj yzy|m`kjl wjejmyj 9>> oc gpodz|h jrjwp =7 hdzwy+G+ \hjd~hpee`kj yzy|m`kjl wjejmyj 2>> oc gp
odz|h jrjwp =7 hdzwy+I+ \hjd~hpee`kj yzy|m`kjl wjejmyj <>> oc gp
odz|h jrjwp 8 hdzwy+L+ \hjd~hpee`kj yzy|m`kjl wjejmyj 2>> oc gp
odz|h jrjwp 8 hdzwy+
2+ E+W+ `y m <0/pjmw/del ~m|`jk| s`|h l mgj|jy ojee |zymkl wjkme bm`ezwj+ Hj smy wjijk|ep `k m imw mii`ljk|mkl yzy|m`kjl hjml |wmzom+ Hj izwwjk|ep wjij`rjy
7
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
~hjkp|d`k =>> oc `k|wmrjkdzyep 9 |`ojy$ lmp% mklh`y ody| wjijk| idkijk|wm|`dk smy :+2 oic$oE+Pdz mwj myajl |d yzccjy| m kjs ldyj |d mih`jrj midkijk|wm|`dk s`|h`k |hj |hjwm~jz|`i wmkcj+ Emgd/wm|dwp wjyze|y `kiezlj ydl`zo =<: oJ}$E% ~d|my/y`zo 9+0 oJ}$E% ihedw`lj =>= oJ}$E% imwgdk l`/dx`lj 72 oJ}$E% geddl zwjm k`|wdcjk (GZK) 0:oc$lE% YIw :+< oc$lE% cezidyj 79> oc$lE% mklmegzo`k (Meg) 7+8 c$lE+ Sh`ih dkj db |hj bdeeds/`kc ihd`ijy `y |hj gjy| wjidoojklm|`dk4M+ @kiwjmyj |hj ldyj |d 7>> oc `k|wmrjkdzyep 9
|`ojy$lmp+G+ @kiwjmyj |hj ldyj |d 7>> oc `k|wmrjkdzyep 7
|`ojy$lmp+I+ Ljiwjmyj |hj ldyj |d =>> oc `k|wmrjkdzyep 7
|`ojy$lmp+L+ Ajj~ |hj ldyj |hj ymoj+
3+ Pdz mwj myajl hds |hj \Lx (bezdwjyijkij ~demw/`vm|`dk `oozkdmyymp) mkl JO@\ (jkvpoj oze/|`~e`jl `oozkdmyymp |jihk`}zj) myympy ido~mwjs`|h jmih d|hjw+ Sh`ih dkj db |hj bdeeds`kc y|m|j/ojk|y `y ody| miizwm|j4M+ Me|hdzch gd|h mwj `oozkdmyympy% dkj emgjey
mk|`gdlp% shjwjmy |hj d|hjw emgjey mk|`cjk+G+ Me|hdzch gd|h mwj `oozkdmyympy% dkj zyjy
mk|`gdlp my m omwajw% shjwjmy |hj d|hjw zyjym wml`d`yd|d~j+
I+ Me|hdzch gd|h mwj `oozkdmyympy% dkj zyjymk jkvpoj emgje% shjwjmy |hj d|hjw zyjy mbezdwjyijk| emgje+
L+ \hjp mwj gd|h kmojy bdw |hj ymoj myymp|jihk`}zj+
8+ Mk jeljwep ~m| jk| `y yjjk `k |hj odwk`kc ojl i`kjie`k`i bdw m wdz|`kj bdeeds/z~+ Ojl`im|`dk h`y|dwp`kiezljy l`cdx`k >+7: oc$lmp gp odz|h% bzwdyj/o`lj <> oc$lmp gp odz|h% mkl ~d|myy`zo ihedw`lj=> oJ}$lmp gp odz|h+ Mee ldyjy sjwj emy| |majkm| 86>> mo |dlmp m| hdoj+ \hj ~m|`jk| hmy rmczjido~em`k|y db y|domih z~yj|% sh`ih gjcmk 7 lmpymcd% gz| `y d|hjws`yj `k kd m~~mwjk| l`y|wjyy+ M yj/wzo l`cdx`k idkijk|wm|`dk lwmsk |dlmp m| =>6>>mo `y 7+: oic$E+ Sh`ih dkj db |hj bdeeds`kc y|m|j/ojk|y gjy| ljyiw`gjy shm| yhdzel gj ldkj kjx|4M+ Mlo`| |hj ~m|`jk| bdw mlo`k`y|wm|`dk db
l`cdx`k Bmg+G+ \jee |hj ~m|`jk| |d ya`~ |dodwwds#y ldyj db
l`cdx`k mkl gjc`k >+=7: oc$lmp gp odz|h+I+ Mlo`k`y|jw m ldyj db mi|`rm|jl ihmwidme+L+ Ld kd|h`kc |dlmp mgdz| |hj l`cdx`k+
0+ M wjyjmwih cwdz~ `y mkmepv`kc |hj wjem|`dkyh`~ gj/|sjjk rmw`dzy `klj~jkljk| ~m|`jk| ljodcwm~h`iy(j+c+% mcj% hj ch|% sj`ch|% Meg% iwjm|`k`kj iejmwmkijQIwIe_) mkl ~hjkp|d`k ~hmwomida`kj|`iy+ Sh`ihdkj db |hj bdeeds`kc y|m|`y|`ime |jy|y s`ee kjjl |d gjzyjl |d myyjyy |hj wjem|`dkyh`~4M+ Dkj/smp mkmepy`y db rmw`mkij+G+ Mkmepy`y db idrmw`mkij+I+ Oze|`~ej edc`y| i wjcwjyy`dk+L+ Y~jmwomk wmka idwwjem|`dk+
=>+ K+\+ `y m 7</pjmw/del sdomk wjij`r`kc rme~wd`imi`l bdw |dk`i/iedk`i yj`vzwjy+ Hjw ody| wjijk||wdzch rme~wd`i mi`l idkijk|wm|`dk smy 77 oc$E+Hjw ody| wjijk| Meg idkijk|wm|`dk smy <+= c$lE+Gmyjl dk |h`y yjwzo idkijk|wm|`dk% sh`ih dkj db |hj bdeeds`kc wjidoojklm|`dky `y gjy| idkijwk`kchjw ldyj4M+ Idk|`kzj s |h |hj izwwjk| ldyj1 |hj
idkijk|wm|`dk `y iedyj jkdzch |d |hj|hjwm~jz|`i wmkcj+
G+ Myyjyy mlhjwjkij mkl kiwjmyj hjw ldyj1 |hjidkijk|wm|`dk `y gjeds |hj |hjwm~jz|`i wmkcj+
I+ Ljiwjmyj hjw ldyj1 |hj idkijk|wm|`dk `yye`ch|ep mgdrj |hj |hjwm~jz|`i wmkcj+
L+ Myyjyy mlhjwjkij mkl |hjk ihjia m bwjjrme~wd`i mi`l idkijk|wm|`dk mkl mlfzy|miidwl`kcep+
9
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
^m|`jk| Imyjy
=+ H+W+ `y wjij r`kc rmkidopi`k bdw m oj|h`i`ee`k/wjy`y|mk|Y|m~hpedidiizy mzwjzy gmi|jwjo`m+ H+W+ hmy ihwdk`iwjkme bm`ezwj+ M =/c `k|wmrjkdzy ldyj db rmkidopi`k `y c`rjk m| kddk dk Omwih 7=+ M idkijk|wm|`dk lwmskm| 76>> ~o dk Omwih 7= `y 79+8 oic$oE+ M idkijk|wm|`dk lwmsk m| 76>> ~o dk Omwih 7< `y =7+= oic$oE+ @b pdz sjwj |d c`rj m ldyj m| <6>> ~o dk Omwih 7< mkl pdzw cdme |wdzch idkijk|wm|`dk smy =>/=: oc$E% shjksdzel `| gj gjy| |d c`rj |hj kjx| ldyj4M+ = lmp mb|jw |hj ldyj dk |hj 7<|h+G+ 9 lmpy bwdo |hj ldyj dk |hj 7<|h+I+ 2 lmpy bwdo |hj ldyj dk |hj 7<|h+L+ \hjwj `y kd| jkdzch `kbdwom|`dk |d imeizem|j shjk |d wjldyj+
7+ Mb|jw |hj mlo`k`y|wm|`dk db =>> oc db m lwzc `k|wmrjkdzyep mkl 7>> oc db |hj ymoj lwzc gp odz|h% |hj mwjmyzkljw |hj izwrjy mwj :> mkl 7: oc$E$hdzw+ Sh`ih dkj db |hj bdeeds kc `y |hj g`dmrm`emg`e`|p db |h`y lwzc4M+ 7:*+G+ 93+:*+I+ :>*+L+ =>>*+
9+ Mk `kbzy`dk db 7> oc$hdzw db |hjd~hpee`kj `y `k`| m|jl+ Sh`ih dkj db |hj bdeeds kc gjy| wj~wjyjk|y shm| |hjyjwzo idkijk|wm|`dk sdzel gj m| <8 hdzwy `b |hj | =$7 db |hj lwzc sjwj < hdzwy mkl |hj R l sjwj >+: E$ac (pdzw ~m|`jk| sj`chy 2: ac)4M+ 9+2 oc$E+G+ :+> oc$E+I+ =8+7 oc$E+L+ 9>+ < oc$E+
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8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
@@+ MGYDW^\@DK
M+ B`wy|/~myy Jbbji|=+ Geddl ~jwbzy`kc r`w|zmeep mee |hj cmy|wd`k|jy|`kme |`yyzjy ~myyjy |hwdzch |hj e`rjw gp ojmky db
|hj hj~m|`i ~dw|me rj`k+m+ B`b|p ~jwijk| db |hj wji|me geddl yz~~ep gp~myyjy |hj e`rjw (o`llej mkl `kbjw`dw
hjodwwhd`lme rj`ky)+ g+ Lwzcy mgydwgjl `k |hj gziime imr `|p gp~myy |hj e`r jw+
7+ Lwzcy mbbji|jl ody| gp |hj b`wy|/~myy jbbji| mwj |hdyj s`|h m h`ch hj~m|`i jx|wmi|`dk wm|`d+
9+ Jxmo~ej
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Ldxj~`k Odw~h`kj ^wd~wmkdede
@o`~wmo`kj K`imwl`~`kj Rjwm~mo`e
@ydydwg`lj l k`|wm|j K`bjl`~`kj
:
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
Cezizwdk`lj idkfzcm|j^mwjk|^mwjk|^mwjk| mkl ljyoj|hpe oj|mgde`|j^mwjk| mkl cezizwdk`lj^mwjk|^mwjk|Cezizwdk`ljy db ~mwjk| mkl oj|mgde`|jyIdkfzcm|jyCezizwdk`lj idkfzcm|jCezizwdk`lj idkfzcm|jyIdkfzcm|jy
G+ Jk|jwdhj~m|`i Wji`wizem|`dk=+ Lwzcy mwj jxiwj|jl gp |hj g`ej `k|d |hj lzdljkzo% oj|mgde`vjl gp |hj kdwome bedwm `k |hj
cmy|wd`k|jy|`kme |wmi|% mkl wjmgydwgjl `k|d |hj ~dw|me i`wizem|`dk+
7+ Diizwy `k lwzcy s`|h =) g`e`mwp (hj~m|`i) je`o`km|`dk mkl 7) cddl dwme mgydw~|`dk9+ Lwzc `y idkijk|wm|jl `k |hj cmeegemlljw mkl jx~jeejl dk y`ch|% yojee% dw `kcjy|`dk db bddl+
Jxmo~ejy db Ido~dzkly Jxiwj|jl k G`ej mklYzgfji| |d Jk|jwdhj~m|`i Ipie`kc
Ido~dzkl Jk|`|p `k G`ejIhedwmo~hjk`ideL`cdx`kJy|wdcjky@o`~wmo`kj@kldoj|hmi`k Kmbi`ee`kW`bmo~`kYze`klmi\jy|dy|jwdkj\`mcmg`kjRme~wd`i mi`lR`|mo`k M
^m|`jk| Imyj
<+ Sh`ih dkj db |hj bdeeds`kc y|m|jojk|y gjy| ljyiw`gjy ^/cepid~wd|j`k4
M+ @| `y m ~emyom ~wd|j`k |hm| g`kly gmy`i lwzcy+
G+ @| |wmkybjwy lwzcy |hwdzch |hj cmy|wd`k|jy|`kme ozidym% `kiwjmy`kc mgydw~|`dk+I+ @| l`o`k`yhjy |hj jbbji| db ip|dihwdoj <:> 9M< (IP^9M<) `k |hj cmy|wd`k|jy|`kme ozidym+L+ @| `y mk jbbezx ~zo~ |hm| ljiwjmyjy cmy|wd`k|jy|`kme ozidyme |wmky~dw|+
=+ ^/cepid~wd|j`k `y mk jbbezx ~zo~ (edim|jl `k |hj jyd~hmczy% y|domih% mkl yomee mkl emwcj`k|jy|`kjy) |hm| ~zo~y lwzcy gmia `k|d |hj cmy|wd`k|jy|`kme ezojk1 `| `y m odwj `o~dw|mk| bmi| dw `k lwzc mgydw~|`dk lwzc `k|jwmi|`dky |hmk `k|jy|`kme IP^9 M<+
7+ IP^9M< mkl ^/cepid~wd|j`k edim|jl `k yomee `k|jy|`kme jk|jwdip|jy sdwa |dcj|hjw |d ljiwjmyj|hj mgydw~|`dk db xjkdg `d|`iy+
9+ Ody| IP^9M< yzgy|wm|jy mwj meyd ^/cepid~wd|j`k yzgy|wm|jy+
<+ Omkp IP^9M< `kh`g |dwy$`klzijwy meyd `kh`g`|$`klzij ^/cepid~wd|j`k% ejml`kc |d `kiwjmyjy dw ljiwjmyjy `k g`dmrm`emg`e`|p+
:+ Jxmo~ejy db ^/cepid~wd|j`k mgydw~|`dk lwzc `k|jwmi|`dky `kiezlj }z`k`l`kj dw rjwm~mo`e mkll`cdx`k1 w`bmo~`k dw Y|+ Fdhk#y sdw|1 mkl hzomk `oozkdljb`i`jkip r`wzy ~wd|jmyj `kh`g`|dwy+
2
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
@@@+ L@Y\W@GZ\@DK
G
M+ Ljb`k`|`dk6 M~~mwjk| Rl “~wd~dw|`dkme` |p idky|mk| |hm| wjem |jy |hj modzk| db lwzc `k |hj gdlp |d mk dg /yjwrjl idkijk|wm|`dk db lwzc
^wd|j`k G`kl`kc
^wd|j`k \p~jy db Lwzcy Gdzkl Odejizemw Sj`ch| Kdwome Idkijk|wm|`dky(c$E) (ºode)
Megzo`k Mi`l`i 2:%>>> 9:/:> :>>/3>>
ν /=/mi`l cepid~wd|j`k Gmy`i <<%>>> >+</=+> 0/79
E`~d~wd|j`k E`~d~h`e`i mkl gmy`i 7>>%>>>/9%<>>%>>> Rmw`mgej Rmw`mgej
I+ /cepid~wd|j`k=+ ^/cepid~wd|j`k `y mk jbbezx ~zo~ |hm| ojl`m|jy geddl/gwm`k gmww`jw |wmky~dw| gp e`o`|`kc
z~|maj `k|d dw `kiwjmy`kc |hj jbbezx dz| db gwm`k j~`|hje`me ijeey+7+ @| omp gj jy~ji`meep `o~dw|mk| s`|h d~`d`ly“`klzi|`dk db ^/cepid~wd|j`k gp ihwdk`i zyj db
d~`d`ly ljiwjmyjy |hj d~`d`l jbbji| (|dejwmkij)+9+ ^/cepid~wd|j`k `y meyd bdzkl `k |zodw ijeey% wjyze|`kc `k |hj jbbezx db ihjod|hjwm~jz|`i mcjk|y
dz| db |hj ijee mkl% ze|`om|jep% oze|`lwzc wjy`y|mkij+
@R+ IEJMWMKIJ
Jkvpojy @krderjl k Lwzc Oj|mgde`yo
Dxpcjkmyjy
IP^<:>y
Odkdmo`kj dxpcjkmyjy
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IP^ ? ip|dihwdoj ^<:>+
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\hj ~m|`jk| `y mlo`||jl |d |hj hdy~`|me mkl `k`|`m|jl dk ijb|w`mxdkj mkl m omiwde`lj+ Sh`ih dkj db |hjbdeeds`kc omiwde`ljy `y ejmy| e`ajep |d `k|jwmi| s`|h ipiedy~dw`kj4
M+ Jwp|hwdopi`k+G+ Iemw` |hwdopi`k+I+ Mv`|hwdopi `k+L+ Mee |hj omiwde`ljy kh`g`| IP^9M<+
3
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
Yzgbmo`ep (; 3>* ljk|`ime)
Bmo`ep (; <>* `ljk|`ime)
CJKJ bdw omoome`mk ip|dihwdoj
B`czwj =+
7+ L`y|w`gz|`dk db IP^<:> `ydjkvpojy `k h zomk e`rjw
=+ @k|wdlzi|`dkm+ M cwdz~ db hjoj/idk|m`k`kc jkvpojy wjy~dky`gej bdw ~hmyj = oj|mgde`i wjmi|`dky
g+ Ihmwmi|jw`y |`i mgydwgmkij db e `ch | m | <:> ko ( |hzy IP^<:>)i+ ^w`omw`ep edim|jl `k |hj ojogwmkjy db |hj yodd|h jkld~emyo`i wj| izezo `k =) e`rjw% 7)
yomee `k|jy|`kj% mkl 9) gwm`k% ezkc% mkl a lkjpl+ Jkidljl gp m yz~jwcjkj bmo`ep dw yzgbmo`ep1 yj~mwm|j cjkjy idlj bdw l`bbjwjk|
`ydjkvpojyj+ Lwzcy s`ee cjkjwmeep hmrj m h`ch mbb`k`|p bdw dkj ~mw|`izemw IP^ <:>% gz| ody| lwzcy meyd
hmrj yjidklmwp ~m|hsmpy+b+ Kdojkiem|zwj
IP^ 9 M <Y~ji`b`i jkvpoj
Idk|jk| Wdej `k IP^/ojl`m|jl Lwzc Je`o`km|`dk
B`czwj 7+
8
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
9+ L`y|w`gz|`dk db IP^<:> `ydjkvpojy `k hzomk cmy|wd`k|jy|`kme |wmi|
d|hjw IP
9>*
IP^9M<
3>*
B`czwj 9+
<+ Ihmwmi|jw`y|`iy db IP^<:> oj|mgde`yom+ @kh`g`|`dk `y yzgy|wm|j/`klj~jkljk|+
g+ Ydoj yzgy|wm|jy mwj oj|mgde`vjl gp odwj |hmk dkj IP^<:> (j+c+% \IMy Q|w`ipie`imk|`lj~wjyymk|y_% YYW@y Qyjeji|`rj yjwd|dk`k wjz~|maj `kh`g`|dwy_)+
i+ Jkmk|`dojwy omp gj oj|mgde`vjl gp m l`bbjwjk| IP^<:> (j+c+% smwbmw`k)+l+ L`bbjwjkijy `k `kh`g`|`dk omp jx`y| s`|h`k |hj ymoj iemyy db mcjk|y (j+c+% bezdwd}z`kdedkjy%
mvdej mk|`bzkcmey% omiwde`ljy% imei`zo ihmkkje gediajwy% H7 ged iajwy)+j+ Yzgy|wm|jy imk meyd gj `kh`g`|dwy (j+c+% jwp|hwdopi`k% rjwm~mo`e% l`e|`mvjo)+b+ Ody| klzijwy mkl ydoj kh`g |dwy imk mbbji| odwj |hmk dkj `ydvpoj (j+c+% i`oj|`l`kj%
w`|dkmr`w% bezdxj|`kj% jwp|hwdopi`k)+c+ @kh`g`|dwy omp mbbji| l`bbjwjk| `ydvpojy m| l`bbjwjk| ldyjy (j+c+% bezidkmvdej)+
G+ ^/cepid~wd| j`k=+ ^/cepid~wd|j`k `y mk jbbezx ~zo~ |hm| ~zo~y lwzcy `k|d |hj g`ej1 |hj ie`k`ime jbbji| db
^/cepid~wd|j`k lwzc `k|jwmi|`dky `k |hj g`ej `y zkakdsk+7+ ^/cepid~wd|j`k ~zo~y lwzcy bwdo wjkme |zgzejy `k|d |hj zw`kj1 `| meyd ~d|jk|`meep e`o`|y |hj ljcwjj
db wjmgydw~|`dk+9+ Jxmo~ejy db lwzc `k|jwmi|`dky6 }z`k`l`kj/l`cdx`k% ipiedy~dw`kj/l`cdx`k% mkl ~wd~mbjkdkj/l`cdx`k
I+ ^hmwomidcjkj|`iy$^depodw~h`i Lwzc Oj|mgde`yo=+ ^d~zem|`dk `y l`r`ljl `k|d ~ddw oj|mgde`vjwy mkl jx|jky`rj oj|mgde`vjwy1 |hjwjbdwj% oj|mgde`yo `y
idky`ljwjl ~depodw~h`i+7+ Ljb`k`|`dk6 idjx`y|jkij db odwj |hmk dkj cjkj| i rmw`mk| (meejejy)% sh`ih mwj y|mgej ido~dkjk|y `k
|hj ~d~zem|`dk (odwj |hmk =* db ~d~zem|`dk)9+ Iejmw mk|`odlj wjyze|y
Kd+ db ^m|`jk|y
Oj|mgde`i Wm|`d (`kiwjmy`kc oj|mgde`i im~mi`|p /////////
JO ? jx|jky`rj oj|mgde`vjw1 ^O ? ~ddw oj|mgde`vjw1 ZWO ? ze|wmwm~`l jx|jky`rj oj|mgde`vjw+B`czwj <+
0
8/7/2019 Pharmacokinetics : A Refresher
http://slidepdf.com/reader/full/pharmacokinetics-a-refresher 10/28
^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
<+ ^hjkd|p~j6 jx~wjyy`dk db |hj |wm`|m+ Omk`bjy|m|`dk db |hj |wm`| ie`k`imeep
g+ Kd| k jijyymw`ep idky|mk |:+ Cjkd|p~j6 cjkj | i omajz~
m+ Idky|mk|6 imk gj |jy|jl
\mgej =+
^m|hsmp Yzgy|wm|j Jkvpoj Lwzc Jxmo~ejy
Dx`lm|`dk Ljgw`yd}z`kj% ljx|wdoj|hdw~hmk IP^7L2 \jw|`mwp mo`kjyBezdxj|`kjBejim`k`lj^wd~mbjkdkjOj|d~wdede^wd~wmkdede\`odedeIdlj`kj
Dx`lm|`dk Oj~hjkp|d`k IP^7I=0 \jw|`mwp mo`kjy (l`mvj~mo)^hjkp|d`kDoj~wmvdej
Mij|pem|`dk @ydk`mv`l% imbbj`kj K /mij|pe |wmkybjwmyj Iedkmvj~moLm~ydkjHplwmemv`kj@kmow`kdkj^wdim`kmo`ljYzebdkmo`ljy
R+ KDKE@KJMW ^HMWOMIDA@KJ\@IY
^m|`jk| Imyj2+ I+O+ `y m ::/pjmw/del omk shd `y `k`|`m|jl dk ~hjkp|d`k mb|jw m iwmk`d|dop+ H`y izwwjk| y|jmlp/y|m|j ~hjkp|d`k
idkijk|wm|`dk `y 2 oc $E m| m ldyj db 7>> oc$lmp gp odz|h+ @b h`y mbb`k`|p idky|mk| (A o ) `y imeizem|jl |d gj :oc$E% shm| s`ee hm~~jk |d h`y idkijk|wm|`dk `b |hj ldyj `y ldzgejl (|d <>> oc$lmp gp odz|h)4
M+ H`y idkijk|wm|`dk s`ee ldzgej gjimzyj ~hjkp|d`k iejmwmkij `y e`kjmw mgdrj |hj A o +G+ H`y idkijk|wm|`dk s`ee odwj |hmk ldzgej gjimzyj ~hjkp|d`k iejmwmkij `y kdke`kjmw mgdrj |hj A o +I+ H`y idkijk|wm|`dk s ee y|mp |hj ymoj gjimzyj ~hjkp|d`k `y mk mz|d`klzijw% mkl iejmwmkij `kiwjmyjy s`|h |`oj+L+ H`y idkijk|wm|`dk s`ee kiwjmyj gp dkep :>* gjimzyj ~hjkp|d`k mgydw~|`dk ljiwjmyjy y`ck`b`imk|ep s`|h
ldyjy cwjm|jw |hmk 9>> oc+
M+ O`ihmje`y/Ojk|jk hmwomida`kj|`iy
Rjedi`|p ? Romx & YAo ! Y
R omx ? im~mi`|p idky|mk| (modzk|$|`oj)A o ? mbb`k`|p idky|mk| (modzk|$rdezoj)Y ? yzgy|wm|jidkijk|wm|`dk (modzk|$rdezoj)
=>
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
R@+ KDKIDO^MW\OJK\ME ^HMWOMIDA@KJ\@IY
M+ Shp Kdkido~mw|ojk|me ^hmwomida`kj|`iy4=+ @ljk|`b`im|`dk db |hj 'idwwji|' odlje `y db|jk `o~dyy`gej+7+ M ido~mw|ojk|me r`js db |hj gdlp `y zkwjme`y|`i+9+ E`kjmw wjcwjyy`dk `y zkkjijyymwp“`| `y jmy`jw |d mz|dom|j mkmepy`y+<+ Wj}z`wjy bjsjw mkl ejyy y|w`kcjk| myyzo~|`dky:+ Odwj cjkjwme oj|hdly mkl j}zm|`dky2+ \hjwj `y kd kjjl |d om|ih mee lm|m yj|y |d |hj ymoj ido~mw|ojk|me odlje+
G+ Kdke`kjmw Je`o`km|`dk=+ Ym|zwm|`dk dw ~mw|`me ym|zwm|`dk db |hj je`o`km|`dk ~m|hsmp
Wm|j db je`o`km|`dk ? Romx & IAo ! I
R omx ? omx`ozo wm|j d b je`o`km|`dk (modzk|$|`oj)
A o ? idkijk|wm|`dk shjwj je`o`km|`dk `y =$7 R omx (mbb`k`|p idky|mk|)
I ? lwzc idkijk|wm|`dk
7+ Kd|j6 Kdke`kjmw`|p diizwy shjk idkijk|wm|`dk `y m| dw mgdrj A om+ Jxmo~ej6 ~hjkp|d`k
`+ Romx kdwome ? 3 oc$ac$lmp``+ A o kdwome ? :+2 oc$E```+ :>* rmw`mg`e`|p gj|sjjk `kl`r`lzmey
==
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
7+ Rdezoj db l`y|w`gz|`dk m| y|jmlp y|m|j
R YY ? ldyj & MZOI
MZI7
9+ Je`o`km|`dk wm|j idky|mk|
a ? =OW\
<+ Mgydw~|`dk wm|j idky|mk|
A m? =OM\
:+ G`dmrm`emg`e`|p
B ? L`r & MZIjrLjr & MZI`r
R@@+ LM\M IDEEJI\@DK MKL MKMEPY@Y
^m|`jk| Imyj3+ W+A+ `y m :</pjmw/del sdomk s`|h m h`y|dwp db l`mgj|jy ojee`|zy mkl jkl/y|mcj wjkme l`yjmyj+ Yhj `y wjij`r`kc
cjk|mo`i`k bdw ^yjzldodkmy ~kjzodk`m+ M cjk|mo`i`k idkijk|wm|`dk `y dwljwjl mb|jw l`mepy`y+ Sh`ih dkjdb |hj bdeeds`kc y|m|jojk|y `y |wzj mgdz| dg|m`k`kc |h`y ymo~ej4M+ \hj ody| miizwm|j idkijk|wm| dk `y dg|m`kjl `oojl`m|jep mb|jw hjodl`mepy`y+G+ Sm`| m bjs hdzwy |d dg|m`k |hj idkijk|wm| dk gjimzyj `| s`ee ljiwjmyj
y`ck`b`imk|ep s`|h`k |hj b`wy| bjs hdzwy mb|jw hjodl`mepy`y+I+ Sm`| m bjs hdzwy |d dg|m`k |hj idkijk|wm| dk gjimzyj `| s`ee `kiwjmyj
y`ck`b`imk|ep s`|h`k |hj b`wy| bjs hdzwy mb|jw hjodl`mepy`y+L+ Sm`| zk| e |hj kjx| lmp yd |hm| mee |hj jbbji|y db hjodl`mepy`y hmrj mgm|jl+
M+ \`o`kc db Ideeji|`dk=+ Jkyzwj ido~ej|`dk db mgydw~|`dk mkl l`y|w`gz|`dk ~hmyjy (jy~ji`meep l`cdx`k mkl
rmkidopi`k% j|i+)+7+ Jkyzwj ido~ej|`dk db wjl`y|w`gz|`dk ~dy|l`mepy`y (jy~ji`meep mo`kdcepidy`ljy)+
G+ Y~ji`ojk Wj}z`wjojk|y=+ Shdej geddl6 Zyj mk|`idmczem|jl |zgj+
7+ ^emyom6 Zyj mk|`idmczem|jl |zgj mkl ijk|w`bzcj1 ied||`kc ~wd|j`ky mkl ydoj geddl ijeey mwjom`k|m`kjl+
9+ Yjwzo6 Zyj wjl |d~% meeds |d ied|% mkl ijk|w`bzcj+
=7
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8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
L+ Myymp Oj|hdldedcp=+ @oozkdmyympy
m+ Wml`d`oozkdmyymp
`+ Mlrmk|mcjy6 jx|wjojep yjky`|`rj (~`idcwmo wmkcj)``+ L`ymlrmk|mcjy6 Wml`d`oozkdmyymp a`|y hmrj e`o`|jl yhjeb e`bj gjimzyj db |hj yhdw|| _$ 7 db emgjey% kziejmw smy|j% mkl iwdyy/wjmi|`r`|p+
&&Ie`k`ime zyj bdw myymp`kc l`cdx`k mkl ipiedy~dw`kj
g+ Jkvpoj `oozkdmyympjx+ JO@\ (jkvpoj oze|`~e`jl `oozkdmyymp |jihk`}zj)
i+ Bezdwjyijkij oozkdmyymp\Lx (Mggd||) (bezdwjyijkij ~demw`vm|`dk `oozkdmyymp)6 ody| idoodk |hjwm~jz|`ilwzc odk`|dw`kc myympMlrmk|mcjy6 y`o~ej% mz|dom|jl% h`chep yjky`|`rj% mkl y|mgej wjmcjk|yL`ymlrmk|mcjy6 gmiacwdzkl `k|jwbjwjkij m||w`gz|mgej |d jkldcjkdzy yjwzobezdwjyijkij
7+ H`ch/~wjyyzwj e`}z`l ihwdom|dcwm~hp9+ Bemoj ~hd |doj|wp<+ G`dmyymp
J+ ^d~zem|`dk ^hmwomida`kj|`iy `k \hjwm~jz|`i Lwzc Odk`|dw`kc=+ ^d~zem|`dk ~hmwomida`kj|`iy zyjbze shjk6
m+ Lwzc idkijk|wm|`dky mwj dg|m`kjl lzw`kc ido~e`im|jl ldy`kc wjc`ojky+ g+ Lwzc idkijk |wm|`dky mwj dg |m`kjl g jbdwj y|jmlp y|m |j+i+ Dkep m bjs lwzc idkijk|wm|`dky mwj bjmy`gep dg|m`kjl (e`o`|jl ymo~e`kc y|wm|jcp)+
7+ Gmpjy`mk ~hmwomida`kj | iym+ ^w`dw ~d~zem|`dk `kbdwom|`dk `y idog`kjl s`|h ~m|`jk|/y~ji`b`i lm|m |d ~wjl`i| |hj ody|
~wdgmgej `kl `r`lzme ~mwmoj|jwy+ g+ Shjk ~ m|`jk |/y~ji`b`i lm|m mwj e `o`|j l% |hjwj `y cwjm|jw `kbezjki j bwdo ~d~zem|`dk
~mwmoj|jwy1 shjk ~ m|` jk|/y~ji`b`i l m|m mwj jx|jk y`r j% |hjwj `y ejyy `kbezjki j+i+ S`|h yomee modzk|y db `kl`r`lzme lm|m% Gmpjy`mk bdwjimy|`kc cjkjwmeep p`jely odwj
~wj i`yj wjyze|y+
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8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
R@@@+ ^HMWOMIDA@KJ\@IY @K WJKME L@YJMYJ
^m|`jk| Imyjy
0+ A+O+% mk 8>/pjmw/del sh`|j sdomk (<8 ac% :#<')% `y mlo`||jl |d |hj hdy~ |me bdw ~pjedkj~hw |`y s`|h yj~y`y+Yhj hmy m h`y|dwp db opdimwl`me `kbmwi|`dk x7% idkcjy|`rj hjmw| bm`ezwj% hp~jw|jky`dk% dy|jd~dwdy`y% whjzom/|d`l mw|hw`|`y% mkl ijwjgwdrmyizemw mii`ljk|+ Dk mlo`yy`dk% hjw GZK `y == oc$lE% hjw YIw `y >+: oc$lE% mklhjw Meg `y 7+0 c$lE+ A+O+ `y `k`|`m|jl dk |hj bdeeds`kc lwzcy6 |w`oj|hd~w`o/yzebmoj|hdxmvdej `k|wmrjkdzyep67<> oc db |w`oj|hd~w`o jrjwp =7 hdzwy1 e`y`kd~w`e => oc$lmp gp odz|h1 l`cdx`k >+=7: oc$lmp gp odz|h1bzwdyjo`lj <> oc$lmp gp odz|h1 i`oj|`l`kj <>> oc gp odz|h 7 |`ojy$lmp1 mij|mo`kd~hjk 97: oc `` gpodz|h jrjwp 2 hdzwy1 imei`zo imwgdkm|j :>> oc gp odz|h 9 |`ojy$lmp1 mkl imwrjl ede 2+7: oc gp odz|h7 |`ojy$lmp+ Gp |hj idwwji|jl Idiaiwdb| mkl Cmze| (I"C) oj|hdl% sh`ih dkj db |hj bdeeds`kc ihd`ijy gjy|jy|`om|jy A+O+#y IwIe4
M+ 2< oE $o`kz |j+G+ 3: oE$o`kz|j+I+ = >7 oE$o`kz| j+L+ =7> oE$o`kz |j+
=>+ Sh`ih dkj db A+O+#y lwzc idog`km|`dky y ody| e`ajep |d me|jw hjw YIw idkijk|wm|`dky4M+ E`y`kd~w`e mkl l`cdx`k+G+ \w`oj|hd~w`o/yzebmoj|hdxmvdej mkl i oj| l`kj+I+ Bzwdyjo`lj mkl imei`zo imwgdkm|j+L+ Mij|mo`kd~hjk mkl imwrjl`ede+
M+ Jy|`om|`dk db Cedojwzemw B`e|wm|`dk Wm|j (CBW)$IwIe=+ Iwjm|`k`kj ~wdlzi|`dk mkl je`o`km|`dk
m+ Iwjm|`kj `y ~wdlzijl `k |hj e`rjw+
g+ Iwjm|`k `kj `y |hj ~wdlzi| db iwjm|`kj oj |mgde`yo `k yajej |me ozy iej +i+ Iwjm|`k`kj `y b`e|jwjl m| |hj cedojwzezy% shjwj `| zkljwcdjy e`o`|jl yjiwj|`dk+l+ Iwjm|`k`kj y zyjbze k m~~wdx`om| kc CBW gjimzyj
`+ M| kdwome idkijk|wm|`dky db iwjm|`k`kj% yjiwj|`dk y eds+``+ \hj iwjm|`k`kj myymp ~`iay z~ m kdkiwjm|`k`kj ihwdodcjk `k |hj geddl gz| kd| `k |hj
zw`kj+7+ IwIe imeizem|`dk |d jy|`om|j CBW
‧ IwIe `y imeizem|jl bwdo m 7</hdzw zw`kj ideeji|`dk mkl |hj bdeeds`kc j}zm|`dk6
‧ Kdwome IwIeHjme|hp pdzkc ojk ? =7: oE$o`kz|j$=+39 o 7
Hjme|hp pdzkc sdojk ?==: oE$o`kz|j$=+39 o 7
‧ Mb|jw mcj 9>% =* db CBW `y edy| ~jw pjmw+
=:
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
9+ IwIe jy|`om|`dk |d jy|`om|j CBW m+ Bmi|dwy mbbji|`kc YIw idkijk|wm|`dky6
`+ Cjkljw ``+ Mcj```+ Sj`ch|`r+ Wjkme bzki|`dk
Imrjm|y6IwIe jy|`om|`dky sdwyjk my wjkme bzki|`dk sdwyjky (zyzmeep mk drjwjy|`om|`dk)+
g+ Fje`bb j
=2
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
(m) Idwwji|jl I"C j}zm|`dk `y kdwome`vjl |d m 37/ac ~jwydk (y`o`emw |d ody| d|hjw jy|`om|`dk j}zm|`dky)+
(g) Idwwji|jl I"C `y kd| `kbezjkijl gp m ~m|`jk|#y sj`ch| (`| `y mi|zmeep `kbezjkijl gp hj`ch |% gj imzyj |hj zkidwwji |jl j}zm|`dk zyjy @GS “m bzki|`dk db h j`ch|)+
(i) Idwwji|jl I"C (dw sj`ch|/mlfzy|jl I"C) `y gj||jw |d zyj bdw jy| om|`kc wjkmebzki|`dk |d omaj ldymcj mlfzy|ojk|y+
j+ Odl`b`im|`dk db l`j| `k wjkme l`yjmyj y|zlp j}zm|`dkBzee j}zm|`dk6
CBW (oE$o`kz|j$=+39 o 7) ? =2=+: & (YIw)/>+000 & (mcj `k pjmwy)/>+=32 & =+=8> (`b ~m| jk| `yMbw`imk Mojw`imk) & >+327 (`b ~m|`jk| `y m sdomk) & (GZK)/>+=3>& (Meg)!>+9=8
Y`o~e`b`jl bdzw/rmw`mgej j}zm|`dk6
CBW (oE$o`kz|j$=+39 o 7) ? =3: & (YIw) /=+=:< & (mcj `k pjmwy)/>+7>9 & =+7=7 (`b ~m| jk| `yMbw`imk Mojw`imk) & >+3<7 (`b ~m|`jk| `y m sdomk)
(m) \hjyj j}zm|`dky mi|zmeep l`wji|ep jy|`om|j CBW (KD\ IwIe)+(g) \hjyj j}zm|`dky mwj wjidoojkljl gp |hj M ojw`imk A`lkjp Bdzklm| dk mkl |hj
Jzwd~jmk Wjkme Myydi`m|`dk |d jy|`om|j wjkme bzki|`dk (y`ck`b`imk|ep gj||jw |hmkI"C)+
(i) Kd| my miizwm|j shjk CBW `y cwjm|jw |hmk 2> oE$o`kz|j$=+39 o7
(l) Idk|wdrjwyp6 wdzkl`kc z~ YIw `k ~m|`jk|y s`|h eds idkijk|wm|`dky (ejyy |hmk>+3/= oc$lE)
b+ Ihwdk`i A`lkjp L`yjmyj J~`ljo`dedcp Ideemgdwm|`dk j}zm|`dk
Wmij mkl Yjx Yjwzo Iwjm|`k`kj(oc$lE)
J}zm|`dk
Mbw`imk Mojw`imk
Bjomej ≬ >+3 CBW ? =22 & (YIw$>+3)/>+970 & (>+009)Mcj
;>+3 CBW ? =22 & (YIw$>+3)/=+7>0 & (>+009)Mcj
Omej ≬ >+0 CBW ? =29 & (YIw$>+0)/>+<== & (>+009)Mcj
;>+0 CBW ? =29 & (YIw$>+0)/=+7>0 & (>+009)Mcj
Sh`|j dw d|hjw
Bjomej ≬ >+3 CBW ? =<< & (YIw$>+3)/>+970 & (>+009)Mcj
;>+3 CBW ? =<< & (YIw$>+3)/=+7>0 & (>+009)Mcj
Omej ≬ >+0 CBW ? =<= & (YIw$>+0)/>+<== & (>+009)Mcj
;>+0 CBW ? =<= & (YIw$>+0)/=+7>0 & (>+009)Mcj
CBW ? cedojwzemw b`e|wm|`dk wm|j1 YIw ? yjwzo iwjm|`k`kj+
(m) \hjyj j}zm|`dky l`wji|ep jy|`om|j CBW (KD\ IwIe)+(g) \hjyj j}zm|`dky mwj odwj miizwm|j |hmk odl`b`im| dk db l`j| `k wjkme l`yjmyj m|
h`chjw CBWy (`+j+% cwjm|jw |hmk 2> oE$o`kz|j$=+39 o7
)+(i) Idk|wdrjwyp6 wdzkl`kc z~ YIw `k ~m|`jk|y s`|h eds idkijk|wm|`dky (ejyy |hmk>+3/= oc$lE)
=3
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
c+ ^jl`m|w`i bdwozemyLD KD\ wdzkl z~ eds YIw rmezjy `k ~jl`m|w`i ~m|`jk|y+
Yihsmw|v
A & h| (io)IwIe (oE$o`kz|j) ? /////////////////////
YIw
Mcj A
Eds g`w|h sj`ch| ≬ = pjmw >+99
Bzee |jwo ≬ = pjmw >+<:
= pjmw |d mldejyijkij >+::
Ozyizemw mldejyijk| omejy >+3
Y h z e e
‧ \h`y `y dkep bdw |hdyj mcjl =/=8 pjmwy+
<+ Bmi|dwy `kbezjki`kc IwIe jy|`om|jym+ ^m|`jk| ihmwmi|jw`y|`iy
`+ Mcj (ljiwjmyj% ~wdlzi|`dk db iwjm|`k`kj s`|h mcj)``+ Bjomej yjx (ljiwjmyj+ ~wdlzi|`dk db iwjm|`k`kj)```+ Wmij ( ~wdlzi|`dk db iwjm|`k`kj `k Mbw`imk Mojw imky)
g+ L`yjmyj y|m |jy$ie`k`ime idkl` |`dky`+ Y~`kme idwl `kfzw`jy (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)``+ Mo~z|m|`dky (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)```+ Izyh`kc ypklwdoj (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)`r+ Ozyizemw lpy|wd~hp (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)r+ Cz`eem`k/Gmwwj ypklwdoj (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)r`+ Whjzom|d`l mw|hw`|`y (ljiwjmyj ozyiej omyy1 ljiwjmyj iwjm|`k`kj)r``+ E`rjw l`yjmyj (ljiwjmyj iwjm|`kj1 ljiwjmyj iwjm|`k`kj)r```+ Cedojwzed~m|h`i l`yjmyj (cwjm|jw modzk| db iwjm|`k`kj yjiwj|`dk `k wjem|`dk |d b`e|wm|`dk)
i+ L`j|`+ H`ch/ojm| ~wd|j`k l j |y ( iwjm|`k`kj `kcjy|`dk)``+ Rjcj|mw`mky (ljiwjmyj iwjm|`k`kj `kcjy|`dk)```+ ^wd|j`k/imedw`j omekz|w`|`dk (ljiwjmyj iwjm| k`kj kcjy|`dk)
l+ Lwzcy$jkldcjkdzy yzgy|mkijy`+ Emgdwm|dwp `k|jwmi|`dk6 meame`kj ~`iwm|j oj|hdl (KD\ a`kj| i meame`kj ~`iwm|j oj|hdl%
sh`ih `y odwj idoodkep zyjl)+ Kdkiwjm|`k`kj ihwdodcjky6 `k geddl gz| kd| `k zw`kj+Ij~hmedy~dw`ky (jy~ji`meep ijbdx`|`k)6 ihwdodcjk`i imzy`kc bmeyj jejrm|`dky“ozihcwjm|jw `k zw`kj |hmk `k geddl+ Mij|dmij|m|j (`kiwjmyjl `k bmy|`kc `kl`r`lzmey% ~m|`jk|ys`|h l`mgj|`i aj|dmi`ldy`y)6 ihwdodcjk`i imzy`kc bmeyj jejrm|`dky
``+ ^hmwomida`kj|`i `k|jwmi| dk6 lwzcy ido~j|j s`|h iwjm|`k`kj bdw wjkme yjiwj|`dk(imzy`kc bmeyj jejrm|`dky)% |w`oj|hd~w`o% i`oj|`l`kj% b`gw`i mi`l ljw`rm|`rjy (d|hjw |hmk cjob`gwdv`e)% lwdkjlmwdkj
=8
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
G+ Lwzc Ldy`kc `k Wjkm e L`yjmyj=+ Edml`kc ld yj
m+ @k cjkjwme% kd me|jwm|`dk `y wj}z`wjl% gz| `| yhdzel gj c`rjk |d hmy|jk mih jrjojk| db |hjwm~jz|`i lwzc idkijk|wm|`dky+
g+ Me| jwm|`dky `k edml`kc ldyj ozy| diizw `b |hj Rl `y me|jwjl yjidklmwp |d wjkme lpybzki|`dk%`+ Jxmo~ej6 l`cdx`k
7+ Om`k |jkmkij ldyjm+ Me|jwm|`dky yhdzel gj omlj `k j`|hjw |hj ldyj dw |hj ldy`kc `k|jwrme+
`+ Ihmkc`kc |hj ldy`kc `k|jwrme6(m) Zyj shjk |hj cdme `y |d mih`jrj y`o`emw y|jmlp/y|m|j idkijk|wm|`dky+(g) Ejyy idy|ep(i) @ljme bdw e`o`|jl/ldymcj bdwoy (`+j+% dwme ojl`im|`dky)
``+ Ihmkc`kc |h j ldyj6(m) Zyj shjk |hj cdme `y |d om`k|m`k m y|jmlp |hjwm~jz|`i idkijk|wm|`dk+(g) Odwj idy|ep
```+ Ihmkc`kc |hj ldyj mkl |hj ldy`kc `k|jwrme6(m) Db|jk wj}z`wjl bdw yzgy|mk|`me ldymcj mlfzy|ojk| s`|h e`o`|jl/ldymcj bdwoy(g) Db|jk wj}z`wjl bdw kmwwds |hjwm~jz|`i `kljx lwzcy s`|h |mwcj| idkijk|wm|`dky
(=) @b m lwzc `y c`rjk odwj |hmk dkij lm`ep% |hjk mlfzy| |hj `k|jwrme+(7) @b m lwzc `y c`rjk dkij lm`ep dw ejyy db|jk% |hjk mlfzy| |hj ldyj+
@X+ ^HMWOMIDA@KJ\@IY @K HJ^M\@I L@YJMYJ
^m|`jk| Imyj
==+ Y+F+ `y m ::/pjmw/del omk s`|h hj~m| i lpybzki| dk mkl bzkcjo`m imzyjl gpImkl`lm awzyj`+ Hj hmy m yomeemodzk| db myi`|jy gz| `y kd| jkij~hmed~m|h`i+ Hj `y `k`|`m|jl dk imy~dbzkc`k% mkl |hj ~miamcj `kyjw| y|m|jy|hm| ldyjy yhdzel gj ljiwjmyjl `k ~m|`jk|y s`|h m Ih`el/^zch yidwj db 3/0+ @b hj hmy |hj bdeeds`kc hj~m|`iemgdwm|dwp rmezjy% sh`ih dkj db |hj bdeeds`kc ihd`ijy `y h`y Ih`el/^zch yidwj4My~mw|m|j |wmkymo`kmyj ? 8: Z$E% memk`kj |wmkymo`kmyj ? :2 Z$E% meame`kj ~hdy~hm|myj ? =0> Z$E% |d|me
g`e `wzg`k ? =+8 oc$lE% Meg ? 7+0 c$lE% emi |`i ljhplwdcjkmyj ? 73> Z$E% ~wd|hwdog`k |`o j$`k| jwkm|`dkmekdwome`vjl wm|`d ? =<+2$=+3% c/cez|mope |wmkybjwmyj ? 2> Z$EM+ 9+G+ :+I+ 8+L+ ==+
M+ Ldymcj Mlfzy|ojk| `k Hj~m|`i L`yjmyj=+ Ie`k`ime wjy~dkyj `y |hj ody| `o~dw|mk| bmi|dw `k mlfzy|`kc ldyjy `k hj~ m|`i l`yjmyj+7+ Eds hj~m|`i jx|wmi|`dk wm|`d lwzcy
m+ Mlfzy|ojk| db om`k|jkmkij ldyj `y kjijyymwp dkep shjk hj~m|`i l`yjmyj me|jwy Ie `k| + g+ Me| jwm|`dky `k ~wd |j`k g`k l`kc m edkj ld kd| wj}z`wj me|jwm|`dk db om`k| jkmki j ldyj% jr jk
|hdzch |d|me lwzc idkijk|wm|`dky ljie`kj+
=0
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8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
Idkijk|wm| dk/wjy~dkyj ed|
B`czwj :+
I+ Hpy|jwjy`y Edd~y
Ljb`k`|`dk6 Idkijk|wm|`dky em|j mb|jw m l dyj ~wdlzij mk jbbji| l`bbjwjk| bwdo |hm| ~wdlzijl gp |hjymoj idkijk|wm|`dk yddk mb|jw |hj ldyj+
Idzk|jwiedias`yj Hpy|jwjy`y
Imzyjy6=+ @kiwjmyjl yjky | `r |p7+ Bdwom| `dk db mk
mi|`rj oj|mgde`|j9+ Ljemp `k j}z`e`gw`zo
gj| sjjk ~emyomidkijk|wm|`dky mkl|hj y`|j db mi|`dk
B`czwj 2+
7=
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
Iedias`yj Hpy|jwjy`y
Idkijk|wm|`dk
Imzyjy6=+ \dejwmkij7+ Bdwom|`dk db mk
`kh`g`|dwp oj|mgde`|j9+ J}z`e`gw`zo wjmihj l
bmy|jw gj|sjjk mw|jw`me geddl mkl y`| j db mi|`dk ry+ rjkdzy
geddl mkl y`| j db mi|`dk
Jbbji|
B`czwj 3+
^m|`jk| Imyjy=9+ ^+E+% m <:/pjmw/del omk s`|h ihwdk`i wjkme bm`ezwj% `y wjij r`kc ~hjkp|d`k <>> oc$lmp bdw m h`y|dwp db |dk i /
iedk`i yj`vzwjy+ H`y ~hjkp|d`k idkijk|wm|`dk |dlmp `y =9+2 oc$E% mkl h`y Meg idkijk|wm|`dk `y <+7 c$lE+Gmyjl dk h`y izwwjk| idkijk|wm|`dk% sh`ih dkj db |hj bdeeds`kc ihd`ijy yhdzel gj wjidoojkljl s`|h h`yldyj4M+ Omaj kd ihmkcjy |d h`y lwzc wjc`ojk+G+ Ajj~ |hj |d|me lm`ep ldyj |hj ymoj% gz| ihmkcj |hj wjc`ojk |d 7>> oc 7 |`ojy$lmp+I+ @kiwjmyj |hj ldyj bdw gj||jw yj`vzwj idk|wde+L+ Ljiwjmyj |hj ldyj |d ~wjrjk| |dx`i`|p+
=<+ K+W+ `y m 29/pjmw/del omk s`|h wjkme `kyzbb`i jkip shd idojy |d |hj jojwcjkip lj~mw|ojk| `k m|w`me b`gw`e/em|`dk s`|h m rjk|w`izemw wm|j db =7> gjm|y$o`kz|j+ Gjimzyj db h`y h`y|dwp db rjk|w`izemw lpybzki|`dk% `| `ylji`ljl |d `k`|`m|j h`o dk l`cdx`k bdw wm|j idk|wde+ Sh`ih dkj db |hj bdeeds`kc `y idwwji| wjcmwl`kc ldy`kc`k |h`y ~m|`jk|4M+ \hj edml`kc ldyj yhdzel wjom`k |hj ymoj% gz| |hj om`k|jkmkij ldyj kjjly |d gj ljiwjmyjl+G+ \hj edml`kc ldyj kjjly |d gj ljiwjmyjl% mkl |hj om`k|jkmkij ldyj yhdzel wjom`k |hj ymoj+I+ Kj`|hjw |hj edml`kc ldyj kdw |hj om`k|jkmkij ldyj kjjly |d gj mlfzy|jl+L+ Gd|h |hj edml`kc ldyj mkl |hj om`k|jkmkij ldyj kjjl |d gj ljiwjmyjl+
=:+ ^+^+ `y m 9</pjmw/del omk s`|h m h`y|dwp db ijwjgwme ~meyp mkl ihwdk`i zw`kmwp |wmi| `kbji|`dky+ Hj `y mlo ||jl|d |hj hdy~`|me s`|h m ^yjkldodkmy zw`kmwp |wmi| `kbji|`dk |hm| `y wjy`y|mk| |d mee mk|`g`d|`iy gz| mo`kdcep/idy`ljy+ Hj `y `k`|`m|jl dk dkij/lm`ep |dgwmopi`k m| <>> oc$lmp `k|wmrjkdzyep+ Sh`ih dkj db |hj bdeeds`kcy|m|jojk|y gjy| ljyiw`gjy |h`y h`ch/ldyj% jx|jkljl/`k|jwrme mo`kdcepidy`lj wjc`ojk4M+ @| |majy mlrmk|mcj db |hj idkijk|wm|`dk/lj~jkljk| a`ee`kc db mo`kdcepidy`lj+G+ @| `y odwj jbb`imi`dzy |hmk y|mklmwl mo`kdcepidy`lj ldy`kc+I+ @| ldjy kd| wj}z`wj odk`|dw`kc db mo`kdcepidy`lj idkijk|wm|`dky+L+ @| s`ee kd| imzyj kj~hwd|dx`i |p+
77
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
X@+ Y^JI@B@I LWZC \MGEJ
\mgej 9+
Lwzc \hjwm~jz|`i Wmkcj Ymo~e`kc @yyzjy Idoojk|y
Mo`kdcepidy`ljy I~ omx ? </=> oc$E
Mo`ami`k ? 7>/9> oc$EI~ omx 5 7 oc$E
Mo`ami`k 5 => oc$E
Lzwm|`dk db `kbzy`dk% |`o`kcdb b`wy| ymo~ej ~dy|`kbzy`dk(cjkjwmeep yhdzel gj >+:/=hdzw)
Gj bmo`e`mw s`|h Ymsihza/Vmyajoj|hdl mkl h`ch/ldyj% jx|jkljl/`k|jwrme ldy`kc
Rmkidopi`k I~ omx ?=>/=: oc$E(=:/7> oc$E bdw ijw|m`k`kbji|`dky `kiezl`kc ~kjzodk`m% ojk`kc`|`y% mkldy|jdopje`|`y
Idk|wdrjwy`me shj|hjw |ddg|m`k ~jmay dw idkijk|wm|`dkyme|dcj|hjw
Gj bmo`e`mw s`|h ihmkcjy`k |wdzch idkijk|wm|`dkwjidoojklm|`dky
^hjkp|d`k =>/7> oc$EBwjj6 =/7 oc$E @k cjkjwme% dg|m`k |wdzchidkijk|wm|`dky ^jwijk| bwjj `kiwjmyjy s`|h wjkmebm`ezwj mkl hp~dmegzo`kjo`m1`klzijy e`rjw jkvpojy1yzyij~|`gej |d oj|mgde`i lwzc`k|jwmi|`dky
Imwgmomvj~`kj </=7 oc$E Mz|d`klzi|`dk1 mi|`rj oj|mgde`|j=>%== j~dx`lj
^hjkdgmwg`|me =:/<> oc$E Jkvpoj `klzijw
Rme~wd`i mi`l :>/=>> oc$E Ym|zwmgej ~wd|j`k g`kl`kc1 ~jw ijk | bwjj `kiwjmyjy s`|h wjkmebm`ezwj mkl hp~dmegzo`kjo`m
L`cdx`k >+8/7+> oic$E ^wdedkcjl l`y|w`gz|`dk ~jw`dlkjijyy`|m|jy ymo~e`kc ; 2/=7hdzwy ~dy|ldyj
R l ihmkcjy s`|h l`yjmyj y|m|jy1yzyij~|`gej |d lwzc `k|jwmi|`dky
Ipiedy~dw`kj =>>/7:> oic$E Shdej geddl ymo~ejy Omkp lwzc k|jwmi|`dky
E`|h`zo >+9/=+9 oode$E ^wdedkcjl l`y|w`gz|`dkkjijyy`|m|jy ymo~e`kc =7 hdzwy ~dy |ldyj
\hjd~hpee`kj =>/7> oc$E \wjm| my idk|`kzdzy `kbzy`dk s`|hyzy|m`kjl/wjejmyj ldymcj bdwoy
I~ ? idkijk|wm|`dk db lwzc ~ emyom+
\mgej <+ IP^<:> Lwzc @k|jwmi|`dky
79
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
7<
8/7/2019 Pharmacokinetics : A Refresher
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^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
WJBJWJKIJY
=+ Gzw|dk OJ% Yhms EO% Yihjk|mc FF% jly+ M~~e`jl^hmwomida`kj|`iy " ^hmwomidlpkmo`iy6 ^w`ki`/
~ejy db \hjwm~jz| `i Lwzc Odk` |dw`kc% <|h jl+ Gme |`/odwj% OL6 E`~~`kid|| S`ee`moy " S`ea`ky% 7>>2+
7+ Gmzjw EM+ Ie`k`ime ~hmwomida`kj| iy mkl ~hmwom/idlpkmo`iy+ @k6 L`^`wd F\% \megjw| WE% Pjj CI% j|me+% jly+ ^hmwomid|hjwm~p6 M ^m|hd~hpy`dedc`i M~/ ~wdmih% <|h jl+ Y|mobdwl% I\6 M~~ej|dk " Emkcj%=00067=/<9+
9+ S`k|jw OJ+ Gmy`i Ie`k`ime ^hmwomida`kj| iy% 9wljl+ Rmkidzrjw6 M~~e`jl \hjwm~jz|`iy% =00<+
<+ Gmzjw EM+ M~~e`jl Ie`k`ime ^hmwomida`kj|`iy+ Kjs Pdwa6 OiCwms/H`ee Ojl`ime% 7>>=+
:+ Om|hjkp IF% Emog OS% Gwdzsjw AEW% ^deemia
CO+ ^hmwomida`kj|`i mkl ~hmwomidlpkmo`i `o/ ~e` im| `dky db ^/cepid~wd|j`k odlzem|`dk+ ^hmwom/id|hjwm~p 7>>=17=6338/02+
7:
8/7/2019 Pharmacokinetics : A Refresher
http://slidepdf.com/reader/full/pharmacokinetics-a-refresher 26/28
^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
MKYSJWY MKL JX^EMKM\@DKY \D ^M\@JK\ IMYJY
=+ Mkysjw6 I@k 2 lmpy (7 |=$7)% |hj idkijk|wm|`dk s`ee ljiwjmyj bwdo9:+0 oc$E |d mgdz| 0 oc$E1 kds `y |hj |`oj |d wjldyj+M =/c ldyj c`rjk dk Omwih 7< s`ee `kiwjmyj |hj idkijk/|wm|`dk `k |hj geddl bwdo =7+= |d 9:+0 oc$E (=7+= !79+8oc$E)+ C`rjk |hm| |hj | =$7 `y mgdz| 9 lmpy% `| s`ee |majedkcjw |hmk = lmp |d wjmih m idkijk|wm|`dk db mgdz| =>oc$E+ @k 9 lmpy (= |=$7)% |hj idkijk|wm|`dk s`ee ljiwjmyjbwdo 9:+0 oc$E |d mgdz| =8 oc$E“y|`ee |dd jmwep |dwjldyj+ Wjldy`kc imk gj b`czwjl gjimzyj ~ejk|p db `k/bdwom|`dk jx`y|y mgdz| hds |d imeizem|j shjk |d wjldyj+
7+ Mkysjw6 M
B? (=>> oc & 7: oc$E$hdzw)$ (7>> oc & :> oc$E$hdzw)+
9+ Mkysjw6 M\hj je`o`km|`dk wm|j idky|mk| j}zmey >+209$< hdzwy ?>+=3 hdzw =+ \hj iejmwmkij imk gj imeizem|jl gp oze|`/ ~ep`kc |hj R l (>+: E$ac & 2: ac) gp |hj je`o`km|`dk wm|jidky|mk|+ Iejmwmkij j}zmey :+: E$hdzw+ Idkijk|wm|`dkm| y|jmlp y|m|j s`ee j}zme |hj `kbzy`dk wm|j l`r`ljl gpiejmwmkij+ Y|jmlp/y|m|j idkijk|wm|`dk ? 9+2 oc$E+
<+ Mkysjw6 L^/cepid~wd|j`k `y mk jbbezx ~zo~ |hm| ~zo~y lwzcy gmia `k|d |hj cmy|wd`k| jy| `kme ezojk+ ^/cepid~wd| j`k`y kd| m ~emyom ~wd|j`k% mkl `| ldjy kd| |wmkybjw lwzcy
|hwdzch |hj cmy|wd`k|jy|`kme ozidym gz| wm|hjw ~zo~ylwzcy gmia `k|d |hj cmy|wd`k|jy|`kme ezojk+ @k mll`|`dk%^/cepid~wd|j`k mi|y `k idkijw| s`|h IP^9M< |d l`o`k/`yh dwme mgydw~|`dk+
:+ Mkysjw6 IMv`|hwdopi`k ldjy kd| `kh`g`| IP^9M<+ Jwp|hwdopi`kmkl iemw`|hwdopi`k mwj ~d|jk| `kh`g`|dwy db IP^9M<mkl sdzel gj jx~ji|jl |d `kiwjmyj ipiedy~dw`kj idk/ijk|wm|`dky+ Ip|dihwdoj ^<:> `kh`g`|`dk `y kd| m lwzciemyy jbbji|+
2+ Mkysjw6 G
Gp ljb`k`|`dk% iejmwmkij gjidojy kdke`kjmw dkij |hjidkijk|wm|`dk jxijjly |hj A o 1 |h jw jbdwj% |hj idkij k/ #|wm|`dky s`ee odwj |hmk ldzgej+ ^hjkp|d`k `y kd| m y`c/k`b`imk| mz|d`klzijw+ Me|hdzch ~hjkp|d`k mgydw~|`dkljiwjmyjy my |hj ldyj `y `kiwjmyjl% `| `y kd| ie`k`imeepy`ck`b`imk| zk|`e m y`kcej ldyj jxijjly <>> oc+
3+ Mkysjw6 I\hj idwwji| mkysjw% lzj |d wjl`y|w`gz|`dk% `y |d sm`| mbjs hdzwy |d dg|m`k |hj idkijk|wm|`dk gjimzyj `| s`ee`kiwjmyj y`ck`b`imk|ep s`|h`k |hj b`wy| bjs hdzwy mb|jw hjodl`mepy`y+ Sm`|`kc m bzee 7< hdzwy `y kd| kjijyymwp+
8+ Mkysjw6 L\hj idwwji| mkysjw `y |hm| |hj myymp s`ee gj mgej |d l`y/|`kcz`yh |hj lwzc bwdo e`aj ~wdlzi|y gz| s`ee kd| gj mgej|d lj|ji| jx|wjojep eds idkijk|wm|`dky+ H`ch y~ji`b`i/`|p ojmky |hj myymp imk l`y|`kcz`yh |hj lwzc bwdo e`aj ~wdlzi |y% mkl eds yjky`| `r` |p ojmky |hj myymp imkkd|lj|ji| jx|wjojep eds idkijk|wm|`dky+
0+ Mkysjw6 M\hj idwwji| mkysjw `y 2< oE$o`kz|j gjimzyj m eds YIw yhdzel gj wdzkljl z~ mkl gjimzyj |hj rmezj ozy| gjoze|`~e jl gp >+8: %c`rjk |hm| |hj ~m|`jk| `y m sdomk+\hj d|hjw mkysjwy mwj `kidwwji| gjimzyj |hj YIw `y kd|wdzkljl z~ mkl gjimzyj |hj rmezj `y kd| oze|`~e`jl gp>+8:+
=>+ Mkysjw6 GGd|h |w`oj|hd~w`o/yzebmoj|hdxmvdej mkl i`oj|`l`kjido~j|j s`|h iwjm|`k`kj bdw yjiwj|`dk `k |hj a`lkjpy%`kiwjmy`kc YIw idkijk|wm|`dky+ Me|hdzch mkc`d|jky`k/idkrjw|`kc jkvpoj `kh`g`|dwy omp |wmky`jk|ep `kiwjmyj
YIw idkijk|wm|`dky% l`cdx`k ldjy kd| mbbji| wjkme bzki/|`dk+ Me|hdzch bzwdyjo`lj omp yjidklmw`ep mbbji| YIw idkijk|wm|`dky% imei`zo ldjy kd| mbbji| wjkme bzki|`dk+Mij|mo`kd~hjk mkl imwrjl`ede cjkjwmeep s`ee kd| mbbji|YIw idkijk|wm|`dky+
= =+ Mk ysj w6 IY+F+ hmy = ~d`k| bdw kd| gj kc jkij~hmed~m|h`i% 7 ~d`k|ybdw o`el myi`|jy% 7 ~d`k|y bdw |hj g`e`wzg`k idkijk|wm|`dk%7 ~d`k|y bdw |hj Meg idkijk|wm|`dk% mkl = ~d`k| bdw |hj ~wd|hwdog`k |`o j rmezj% bdw m |d |me db 8 ~d`k|y+ Kdwome ~m| `jk |y hmrj m Ih`el /^zch yidwj db :% sh`ih ojmky kdhj~m|`i lpybzki|`dk+
=7+ Mkysjw6 I\dejwmkij ejmly |d m ljiwjmyj `k jbbji| s`|h |`oj1 |h`y `yiedias`yj hpy|jwjy`y+ Bdwom|`dk db mk mi|`rj oj|mgd/e`|j% ljemp `k j}z`e`gw`zo gj|sjjk |hj geddl mkl y`|j db mi|`dk% mkl `kiwjmyjl yjky`|`r`|p s`|h |`oj sdzel meeejml |d mk `kiwjmyj `k jbbji| s`|h |`oj1 |h`y `y idzk|jw/iedias`yj hpy|jwjy`y+
72
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http://slidepdf.com/reader/full/pharmacokinetics-a-refresher 27/28
^hmwomida`kj|`iy6 M Wjbwjyhjw
7>=> Mojw`imk Ideejcj db Ie`k`ime ^hmwomip
=9+ Mkysjw6 L\hj ldyj yhdzel gj ljiwjmyjl |d ~wjrjk| |dx`i`|p+ @kwjkme bm`ezwj% mi`l`i gp/~wdlzi|y gz`el z~ `k |hj geddlmkl ido~j|j s`|h ~hjkp|d`k bdw ~wd|j`k g`kl`kc+ \d|meidkijk|wm|`dky kjjl |d gj idwwji|jl% mkl |h`y idwwji|`dkejmly |d m ldzge`kc db |hj idkijk|wm|`dk+ \hjwjbdwj% |hjizwwjk| idkijk|wm|`dk `y |dd h`ch% mkl |hj ldyj yhdzel gj ljiwjmyjl+ Y`kcej ldyjy db <>> oc mwj b`kj (ldyjyh`chjw |hmk <>> oc yhdzel gj l`r`ljl)+
=<+ Mkysjw6 LGd|h |hj edml`kc ldyj mkl |hj om`k|jkmkij ldyj kjjl|d gj ljiwjmyjl+ @k cjkjwme% edml`kc ldyjy ld kd| kjjl|d gj me|jwjl `k wjkme lpybzki|`dk gjimzyj |hjp mwj ~w`/omw`ep lj~jkljk| dk |hj R l Hdsjrjw% |hj l`cdx`k R l
`y ljiwjmyjl `k wjkme lpybzki|`dk+ Gjimzyj l`cdx`k `yje`o`km|jl wjkmeep% |hj om`k|jkmkij ldyj kjjly |d gjljiwjmyjl+
=:+ Mkysjw6 MMo`kdcepidy`ljy yhds idkijk|wm|`dk/lj~jkljk|a`ee`kc% mkl m h`ch/ldyj% jx|jkljl/`k|jwrme mo`kd/cepidy`lj ldyj |majy mlrmk|mcj db |h`y ihmwmi|jw`y|`i+Hdsjrjw% `| hmy kd| ~wdrjl |d gj odwj jbb`imi`dzy |hmk|wml`|`dkme ldy`kc+ Mo`kdcepidy`lj idkijk|wm|`dky y|`eekjjl |d gj odk`|dwjl s`|h h`ch/ldyj% jx|jkljl/`k|jwrme|hjwm~p+ @k mll`|`dk% h`ch/ldyj% jx|jkljl/`k|jwrme mo`/kdcepidy`lj ldy`kc imk y|`ee imzyj kj~hwd|dx`i`|p (me/|hdzch |hj `ki`ljkij `y cjkjwmeep l`o`k`yhjl)+
73
8/7/2019 Pharmacokinetics : A Refresher
http://slidepdf.com/reader/full/pharmacokinetics-a-refresher 28/28
^hmwomida`kj|`iy6 M Wjbwjyhjw
MKYSJWY MKL JX^EMKM\@DKY \D YJEB/MYYJYYOJK\ ]ZJY\@DKY
=+ Mkysjw6 GS`|h |sd idkijk|wm|`dky% |hjwj mwj jkdzch lm|m |d ime/
izem|j mk je`o`km|`dk wm|j idky|mk| mkl% |hjwjbdwj% m |=$7
@k mll`|`dk% |hj Rl imk gj imeizem|jl gp gmia jx|wm~dem/|`dk |d |hj I omx mkl zyj db m~~wd~w`m|j j}zm|`dky (gj/imzyj |h`y smy |hj b`wy| ldyj% mkl |hjwjbdwj% `| `y akdsk|hm| |hj |dgwmopi`k idkijk|wm|`dk smy > oc$E gjbdwj|hj ldyj smy c`rjk)+
7+ Mkysjw6 M\hj | =$7 `y mgdz| 7 hdzwy+ \hj Iomx `y mgdz| : oc$E% mkl|hj R l % `y mgdz| 7> E+
9+ Mkysjw6 G
Hjw iejmwmkij `kiwjmyjl gjimzyj db |hj `o~wdrjojk|`k wjkme bzki|`dk% sh`ih `kiwjmyjl hjw je`o`km|`dk wm|jidky|mk| mkl ljiwjmyjl hjw | =$7 \hj R l sdzel kd| gj me|jwjl
gp ihmkcjy `k iejmwmkij (|h jp mwj `kl j~jkljk|)+S`|h |hj l`zwjy`y mkl mkc`d|jky`k/idkrjw|`kc jkvpoj`kh`g`|dw% hjw Rl ~wdgmgep ljiwjmyjl% gz| iejmwmkijsdzel kd| gj me|jwjl gp ihmkcjy `k R l (|hjp mwj `klj/
~jk ljk |)+ @k mll`| `dk% `b hjw Rl ljiwjmyjl% hjw je`o`km/|`dk wm|j idky|mk| sdzel ljiwjmyj% kd| `kiwjmyj+
<+ Mkysjw6 IGjimzyj |hj |wdzch `y |dd eds% |hj `k|jwrme s`ee hmrj |d
gj yhdw|jkjl |d `kiwjmyj |hj idkijk|wm|`dk+ Ihmkcjy `kldyj s`ee hmrj |hj cwjm|jy| jbbji| dk |hj ~jma idkijk/|wm|`dk% mkl ihmkcjy `k `k|jwrme s`ee hmrj |hj cwjm|jy|jbbji| dk |hj |wdzch idkijk|wm|`dk+
:+ Mkysjw6 IHjw ldyj kjjly |d gj `kiwjmyjl% mkl gjimzyj yhj `y myodajw% |hj `k|jwrme yhdzel gj jrjwp 8 hdzwy+ Ldzge`kc|hj |d|me lm`ep ldyj s`ee mlj}zm|jep `kiwjmyj hjw idk/ijk|wm|`dk s`|hdz| imzy`kc |dx`i wjmi|`dky+
2+ Mkysjw6 LGjimzyj db |hj ~m|`jk|#y wjkme bm`ezwj mkl eds Meg% |hj|d|me idkijk|wm|`dk kjjly |d gj idwwji|jl+ \hj ~m|`jk|#y
idwwji|jl ~hjkp|d`k idkijk|wm|`dk `y =<+3 oic$oE+\hjwjbdwj% kd ihmkcjy kjjl |d gj omlj |d |hj ldyj+
3+ Mkysjw6 IGd|h db |hjyj mwj `oozkdmyympy+ \Lx `y m gwmkl kmojbdw |hj Mggd|| bezdwjyijkij ~demw`vm|`dk `oozkdmyymp%sh`ih zyjy m bezdwjyijk| emgje+ \hj |jwo JO@\ y|mklybdw jkvpoj oze|`~e`jl `oozkdmyymp |jihk`}zj% sh`ih`y mk `oozkdmyymp |hm| zyjy mk jkvpoj emgje+
8+ Mkysjw6 L\hj l`cdx`k idkijk|wm|`dk smy lwmsk gjbdwj |hj ldyj
|majk m| 86>> mo hml m ihmkij |d ido~ej|j |hj l`y|w`/ gz| `dk ~hmyj+ Dki j l`y |w`gz|`dk `y ido~ej|j (cjkjw /meep 2/=7 hdzwy mb|jw |hj ldyj)% |hj idkijk|wm|`dk s`ee gj edsjw mkl ~wdgmgep s`|h`k |hj |hjwm~jz| `i wmkcj+\hjwjbdwj% |hjwj `y kd kjjl bdw |hj l`cdx`k mk|`gdlp%mi|`rm|jl ihmwidme% dw edsjw`kc db |hj ldyj+
0+ Mkysjw6 I\hj idwwji| y|m|`y|`ime |jy| `y oze|`~ej edc`y|`i wjcwjy/y`dk+ Oze|`~ej wjcwjyy`dk `y zyjl |d ljyiw`gj |hj wjem/|`dkyh`~ gj|sjjk m lj~jkljk| rmw`mgej mkl |sd dw odwj`klj~jkljk| rmw`mgejy shjk gd|h |hj lj~jkljk| mkl `k/lj~jkljk| rmw`mgejy mwj kzojw`i+ Mkmepy`y db rmw`mkij`y zyjl |d ljyiw`gj |hj wjem|`dkyh`~ gj|sjjk m lj~jkljk|rmw`mgej mkl |sd dw odwj `klj~jkljk| rmw`mgejy shjk|hj lj~jkljk| rmw`mgej `y kzojw`i mkl |hj `klj~jkljk|rmw`mgejy mwj kdo`kme+ E`ajs`yj% mkmepy`y db idrmw`mkij`y zyjl |d ljyiw`gj |hj wjem|`dkyh`~ gj|sjjk m lj~jkljk|rmw`mgej mkl |sd dw odwj `klj~jkljk| rmw`mgejy shjk|hj lj~jkljk| rmw`mgej `y kzojw`i mkl |hj `klj~jk/ljk| rmw`mgejy mwj kdo`kme s`|h idkbdzkl`kc bmi|dwy+Y~jmwomk wmka idwwjem|`dk `y m kdk~mwmoj|w`i |jy| zyjl|d ljyiw`gj |hj wjem|`dkyh`~ gj|sjjk dkj lj~jkljk| mkldkj `klj~jkljk| rmw`mgej shjk |hj lm|m mwj dwl`kme dw kzojw`i mkl kd| kdwomeep l`y|w`gz|jl+
=>+ Mkysjw6 GMyyjyy`kc mlhjwjkij mkl `kiwjmy`kc hjw ldyj% gjimzyj|hj idkijk|wm|`dk `y gjeds |hj |hjwm~jz|`i wmkcj% `y|hj idwwji| mkysjw+ \hj rme~wd`i mi`l |hjwm~jz|`i wmkcj`y :>/=>> oc$E% mkl yhj `y sjee gjeds |h`y idkijk|wm/|`dk+ Me|hdzch ydoj ~m|`jk|y mwj idk|wdeejl m| edsjw idkijk|wm|`dky% |h`y idkijk|wm|`dk `y ody| e`ajep |ddeds+ Yhj ljb`k`|jep ldjy kd| kjjl m ljiwjmyj `k ldyj+Me|hdzch |d|me rme~wd`i mi`l idkijk|wm|`dky mwj mbbji|jl gp ihmkcjy `k Meg% K+\+#y Meg `y kdwome% mkl dg|m`k`kcm bwjj idkijk|wm|`dk `y zkkjijyymwp+
![A Calculus Refresher a2 [1]](https://img.pdfslide.net/doc/110x75/577ce50d1a28abf1038fb834/a-calculus-refresher-a2-1.jpg)
