Pharmacology and Therapeutics Publications 2010 Alaoui-Jamali, Moulay (See Department of Medicine) Allen, Bruce Dingar D, Merlen C, Grandy S, Gillis MA, Villeneuve LR, Mamarbachi AM, Fiset C, Allen BG. (2010) Effect of pressure overload-induced hypertrophy on the expression and localization of p38 MAP kinase isoforms in the mouse heart. Cell Signal. 22(11):1634-44. Moïse N, Dingar D, Mamarbachi AM, Villeneuve LR, Farhat N, Gaestel M, Khairallah M, Allen BG. (2010) Characterization of a novel MK3 splice variant from murine ventricular myocardium. Cell Signal. 22(10):1502-12. Tadevosyan A, Maguy A, Villeneuve LR, Babin J, Bonnefoy A, Allen BG, Nattel S. (2010) Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem. 285(29):22338-49. Robitaille M, Gora S, Wang Y, Goupil E, Pétrin D, Del Duca D, Villeneuve LR, Allen BG, Laporte SA, Bernard DJ, Hébert TE. (2010) Gbetagamma is a negative regulator of AP-1 mediated transcription. Cell Signal. 22(8):1254-66. Dingar D, Benoit MJ, Mamarbachi AM, Villeneuve LR, Gillis MA, Grandy S, Gaestel M, Fiset C, Allen BG. (2010) Characterization of the expression and regulation of MK5 in the murine ventricular myocardium. Cell Signal. 22(7):1063-75. Burelle Y, Khairallah M, Ascah A, Allen BG, Deschepper CF, Petrof BJ, Des Rosiers C. (2010) Alterations in mitochondrial function as a harbinger of cardiomyopathy: lessons from the dystrophic heart. J Mol Cell Cardiol. 48(2):310-21. Almazan, Guillermina Rodriguez-Gabin AG, Ortiz E, Demoliner K, Si Q, Almazan G and Larocca JN (2010) Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-Phosphate receptors. J Neurosci Res. 88:589-604. Hossain S, Fragoso G, Mushynski WE and Almazan G (2010). Regulation of peripheral myelination by src-like kinases. Exp. Neurol. PMID: 20696161. Haines JD, Fang J, Mushynski WE and Almazan G (2010). Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation. Glia 58:1384-93. Cui QL, Fragoso G, Miron VE, Darlington PJ, Mushynski WE, Antel J, and Almazan G (2010) Response of human oligodendrocyte progenitors to growth factors and axon signals. J. Neuropathol. Exp. Neurol. 69:930-944. Gomez O, Arevalo-Martin A, Garcia-Ovejero D, Ortega-Gutierrez S, Cisneros JA, Almazan G, Sanchez-Rodriguez MA, Molina-Holgado F and Molina-Holgado E (2010) The constitutive activation of the endogenous cannabinoid system participates in oligodendrocyte differentiation. Glia. 58:1913-27.

Pharmacology and Therapeutics Publications 2010 Doukhanine E, Gavino C, Haines JD, Almazan G, and Richard S. (2010). The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell. 21: 3029-3040. Mimouni-Rongy M, White JH, Weinstein DE, Desbarats J, Almazan G (2010) Fas ligand acts as a counter-receptor in Schwann cells and induces the secretion of bioactive growth factor. J. Neuroimmunol. [Epub ahead of print] PMID: 20828835. Wang Y, Lacroix G, Haines J, Doukhanine E, Almazan G and Richard S (2010) The QKI-6 isoform localizes with the MBP mRNAs in stress granules of glial cells. PLoS One. 5 (9) E12824. Batist, Gerald (See Department of Oncology) Bernard, Daniel Fortín J, Bernard DJ (2010) SMAD3 and EGR1 physically and functionally interact in promoter-specific fashion. Cell Signal 22(6): 936-943. Robitaille M, Gora S, Wang Y, Goupil E, Pétrin D, Del Duca D, Villeneuve LR, Allen BG, Laporte SA, Bernard DJ, Hébert TE (2010) Gbetagamma is a negative regulator of AP-1 mediated transcription. Cell Signal 22(8): 1254-1266. Wang Y, Libasci V, Bernard DJ (2010) Activin A induction of FSHbeta subunit transcription requires SMAD4 in immortalized gonadotropes. J Mol Endocrinol 44(6): 349-362. Ho CC, Bernard DJ (2010) Bone morphogenetic protein 2 acts via inhibitor of DNA binding proteins to synergistically regulate follicle-stimulating hormone β transcription with activin A. Endocrinology 151(7): 3445-3453. Lamba P, Wang Y, Tran S, Ouspenskaia T, Libasci V, Miller GJ, Hébert TE, Bernard DJ (2010) Activin A regulates porcine follicle-stimulating hormone β subunit transcription via cooperative actions of SMADs and FOXL2. Endocrinology 51(11): 5456-5467. Bowie, Derek Bowie, D. and McKinney R.A. (2010) Neurophysiology of inhibitory and excitatory amino acid receptors. J. Physiol. (Lond.). 588.1:29-32. Bowie, D. (2010) Iondependent gating of kainate receptors. J. Physiol. (Lond.) 588.1:67-81. Čapek, Radan Čapek, R., McLeod, P., Chalk, C. and Brawer, J.R. (2010) Do accompanying clinical vignettes improve student scores on multiple choice questions (MCQs) testing factual knowledge? Journal of the International Association of the Medical Science Educators (JIAMSE), 20:110-119. Chemtob, Sylvain Picard E, Houssier M, Bujold K, Sapieha P, Lubell W, Dorfman A, Racine J, Hardy P, Febbraio M, Lachapelle P, Ong H, Sennlaub F, Chemtob S. (2010) CD36 plays an important role in the

Pharmacology and Therapeutics Publications 2010 clearance of oxLDL and associated age-dependent sub-retinal deposits. Aging (Albany NY). 2(12):981-9. Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LE. (2010) Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 177(6):2715-23. Sapieha P, Joyal JS, Rivera JC, Kermorvant-Duchemin E, Sennlaub F, Hardy P, Lachapelle P, Chemtob S. (2010) Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest. 120(9):3022-32. Review. Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA. (2010) A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem. 285(33):25624-36. Honoré JC, Kooli A, Hou X, Hamel D, Rivera JC, Picard E, Hardy P, Tremblay S, Varma DR, Jankov RP, Mancini JA, Balazy M, Chemtob S. (2010) Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress. Am J Physiol Regul Integr Comp Physiol. 298(6):R1522-30. Chemtob S. (2010) A convenient alternative approach to screen for retinopathy of prematurity. Acta Paediatr. 99(4):494-6. Ronga L, Jamieson AG, Beauregard K, Quiniou C, Chemtob S, Lubell WD. (2010) Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns. Biopolymers. 94(2):183-91. Clyman R, Chemtob S. (2010) Vessel remodeling in the newborn: platelets fill the gap. Nat Med. 16(1):33-5. Deschênes MC, Descovich D, Moreau M, Granger L, Kuchel GA, Mikkola TS, Fick GH, Chemtob S, Vaucher E, Lesk MR. (2010) Postmenopausal hormone therapy increases retinal blood flow and protects the retinal nerve fiber layer. Invest Ophthalmol Vis Sci. 51(5):2587-600. Dorfman AL, Chemtob S, Lachapelle P. (2010) Postnatal hyperoxia and the developing rat retina: beyond the obvious vasculopathy. Doc Ophthalmol. 120(1):61-6. Review. Kermorvant-Duchemin E, Sapieha P, Sirinyan M, Beauchamp M, Checchin D, Hardy P, Sennlaub F, Lachapelle P, Chemtob S. (2010) Understanding ischemic retinopathies: emerging concepts from oxygen-induced retinopathy. Doc Ophthalmol. 120(1):51-60. Review. Sapieha P, Hamel D, Shao Z, Rivera JC, Zaniolo K, Joyal JS, Chemtob S. (2010) Proliferative retinopathies: angiogenesis that blinds. Int J Biochem Cell Biol. 42(1):5-12. Review. Clarke, Paul Wright, JM, Gourdon J, Clarke PB (2010) Identification of multiple call categories within the rich repertoire of adult rat 50-kHz ultrasonic vocalizations: effects of amphetamine and social context. Psychopharmacology 211(1):1-13.

Pharmacology and Therapeutics Publications 2010 Marcangione C, Constantin A, Clarke PB. (2010) Lack of effect of dopaminergic denervation on caudate-putamen hyperthermia or hypothermia induced by drugs and mild stressors. Pharmacol Biochem Behav. 96(1):32-9.. Cuello, A. Claudio Cuello A.C., Bruno M.A., Allard S., Leon W., Iulita M.F. (2010) Cholinergic Involvement in Alzheimer's Disease. A Link with NGF Maturation and Degradation. J. Mol Neurosci. 40:230-235. Cuello A.C., Ferretti M.T., Leon W.C., Iulita M.F., Melis T., Ducatenzeiler A. (2010) Early-stage inflammation and experimental therapy in transgenic models of the Alzheimer-like amyloid pathology. Neuro-degenerative Dis. 7:96-98. Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, de Wilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L and Cuello AC. (2010) A Novel Transgenic Rat Model with a Full Alzheimer's-Life Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-beta-Associated Cognitive Impairment. Journal of Alzheimer's Disease 20:113-126. Leon WC, Bruno MA, Allard S, Nader K, Cuello AC. (2010) Engagement of the PFC in consolidation and recall of recent spatial memory. Learn Mem. 17(6):297-305. Culty, Martine (See Department of Medicine) De Koninck, Yves No publications in 2009. Di Battista, Giovanni (John) (See Department of Anatomy and Cell Biology) Fellows, Lesley (See Department of Neurology and Neurosurgery) Fiset, Pierre (See Department of Anesthesia) Gauthier, Serge (See Departments of Neurology and Neurosurgery, Psychiatry) Geary, Timothy (See Department of Parasitology) Hales, Barbara O'Flaherty, C., Hales, B.F., Chan, P., and Robaire, B. (2010) Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertil Steril. 94(4):1374-1379. Delbès, G., Vaisheva, F., Luu, T., Marcon, L., Hales, B. F., and Robaire, B. (2010) Reversibility of the Effects of the Chemotherapeutic Regimen for Non-Hodgkin Lymphoma,

Pharmacology and Therapeutics Publications 2010 Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone, on the Male Rat Reproductive System and Progeny Outcome. Reprod. Toxicol. 29(3):332-328. Grenier, L., Robaire, B., and Hales, B. F. (2010) Paternal Exposure To Cyclophosphamide Affects The Progression of Sperm Chromatin Decondensation And Activates A DNA Damage Response In The Pre-Pronuclear Rat Zygote. Biol Reprod. 83:195-20. Marcon, L., Zhang, X., Hales, BF, Nagano, MC, and Robaire, B. (2010) Development of a Short-term Fluorescence-based Assay to Assess the Toxicity of Anticancer Drugs on Rat Stem/Progenitor Spermatogonia in vitro. Biol Reprod. 83: 228–237. Schlisser, A. E., Yan, J. and Hales B. F. (2010) Teratogen-Induced Oxidative Stress Targets Glyceraldehyde-3-Phosphate Dehydrogenase in the Organogenesis Stage Mouse Embryo. Toxicol. Sci.118:686-695. Hébert, Terry Lamba P, Wang Y, Tran S, Ouspenskaia T, Libasci V, Hébert TE, Miller GJ, Bernard DJ. (2010) Activin A regulates porcine follicle-stimulating hormone beta-subunit transcription via cooperative actions of SMADs and FOXL2. Endocrinology. 151(11):5456-67. Ross B, McIntosh M, Rodaros D, Hébert TE, Rohlicek CV. (2010) Systemic arterial pressure at maturity in rats following chronic hypoxia in early life. Am J Hypertens. 23(11):1228-33. Hudson BD, Hébert TE, Kelly ME. (2010) Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors. Br J Pharmacol. 160(3):627-42. Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA. (2010) A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem. 285(33):25624-36. Robitaille M, Gora S, Wang Y, Goupil E, Pétrin D, Del Duca D, Villeneuve LR, Allen BG, Laporte SA, Bernard DJ, Hébert TE. (2010) Gbetagamma is a negative regulator of AP-1 mediated transcription. Cell Signal. 22(8):1254-66. Hudson BD, Hébert TE, Kelly ME. (2010) Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor. Mol Pharmacol. 77(1):1-9. Guan R, Wu X, Feng X, Zhang M, Hébert TE, Segaloff DL. (2010) Structural determinants underlying constitutive dimerization of unoccupied human follitropin receptors. Cell Signal. 22(2):247-56. Jean-Claude, Bertrand (See Department of Medicine) Kimmins, Sarah (See Department of Animal Science)

Pharmacology and Therapeutics Publications 2010 Laird, Jennifer Yu XH, Cao CQ, Martino G, Puma C, Morinville A, St-Onge S, Lessard E, Perkins MN, Laird JM. (2010) A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain. Pain. 151(2):337-44. Pradhan AA, Yu XH, Laird JM. (2010) Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain. Eur J Pain. 14(5):503-9. Laporte, Stéphane (See Division of Experimental Medicine) Mancini, Joseph Honoré JC, Kooli A, Hou X, Hamel D, Rivera JC, Picard E, Hardy P, Tremblay S, Varma DR, Jankov RP, Mancini JA, Balazy M, Chemtob S. (2010) Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress. Am J Physiol Regul Integr Comp Physiol. 298(6):R1522-30. Maysinger, Dusica Hutter E, Maysinger D. (2010) Gold nanoparticles and quantum dots for bioimaging. Microsc Res Tech. Soliman GM, Sharma R, Choi AO, Varshney SK, Winnik FM, Kakkar AK, Maysinger D. (2010) Tailoring the efficacy of nimodipine drug delivery using nanocarriers based on A2B miktoarm star polymers. Biomaterials. 31(32):8382-92. Lalancette-Hébert M, Moquin A, Choi AO, Kriz J, Maysinger D. (2010) Lipopolysaccharide-QD micelles induce marked induction of TLR2 and lipid droplet accumulation in olfactory bulb microglia. Mol Pharm. 7(4):1183-94. Hourani R, Jain M, Maysinger D, Kakkar A. (2010) Multi-tasking with single platform dendrimers for targeting sub-cellular microenvironments. Chemistry. 16(21):6164-8. Hutter E, Boridy S, Labrecque S, Lalancette-Hébert M, Kriz J, Winnik FM, Maysinger D. (2010) Microglial response to gold nanoparticles. ACS Nano. 4(5):2595-606. Soliman GM, Choi AO, Maysinger D, Winnik FM. (2010) Minocycline block copolymer micelles and their anti-inflammatory effects on microglia. Macromol Biosci. 10(3):278-88. McKinney, Anne Queval, A., Ghattamaneni, N.R., Perrault, C.M., Gill, R., Mirzael, M., McKinney, R.A. and Juncker, D. (2010) Chamber and microfluidic probe for microperfusion of organotypic brainslices. Lab on Chip 20:326-334. Bowie, D. & McKinney, R.A. (2010) Neurophysiology of inhibitory and excitatory amino acid receptors. J. Physiology (London) 558: 29-32. McKinney, R.A. (2010) Excitatory amino acid involvement in dendritic spine formation, maintenance and remodeling. J. Physiology (London) 558:107-116.

Pharmacology and Therapeutics Publications 2010 McLeod, Peter McLeod P, Steinert Y. (2010) The Evolution of Faculty Development in Canada Since the 1980’s. Coming of Age or Time for a Change? Medical Teacher. 32:e31-e35. McLeod P, Steinert Y, Boudreau D, Snell L, Wiseman J. (2010) Twelve tips for conducting a medical education journal club. Medical Teacher. 32:368-370. Capek R, McLeod P, Brawer J, Chalk C. (2010) Do Accompanying Clinical Vignettes Improve Student Scores on Multiple Choice Questions (MCQs) Testing Factual Knowledge? Journal of the International Association of Medical Science Educators. 20: 2110-2119. Steinert Y, Macdonald ME, Boillat M, Elizov M, Meterissian S, Razack S, Ouellet M-N & McLeod PJ. (2010) Faculty Development: If you build it they will come. Medical Education 44:900-907. Miller, Gregory Lamba, P., Wang, Y., Tran, S., Ouspenskaia, T., Libasci, V., Hébert, T.E., Miller, G.J., Bernard, D.J. (2010). Activin A regulates porcine follicle-stimulating hormone β subunit transcription via cooperative actions of SMADs and FOXL2. Endocrinology 151(11):5456-67. Nattel, Stanley Naud P, Guasch E, Nattel S. (2010) Physiological versus pathological cardiac electrical remodelling: potential basis and relevance to clinical management. J Physiol. 588(Pt 24):4855-6. Nishida K, Sarrazin JF, Fujiki A, Oral H, Inoue H, Morady F, Nattel S. (2010) Roles of the left atrial roof and pulmonary veins in the anatomic substrate for persistent atrial fibrillation and ablation in a canine model. J Am Coll Cardiol. 56(21):1728-36. Voigt N, Makary S, Nattel S, Dobrev D. (2010) Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods Enzymol. 484:653-75. Benito B, Guasch E, Rivard L, Nattel S. (2010) Clinical and mechanistic issues in early repolarization of normal variants and lethal arrhythmia syndromes. J Am Coll Cardiol. 56(15):1177-86. Review. Blana A, Kaese S, Fortmüller L, Laakmann S, Damke D, van Bragt K, Eckstein J, Piccini I, Kirchhefer U, Nattel S, Breithardt G, Carmeliet P, Carmeliet E, Schotten U, Verheule S, Kirchhof P, Fabritz L. (2010) Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability. Heart Rhythm. 7(12):1862-9. Levine RA, Nattel S. (2010) Looking into the left atrial crystal ball: a ray of hope for patients with organic mitral regurgitation. J Am Coll Cardiol. 56(7):579-81. Koo SH, Wakili R, Heo JH, Chartier D, Kim HS, Kim SJ, Lee JW, Qi XY, Nattel S, Cha TJ. (2010) Role of constitutively active acetylcholine-mediated potassium current in atrial contractile dysfunction caused by atrial tachycardia remodelling. Europace. 12(10):1490-7.

Pharmacology and Therapeutics Publications 2010 Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S. (2010) Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ Arrhythm Electrophysiol. 3(5):530-41. Voigt N, Trausch A, Knaut M, Matschke K, Varró A, Van Wagoner DR, Nattel S, Ravens U, Dobrev D. (2010) Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol. 3(5):472-80. De Souza AI, Cardin S, Wait R, Chung YL, Vijayakumar M, Maguy A, Camm AJ, Nattel S. (2010) Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure. J Mol Cell Cardiol. 49(5):851-63. Guasch E, Benito B, Nattel S. (2010) Exercise training, inflammation and heart failure: working out to cool down. J Physiol. 588(Pt 14):2525-6. Gaborit N, Varro A, Le Bouter S, Szuts V, Escande D, Nattel S, Demolombe S. (2010) Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts. J Mol Cell Cardiol. 49(4):639-46. Nattel S. (2010) Sudden cardio arrest: when normal ECG variants turn lethal. Nat Med. 16(6):646-7. Tadevosyan A, Maguy A, Villeneuve LR, Babin J, Bonnefoy A, Allen BG, Nattel S. (2010) Nuclear-delimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem. 285(29):22338-49. Talajic M, Khairy P, Levesque S, Connolly SJ, Dorian P, Dubuc M, Guerra PG, Hohnloser SH, Lee KL, Macle L, Nattel S, Pedersen OD, Stevenson LW, Thibault B, Waldo AL, Wyse DG, Roy D; AF-CHF Investigators. (2010) Maintenance of sinus rhythm and survival in patients with heart failure and atrial fibrillation. J Am Coll Cardiol. 55(17):1796-802. Erratum in: J Am Coll Cardiol. 55(24):2788. AF-CHF Investigators [added]. Le Polain DE Waroux JB, Nattel S, Dubuc M, Talajic M, Macle L. (2010) Concealed automaticity from an island of atrial myocardium post cavotricuspid ablation. J Cardiovasc Electrophysiol. 21(12):1408-9. Dobrev D, Nattel S. (2010) New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet. 375(9721):1212-23. Farkas AS, Nattel S. (2010) Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. Drugs. 70(5):573-603. Review. Nattel S. (2010) Mechanisms of lethal arrhythmias due to acute myocardial ischemia: regional factors and challenges in sudden death prevention. Heart Rhythm. 7(3):387-8. Datino T, Macle L, Qi XY, Maguy A, Comtois P, Chartier D, Guerra PG, Arenal A, Fernández-Avilés F, Nattel S. (2010) Mechanisms by which adenosine restores conduction in dormant canine pulmonary veins. Circulation. 121(8):963-72.

Pharmacology and Therapeutics Publications 2010 Horduna I, Nattel S, Talajic M, Macle L. (2010) Dormant pulmonary vein conduction unmasked by external electrical cardioversion. Heart Rhythm. 7(11):1706-7. Aubin MC, Cardin S, Comtois P, Clément R, Gosselin H, Gillis MA, Le Quang K, Nattel S, Perrault LP, Calderone A. (2010) A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia. J Appl Physiol. 108(4):933-40. Nishida K, Michael G, Dobrev D, Nattel S. (2010) Animal models for atrial fibrillation: clinical insights and scientific opportunities. Europace. 12(2):160-72. Review. Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S. (2010) Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates. J Mol Cell Cardiol. 48(1):96-105. O’Flaherty, Cristian (See Department of Urology) Papadopoulos, Vassilios (See Department of Medicine) Prichard, Roger (See Department of Parasitology) Quirion, Remi (See Department of Psychiatry) Ribeiro-da-Silva, Alfredo J. C. Peleshok and A. Ribeiro-da-Silva (2010) Delayed reinnervation by non-peptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. J.Comp.Neurol. 519(1):49-63. S. Lee, Y. Q. Zhao, A. Ribeiro-da-Silva, and J. Zhang (2010) Distinctive response of CNS glial cells in oro-facial pain associated with injury, infection and inflammation. Mol.Pain 6(1):79. Robaire, Bernard O’Flaherty C, Hales B.F, Chan P, and Robaire B. (2010) Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm DNA integrity. Fertil Steril. 94:1374-9. Delbes, G., Hales, B.F., and Robaire, B. (2010) Toxicants and human sperm chromatin integrity. Molecular Human Reproduction 16:14-22. Delbès G, Vaisheva F, Luu T, Marcon L, Hales B.f, and Robaire B. (2010) Reversibility of the effects of the chemotherapeutic regimen for non-Hodgkin lymphoma, cyclophosphamide, doxorubicin, vincristine, and prednisone, on the male rat reproductive system and progeny outcome. Reprod Toxicol. 29:332-8.

Pharmacology and Therapeutics Publications 2010 Barratt CL, Aitken RJ, Björndahl L, Carrell DT, de Boer P, Kvist U, Lewis SE, Perreault SD, Perry MJ, Ramos L, Robaire B, and Ward S Zini A. (2010) Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report. Hum Reprod. 25:824-38. Marcon, L., Zhang, X., Hales, B.F., Nagano, M.C., and Robaire, B. (2010) Development of a Short-Term Flourescence-Based Assay to Assess the Toxicity of Anticancer Drugs on Rat Stem/ Progenitor Spermatogonia In Vitro. Biol. Reprod. 83:228-237. Grenier, L., Robaire, B., and Hales, B.F. (2010) Parental Exposure to Cyclophosphamide Affects the Progression of Sperm Chromatin Decondensation and Activates a DNA Damage Response in the Prepronuclear Rat Zygote. Biol. Reprod. 83:195-204. Hamzeh, M., and Robaire B. (2010) Identification of early response genes and pathway activated by androgens in the initial segment and caput regions of the regressed rat epididymis. Endocrinology. 151:4504-4514. Yanagiya, A., Delbes, G., Svitkin, Y.V., Robaire, B., and Sonenberg, N. (2010) The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. J Clin Invest. 120:3389-400. Rousseau, Simon (See Department of Medicine) Saragovi, Uri Bassili M, Birman E, Schor NF, Saragovi HU. (2010) Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo. Cancer Chemother Pharmacol.65(6):1047-56. Y. Bai, J. Xu, M.V. Sarunic, Y. Zhuo, H.U. Saragovi. (2010) An agonistic anti-TrkB mAb, but not BDNF, protects RGCs and retinal structure from acute or chronic neurodegeneration in vivo. Investigative Ophthalmology & Visual Science (IOVS). 51(9):4722-31. V. Guillemard, L. Ivanisevic, V. Scholten, Oscar Lazo, F. Bronfman, and H. Uri Saragovi. (2010) An agonistic anti-TrkC mAb directed to the juxtamembrane ectodomain defines a functional hot spot interacting with p75 co-receptors. Develop. Neurobiol. 70(3):150-64. Wenyong Tong, Martin Gagnon, Tara Sprules, Michel Gilbert, Shafinaz Chowdhury, Karen Meerovitch, Karl Hansford, Enrico O. Purisima, John W. Blankenship, Nai-Kong V. Cheung, Kalle Gehring, William D. Lubell, H. Uri Saragovi. (2010) Small Molecule Ligands of GD2 Ganglioside, Designed from NMR Studies, Exhibit Induced-Fit Binding and Bioactivity. Chem Biol. 17(2):183-94. Bai Y, Shi Z, Zhuo Y, Liu J, Malakhov A, Ko E, Burgess K, Schaefer H, Esteban PF, Tessarollo L, Saragovi HU. (2010) In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death. Invest Ophthalmol Vis Sci. 51(12):6639-51.

Pharmacology and Therapeutics Publications 2010 Sarunic MV, Yazdanpanah A, Gibson E, Xu J, Bai Y, Lee S, Saragovi HU, Beg MF. (2010) Longitudinal study of retinal degeneration in a rat using spectral domain optical coherence tomography. Opt Express. 18(22):23435-41. Bai Y, Dergham P, Nedev H, Xu J, Galan A, Rivera JC, ZhiHua S, Mehta HM, Woo SB, Sarunic MV, Neet KE, Saragovi HU. (2010) In chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism. J Biol Chem. 285(50):39392-400. Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA. (2010) A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem. 285(33):25624-36. Brahimi F, Liu J, Malakhov A, Chowdhury S, Purisima EO, Ivanisevic L, Caron A, Burgess K, Saragovi HU. (2010) A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist. Biochim Biophys Acta. 1800(9):1018-26. Liu J, Brahimi F, Saragovi HU, Burgess K. (2010) Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists. J Med Chem. 53(13):5044-8. Shir, Yoram (See MUHC Pain Center) Stone, Laura (See Faculty of Dentistry) Szyf, Moshe Szyf, M. (2010) Epigenetic Therapeutics in Autoimmune Disease. Clinical Reviews in Allergy and Immunology. 39(1): 62-77. McGowan, P.O., & Szyf, M. (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiol. Dis. 39(1):66-72. Leon, W. C., Canneva, F., Partridge, V., Allard, S., Ferretti, M. T., DeWilde, A., Vercauteren, F., Atifeh, R., Ducatenzeiler, A., Klein, W., Szyf, M., Alhonen, L., & Cuello, A. C. (2010) A novel transgenic rat model with a full Alzheimer’s-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. Journal of Alzheimers Disease. 20(1):113-26. Szyf, M. DNA methylation and demethylation probed by small molecules. (2010) Biochimica Biophys Acta. 1799(10-12):750-9. Review. Szyf, M. (2010) A dynamic methylome; implications of non-CG methylation/demethylation. Cell Cycle. 9(19):3846-7. McGowan P.O, & Szyf, M. (2010) Environmental epigenomics: understanding the effects of parental care on the epigenome. Essays Biochem. 48(1):275-87.

Pharmacology and Therapeutics Publications 2010 McGowan PO, Szyf M. (2010) Developmental origins of chronic physical aggression and epigenetics. Epigenomics. 2(4):495-9. Tanny, Jason No publications in 2010. Trasler, Jacquetta Chan D, Cushnie DW, Neaga OR, Lawrance A, Rozen R and Trasler JM. (2010) Strain-specific defects in testicular development and sperm Epigenetic patterns in 5,10- methylenetetrahydrofolate reductase (MTHFR)-deficient mice. Endocrinology. 151:3363-73. Varma, Daya Honoré JC, Kooli A, Hou X, Hamel D, Rivera JC, Picard E, Hardy P, Tremblay S, Varma DR, Jankov RP, Mancini JA, Balazy M, Chemtob S. (2010) Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress. Am J Physiol Regul Integr Comp Physiol. 298(6):R1522-30. Sarangi S, Zaidi T, Pal RK, Katgara D, Gadag VG, Mulay S, Varma DR. (2010) Effects of exposure of parents to toxic gases in Bhopal on the offspring. Am J Ind Med. 53(8):836-41. Yang, Xiang-Jiao (See McGill University Rosaline & Morris Goodman Cancer Center) Zingg, Hans Viero C, Shibuya I, Kitamura N, Verkhratsky A, Fujihara H, Katoh A, Ueta Y, Zingg HH, Chvatal A, Sykova E, Dayanithi G. (2010) Oxytocin: Crossing the bridge between basic science and pharmacotherapy. CNS Neurosci Ther. 16(5):e138-56. Review. Goupil E, Tassy D, Bourguet C, Quiniou C, Wisehart V, Pétrin D, Le Gouill C, Devost D, Zingg HH, Bouvier M, Saragovi HU, Chemtob S, Lubell WD, Claing A, Hébert TE, Laporte SA. (2010) A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem. 2010 285(33):25624-36. Zorychta, Edith (See Department of Pathology)