PhD ACADEMIC STUDIES pl… · Radiographic procedures in dentistry . 13. ... Lectures and practical work (analysis of scientific papers, writing and analysis of researches and PhD

SCHOOL OF DENTAL MEDICINE

UNIVERSITY IN BELGRADE

PhD ACADEMIC STUDIES

Study programme

BASIC AND CLINICAL RESEARCH IN DENTAL MEDICINE

COURSE BOOK

Belgrade 2013

School of Dental Medicine - University in Belgrade 1


No Code Course title page

1. DS13MNIR Introduction to Methodology and Ethics of Scientific Research 3

2. DS13STAT Medical Statistics 4

3. DS13LABO Laboratory procedures and functional testing of the orofacial region 5

4. DS13PUBL Publishing in Biomedical Sciences 6

5. DS13NAUK Principles of Epidemiological Sciences in Dental Public Heath 7

6. DS13BIOL Stem Cell Biology and Cell Signalling 8

7. DS13EKSP Procedures in Operating With Experimental Animals 9

8. DS13INFO Biomedical Scientific Inofrmatics 10

9. DS13BIOM Biomechanical Principles in Dental Sciences 11

10. DS13RAZV Development and Anomalies of the Orofacial Region 12

11. DS13RADI Radiographic procedures in dentistry 13

12. DS13FOTO Principles of Photography of the Orofacial Region in Scientific Research 14

13. DS13MATE Research of Biomaterials for Application in Dentistry 15

14. DS13ISRE Research of Reconstructive Methods and Materials 16

15. DS13RAST Growth, Differentiation and Regeneration of Oral Tissues 17

16. DS13FIZI Physiological States and Systemic Diseases – Impact on Orofacial Region 18

17. DS13MOGE Molecular-Genetic Studies of the Orofacial Region 19

18. DS13TRAN Transduction signalling Molecules in Oral Tissues in Physiological and Disease Conditions

20

19. DS13BIMA Biochemical Markers in Oral Diseases 21

20. DS13BIMO Biologically active molecules as inducers of the pulp-dentin reparation 22

21. DS13PAKA Pathohistological characteristics of tumors of the orofacial region 23

22. DS13EPID Epidemiological studies of orofacial diseases 24

23. DS13KVAL Quality of Life of Patients with Orofacial Diseases 25

24. DS13RIZI Research and Defining Risk of Occurrence of Orofacial Diseases and Teeth Injuries

26

25. DS13POTP Experimental Research of Periodontal Tissues 27

26. DS13OROF Prospective and Retrospective Research in Rehabilitation of the Orofacial Complex

28

27. DS13REZU Prospective and Retrospective Research of Dental Tissue Reconstruction 29


Course title: Introduction to Methodology and Ethics of Scientific Research Course status: compulsory Professor in charge: Bozidar Brkovic ECTS: 5 Study year: I/1st Semester DS13MNIR Course prerequisites: none Learning objective: The aim is to familiarize PhD students with the basic principles of the scientific methodology for the scientific and PhD thesis work. Learning outcomes: Outcomes refer to the capacity of the PhD students to recognize the importance of the scientific problem and qualitatively realize it in the term of the scientific and PhD thesis work. Course description: Closer insight into the understanding of the scientific method and scientific clinical and laboratory research as well as ethical principles of the science. Concerning that, the conditions and procedures of research preparation and submission will be analyzed. A particular aspect will be related to practical scientific work on its implementation in the form of current literature and the exercise of all structures of the scientific writing and PhD thesis work. Recommended literature: Turabain K. A manual for Writers or Research Papers, Thesis and Dissertations. 7th ed. The University of Chicago Press, 2007. Scientific papers and reviews No. of active classes: 30

Lectures and practical work:

Course research study 30

Methods of teaching: Lectures and practical work (analysis of scientific papers, writing and analysis of researches and PhD thesis) Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 7.5 Test 40 Course research study 22.5 Practical part Colloquium Oral part Seminars 30


Course title: Medical Statistics Course status: compulsory Professor in charge: Biljana Miličić ECTS: 6 Study year: I/1st semester DS13STAT Course prerequisites: none Learning objective: The aim of this course is to familiarize students with the necessary biostatistical methods, tools, techniques, computational skills and writing rules, necessary for: statistical thinking, in particular the role and limitations of scientific work and practice, practice reading the statistical aspects of published papers and other literature. Learning outcomes: Students will be required biostatistical methods, tools, techniques, computational skills and rules of writing apply to independently solve quantitative problems in the field of dental research and practice and critical evaluation of literature and research. The techniques and methods that are an integral part of these classes are the basis for the introduction of advanced and complex methods. Course description: Biostatistics is an essential tool in advancing health sciences research. It helps assess treatment effects, compare different treatment options, understand how treatments interact, and evaluate many life and death situations in medical sciences. Statistical rigor is necessary to be an educated researcher or clinician who can shun the overgeneralization, objectively criticize, and appreciate the research results published in the literature. An important part of students' training is to develop an ability to critically read literature in their speciality areas The amount of statistics used in journal articles in biomedical and health sciences can easily intimidate readers who lack background in statistics. They must understand statistics sufficiently to read the literature critically, assessing the adequacy of the research and interpreting the results and conclusion correctly so that they may properly implement the new discovers in diagnosis and treatment. Recommended literature:

1. Kim JS, Dailey R (2007). Biostatistics for Oral Healthcare. Blackwell Pub Professional, Iowa State University Press, Iowa USA.

2. http://davidmlane.com/hyperstat/ (HyperStat Online Textbook © 1993-2003 David M. Lane) 3. http://www.bmj.com/collections/statsbk/index.shtml (Statistics at Square one, Ninth edition, TDV

Swinscow, Revised by M J Campbell, University of Southampton, Copyright BMJ Publishing Group 1997.) 4. http://www.psychstat.smsu.edu/sbk00.htm (Introductory statistics: concepts, models, and applications, by

David W. Stockburger, Revised 2/19/98) 5. http://www.stattsoft.com/textbook/statshome.html (Electronic Statistics Textbook - Statsoft)

No. of active classes: 45



Methods of teaching:

Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test 20 Course research study 25 Practical part 20 Colloquium 15 Oral part Seminars 10

http://davidmlane.com/hyperstat/

http://www.bmj.com/collections/statsbk/index.shtml

http://www.psychstat.smsu.edu/sbk00.htm

http://www.stattsoft.com/textbook/statshome.html


Course title: Laboratory procedures and functional testing of the orofacial region Course status : compulsory Professor in charge: Elena Kršljak ECTS: 14 Study year: I/2nd

semester DS13LABO

Course prerequisites: none Learning objective: The aim of this course is to give students basic knowledge in several key laboratory methods that will enable them to rationally choose the method / methods in the appropriate field of dentistry and apply them later scientific work. Learning outcomes: Theoretical and practical skills in modern methods of scientific research that enables PhD students to select the appropriate methodology that they will apply in their PhD dissertation and in scientific projects Course description: Monitoring components of saliva and gingival fluid, determining second messengers and other biologically active molecules in oral tissues, blood flow and vascular reactivity of the orofacial region, molecular biology and genetics (PCR and PCR related techniques), routine histological and immunohistochemical methods. Recommended literature: 1.Alberts B, Johanson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell,.Garland Science, New York, 2006. 2. McKenzie J, Klein RM. Basic conepts in cell biology and histology, Mcgraw-Hill, New York, 2000. 3. Concepts in biochemistry / Rodney Boyer. - 3rd ed. - [s.l.] : John Wiley (Asia), 2006. - xvi, 666, G11, A31, I12 str. : ilustr. ; 28 cm. - (Wiley Asia Student Edition) Appropriate review articles No. of active classes: 60



Methods of teaching: theoretical courses, lab work, seminars, journal clubs

Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test 40 Course research study 50 Practical part Colloquium Oral part Seminars


Course title: Publishing in Biomedical Sciences Course status: compulsory Professor in charge: Miroslav Andric ECTS: 5 Study year: I/2nd

Semester DS13PUBL

Course prerequisites: none Learning objective: To present basic principles of publishing of scientific results in biomedicine, with an emphasis on intellectual and ethical principles of publishing and to provide basic knowledge and skills needed for writing and presentation of scientific publications Learning outcomes: Upon course completion, student has knowledge about entire process of scientific publishing, recognizes requirements for a high quality scientific paper and has basic skills needed for writing of scientific publications. Student is also informed about process of peer review and has ability to prepare and present oral presentations in scientific meetings. Course description: Course will include presentation of different types of scientific publications, importance of publishing of scientific results and ethical principles in this process. Through the classes students learn about principles of writing and evaluation of scientific publications and publication process. Recommended literature: Literature 1. Ј. Peat, E. Elliott, L. Baur, V. Keena. Scientific Writing. London: BMJ Books, 2002. 2. T. Greenhalgh. How to Read a Paper. London: BMJ Books, 2001. 3. GM Hall. How to Write a Paper. London: BMJ Books, 1998. 4. GM Hall. How to Present at meetings. London: BMJ Books, 2001. 5. JĐ Savić. Kako napisati, objaviti i vrednovati naučno delo u biomedicini. Beograd: Kultura, 1996. 6. RA Day. How to Write and Publish a Scientific Paper. Phoenix: Oryx, 1998. 7. JĐ Savić. Kako stvoriti naučno delo u biomedicini. Beograd: Kultura, 1999. No. of active classes: 30



Methods of lecturing Lectures, seminars, study work

Evalution of results (maximum 100 points) During the course points Final exam points lectures 7,5 Test 40 Study work 22,5 Practical exam test Oral exam Seminars 30


Course title: Principles of Epidemiological Sciences in Dental Public Heath Course status : elective Professor in charge: Ivanka Gajić ECTS: 6 Study year: I/1st semester DS13NAUK Course prerequisites: none Learning objective: To get students familiar with epidemiological research in clinical and dental public health practice Learning outcomes: Students should be able to: - apply epidemiological data to clinical practice - design epidemiological study for purpose of clinical and public health research - create sample (selection of patients), choose sources and health indicators for research - evaluate process and outcomes of investigation - design the intervention program on a community level Course description: The understanding of different epidemiological studies is necessary for dentists and for the benefit of their good clinical and dental public health practice. Also, each professional and scientific research in dentistry demands the basic knowledge and skills related to epidemiology and dental public health. The course is comprised of topics regarding data sources, health indicators, prospective and retrospective studies, diagnostic tests, evaluation, technologies in dentistry and elements of evidence-based dentistry. Recommended literature: 1. Radovanović Z, Vlajinac H. General epidemiology. Science. Belgrade, 2001. 2. Daly B, Watt R, Batchelor P, Treasure E. Essential Dental Public Health. Oxford, 2002. 3. Katz LD. Epidemiology Biostatistics and Preventive Medicine Review. Philadelphia, United state of America, 1997. No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 5 Test 40 Course research study 25 Practical part Colloquium 15 Oral part Seminars 15


Course title: Stem Cell Biology and Cell Signalling Course status : elective Professor in charge: Vesna Danilović ECTS: 6 Study year: I/2nd

semesterDS13BIOL

Course prerequisites: none Learning objective: The aim of the subject Stem cell biology and cell signalling is to provide a student of doctoral studies with basic knowledge about origin, characteristics and role of stem cells, as well as the possibilities of their appliances in regenerative therapy and potential role in oncogenesis. The aim is also addressed to basis of gene regulatory mechanisms and mechanisms of intercellular communication. Learning outcomes: The student has gained insight into morphological and functional characteristics of stem cells and their role in different physiological and pathological processes. This knowledge allows the student more complete understanding of the mechanisms of tissues integrity maintenance, tissue repair and regeneration and malignant alteration. Course description: The origin, phenotype characterisation, and differentiation potency of embryonic, fetal and adult stem cells, as well as carcinoma stem cells. Basic function of stem cells and their regulatory mechanisms. Possible application of stem cells in regenerative medicine. Recommended literature: 1. Alberts B, Johanson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell,.Garland Science, New York, 2006. 2. McKenzie J, Klein RM. Basic conepts in cell biology and histology, Mcgraw-Hill, New York, 2000. 3. Garant PR. Oral cells and tissues. Quintessence Publishing Co, Inc. 2003. 4. Avery J, Chiego D. Essentials of oral histology and embriology. Elsevier, 2013. No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 20 Test 40 Course research study Practical part Colloquium Oral part Seminars 40


Course title: Procedures in Operating With Experimental Animals Course status : elective Professor in charge: Elena Kršljak ECTS: 6 Study year: I/2nd

semester DS13EKSP

Course prerequisites: none Learning objective: Teaching candidates about Legal Standards, General ethical principles, techniques for using experimental animals in scientific research. Learning outcomes: Candidates are familiar with experimental work and trained to work with experimental animals according to basic ethical and legal standard principles for using experimental animals in research Course description: Legal and ethical standards referring to work on experimental animals, principles of Good Laboratory Practices, advantages and disadvantages of animal models, selecting in vivo models, benefit of experiments on animals in dental science, healing of animals bone defects, drug administration methods on experimental animals, genetically modified organisms. Recommended literature: Scientific articles from Medline No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test 40 Course research study 30 Practical part Colloquium Oral part Seminars 20


Course title: Biomedical Scientific Inofrmatics Course status: elective Professor in charge: Đorđe Stratimirović ECTS: 6 Study year: I/1st semester DS13INFO Course prerequisites: none Learning objective: The goal of this course is to improve PhD students’ information literacy skills, providing them with the ability to solve research problems independently and make informed choices relevant to their study. Introducing students to all aspects of scientific information and helpful research tools, the course aims to support and help them in order to ensure a successful and timely completion of the PhD degree. Learning outcomes: The student recognizes the need for information and has the ability to locate, organize, store and use information effectively to address specific PhD research issues. The student is able to evaluate information and its sources critically, and to understand the economic, legal, social and cultural issues surrounding the use of information, as well as to access and use information ethically and legally. Course description: Scientific communication system transformations; Scientific publication modalities; Library Information System of Serbia and availability of print and electronic resources; Bibliographic information sources; Bibliometric indicators and the evaluation of scientific research; Open Access publishing; Search strategies and bibliographic information retrieval; Organizing information and ethical and legal information use; Web 2.0 Science Tools (creation and retrieval of scientific information) Recommended literature: Huvila, Isto. Information Services and Digital Literacy: In Search of the Boundaries of Knowing. Oxford: Chandos Publishing; 2012. Rowley, J E. Organizing Knowledge: An Introduction to Information Retrieval. Aldershot, Hants, England: Ashgate; 1992. Guedon J-C. Mixing and maching the green and gold roads to open access – take 2. Serials Review. 2008; 34(1): 41-51. The lwall M. Bibliometrics to webometrics. Journal of Information Science. 2008; 34(4): 605-621. Virtual Library of Serbia - http://www.vbs.rs/cobiss/ PubMed - http://www.nlm.nih.gov/bsd/disted/pubmed.html KoBSON - http://kobson.nb.rs PloS - http://www.plos.org/ Creative Commons License - http://creativecommons.org/ No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 5 Test Course research study 20 Practical part Colloquium 10 Oral part 40 Seminars 25

http://www.vbs.rs/cobiss/

http://www.nlm.nih.gov/bsd/disted/pubmed.html

http://kobson.nb.rs/

http://www.plos.org/

http://creativecommons.org/


Course title: Biomechanical Principles in Dental Sciences Course status: elective Professor in charge: Branislav Glišić ECTS: 6 Study year: 1/1st

Semester DS13BIOM

Course prerequisites: none Learning objective: The aim of this subject is to introduce the candidates to the effects of orthodontic force on skeletal and dentoalveolar structures, as well as to the possibilities for growth modification. Learning outcomes: The candidate needs to be able to understand biomechanical principles of the effect of forces used in contemporary dentistry, especially during tooth movement Course description: The first part of the course is introduction in biomechanics. The next step will include hands on course on typodonts with practical approach to orthodontic treatment of malocclusions. Recommended literature: Nanda R. Biomechanics and esthetic strategies in clinical orthodontics Proffit WR, Fields HW. Contemporary orthodontics Graber TM, Neumann B. Removable orthodontic appliances McLaughlin RP, Benett JC, Trevisi HJ: Systemized orthodontic treatment mechanics No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test 20 Course research study 50 Practical part 20 Colloquium Oral part Seminars


Course title: Development and Anomalies of the Orofacial Region Course status : elective Professor in charge: Gordana Kuburović ECTS: 6 Study year: I/2nd

semester DS13RAZV

Course prerequisites: none Learning objective: The aim of the course is to provide basic knowledge to students related to the cells and tissues involved in face and neck development and basic control developmental mechanisms in normal and pathologically changed conditions. The student becomes familiar with the disfunctions of embryonic cells and tissues that give rise to the formation of congenital anomalies. Learning outcomes: Knowledge that students gain after the course allows better insight of the nature of head and neck development in normal conditions and congenital malformations of this region, as well as more complete understanding of their pathogenesis, prognosis, and therapy. Course description: Basic characteristics of the tissue development and growth and cell and tissue processes involved in development such are induction, adhesion, differentiation, histogenesis and morphogenesis. Basic concepts in head and neck tissues development, as well as development-related disorders.

Recommended literature: 1. Nancy A.Ten Cate’s Oral Histology: Development, Structure, and Function. Mosby, 2007. 2. Avery JK. Oral Development and Histology. Thieme, 2002. 3. DanilovićV. Kuburović G. Oralna histologija i embriologija. Zavoda za udžbenike, Beograd, 2012.





Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test 40 Course research study 20 Practical part Colloquium 30 Oral part Seminars


Course title: Radiographic procedures in dentistry Course status : elective Professor in charge: Zoran Rakočević ECTS: 6 Study year: I/2nd

semester DS13RADI

Course prerequisites: none Learning objective: Educating students in order to be able to choose diagnostic imaging procedures for diseases of the orofacial region and neck and to analyse the results Learning outcomes: PhD student is qualified to interpret the results of imaging studies from the contemporary scientific literature and organise independent research of both methodological and clinical type, based on radiographic techniques. Course description: During the training, basic principles related to the performance possibilities of particular radiological methods are provided to students, as well as analysis of images and radiographs of certain pathological conditions related to the head and neck region Recommended literature: 1. C Peter-Adler: Bone diseases. Macroscopic, Histological, and Radiological Diagnosis of structural changes in the Skeleton. Springer, 2000. 2. S Curtin. Haed and Neck Imaging. Mosby, 2002. 3. Langalis, Langlang and Nortie: Diagnostic Imaging of the jaws, Baltimore, Williams and Vilkins, 1995 . No. of active classes: 30






Course title: Principles of Photography of the Orofacial Region in Scientific Research Course status:elective Professor in charge: Branislav Glišić ECTS: 6 Study year: I/2nd

Semester DS13FOTO

Course prerequisites: none Learning objective: To capacitate the candidate to singly obtain patient, dental procedure and dental work photographs Learning outcomes: The candidate is qualified for documenting research results using different photographic techniques Course description: Students will be thought how to take intraoral and extraoral photos of patients with malocclusions and maxillofacial deformities. Editing, special considerations in dental digital photography and ways of presenting will be discussed. Recommended literature: Bengel, Wolfgang. Mastering digital dental photography. Quintenssence Publishing Co, Ltd, 2006. No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test Course research study Practical part 40 Colloquium Oral part Seminars 50


Course title: Research of Biomaterials for Application in Dentistry Course status : elective Professor in charge: Dragoslav Stamenković ECTS: 6 Study year: I/2nd

semester DS13MATE

Course prerequisites: none Learning objective: Is to introduce students to the characteristics of biomaterials, basic legal and regulatory requirements and standards as well as contemporary methods of testing of biomaterials. Learning outcomes: PhD student is qualified to interpret scientific studies of biomaterials research, and to organise independent in vitro and in vivo studies. Course description: Biomaterials, their biocompatibility and toxicity are the main topics of this course with a special focus on test methods, standards and legislations which apply to certain biomaterials market. It also discusses nanotechnology and nanomaterials as materials of the future. Recommended literature:

1. O´Brien WJ, Dental Materials and Their Selection, Quintessence, Chicago, 2008. 2. Eliades G, Eliades T, Brantley WA, Watts DC: Dental Materials In Vivo, Aging and Related Phenomena,

Quintessence, Chicago, 2003. 3. Craig R, Powers J, Wataha J: Dental materials, Mosby, 2004. 4. Groten M, Janda R, Latta M: Clinical Investigation of Medical Devices in Dentistry, Quintenssence,

London, 2004. 5. ISO: 7405: 1997, Preclinical Evaluation of Biocompatibiliti of Medical Devices Used in Dentistry – Test

Methods for Dental Materials. 6. ISO 1942-2: 1989/ Amd.2:1992, Dental Vocabulary – part 2, Dental materials.

. No. of active classes: 30




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test Course research study 20 Practical part Colloquium 30 Oral part 40 Seminars


Course title: Research of Reconstructive Methods and Materials Course status: elective Professor in charge: Sasa Jankovic ECTS: 6 Study year: I/ 2nd

Semester DS13ISRE

Course prerequisites: none Learning objective: Mastering the theoretical knowledge of the principles of reconstruction of hard and soft oral tissues in modern oral implantology Learning outcomes: PhD informed contemporary views on regeneration of alveolar bone defects and osseointegration dental implants and mastered the methodology of testing biocompatibility of dental materials and using modern methods and techniques of oral implantation Course description: Overview to surgicalaugmentation procedures for attached and keratinized gingiva, application of the graft to achieve anatomical requirements for endosseus iplants placement. Principles of implants of different designs; principles of osseointegration and the possibility of usingsubstitute to the bone and bone reaction Recommended literature: 1. Garg AK. Bone Biology, Harvesting, and Grafting For Dental Implants: Rationale and Clinical Applications. Quintessence Publishing Co, 2003. 2. Lambrecht TJ. 3D Modeling Technology in Oral and Maxillofacial Surgery. Quintessence Publishing Co, 2000. 3. O'Brien J. Dental Materials and Their Selection. Quintessence Publishing Co, 2003. No. of active classes: 30



Methods of teaching: laboratory work, seminars, consultation



Course title: Growth, Differentiation and Regeneration of Oral Tissues Course status: compulsory Professor in charge: Bozidar Dimitrijevic ECTS: 10 Study year: II/ 3rd

semester DS13RAST

Course prerequisites: none Learning objective: Getting the necessary knowledge of the process of growth, development and regenerative potential of hard and soft dental tissues as a precondition for further fundamental and applicative / clinical research Learning outcomes: PhD student understands the processes of growth, development and regenerative potential of dental hard and soft tissues, as well as methods for their analysis and understanding the capabilities of management of hard and soft oral tissues applying the concept of tissue engineering and nanotechnology, as well as the biological basis of the process of osseointegration when implant procedures Course description: The study of genes for mineralization of dental tissues, dental embryology and function of proteins of the extracellular matrix of normal and pathologic bone remodeling and possibilities of gene therapy and the concept of biomimetics in the treatment of periodontal tissue Recommended literature: 1. Bartold M, Sampat A. Biology of the Periodontal Connective Tissues. Quintessence Publishing Co, 2003. 2. Brunette D. Critical Thinking: Understanding and Evaluating Dental Research. Quintessence Publishing Co, 2006. 3. Lindhe J (Ed). Clinical Periodontology and Implant Dentistry. Blackwell Publishing Co, 2003. 4. Garant P. Oral Cells and Tissues. Quintessence Publishing Co, 2003. No. of active classes: 45

Lectures and practical work: Seminars


Methods of teaching: Preparation and presentation of seminar papers, consultation, „journal clubs“.



Course title: Physiological States and Systemic Diseases – Impact on Orofacial Region Course status: compulsory Professor in charge: Ljiljana Jankovic ECTS: 10 Study year: II/ 3rd

semester DS13FIZI

Course prerequisites: exam passed from the previous school year Learning objective: Introduction to molecular mechanisms in physiological conditions, and in systemic disease development. Oral medicine aspects of physiological conditions and systemic diseases. Learning outcomes: A student has acquired knowledge in physiological conditions and systemic disease development molecular mechanisms. A student has learned basic principles and techniques of molecular and cell biology in diagnostics and potential treatment. Course description: Overview of molecular mechanisms of physiological conditions. Overview of molecular mechanisms of systemic diseases. Summary of correlation of the systemic diseases with oral pathology and periodontal disease. Knowledge in early diagnostics and treatment, applying principles of molecular and cell biology. The relevance of the systemic diseases and their immuno-pathological course on the population. Literature review on the above-mentioned topics. Recommended literature: Scully C,et al . Oral Medicine And Pathology At A Glance. Taylor, 2010. Scully, C. Common Medical Conditions: A Guide for the Dental Team. 2010 Scully C, Cawson RA. Medical Problems in Dentistry. Elsevier Churchill Livingstone,200). Scully C, Cawson RA. Colour Guide To Oral Disease. Churchill-Livingstone, 2006. Scully, C. Oral and maxillofacial medicine: the basis of diagnosis and treatment. Elsevier, 2008. Lindhe, J. Clinical periodontology and implant dentistry. Wiley-Blackwell, 2008. No. of active classes: 45



Methods of teaching: theoretical, study clubs



Course title: Molecular-Genetic Studies of the Orofacial Region Course status: compulsory Professor in charge: Jelena Milašin ECTS: 10 Study year: II/3rd

semester DS13MOGE

Course prerequisites: none Learning objective: Introduction to genetic mechanisms involved in the pathogenesis of monogenic and polygenic multifactorial diseases of the orofacial and craniofacial region Learning outcomes: The student understands the genetic basis of developmental, malignant and inflammatory diseases of the orofacial region Course description: Overview of mutational events involved in monogenic diseases of the oro- and maxillofacial region (mutations leading to mineralization defects resulting in amelogenesis imperfecta and dentinogenesis imperfecta; chromosome aberrations leading to abnormal development of the craniofacial complex. Analysis of somatic genetic alterations (point mutations, genomic instability, telomere length, etc) leading to neoplastic transformation. Analysis of germline mutations (gene polymorphisms) and their role in determining the susceptibility to developing multifactorial diseases. Analysis of the role of viruses in the pathogenesis of oral and maxillofacial tumours. Epigenetic studies (hypo and hypermethylation) of orofacial tumours. Recommended literature: Alberts B, Johanson A, Lewis J, Raff M, Roberts K, Walter P. Molecular biology of the cell. Garland Science, New York, 2006. Scientific papers and reviews No. of active classes: 45






Course title: Transduction signalling Molecules in Oral Tissues in Physiological and Disease Conditions Course status : elective Professor in charge: Dragica Stojić ECTS: 10 Study year: II/4th

semester DS13TRAN

Course prerequisites: none Learning objective: Aim of the course is designed to introduce the PhD student into contemporary achievements in the molecular and cellular mechanisms involved in the control of physiological and pathological function of oral cavity organs and tissues and principles of rational therapy. Concerning the mentioned mechanisms, emphasis is given to the detailed role of transductional signalling molecules such as: NO, VEGF, BMP, TGF and HIF. Learning outcomes: The competence of each PhD student to comprehensively and critically engage in contemporary scientific achievements in this field as well as to make competent choice of the scientific problem which would be solved from basic or clinical point of view. Course description: Contemporary scientific achievements in the field of the transductional signalling molecules (NO, VEGF, BMP, TGF and HIF): synthesis, release, receptors and function. The underlying mechanisms of mentioned signalling molecules in physiological control of oral cavity organs and tissues (blood vessels, salivary glands, dental pulp, gingiva, bone tissue of jaws), as well as in disease-induced impaired function (atherosclerosis, diabetes mellitus, periodontitis). Special attention will be paid on the involvement of mentioned growth factors in the mechanisms of oral wound healing under physiological and pathological conditions. This basic science course also serves as an introduction to clinical aspects of oral tissue regenerative therapy (dental pulp, oral soft tissues, bone tissue) involving NO, VEGF, BMP, TGF and HIF. Recommended literature:

1. Stojić D, Roganović J, Brković B. Functionality of Orofacial Branches Feeding: salivary glands, dental pulp and intraoral anesthetic field.Berhardt L. Editor. In: Advances in Medicine and Biology, vol. 29.New York: Nova publishers, 2012; pp. 59-96.

2. Tziafas D, Smith AJ, Lesot H. Designing new treatment strategies in vital pulp therapy. Journal of Dentistry 2000; 28:77-92.

3. Hamdy R, Rendon J, Tabrizian M. Ch.8: Distraction Osteogenesis and Its Challenges in Bone Regeneration. Tal H. Editor. In: Bone Regeneration. Rijeka: In Tech, 2012;

4. Zohar R. Signals between cells and matrix mediate bone regeneration. Tal H. Editor. In: Bone Regeneration. Rijeka: In Tech, 2012;

5. Tal H. Augmentation and preservation of the alveolar process and alveolar ridge of bone. Tal H. Editor. In: Bone Regeneration. Rijeka: In Tech, 2012;

6. Granjeiro JM, Oliveira RC, Bustos-Valenzuela JC, Sogayar MC, Taga R. Bone morphogenetic proteins: from structure to clinical use. Braz J Med Biol Res 2005; 38: 1463-1473.

7. Riddle RC, Khatri R, Schipani E, Clemens TL. Role of hypoxia-inducible factor 1α in angiogenic-osteogenic coupling. J Mol Med 2009; 87:583-590.







Course title: Biochemical Markers in Oral Diseases Course status: elective Professor in charge: Ivan Dožić ECTS: 10 Study year: II/4th semester DS13 BIMA Course prerequisites: none Learning objective: Biochemical markers in blood and saliva is one of the most promising tools in the detection and prevention of oral-systemic diseases. Learning outcomes: Student should understand biochemical parameters in saliva and blood for investigation of basis of developmental, malignant and inflammatory diseases of orofacial region. Course description: - Review the composition of saliva and how it supports the many functions within the oral cavity. - Understand many advantages that salivary diagnostics has over methods of detection of biochemical markers. - Learn how it aids in detecting biochemical markers in saliva (blood) for the most common oral diseases, such as caries, periodontal disease, and oral cancer. - Become acquainted with the different ways of using salivary diagnostics to diagnostic systemic disease. Recommended literature: No. of active classes: 45




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 15 Test Course research study 30 Practical part 20 Colloquium 8 Oral part 20 Seminars 7


Course title: Biologically active molecules as inducers of the pulp-dentin reparation Course status : elective Professor in charge: Nevenka Teodorović ECTS: 10 Study year: II/4th semester Course prerequisites: none Learning objective: The goal of this course is to introduce the basic principles on which tissue engineerinreliesg as well as the potential of regenerative endodontic therapy procedures in dental practice. Learning outcomes: After completion of the course and study research, PhD students understand the basic principles and strategies of alternative therapies of teeth using regenerative endodontic procedures, the role of growth factors and stem cells in the apical pulp/dentine regeneration, and root canal engineering. Students are able to apply modern bioactive materials in endodontic root canal therapy. Course description: Case study of the basic principles and methodology for regenerative therapy (mainly revascularisation) in teeth with immature roots and teeth in the adult population, the possibility of use of modern drugs and bioactive ceramic endodontic materials. Emphasis on the mechanical action of bioactive mediators (growth factors), the use of stem cells, mechanisms of stimulation of reparative dentinogenesis and pulp and periapical tissues repair. Recommended literature:

1. Stephen Cohen, Richard C. Buens. Pathways of the pulp. St. Louis: Mosby 2. Dimitros Tziafas. Reparative dentinogenesis, University studio Press, Thessaloniki, 1997. 3. Ivar A. Mjor. Pulp-dentin biology in restorative dentistry. Quintessence Publishing, 2002.







Course title: Pathohistological characteristics of tumors of the orofacial region Course status: elective Professor in charge: Zvezdana Tepavčević ECTS: 10 Study year: II/4th

semester DS13PAKA

Course prerequisites: none Learning objective: The aim of this course is to give PhD students knowledge of the morphological changes and structural damage of cells, tissues and organs, as well as the ability to connect the mechanisms of pathogenesis with the consequences, which is an important prerequisite for understanding the essence of the pathological process, and therefore human malignant diseases Learning outcomes: To understand the essence of the pathological processes underlying human diseases, especially malignant diseases of the orofacial region Course description: The course introduces students to the development of morphological changes - damage of cells, tissues and organs, more specifically to the most common changes in the orofacial system, to the relationship between histopathological changes and clinical features, to diagnosis and differential diagnosis. Recommended literature: 1. Cumar, Cortran, Robbins – Pathologic basis of diseases 2. J.V.Soames and J.C.Southam – Oral pathology, Oxford Medical University No. of active classes: 45




Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 10 Test Course research study 10 Practical part Colloquium 30 Oral part 40 Seminars 10


Course title: Epidemiological studies of orofacial diseases Course status: elective Professor in charge: Aleksa B. Marković ECTS: 10 Study year: II/4th

semester DS13EPID

Course prerequisites: none Learning objective: To introduce students to the basics of epidemiological studies of diseases of the orofacial region, which include the latest diagnostic and therapeutic procedures Learning outcomes: After completing theoretical study and research, by using modern diagnostic and therapeutical techniques, the student will be able to successfully diagnose and provide appropriate treatment Course description: Epidemiological studies of diseases of the orofacial region include lectures, where students will be introduced to the latest diagnostic and therapeutic procedures in the treatment of maxillary sinus, jaw cysts, periapical lesions, and the special role of modern radiological diagnostics. In the course of scientific research the students will also get familiar with the practical application of these techniques and methods. Recommended literature:

1. Jensen, Ole T.: The Sinus Bone Graft, Second Edition. 2. Katsuyama H., Jensen SS.: Sinus floor elevation procedures, Quintessence Publishing C. Ltd, 2011 3. Langalis, Langlang and Nortie: Diagnostic Imaging of the jaws, Baltimore, Williams and Vilkins, 1995.







Course title: Quality of Life of Patients with Orofacial Diseases Course status: elective Professor in charge: Vitomir Konstantinović ECTS: 10 Study year: II/4th

Semester DS13KVAL

Course prerequisites: none Learning objective: Introducing candidate to the term and meaning of quality of life of patients with maxillofacial disseases Learning outcomes: Candidate should understand essence of quality of life of patients with diseases of maxillofacial region Course description: Candidate study term and definitions of quality of life as well as methods of objective and subjective estimation. Candidate should learn about quality of life of patients with maxillofacial trauma, jaw and face deformities, oral malignant tumors, acquired and congenital deformities of face, upper jaw and palate. Quality of life of patient’s polyhemiotherapy or radiotherapy is separately highlighted. Also, he/she meets with implantological systems which are used in patients with inadequate bone dimensions of jaws. Recommended literature:

1. Miloro M, Peterson LJ. Peterson`s principles of oral and maxillofacial surgery. 3rd ed. Shelton, CT : People's Medical Pub. House-USA, 2012

2. Fonseca RJ et al. Oral and Maxillofacial trauma. 4th edition. St. Louis, Mo. Elsevier/ Saunders, 2013 3. Reyneke JP. Essentials of orthognathic surgery. 2nd ed. Chicago: Quintessence, 2010 4. Beumer J, Curtis TA, Nishimura R, Beumer J, editors.Maxillofacial rehabilitation: prosthodontic and

surgical considerations. St.Louis: Ishiyaku EuroAmerica Inc.; 1996; Radiation therapy of head and neck tumors: oral effects, dental manifestations, and dental treatment. 43-72.

5. Bjordal K, Hammerlid E, Ahlner-Elmqvist M, et al., for the European Organization for Research and Treatment of Cancer Quality of Life Study Group. Quality of Life in Head and Neck Cancer Patients: Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35 Journal of Clinical Oncology, 1999; 17:1008

6. Byrne M. Cancer chemotherapy and quality of life: cancer trials should include measures of patients’ well-being. Br Med J 1992; 304: 1523-4.

7. Camilleri-Brennan J, Steele R.J.C. Measurement of quality of life in surgery. J.R.Coll.Surg.Edinb., 1999; 44: 252-9.

8. Gritz ER, Carmack C L, de Moor C, et al. First Year After Head and Neck Cancer: Quality of Life. Journal of Clinical Oncology, 1999; 17: 352.

9. Konstantinović, V.S. Quality of life after surgical excision followed by radiotherapy for cancer of the tongue and floor of the mouth: evaluation of 78 patients. J Cranio Max.-fac Surg. 1999;27:192-197.

10. List MA, Siston A, Haraf D, Schumm P, Kies M, Stenson K, Vokes E. Quality of life and performance in advanced head and neck cancer patients on concomitant chemoradiotherapy: a prospective examination. J Clin Oncol 1999; 17: 1020-8.

11. Moore GJ, Parsons JT, Mendenhall WM. Quality of life outcomes after primary radiotherapy for squamous cell carcinoma of the base of tongue. Int J Radiat Oncol Biol Phys 1996; 36: 351-4.

12. Slevin ML, Plant H, Lynch D, Drinkwater J, Gregory WM. Who should measure quality of life, the doctor or the patient? Br J Cancer 1988; 57: 109-12.





Grading (max 100 points): Exam pre-requisites 60 points Final exam 40 points Activity during classes 20 Test 20 Course research study 20 Practical part Colloquium Oral part 20 Seminars 20

http://www.worldcat.org/search?q=au%3AReyneke%2C+Johan+P.&qt=hot_author


Course title: Research and Defining Risk of Occurrence of Orofacial Diseases and Teeth Injuries Course status : elective Professor in charge: Zoran Vulićević ECTS: 10 Study year: II/4th

semester DS13RIZI

Course prerequisites: none Learning objective: is to introduce students to modern understanding of the etiology and how to explore risk factors for oral disease Learning outcomes: the student has acquired the methodology for studying the etiology of oral diseases and the assessment of risk for oral disease, with emphasis on the tests for early diagnosis of risk factors for oral disease. Course description: students will be introduced to contemporary understanding of the aethiology and how to explore risk factors for oral diseases, how to determine risk factors and how to apply their knowledge to design studies aimed at defining risk factors for oral diseases. Recommended literature: 1. JJ Murray, J Nunn , JG Steele. The Prevention of Oral Disease. Oxford University Press,2003 2. NO harris, FG Godoy. Primary Preventive Dentistry, Prentice Hall, 2003 3. RR Tierman. Risk Managament in General Dental Practice, 2004 4. P Axelsson . Diagnosis and risk prediction of dental caries. Quintessence Publishing No. of active classes: 45






Course title: Experimental Research of Periodontal Tissues Course status: elective Professor in charge: Zoran Aleksic ECTS: 10 Study year: II/4th

semester DS13POTP

Course prerequisites: exam passed from the previous school year Learning objective: Introduction to the concepts of active and passive regeneration. Introduction to the concepts of bioengineering. Learning outcomes: Up-to-date knowledge on active and passive regeneration application, as well as on the use of bioengineering principles in regenerative periodontal treatment. Course description: Overview of concepts of passive and active regeneration in periodontal regenerative treatment. Treatment possibilities applying contemporary concepts in regenerative flap surgery, periodontal plastic surgery, pre-prosthetic surgery and oral implantology. Experimental analysis of soft and hard tissue augmentation procedures in oral implantology. Augmentation procedures’ impact on osseointegration and wound healing in oral implantology. Introduction to biomimetics and bioengineering principles in periodontology and implantology. Literature review on the above-mentioned concepts. Recommended literature: Lindhe, J. Clinical periodontology and implant dentistry. Wiley-Blackwell, 2008. Bartold M, Narayanan AS. Biology of the Periodontal Connective Tissues. Quintessence Publishing Co, 2003. Cochran D. Biomimetics in Periodontal Regeneration. Quintessence Publishing Co, 2003. Lynch SE ,Genco R, Marx RE. Tissue Engineering: Applications in Maxillofacial Surgery and Periodontics. Quintessence Publishing Co, 2000. Romanos GE. Immediate Loading of Endosseous Implants in the Posterior Area of the Mandible: Animal and Clinical Studies. Quintessence Publishing Co, 2005. No. of active classes: 45



Methods of teaching: theoretical, study clubs



Course Title: Prospective and Retrospective Research in Rehabilitation of the Orofacial Complex Professor in charge: Ljiljana Tihaček Šojić Course status: elective Number of ЕCTS: 10 Prerequisit for examination (courses passed from the previous years): /

Study year: II / 4th semester

DS13OROF

Learning objective: To train a PhD student to acquire a basic level of scientific preconditions for applying in the scientific research. Also, to train the students to critically examine and review scientific information, to apply the procedures and methods that are based on the scientific facts, minimizing the errors in diagnostic procedure thus providing the optimal choice of the therapeutical modality. Learning outcomes : After completing this course, the student will be able to look at the problems of orofacial rehabilitation, analyzes them, and set the possible scientific research Course description: The course deals with the various topics in the field of prosthetics and rehabilitation of the orofacial system using different dental restorations. Special attention is given to research methods in the field of prosthodontics Literature Ј. Peat, E. Elliott, L. Baur, V. Keena. Scientific Writing. London: BMJ Books, 2002 T. Greenhalgh. How to Read a Paper. London: BMJ Books, 2001. GM Hall. How to Write a Paper. London: BMJ Books, 1998. GM Hall. How to Present at meetings. London: BMJ Books, 2001 F. Chiappelli, P. Prolo, M. Newman, M. Cruz, E. Sunga, E. Concepcion and M. Edgerton Evidence-based Practice in Dentistry: Benefit or Hindrance. J Dent Res 2003 82: 6 Total number of classes in active teaching per academic year Lectures: 45

Other types of teaching: Study research work: 60

Professional practice

Methods of teaching: lectures, lab work, seminars Exam score (max score number 100)

Activties before the exam 60 points Final exam 40 points Lecture activity 20 Test Study research work: 40 Practical exam Colloquim Oral exam 40 Seminars


Course title: Prospective and Retrospective Research of Dental Tissue Reconstruction Course status:elective Professor in charge: Slavoljub Živković ECTS: 10 Study year: II/4th

semester DS13REZU

Course prerequisites: none Learning objective: Introduction to prospective and retrospective research of etiology, pathogenesis, therapy and repair of damaged pulp and apical periodontium Learning outcomes: Understanding of importance of inflammation mediators and specific and nonspecific immune response during the inflammation and repair of pulp and apical periodontium. A student should also understand the effects of materials used in endodontic and restorative therapy. Course description: The course includes prospective and retrospective research of etiology, pathogenesis, therapy and repair of damaged pulp and apical periodontium. Studies about inflammation and immune response should help students understand the effects of materials used in endodontics and restorative therapy. Recommended literature:

4. Mahmoud Torabinejad, Richard E. Walton „Principles and Practices of endodotics, WB Saunders Company, 2002

5. Michael Hulsmann, Edgar Schafer, Problems in Endodontics, Etiology, Diagnosis and Treatment, Quintessence Publishing, 2009

6. William J, O Brien. Dental material and their selection. Quintessence Publishing C, 1997. 7. Summit JB, Robbins JW, Schwartz RS. Fundamentals of operative dentistry. Chicago,

Quintessence, 2001. No. of active classes: 45





Documents

PhD ACADEMIC STUDIES pl… · Radiographic procedures in dentistry . 13. ... Lectures and practical work (analysis of scientific papers, writing and analysis of researches and PhD